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Inhibition of sulfate-reducing bacteria influenced corrosion on hydrophobic poly(dimethylsiloxane)coatings

Journal of Materials Science & Technology 2020年第17期52卷 198-206页

作者： Innocent O.Arukalam c.n.njoku Lihui Yang Baorong Hou Ying Li corrosion and Protection Division Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shenyang national Laboratory for Materials Science Northeastern UniversityShenyang 110819China Department of Polymer and Textile Engineering Federal University of TechnologyP.M.B.1526 Owerri Nigeria Key Laboratory of Marine Environmental corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071China Open Studio for Marine corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Advanced Functional Materials/corrosion Research Group Africa Centre of Excellence in Future Energies and Electrochemical Systems(ACE-FUELS)Federal University of Technology Owerri(FUTO)Nigeria

Sulfate-reducing bacteria(SRB)has been pointed out as one of the causative agents of microbial induced corrosion in the marine *** address this problem,novel strategies are being experimented as against the earlier methods which have been banned due to their toxic effects on useful aquatic ***,the aim of this study was to investigate the effect of non-toxic perfluorodecyltrichlorosilane(PFDTS)on resistance of hydrophobic poly(dimethylsiloxane)/phosphoric acid-treated zinc oxide(PDMS/PA-treated ZnO)coatings to SRB-induced biofouling and *** surface features of the coatings before and after exposure to SRB/nacl solution were analyzed by scanning electron microscopy(SEM).Wettability of the coatings before and after exposure was also *** interaction of SRB with the coatings was investigated by FTIR *** resistance performance of the modified coatings against SRB-induced corrosion was monitored by electrochemical impedance spectroscopy(EIS).The EIS measurements revealed that 0.20 g PFDTS-based coating displayed highest corrosion resistance with impedance modulus of 6.301×10^10 after 15 d of exposure to SRB/nacl *** results were corroborated by surface and chemical interaction analyses,and thus,indicate that 0.20 g PFDTSmodified PDMS/PA-treated ZnO coating has potentials for excellent SRB-induced corrosion resistance and anti-biofouling performance.

关键词： corrosion Hydrophobic coating Perfluorodecyltrichlorosilane Poly(dimethylsiloxane) Sulfate-reducing bacteria

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Antifertility and profertility effects of the leaves and seeds of fluted pumpkin:Sperm quality,hormonal effects and histomorphological changes in the testes of experimental animal models

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Journal of Integrative Medicine 2021年第2期19卷 104-110页

作者： Rex-clovis c.njoku Sunny O.Abarikwu Department of chemistry&Molecular Biology Alex Ekwueme-Federal UniversityNdufu-AlikeIkwoP.M.B.1010AbakalikiNigeria Department of Biochemistry University of Port HarcourtChoba.P.M.B.5323Port HarcourtNigeria

Fluted pumpkin(FP;Telfairia occidentalis)is an edible vegetable,grown in West Africa,that is used in traditional medicine for its regulatory effects on the male *** articles concerning the effects of FP were identified by searching PubMed,Pubchem,Scopus,Springer,ResearchGate,Google Scholar and Web of Science;this literature was to better understand the effects of FP seed(FPS)and leaf(FPL)extracts on the *** showed that in experimental animals extracts of FPL and FPS at 1/100 of the lethal dose promoted testis regeneration and improved testosterone concentration and sperm quality,while at higher doses they had antifertility *** extracts of FPS and FPL,including ethanol,aqueous,methanol and hydroethanolic,had protective effects on the testes of study animals at lower doses(>50 mg/kg body weight),but at higher doses(>200 mg/kg body weight)they inhibited hormone synthesis,sperm quality and histomorphological structure,under both normal and disease *** posttreatment effects of FPS on the gonads were reversible in young mature rats and FPS had slight systemic toxic ***,there are inconsistencies in some of the published results,the current evidence suggests that FPS and FPL have both profertility and reversible antifertility effects in experimental animals.

