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l1 is a potential marker for poorly-differentiated pancreatic neuroendocrine carcinoma

World Journal of Gastroenterology 2006年第1期12卷 94-98页

作者： Jussuf T Kaifi Ulrich Zinnkann Emre F Yekebas paulus G Schurr Uta Reichelt Robin Wachowiak Henning c Fiegel Susann petri Melitta Schachner Jakob RIzbicki Department of General Visceral and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfHamburgGermany Institute for pathology University Medical Center Hamburg-EppendorfHamburgGermany Department of pediatric Surgery University Medical Center Hamburg-EppendorfHamburgGermany center for Molecular Neurobiology University Medical Center Hamburg-EppendorfHamburgGermany

AIM： To determine the expression of l1 in pancreatic neuroendocrine tumor and to correlate it with WHO classification of this tumor. METHODS： We retrospectively analyzed l1 expression in 63 cases of pancreatic neuroendocrine tumor by immunohistochemistry on paraffin sections of primary tumors or metastases. Staining was performed by peroxidase technique with monoclonal antibody U3127.11 against human l1. All tumors were classified according to WHO classification as well-differentiated neuroendo- crine tumors and carcinomas or poorly-differentiated neuroendocrine carcinomas. RESUlTS： lI was detected in 5 （7.9%） of 63 pancreatic neuroendocrine tumors. Four （44.4%） of 9 poorlydifferentiated carcinomas expressed l1. In contrast, only 1 （1.9%） of 54 well-differentiated tumors or carcinomas was positive for lI. No expression was found in langerhans islet cells of normal pancreatic tissue. cross table analysis showed a significant association between l1 expression and classification of neuroendocrine tumors of the pancreas （p〈0.01）. cONclUSION： l1 is specifically expressed in poorlydifferentiated pancreatic neuroendocrine carcinomas that are known to have the worst prognosis. l1 might be a marker for risk prediction of patients diagnosed with pancreatic neuroendocrine carcinomas.

关键词： Neuroendocrine pancreatic tumor Tumor markers cell adhesion molecules l1

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Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis

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World Journal of Hepatology 2017年第35期9卷 1278-1285页

作者： Suelen A S Miozzo Jorge A John Marcelo c Appel-da-Silva Isabella A Dossin cristiane V Tovo Angelo A Mattos Graduate program in Medicine HepatologyUniversidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre CEP 90430-080Brazil

AIM To investigate whether the use of proton pump inhibitors(ppIs) increases the incidence of spontaneous bacterial peritonitis(SBp) in patients with cirrhosis and *** An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. patient charts were reviewed to collect information on the variables of interest as the use of ppIs. primary outcome was defined as development of SBp during the study period. SBp was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of *** Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis c virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBp undergoing secondary prophylaxis and 22 patients with insuffic.ent ppI data were further excluded. Of 258 patients with ascites, 151 used ppIs, and 34 developed SBp(22.5%). Among 107 non-users of ppIs, 23 developed SBp(21.5%)(HR = 1.44, 95%cI: 0.85-2.47, p = 0.176). The median follow-up time of patients using ppI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBp revealed a significant association of SpB with the severity of liver disease according to the child-Turcotte-pugh(cTp) score. Multivariate analysis confirmed that cTp score was the only independent variable influencing the occurrence of SBp. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of ppI, independently of the presence of SBp(58.4% vs 62.7% respectively, p = 0.66). For patients with SBp, survival at 60 mo was 55.1%, vs 61.7% in patients without SBp(p = 0.34). cONclUSION In conclusion, the rate of SBp was not

关键词： cirrhosis Bacterial infection Spontaneous bacterial peritonitis proton pump inhibitors Ascites

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Acupuncture for the Treatment of Hot Flashes in Men with Advanced prostate cancer

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International Journal of clinical Medicine 2011年第1期2卷 51-55页

