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Risk of control failure to insecticides malathion,profenophos+cypermethrin mixture,and fipronil in boll weevil(coleoptera:curculionidae)populations from Bahia,Brazil

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Journal of cotton Research 2023年第4期6卷 240-249页

作者： cOELHO Beatriz S. leite Suzany A. dos santos Mateus P. GUEDES Raul N.c. BASTOS cristina S. MOREIRA Aldenise A. BONFIM Joao E.V. cASTELLANI Maria A. Department of crop Science and Animal Science State University of Southwestern BahiaVitória da ConquistaBA 45031‑900Brazil Department of Entomology Federal University of VicosaVicosaMG 36570‑900Brazil Faculty of Agronomy and Veterinary University of BrasíliaBrasíliaDF 70910‑900Brazil Bonfim Industry and commerce Ltd Varzéa Grande FarmBom Jesus da LapaBA 47600‑000Brazil Departament of crop Science and Animal Science State University of Southwest BahiaVitória da ConquistaBA 45031‑900Brazil.

Background To control the boll weevil Anthonomus grandis grandis(coleoptera:curculionidae),a key pest of cotton in the Americas,insecticides have been intensively used to manage their populations,increasing selection pressure for resistant ***,this study aimed to detect insecticide resistance and assess insecticide control failure likelihood of boll weevil populations exposed to malathion,profenophos+cypermethrin,and fipronil *** Twelve populations of the boll weevil were collected from commercial cotton fileds of the state of Bahia,northeastern *** populations were exposed to malathion,profenophos+cypermethrin mixture,and fipronil,at their respective maximum label dose for field *** replicates of 10 adult beetles were exposed to the insecticides and mortality was recorded after 24 h *** control failure likelihood was determined after 48 *** median lethal times(LT_(50))were observed for malathion and the profenophos+cypermethrin *** to at least one insecticide was detected in 11 populations;three populations were resistant to malathion and profenophos+cypermethrin;seven were resistant to all insecticides *** resistance levels were low(cant risk of control failure for the insecticides malathion and profenophos+*** insecticide fipronil was efficient for the control of the boll weevil in 83%of the *** The results confirm the significant risk of insecticide control failure in the boll weevil populations to the main compounds used in the ***,proper insecticide resistance management plans are necessary for the boll weevil in the region,particularly for malathion and profenophos+cypermethrin insecticides.

关键词： Anthonomus grandis grandis cotton pests Pest insect resistance management Insecticide control failure

Therapeutic Approaches to Post-Mastectomy Pain Syndrome

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Journal of Biosciences and Medicines 2023年第12期11卷 304-317页

作者： Vanessa Ferreira Dias Duarte Da costa Giovanna Schwarz Mazzucca carlos Augusto Pires Zerbini Oscar césar Pires c.mila dos santos leite Laboratory of Pharmacology and Physiology Department of Medicine Taubaté University Taubaté Brazil

Background: Breast cancer is increasingly common in society and post-mastectomy pain is a striking condition associated with surgery, both intra and postoperatively. The post-mastectomy syndrome is characterized by the persistence of pain for more than 3 months after the procedure. It is mostly of neuropathic origin and is highly refractory to treatments, which vary from clinical to surgical measures and alternative techniques. In this context, it is essential to understand the possible approaches to these patients. Objective: Understand alternatives for pain management in patients undergoing mastectomy, especially in those in whom pain persists for more than 3 months. Methods: Systematic literature review, conducted in the Virtual Health Library databases includes: Lilacs, SciELO, Medline, PubMed and cochrane between 2018 and 2023, restricted to articles in English with the descriptors: Mastectomy, chronic Pain, Nerve Blocks and Breast cancer. 317 articles were found involving the descriptors presented, all in English. After reading the abstracts, 28 articles were selected. Results: This review analyzed 28 scientific studies that rigorously met the previously established characteristics in the sample selection. The synthesis included the following aspects: author/year of publication, article title, objective, type of study and database. conclusion: It was concluded that, according to the analyzed studies, post-mastectomy pain is a problem that has increased its incidence and that needs the attention of health professionals. The use of antineuropathic medications, nerve blocks, fat grafting, lymph node transplantation, therapy, physical activity and acupuncture are some examples of therapeutic approaches for these women. Therefore, the team must assist the patients, seeking to provide a better prognosis, quality of life and comfort.

