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Pelvic fractures in blunt trauma patients:A comparative study

World Journal of Orthopedics 2024年第5期15卷 418-434页

作者： Alexander A Fokin Joanna Wycech Knight Madison E Tharp Kyler c Brinton Phoebe K Gallagher Justin Fengyuan Xie Russell d Weisz Ivan Puente Trauma and critical care Services Delray Medical CenterDelray BeachFL 33484United States charles E Schmidt college of Medicine Department of SurgeryFlorida Atlantic UniversityBoca RatonFL 33431United States Trauma and critical care Services Broward Health Medical CenterFort LauderdaleFL 33316United States charles E Schmidt college of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim college of Medicine Department of SurgeryFlorida International UniversityMiamiFL 33199United States

BAcKGROUNd Pelvic fractures(PF)with concomitant injuries are on the rise due to an increase of high-energy *** of the elderly population with age related comorbidities further complicates the *** organ injuries are kindred with PF due to the proximity to pelvic *** of contrast blush(cB)on computed tomography in patients with PF is considered a sign of active bleeding,however,its clinical significance and association with outcomes is *** To analyze polytrauma patients with PF with a focus on the geriatric population,co-injuries and the value of contrast *** This retrospective cohort study included 558 patients with PF admitted to level 1 trauma center(01/2017-01/2023).Analyzed variables included:Age,sex,mechanism of injury(MOI),injury severity score(ISS),Glasgow coma scale(GcS),abbreviated injury scale(AIS),co-injuries,transfusion requirements,pelvic angiography,embolization,laparotomy,orthopedic pelvic surgery,intensive care unit and hospital lengths of stay,discharge disposition and *** study compared geriatric and non-geriatric patients,patients with and without cB and abdominal *** score matching was implemented in comparison *** PF comprised 4%of all trauma admissions.89 patients had cB.286(52%)patients had concomitant injuries including 93(17%)patients with abdominal *** patients compared to non-geriatric had more falls as MOI,lower ISS and AIS pelvis,higher GcS,less abdominal co-injuries,similar cB and angio-embolization rates,less orthopedic pelvic surgeries,shorter lengths of stay and higher *** propensity matching,orthopedic pelvic surgery rates remained lower(8%vs 19%,Pd mortality higher(13%vs 4%,Pc *** of 89 patients with cB,45(51%)were *** propensity matching,patients with cB compared to without cB had more pelvic angiography(71%vs 12%,P<0.001),hi

关键词： Pelvic fractures Geriatric trauma patients Abdominal co-injuries contrast blush contrast extravasation Angioembolization Polytrauma patients Surgical interventions Blunt trauma External and internal fixation for pelvic stabilization

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Leveraging the potential of big genomic and phenotypic data for genome-wide association mapping in wheat

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The crop Journal 2024年第3期12卷 803-813页

作者： Moritz Lell Yusheng Zhao Jochen c.Reif Leibniz Institute of Plant Genetics and crop Plant Research(IPK) Corrensstraße 3D-06466 SeelandGermany

Genome-wide association mapping studies(GWAS)based on Big data are a potential approach to improve marker-assisted selection in plant *** number of available phenotypic and genomic data sets in which medium-sized populations of several hundred individuals have been studied is rapidly *** these data and using them in GWAS could increase both the power of QTL discovery and the accuracy of estimation of underlying genetic effects,but is hindered by data heterogeneity and lack of *** this study,we used genomic and phenotypic data sets,focusing on central European winter wheat populations evaluated for heading *** explored strategies for integrating these data and subsequently the resulting potential for *** interoperability between data sets was greatly aided by some overlapping genotypes and a linear relationship between the different phenotyping protocols,resulting in high quality integrated phenotypic *** this context,genomic prediction proved to be a suitable tool to study relevance of interactions between genotypes and experimental series,which was low in our *** to expectations,fewer associations between markers and traits were found in the larger combined data than in the individual experimental ***,the predictive power based on the marker-trait associations of the integrated data set was higher across data ***,the results show that the integration of medium-sized to Big data is an approach to increase the power to detect QTL in *** results encourage further efforts to standardize and share data in the plant breeding community.

关键词： Big data Genome-wide association study data integration Genomic prediction Wheat

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Learning about good nutrition with the 5-color front-of-package label"Nutri-Score":an experimental study

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Food Science and Human Wellness 2024年第3期13卷 1195-1200页

作者： Robin c.Hau Klaus W.Lange University of Applied Sciences Landshut Landshut 84036Germany Faculty of Human Sciences University of RegensburgRegensburg 93040Germany

The Nutri-Score is a 5-color front-of-pack nutrition label designed to provide consumers with an easily understandable guideline to the healthiness of food *** impact that the Nutri-Score may have on consumers'choices is unclear since different experimental paradigms have found vastly different effect *** the present study,we have investigated how student participants change a hypothetical personal 1-daydietary plan after a learning phase during which they learn about the Nutri-Scores of the available food *** were instructed to compose a healthy diet plan in order that the question of whether the NutriScore would improve their ability to compose a healthy dietary plan could be investigated,independent of the question of whether they would apply this knowledge in their ordinary *** found a substantial(cohen's d=0.86)positive impact on nutritional quality(as measured by the Nutrient Profiling System score of the Food Standards Agency)and a medium-sized(cohen's d=0.43)reduction of energy *** content reduction was larger for participants who had initially composed plans with higher energy *** results suggest that the Nutri-Score has the potential to guide consumers to healthier food *** remains unclear,however,whether this potential will be reflected in real-life dietary choices.