作者： Jillian l. capodice philippa cheetham Mitchell c. Benson James M. McKiernan Aaron E. Katz 不详

pURpOSE: To test the safety and efficacy of acupuncture in reducing hot flashes in men with advanced prostate cancer (cap) undergoing androgen deprivation therapy. METHODS: A single-arm, pilot study was undertaken to evaluate acupuncture treatment for hot flashes experienced by cap patients undergoing hormonal therapy. Sixteen advanced cap patients undergoing androgen deprivation therapy (ADT) received standardized full body and auricular acupunc-ture 1x/week for 14 weeks. patients were evaluated at 0, 7, 14, and an additional 14-wk follow-up (F/U) (28-wks). Safety was measured by monitoring for adverse events over the treatment period. Serum testosterone was measured at 0 and 14-wks. Quality of life (QOl) was measured by the hormone domain of the Expanded prostate Index composite (EpIc), at the 0, 7, 14, and 28-wks and patient reported hot flash frequency was assessed weekly. Safety endpoints were serum testosterone and analysis of adverse events. Efficacy endpoints were scores on the EpIc and the number of pa-tient reported hot flashes. RESUlTS: 17 patients were enrolled and 15 completed the trial. Of 15 evaluable patients the median age was 68 ± 8.19. Serum analysis demonstrated no change in testosterone at baseline 9.5 ng/ml ± 8.9 vs. end-point 14 ± 8.78 (p = 0.101). No adverse events were reported. Data analysis of the EpIc demonstrated a trend toward improvement after 7 wks and a significant improvement following 14 wks of acupuncture (p = 0.01). Analysis of patient reported frequency showed a significant reduction in the number of hot flashes at 7-wk (6, p = 0.04), 14-wk (2.6, p = 0.001), and 28-wk F/U (3.2, p = 0.01) as compared to baseline 9.57 ± 3.98. cONclUSIONS: The administration of acupuncture in men with advanced cap appears to significantly decrease the frequency of hot flashes. No serious ad-verse events were noted and serum testosterone levels were unchanged from baseline suggesting that the mechanism of action of acupuncture for hot flash ameliora

关键词： prostate cancer Acupuncture Hot Flashes

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Extensions of 2-Homogeneous polynomials on c_0

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Acta Mathematica Sinica,english Series 2008年第5期24卷 877-880页

作者： pi-Kee lIN Department of Mathematics University of MemphisMemphis TNUSA 38152

We prove that every 2-homogeneous polynomial on the complex co has a unique normpreserving extension to its bidual l∞.

关键词： Hahn-Banach extension homogeneous polynomial

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Antibacterial Effect of Aqueous Extracts and Bioactive chemical compounds of <i>coffea canephora</i>against Microorganisms Involved in Dental caries and periodontal Disease

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Advances in Microbiology 2014年第14期4卷 978-985页

作者： Flávia M. da Silva Natalia l. p. Iorio leandro A. lobo Kátia Regina N. dos Santos Adriana Farah lucianne c. Maia Andréa G. Antonio Departamento de pós-Graduacao Mestrado Profissional em Odontologia Faculdade de Odontologia Universidade Veiga de Almeida Rio de Janeiro Brasil Departamento de ciência Básica Universidade Federal Fluminense Nova Friburgo Brasil Departamento de Microbiologia Médica Instituto de Microbiologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil Instituto de Nutricao Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil Departamento de Odontopediatria e Ortodontia Faculdade de Odontologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil

This study aimed to evaluate the Minimum Inhibitory concentration (MIc) and Minimum Bactericidal concentration (MBc) of coffea canephora aqueous extract (cc), trigonelline (Tg) and 5-caffeoylquinic acid (5-cQA) against cariogenic microorganisms: Streptococcus parasanguinis ATcc 903 (Sp), lactobacillus rhamnosus ATcc 9595 (lR);and pathogens related to periodontal disease: porphyromonas gingivalis ATcc 33277 (pG), Fusobacterium nucleatum ATcc 25586 (FN), prevotella intermedia ATcc 49046 (pI) and prevotella nigrescens ATcc 33563 (pN). Different concentrations of cc (0.15625 to 10 mg/ml), Tg and 5-cQA (0.005 to 10.24 mg/ml) were tested. chlorhexidine (0.05%) was used as positive control and the substances without the inoculum comprised the blank control. The cc showed bacteriostatic action against Sp (MIc = 5 mg/ml) and lR (MIc = 10 mg/ml). Tg showed bacteriostatic action against Sp (MIc = 2.56 to 1.28 mg/ml), lR (MIc = 2.56 mg/ml), pG (MIc = 2.56 to 1.28 mg/ml), FN (MIc = 5.12 mg/ml), pN (MIc = 2.56 mg/ml), and pI (MIc = 2.56 to 1.28 mg/ml). Also, Tg showed bactericide properties against Sp (MBc = 2.56 mg/ml), pG (MBc = 2.56 mg/ml), FN (MBc = 10.24 mg/ml), pN (MBc = 5.12 mg/ml), and pI (MBc = 2.56 mg/ml). Although 5-cQA has previously shown activity against Streptococcus mutans, in the present study, it showed no activity against all tested microorganisms. c. canephora extract only showed antibacterial activity against cariogenic microorganisms, not presenting action against periodontal pathogens. It was concluded that trigonelline presented the best effect against all pathogens tested, therefore coffee extracts with higher trigonelline content should be tested against these specific pathogens.