关键词： Mastectomy chronic Pain Nerve Blocks Breast cancer

Approach to Pain in Endometriosis Patients: Systematic Literature Review

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Journal of Biosciences and Medicines 2022年第11期10卷 1-27页

作者： Vanessa Ferreira Dias Duarte da costa Maria Eduarda Pazini Modesto Gonçalves c.mila dos santos leite Oscar césar Pires Laboratory of Pharmacology and Physiology Medicine Department Taubaté University Taubaté Brazil Laboratory of Immunopharmacology and Molecular Biology S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazil

Background: Endometriosis is a gynecological, multifactorial condition that affects women’s life quality, especially due to the pain inherent to it. Pain is caused by physical and psychological aspects;therefore, several factors must be analyzed, aiming to treat the whole. conventional, drug or surgical treatments are the most used;however, the search for alternative therapeutic methods is growing. Objective: To analyze the approach to pain in women with endometriosis, seeking a better understanding of the pathophysiological mechanisms of this disease, its impact on life quality, as well as the means of treatments in use and innovations in this field. Methods: Systematic literature review, conducted in the Virtual Health Library databases between 2010 and 2021, restricted to articles in English and Portuguese with the descriptors: Endometriosis, Pain, and Treatment. After reading the abstracts, 197 articles were found, and, after reading them, 59 articles were selected. Results: This review analyzed 59 scientific studies that rigorously met the previously established characteristics in the sample selection. The synthesis included the following aspects: author/year of publication, article title, objective, type of study and database. Related factors such as acute or chronic pain, late diagnosis, discrediting symptomatic complaints and trivialization by health professionals have a profound impact on the physical and mental health of women with endometriosis. On the other hand, there are several classes of drugs, surgical procedures, and alternative therapies available for pain management. conclusion: Given the context addressed, a certain need is suggested for health professionals to better understand the disease and adopt new behaviors or improve existing ones, such as reception, active listening, early diagnosis and comprehensive and individualized treatment. In addition, further studies are needed regarding alternative therapies, seeking to expand the scientific ev

关键词： Endometriosis Pain Treatment

Medical School Students’ Knowledge of Pain and Palliative care: An Observational Study

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Journal of Biosciences and Medicines 2023年第4期11卷 39-49页

作者： carolina Koutras Jacob Marina Perini carlos Augusto P. Zerbini Marta H. R. Pires c.mila dos santos leite Oscar césar Pires Laboratory of Pharmacology and Physiology Medicine Department Taubaté University Taubaté Brazil Vera cruz Hospital Campinas Brazil Laboratory of Immunopharmacology and Molecular Biology S&atildeo Francisco University Medical School Bragan&ccedila Paulista Brazil Laboratory of cell and Molecular Tumor Biology and Bioactive compounds S&atildeo Francisco University Medical School Bragan&ccedila Paulista Brazil

Background: Pain and palliative care are a reality in daily routines of medical treatment. However, the theoretical-practical curricula of traditional medical school course still unsatisfactorily contemplate pain management, as well as the palliative care approach. Objective: To assess the knowledge of medical students about pain and palliative care, as well as to identify their perception of teaching these topics during hospitalization. Methods: A cross-sectional observational study, with a descriptive and exploratory approach, data collection for which was carried out between August and November 2020. The target population was medical students, who responded to an online survey of a quantitative, anonymous and follow-up nature. The survey study variables concerned knowledge about pain management and palliative care. Results: An expressive majority of academics showed difficulty in understanding the pathophysiology of pain related to prescribing drugs for pain management purposes, and all of them believe that it is necessary to acquire more knowledge about pain treatment. In parallel, only 9.3% report having received sufficient information regarding palliative care during medical school. conclusion: The results suggest a certain lack of knowledge and insecurity among medical school students with respect to pain management and care for patients receiving palliative care. The didactical approach to this theme is still deficient in the medical curriculum and requires immediate improvement and new proposals that address the training of these professionals in a more specific and effective way.