关键词： Fluted pumpkin Sperm Male reproduction Seeds Fertility

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia nürnberger Barbara Schaedl James Ferguson nicole Swiadek Xavier Monforte Johannes c.Heinzel Antal nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tnGcs). However, the use of tnGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tnGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tnGcs and compared the various features of these improved silk^(+) tnGcs with the tubes without holes(silk^(–) tnGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tnGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tnGcs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tnGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tnGcs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton cellular communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced center for chronic Diseases(AccDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(cD90)

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The second brain in Parkinson’s disease: fact or fantasy?

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neural Regeneration Research 2022年第8期17卷 1737-1738页

作者： nehal Yemula Paul njoku Joseph Takyi James Paget University Hospital Lowestoft Road Gorleston-on-SeaGreat YarmouthUK norfolk and norwich University Hospital Colney LaneNorwichUK Pinderfields Hospital Aberford WayWakefieldUK

Parkinson’s disease(PD)is a movement disorder characterized by reduced dopamine levels due to degeneration of the substantia *** clinical presentation is underlined by bradykinesia,postural instability,and *** is the second most common neurodegenerative disease worldwide,with a huge monetary *** the United States alone,it is estimated that in 2017,the total economic cost was$51.9 billion,and projected to surpass$79 billion by *** research has been conducted into the pathophysiology and clinical implications of the *** neurodegenerative disorder itself,the entity involving the brain-gut axis has been a fundamental model in understanding the disease *** so than ever in PD,the association between gut health and neurological disease is gaining momentum,with the fascinating idea of influencing neurological health by treating the gut.

关键词： degeneration clinical dopamine

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén cieri Alberto Javier Ramos Laboratorio de neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRnAs or lncRnA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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Sex differences in aging and injured brain

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neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan n.Williamson Yuan Yang University of Illinois Urbana-champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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controversies in fecal incontinence

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World Journal of Gastroenterology 2025年第3期31卷 113-119页

作者： Andreia Albuquerque Satish S c Rao School of Medicine and Biomedical Sciences Fernando Pessoa UniversityGondomar 4420-096PortoPortugal Precancerous Lesions and Early cancer Management Research Group RISE@cI-IPO(Health Research network) Portuguese Oncology Institute of PortoPorto 4200-072Portugal Division of Gastroenterology and Hepatology Department of Internal MedicineAugusta UniversityAugustaGA 30912United States

Fecal incontinence is a common condition that can significantly impact patients’quality of *** anal sphincter injury and anorectal surgeries are common *** ultrasound and anorectal manometry are important diagnostic tools for evaluating *** are various treatment options,including diet,lifestyle modifications,drugs,biofeedback therapy,tibial and sacral nerve neuromodulation therapy,and *** this editorial,we will discuss current controversies and novel approaches to fecal *** for asymptomatic anal sphincter defects after obstetric anal sphincter injury and in patients with inflammatory bowel disease is not generally recommended,but may be helpful in selected *** Garg incontinence score is a new score that includes the assessment of solid,liquid,flatus,mucous,stress and urge fecal *** tests such as translumbosacral anorectal magnetic stimulation and novel therapies such as translumbosacral neuromodulation therapy are promising diagnostic and treatment options,for both fecal incontinence and *** biofeedback therapy can overcome some limitations of the office-based *** muscle-derived cell implantation of the external anal sphincter has been further studied as a possible treatment *** neuromodulation may be useful in scleroderma,congenital fecal incontinence and inflammatory bowel disease but merits further study.

关键词： Fecal incontinence Endoanal ultrasound Anal sphincter defects Biofeedback neuropathy Sacral neuromodulation

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： David Vc Brito clévio nóbrega Algarve Biomedical center-Research Institute(ABc-RI) Campus GambelasFaroPortugal Algarve Biomedical center-(ABc) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMcB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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