关键词： Oral pathogens Dental caries periodontal Disease coffee Trigonelline chorogenic Acid

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习近平新时代“一国两制”治港方略

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湘潭大学学报（哲学社会科学版） 2020年第6期44卷 110-117页

作者：刘恩东中共中央党校国际战略研究院北京100091

党的十八大以来,以习近平同志为核心的党中央全面准确地认识把握并认真贯彻落实“一国两制”方针政策,在继承邓小平“一国两制”总体思想的基础上,提出了新时代治港方略。新时代治港方略秉持了科学的思维方法论,赋予香港“一国两制”新... 详细信息

党的十八大以来,以习近平同志为核心的党中央全面准确地认识把握并认真贯彻落实“一国两制”方针政策,在继承邓小平“一国两制”总体思想的基础上,提出了新时代治港方略。新时代治港方略秉持了科学的思维方法论,赋予香港“一国两制”新的战略定位,推动香港融入国家发展大局,提出了“两个建设好”的总要求。新时代治港新方略更加注重加强党对香港“一国两制”工作的全面集中统一领导,更加注重准确把握“一国两制”的正确方向,更加坚定“一国两制”的制度自信,更加注重从维护国家主权和核心利益践行“一国两制”的根本宗旨,更加注重坚持依法治港,更加注重从政权建设方向思考管治策略,更加注重筑牢“一国两制”社会政治基础,更加注重强力节制特区反建制力量和外部干扰,为保持香港的长期繁荣稳定指明了方向。

关键词：习近平新时代 “一国两制” 治港方略

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Insensitivity of a turbulent laser-plasma dynamo to initial conditions

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Matter and Radiation at Extremes 2022年第4期7卷 50-64页

作者： A.F.A.Bott l.c.en p.Tzeferacos c.A.J.palmer A.R.Bell R.Bingham A.Birkel D.H.Froula J.Katz M.W.Kunz c.-K.li H-S.park R.petrasso J.S.Ross B.Reville D.Ryu F.H.Séguin T.G.White A.A.Schekochihin D.Q.lamb G.Gregori Department of physics University of OxfordOxfordUnited Kingdom Department of Astrophysical Sc.ences University of PrincetonPrincetonNew Jersey 08544USA Department of physics and Astronomy University of RochesterRochesterNew York 14627USA laboratory for laser energetics University of RochesterRochesterNew York 14623USA School of Mathematics and physics Queens University BelfastBelfastUnited Kingdom Rutherford Appleton laboratory ChiltonDidcotUnited Kingdom Department of physics University of StrathclydeGlasgowUnited Kingdom Massachusetts Institute of Technology CambridgeMassachusetts 02139USA lawrence livermore National laboratory LivermoreCalifornia 94550USA Max-planck-Institut für Kernphysik HeidelbergGermany Department of physics School of Natural SciencesUNISTUlsanSouth Korea Department of physics University of NevadaRenoNevada 89557USA Department of Astronomy and Astrophysics University of ChicagoChicagoIllinois 60637USA

It has recently been demonstrated experimentally that a turbulent plasma created by the collision of two inhomogeneous,asymmetric,weakly magnetized,laser-produced plasma jets can generate strong stochastic magnetic fields via the small-scale turbulent dynamo mechanism,provided the magnetic Reynolds number of the plasma is suffic.ently *** this paper,we compare such a plasma with one arising from two pre-magnetized plasma jets whose creation is identical save for the addition of a strong external magnetic field imposed by a pulsed magnetic field *** investigate the differences between the two turbulent systems using a Thomson-scattering diagnostic,x-ray selfemission imaging,and proton *** Thomson-scattering spectra and x-ray images suggest that the external magnetic field has a limited effect on the plasma dynamics in the *** the external magnetic field induces collimation of the flows in the colliding plasma jets and although the initial strengths of the magnetic fields arising from the interaction between the colliding jets are significantly larger as a result of the external field,the energies and morphologies of the stochastic magnetic fields post-amplification are *** conclude that,for turbulent laser-plasmas with supercritical magnetic Reynolds numbers,the dynamo-amplified magnetic fields are determined by the turbulent dynamics rather than the seed fields or modest changes in the initial flow dynamics of the plasma,a finding consistent with theoretical expectations and simulations of turbulent dynamos.