关键词： Pain Palliative care Medical Students Academic Institutions

Effects of Ketoprofen, Ketamine, Lidocaine and Propofol on Fentanyl-Induced Hyperalgesia in Rats

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Journal of Biosciences and Medicines 2022年第7期10卷 53-63页

作者： c.mila dos santos leite Naira correia cusma Pelógia Eliane Stevanato Marília Hidalgo Uchôas Gabriela Apóstulo Silva Guilherme Apóstulo Silva carlos Augusto Pires Zerbini Marta Helena Rovani Pires Oscar césar Pires Laboratory of Immunopharmacology and Molecular Biology S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazil Laboratory of cell and Molecular Tumor Biology and Bioactive compounds S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazi Laboratory of Pharmacology and Physiology Medicine Department Taubaté University Taubaté Brazil Vera cruz Hospital Campinas Brazil

Opioid-induced hyperalgesia negatively affects physiological pain management and presents a complex causal mechanism, involving, pharmacodynamic and pharmacokinetic factors of interactions with receptors, opioid-independent ascending systems and with pro-nociceptive systems. After approval by the cEUA, 42 male Wistar rats were divided into 7 groups: In group 1 (GcSSL) the animals received 1 ml of 0.9% saline solution intraperitoneally (IP);in group 2 (GFTSL), they received fentanyl at a dose of 100 ug·kg-1 IP;in the remaining groups (3, 4, 5, 6 and 7) the animals received IP, fentanyl at a dose of 100 ug·kg-1 followed also by IP route of: group 3 (GFTKP) ketoprofen at a dose of 5 mg·kg-1;group 4 GFTKT), ketamine up to a dose of 10.0 mg·kg-1;group 5 (GFTLI), incisional lidocaine up to a dose of 10 mg·kg-1;group 6 (GFTLP), intraperitoneal lidocaine up to a dose of 10 mg·kg-1 and group 7 (GFTPP), propofol up to a dose of 60 mg·kg-1. Under general anesthesia, all animals with a plantar surgical incision. Hyperalgesia was evaluated by applying Von Frey filaments on the 2nd, 1st, 3rd and 5th days after treatment. In the 2nd hour and on the 5th day after the procedure, there was no hyperalgesia associated with the use of fentanyl, however, on the 1st and 3rd postoperative days there was hyperalgesia that was attenuated by ketoprofen, ketamine, lidocaine infiltrated in the incision and intraperitoneally, an effect not observed with the use of propofol. The results suggest fentanyl-induced hyperalgesia and the efficacy of ketoprofen, ketamine, incisional lidocaine and intraperitoneal lidocaine in reducing this effect.

关键词： Hyperalgesia Fentanyl Ketoprofen Ketamine Lidocaine Propofol Rats

Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America

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World Journal of Gastroenterology 2020年第44期26卷 6993-7004页

作者： Flora Maria Lorenzo Fortes Ney Boa Sorte Victor D Mariano Laila D Andrade Fernanda A Oliveira Monique cA santos claudia Ivanilda N dos santos catharina A Passos mila P Pacheco Valdiana c Surlo Neogelia P de Almeida Jaciane AM Fontes Andrea M Pimentel Raquel Rocha Genoile Oliveira Santana Pharmaceutical Sciences Pos-graduation Program State University of BahiaSalvadorBA 40460-120Brazil Outpatient Gastroenterology Unit General Hospital Roberto SantosSalvadorBA 40286-901Brazil Life Sciences Department State University of BahiaSalvadorBA 41150-000Brazil Department of Medicine FTC UniversitySalvadorBA 41741-590Brazil Department of Sciences of Nutrition School of NutritionFederal University of BahiaSalvadorBA 41701-035Brazil