关键词： Nutri-Score Front-of-package label Nudge Nutrition Health

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connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury

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Neural Regeneration Research 2024年第10期19卷 2119-2131页

作者： Nikita Ollen-Bittle Austyn d.Roseborough Wenxuan Wang Jeng-liang d.Wu Shawn N.Whitehead department of Anatomy and cell Biology Western UniversityLondonONCanada Schulich School of Medicine and dentistry Western UniversityLondonONCanada deparment of clinical Neurological Sciences Western UniversityLondonONCanada

Traumatic brain injury is followed by a cascade of dynamic and complex events occurring at the cellular level. These events include: diffuse axonal injury, neuronal cell death, blood-brain barrier break down, glial activation and neuroinflammation, edema, ischemia, vascular injury, energy failure, and peripheral immune cell infiltration. The timing of these events post injury has been linked to injury severity and functional outcome. Extracellular vesicles are membrane bound secretory vesicles that contain markers and cargo pertaining to their cell of origin and can cross the blood-brain barrier. These qualities make extracellular vesicles intriguing candidates for a liquid biopsy into the pathophysiologic changes occurring at the cellular level post traumatic brain injury. Herein, we review the most commonly reported cargo changes in extracellular vesicles from clinical traumatic brain injury samples. We then use knowledge from animal and in vitro models to help infer what these changes may indicate regrading cellular responses post traumatic brain injury. Future research should prioritize labeling extracellular vesicles with markers for distinct cell types across a range of timepoints post traumatic brain injury.

关键词： axonal injury biomarkers blood-brain barrier chronic traumatic encephalopathy extracellular vesicles glial activation neuroinflammation traumatic brain injury

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Structural,morphological,optical and antibacterial performances of rare earth(Sm)-doped ZnO nanorods

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Journal of Rare Earths 2024年第11期42卷 2119-2127页

作者： A.Ravi J.Samuel S.Sahaya Jude dhas S.Usharani Turibius Simon d.Senthil Kumar S.K.Jasmin Vijitha A.Sivakumar Raju Suresh Kumar c.S.Biju department of Physics University College of Engineering department of Physics and Research centre Malankara Catholic College Manonmaniam Sundaranar University Saveetha School of Engineering Saveetha Institute of Medical and Technical SciencesSaveetha University department of chemistry S.I.V.E.T College department of Biotechnology Vivekanandha College of Arts and Science for Woman (Autonomous) department of Physics Vel Tech Rangarajan Dr.Sagunthala R & D Institute of Science and Technology department of Physics & Research centre Muslim Arts College Key Laboratory of High-temperature and High-pressure Study of the Earth's Interior Institute of GeochemistryChinese Academy of Sciences department of chemistry College of ScienceKing Saud University department of Physics St. Alphonsa College of Arts and Science

The significant rise of ultra-violet（UV） radiation and pathogenic infectious bacteria poses a serious threat to global *** researchers' interests are attracted by novel materials with strong UVblocking ability,antibacterial activity and low toxicity to other *** this case,a simple wet chemical method with different annealing temperatures（400,500,and 600℃） was employed to create highly effective rare earth（Sm）-doped ZnO ***（101） plane of wurtzite ZnO shifts towards a lower angle with increasing annealing temperature,according to the X-ray diffraction（XRd） study findings,which additionally establishes the consequence of lattice *** of doublet peaks of Sm 3d(Sm 3d5/2and Sm 3d3/2) in the X-ray photoelectron spectroscopy（XPS） spectrum clearly validates the substitution of Sm3+ions in the 500℃-annealed *** 500℃-annealed nanorods exhibit combined performances of the wide band gap,improved UV absorbance,and vivid green luminescent emission（563 nm）.Additio nally,the nanorods have favorable UV-blocking execution of 96% for UVA at 360 nm,92% for UVB at 320 nm,and 57% for UVc at 225 nm,which is greater than the majority of ZnO-related materials that have been reported up to this *** doping is also appropriate for improving bacterial inhibition against the two studied strains（Escherichia coli and Staphylococcus aureus）,in addition to the intriguing features discussed ***,with maximum inhibition zone diameters of 20±0.72 and 18±0.57 mm,respectively,these nanorods exhibit high inhibitory action against *** and *** bacterial *** rare earth-doped material developed during the current experiment,which was annealed at 500℃,could potentially serve as an effective replacement for UV-blocking and antibacterial material,especially for biomedical applications.