关键词： turbulent initial stochastic

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心血管外科手术后气管切开的远期预后评价

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 58-59页

作者： Walts p.A. Murthy S.c. Arroliga A.c. 刘宇 Department of Thoracic and cardiovascular Surgery Cleveland Clinic Foundation9500 Euclid AveClevelandOH 44195United States.Dr

Objective: To ascertain long-term survival, identify risk factors for death, and document complications of tracheostomy after cardiovascular surgery. Methods : Between January 1, 1998, and September 1, 2001, 188(1.4%) of 13,191 patients undergoing cardiovascular surgery had tracheostomy for respiratory failure 5 to 79 days(median, 14 days) after surgery. Factors associated with mortality were i dentified in the hazard function domain, and mode of death and complications of tracheostomy were determined by follow-up. Results: Survival was 75%, 50%, an d 31%at 30 days, 3 months, and 2 years, respectively. The most important risk f actors for death were older age(p=.004) and variables representing deteriorating hemodynamic(ppiratory(penal(p=.0001) function betwee n the index cardiovascular operation and tracheostomy. The mode of death was iso lated respiratory failure in only 21(16%) of 130 patients, but multisystem orga n failure in 71(55%). Follow-up of 58 survivors identified voice complaints in 13(24%), tracheal stenosis in 5(9.2%), and permanent tracheostomy in 3(6%). conclusions: Only one third of patients undergoing tracheostomy after cardiovasc ular surgery survive, because it is used primarily in those with deteriorating f unction of multiple organ systems. Although tracheostomy may enhance patient com fort and simplify nursing care, selection algorithms need to be developed if sur vival is the goal of the intervention.

关键词：心血管手术外科手术后气管切开预后评价死亡危险因素多器官功能衰竭远期生存率外科手术治疗

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Establishing a rabbit model of perianal fistulizing crohn's disease

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World Journal of Gastroenterology 2022年第15期28卷 1536-1547页

作者： Shuang-Shuang lu Wen-Jia liu Qiu-Ya Niu chun-Yan Huo Yu-Qing c.eng en-Jing Wang Rong-Nan li Fang-Fang Feng Yi-Ming c.eng Rong liu Jin Huang Gastroenterology center The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Medical Statistics center Changzhou UniversityChangzhou 213000Jiangsu ProvinceChina

BAcKGROUND crohn’s disease(cD)is a chronic nonspecific intestinal inflammatory *** aetiology and pathogenesis of cD are still *** fistula is the main complication of cD and is a difficult problem to solve at *** main limitation of developing new therapies is bound up with the short of preclinical security and effectiveness ***,an ideal animal model is needed to establish persistent anal fistula and an inflamed rectal *** To improve the induction method of colitis and establish a reliable and reproducible perianal fistulizing crohn’s disease animal model to evaluate new treatment *** Twenty male New Zealand rabbits underwent rectal enema with different doses of 2,4,6-trinitrobenzene sulfonic acid to induce *** A was treated with an improved equal interval small dose increasing *** dosage of group B was *** days later,the rabbits underwent surgical creation of a transsphincteric ***,three rabbits were randomly selected from each group every 7 d to remove the seton from the *** rabbits were examined by endoscopy every 7 days,and biopsy forceps were used to obtain tissue samples from the obvious colon lesions for histological *** disease activity index(DAI),colonoscopy and histological scores were *** endoscopic ultrasonography(EUS)was used to evaluate the healing of *** Except for the DAI score,the colonoscopy and histological scores in group A were significantly higher than those in group B(pl model rabbit group,on the 7 th day after the removal of the seton,all animals had persistent lumens on EUS imaging,showing continuous fullthickness high *** inspection of the fistula showed acute and chronic inflammation,fibrosis,epithelialization and peripheral proctitis of the adjoining *** The improved method of cD colitis induction successfully established a rabbit perianal fistula cD pre

关键词： crohn’s disease perianal fistula Model endoscopy Histology

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Terminology in Medical publications in chinese.

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中华医学杂志 1916年第2期02卷 82-86页

作者： c. VOONpING YUI, M. D., D. p. H. (penn.), Shanghai.

china needs a medical nomenclature of her own. We have so far been dependent on a foreign medium of communication to acquire our medical knowledge. This state of affairs is practicable only in the

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