BAcKGROUND There has been an increase in cases of inflammatory bowel disease(IBD)in recent *** is also greater access and availability of immunosuppressive and biological agents,which increase the risk of opportunistic infection despite improving the quality of life and promoting mucosal ***(TB)remains a public health problem,and it has a high incidence in several ***,knowledge of the risk of developing TB in patients with IBD is *** To evaluate the risk of active TB in patients with IBD under treatment from an endemic area in Latin *** A standard questionnaire included demographic variables,clinical aspects of IBD disease,history of active TB during treatment,active TB characteristics and evolution,initial screening and results and time from the start of anti-tumor necrosis factor alpha(TNFα)to TB *** Azathioprine,anti-TNFα and the combination of these two drugs were associated with a higher risk of active TB *** TNFα blockers increased the relative risk of developing active TB compared to other *** four multivariable models showed that the use of TNFα blockers alone or in combination with azathioprine was an important risk factor for the incidence of active *** adjustment for sex,age,type of IBD and latent TB,anti-TNFα with azathioprine increased the relative risk to 17.8 times more than conventional *** TB,which was diagnosed 3 mo after the start of anti-TNFα,was the most *** Treatment with anti-TNFα increased the risk of active TB in IBD patients from an endemic area in Latin *** risk was increased when anti-TNFα was combined with *** time from the beginning of the treatment to the active TB diagnosis suggests a new TB infection.

关键词： Inflammatory bowel disease Therapy Tumor necrosis factor alpha Relative risk Tuberculosis Latent tuberculosis

Musculoskeletal Pain in Medical Students Subject to Remote Teaching during the cOVID-19 Pandemic

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Journal of Biosciences and Medicines 2021年第8期9卷 92-19页

作者： Isabela de Paiva Gomes Vivian Mitleton Luiz Gustavo Benedetti Fiorin c.mila dos santos leite Oscar césar Pires Medicine Department Taubaté University Taubaté Brazil

Musculoskeletal pain is a consequence of repetitive strain, overuse, and work-related musculoskeletal disorders. In 2020, due to the new coronavirus pandemic, social isolation started, and so did online classes in a remote study strategy to replace classroom-based study routines. Thus, students adopted a different physical posture from the usual one for a longer time than usual, representing a possible risk factor for musculoskeletal pain. In this sense, this research aimed to identify the occurrence of musculoskeletal pain in medical students subject to distance learning during the cOVID-19 pandemic. A cross-sectional, descriptive and exploratory study was applied through an online questionnaire, using the Google Forms application, to 154 students from the first to the fourth year of the medical course at a university in the countryside of the state of S?o Paulo. Among the participants, 99 (64.3%) were female, and 54 (35.7%) were male individuals with ages ranging from 18 and 34. In regards to the daily study time in sitting position, 83 (55.0%) reported staying more than 4 hours, 39 (25.8%) between 2 and 4 hours, and 29 (19.2%) less than 2 hours still. As for musculoskeletal pain before the pandemic;98 (63.6%) reported not feeling it, while 56 (36.4%) reported being affected by this type of pain. However, after the pandemic, 51 respondents (33.1%) continued not to feel anything, whereas 103 (66.9%) kept on having some type of musculoskeletal pain. The results obtained suggest an increase in musculoskeletal pain during the pandemic however other studies may confirm these findings.