关键词： Wet chemical method rare earth doping Metal oxide UV-Shielding Bacterial inhibition

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On some new fuzzy entropy measure of Pythagorean fuzzy sets for decision-making based on an extended TOPSIS approach

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Journal of Management Analytics 2024年第1期11卷 87-109页

作者： H.d.Arora Anjali Naithani department of Mathematics Amity Institute of Applied SciencesAmity University Uttar PradeshNoidaIndia

Fuzzy entropy measures are valuable tools in decision-making when dealing with uncertain or imprecise *** exist many entropy measures for Pythagorean Fuzzy Sets(PFS)in the literature that fail to deal with the problem of providing reasonable or consistent results to the *** deal with the shortcomings of the existing measures,this paper proposes a robust fuzzy entropy measure for PFS to facilitate decision-making under *** usefulness of the measure is illustrated through an illustration of decision-making in a supplier selection problem and compared with existing fuzzy entropy *** Technique for Order Performance by Similarity to Ideal Solution(TOPSIS)approach is also explored to solve the decision-making *** results demonstrate that the proposed measure can effectively capture the degree of uncertainty in the decision-making process,leading to more accurate decision outcomes by providing a reliable and robust ranking of alternatives.

关键词： Pythagorean fuzzy sets entropy measures multi criteria decision analysis TOPSIS method supplier selection

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comparative analysis of breast and lung cancer survival rates and clinical trial enrollments among rural and urban patients in Georgia

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Oncology Research 2024年第9期32卷 1401-1406页

作者： TATIANA KURILO REBEccA d.PENTZ Winship cancer Institute Emory University School of MedicineEmory UniversityAtlanta30322USA

Objectives:Rural patients have poor cancer outcomes and clinical trial(cT)enrollment compared to urban patients due to attitudinal,awareness,and healthcare access *** of cancer survival disparities and cT enrollment is important for designing interventions and innovative approaches to address the stated *** study explores the potential disparities in cancer survival rates and clinical trial enrollments in rural and urban breast and lung cancer *** hypotheses are that for both cancer types,urban cancer patients will have longer 5-year survival rates and higher enrollment rates in clinical trials than those in rural ***:We compared breast and lung cancer patients’survival rates and enrollment ratios in clinical trials between rural(RUcc 4-9)and urban counties in Georgia at a comprehensive cancer center(ccc).To assess these differences,we carried out a series of independent samples t-tests and chi-Square ***:The outcomes indicate comparable 5-year survival rates across rural and urban counties for breast and lung cancer patients,failing to substantiate our *** clinical trial enrollment rates demonstrated a significant difference between breast and lung cancer patients at ccc,no significant variation was observed based on rural or urban ***:These findings underscore the need for further research into the representation of rural patients with diverse cancer types at ccc and other cancer ***,the findings have considerable implications for the initiation of positive social change to improve cT participation and reduce cancer survival disparities.

关键词： cancer cancer survival rates clinical trial enrollment Rural patients Health disparities Barriers to clinical trial participation Geographic disparities

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Sex differences in Alzheimer's disease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel Jiménez-Herrera Ana contreras Juan d.Navarro-López Lydia Jiménez-díaz Neurophysiology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

due to increasing life expectancy,the amount of people with dementia worldwide is expected to experience a substantial rise,with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the... 详细信息

关键词： Alzheimer predominant estimates

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Effects of layer interactions on instantaneous stability of finite Stokes flows

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 69-84页

作者： chen ZHAO Zhenli cHEN c.T.MUTASA dong LI School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

The stability analysis of a finite Stokes layer is of practical importance in flow control. In the present work, the instantaneous stability of a finite Stokes layer with layer interactions is studied via a linear stability analysis of the frozen phases of the base flow. The oscillations of two plates can have different velocity amplitudes, initial phases, and frequencies. The effects of the Stokes-layer interactions on the stability when two plates oscillate synchronously are analyzed. The growth rates of two most unstable modes when δ d δ = δ*/h*, where δ*and h*are the Stokes-layer thickness and the half height of the channel, respectively. However, their vorticities are different. The vorticity of the most unstable mode is symmetric, while the other is asymmetric. The Stokes-layer interactions have a destabilizing effect on the most unstable mode when δ d have a stabilizing effect when δ > 0.68. However, the interactions always have a stabilizing effect on the other unstable mode. It is explained that one of the two unstable modes has much higher dissipation than the other one when the Stokes-layer interactions are strong. We also find that the stability of the Stokes layer is closely related to the inflectional points of the base-flow velocity profile. The effects of inconsistent velocity-amplitude, initial phase, and frequency of the oscillations on the stability are analyzed. The energy of the most unstable eigenvector is mainly distributed near the plate of higher velocity amplitude or higher oscillation frequency. The effects of the initial phase difference are complicated because the base-flow velocity is extremely sensitive to the initial phase.

关键词： finite Stokes layer instantaneous stability Stokes-layer interaction asynchronous oscillation

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Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren Tan Mary c.Stephenson Sharifah Badriyah Alhadad Kelvin W.Z.Loh Tuck Wah Soong Jason K.W.Lee Ivan c.c.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore campus for Research Excellence and Technological Enterprise(cREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±Sd))despite fluctuations in T_(re).With the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity cognition Heat stress Hyperthermia Motor function

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