关键词： Musculoskeletal Pain Medical Students Remote Teaching cOVID-19 Pandemic

Effects of Dexamethasone, clonidine, Tramadol and Nalbuphine on Fentanyl-Induced Hyperalgesia in Rats

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Journal of Biosciences and Medicines 2021年第12期9卷 87-97页

作者： c.mila dos santos leite Naira correia cusma Pelógia Eliane Stevanato Marília Hidalgo Uchôas Marta Helena Rovani Pires Oscar césar Pires Laboratory of Immunopharmacology and Molecular Biology S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazil Laboratory of cell and Molecular Tumor Biology and Bioactive compounds S&atilde o Francisco University Medical School Bragan&ccedil a Paulista Brazil Laboratory of Pharmacology and Physiology Medicine Department Taubaté University Taubaté Brazil Vera cruz Hospital Campinas Brazil

Opioids are drugs used to alleviate pain. However, studies have demonstrated that these drugs can cause an increase in pain sensitivity, which is called opioid-induced hyperalgesia. The objective of this study was to describe the effects of dexamethasone, clonidine, tramadol and nalbuphine on fentanyl-induced hyperalgesia in rats. After obtaining approval from the committee for the Ethical Use of Animals (cEUA), 36 male Wistar rats were divided into 6 groups: Group 1 (GcSSL) wherein the rats received 1 ml 0.9% saline solution in two injections;Group 2 (GFTSL), received fentanyl at a dose of 100 ug·kg-1 followed by 1 ml 0.9% saline solution via intraperitoneal;the remaining groups (3, 4, 5, 6) received fentanyl at a dose of 100 ug·kg-1 following doses via intraperitoneal: Group 3 (GFTDX), dexamethasone at a dose of 1.0 mg·kg-1;Group 4 (GFTcL), clonidine at a dose of 20 mg·kg-1;Group 5 (GFTTR), tramadol at a dose of 50 mg·kg-1, and Group 6 (GFTNB), nalbuphine at a dose of 5 mg·kg-1. Under general anestesia using isoflurane, the animals were submitted to a surgical incision. Hyperalgesia was evaluated by applying Von Frey filaments at 2 hours after the incision and on the 1st, 3rd and 5th days afterward. At 2 hours after the surgical procedure, there was lower intensity of pain in the fentanyl group (GFTSL) compared to the other groups, and on the fifth day there were no significant differences for pain intensity between groups. The results suggest the presence of fentanyl-induced hyperalgesia and efficacy in its reduction by dexamethasone, clonidine, tramadol and nalbuphine.

关键词： Hyperalgesia Fentanyl Dexamethasone clonidine Tramadol Nalbuphine Rats

Morphological Patterns of a Hymenopteran Gall on the Leaflets of caryocar brasiliense camb.(caryocaraceae)

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American Journal of Plant Sciences 2012年第7期3卷 921-929页

作者： Ana carolina Ribeiro de castro Germano Leao Demolin leite Denis coelho de Oliveira Rosy Mary dos santos Isaias Departamento de Botanica Universidade Federal de Minas Gerais(UFMG)Belo HorizonteBrasil Instituto de ciências Agrárias Universidade Federal de Minas Gerais(UFMG)Montes ClarosBrasil Instituto de Biologia Universidade Federal de Uberlandia(UFU)UberlandiaBrasil

Anatomical studies in the leaflet globoid galls of caryocar brasiliense, the “pequi”, aimed to answer how oviposition and the feeding behavior of the galling herbivores altered the morphogenical patterns of the host plant. c. brasiliense globoid gall was 1.28 ± 0.20 mm × 0.90 ± 0.25 mm, with hairy surface;it is sessile and projected to the abaxial surface. Young galls were red while the mature ones were green. Preferentially, they were formed next to leaf margin and possessed one larval chamber containing a single galling specimen. Gall epidermis was uniseriate, with thicker cuticle and more hairy. In some spots, epidermis was substituted by periderm, which indicated the expression of a character usually absent in the leaf laminas. Morphological and anatomical features of these gall morphotype, such as its position in leaf lamina, the fact of being truly closed galls, with typical nutritive tissue involved by sclerenchyma, made them next to the pattern proposed for galls induced by some Hymenoptera.

关键词： Gall Anatomy Hymenoptera Morphogenesis Pequi