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Statin-induced Liver Injury Patterns: A clinical Review

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Journal of clinical and Translational Hepatology 2022年第3期10卷 543-552页

作者： Leon D.Averbukh Alla Turshudzhyan David c.wu George Y.wu Department of Medicine Division of Gastroenterology-HepatologyAllegheny Health NetworkPittsburghPAUSA Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Since their introduction in 1987,hydroxymethyl glutaryl coenzyme A reductase(HMG-coA)inhibitors,more commonly known as statins,have become some of the most widely prescribed medications in the *** generally considered to be safe and well tolerated,statins have been associated with several side effects including mild liver dysfunction manifested by increases in ***,statins have been noted to induce more serious hepatic injury,including liver injury with autoimmune *** literature supports statin induced liver injury presenting in either hepatocellular or cholestatic patterns,though with the former being the prevailing pattern of ***,severe liver injury is uncommon with statin use and is generally reversible without any intervention other than offending statin *** evaluating cases of suspected statininduced liver injury,a complete medical history,laboratory tests including a complete metabolic panel,autoimmune markers,and viral panel,as well as hepatic imaging,are crucial for a complete causality analysis with validated tools such as Roussel Uclaf causality Assessment *** aim of this review is to review the current evidence for statininduced liver injury and cholestasis.

关键词： Drug-induced liver injury Statin cholestatic liver injury Hepatocellular liver injury cholestasis Autoimmune hepatitis

An extracellular matrix paradox in myocardial scar formation

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1139-1140页

作者： Sangkyun cho David T.Paik Joseph c.wu Stanford cardiovascular Institute Stanford University School of MedicineStanfordCAUSA Department of Medicine Division of Cardiovascular MedicineStanford University School of MedicineStanfordCAUSA Department of Radiology Stanford University School of MedicineStanfordCAUSA

In a recent article in cell,Yokota et al.1 demonstrate that type V collagen,a minor component of the cardiac extracellular matrix,plays a paradoxical role in limiting scar size after myocardial infarction by altering the mechanical properties of the developing scar tissue and by regulating integrindependent activation of cardiac fibroblasts(Fig.1).

关键词： scar al cardiac

Diagnostic and Therapeutic Strategies for Peritoneal Tuberculosis: A Review

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Journal of clinical and Translational Hepatology 2019年第2期7卷 140-148页

作者： David c.wu Leon D.Averbukh George Y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Peritoneal tuberculosis(PTB),although rarer than its pulmonary counterpart,is a serious health concern in regions of the world with high tuberculosis *** with baseline immunocompromise condition,whether acquired or medically induced,are at greatest risk for experiencing *** medical treatment of the condition is similar to that of the pulmonary disease,the generally immunocompromised state of those infected with PTB,along with a lack of highly sensitive and specific testing methods make early diagnosis *** review discusses the risks factors,clinical features,diagnostic methods,and treatment options for PTB.

关键词： Peritoneal tuberculosis Tuberculosis Liver disease Human immunodeficiency virus

Biliary Mucinous cystadenoma: A Review of the Literature

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Journal of clinical and Translational Hepatology 2019年第2期7卷 149-153页

作者： Leon D.Averbukh David c.wu Woo cheal cho George Y.wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Pathology Hartford HospitalHartfordCTUSA

Biliary mucinous cystadenomas are cystic neoplasms commonly mistaken for simple *** are rare and generally benign tumors,often incidentally found on imaging and during unrelated surgical *** tend to be slow growing though may reach symptomatic *** of biliary mucinous cystadenomas may have serious consequences secondary to their potential for malignant transformation into biliary mucinous ***,we review the epidemiology,etiology,pathology,diagnostic modalities,histology,and available treatment methods for mucinous cystadenomas reported in current literature.

关键词： Biliarymucinous cystadenoma Biliary mucinous cystadenocarcinoma cystic neoplasm

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心肌再生的分子影像评价

中华心血管病杂志 2008年第11期36卷 1045-1047页

作者：曹丰司瑞 Joseph c.wu 王海昌第四军医大学西京医院心血管内科西安710032 美国斯坦福大学放射科

近来的研究显示，将骨骼肌成肌细胞（skeletal myoblasts，SKMs）、内皮祖细胞（endothelial progenitor cells，EPcs）、骨髓干细胞（bone marrow stem cells，BMcs）和胚胎干细胞H0（embryonic stem cells，EScs）移植入梗死心肌可改善心室重构和心脏功能。再生过程的可能机制包括：干细胞分化为心肌细胞；细胞因子的旁分泌或募集外周干细胞到缺血区域。

关键词：影像评价心肌再生骨骼肌成肌细胞骨髓干细胞分子内皮祖细胞胚胎干细胞

catalytic performances of cobalt-based catalysts for hydrogen generation with sodium borohydride solution

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Catalytic performances of cobalt-based catalysts for hydroge...

第九届全国氢能学术会议

作者： c.wu,F.wu,Y.Bai Beijing Institute of Technology,china

Hydrogen supply is one of the most important issues for wide practice of proton exchange membrane fuel cell(PEMFc).There are many ways to get *** instance,mass hydrogen production can be gained with chemical methods,from electrolysis of water,or by biologic ***,it is found that hydrogen generation from catalysis of sodium borohydride(NaBH) is flexible and controllable,and may be a promising way for on-site

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日本预拌混凝土的质量控制

日本预拌混凝土的质量控制

Effects of long-term preservation on amphibian body conditions:implications for historical morphological research

2008中国商品混凝土可持续发展论坛暨第五届全国商品混凝土技术交流大会

作者： S.Nagataki c.wu 王栋民扈士凯 Faculty of Engineering Aichi Institute of Technology1247 yachigusa yakusachio

为保证预拌混凝土的质量,在日本采取了三种措施,一是根据日本工业标准对预拌混凝土搅拌站进行监测;二是除了常规检测外,还要现场测试新拌混凝土中氯离子和水分的含量,因为这两项指标可能会对混凝土结构的强度和耐久性产生影响;三是建立... 详细信息

为保证预拌混凝土的质量,在日本采取了三种措施,一是根据日本工业标准对预拌混凝土搅拌站进行监测;二是除了常规检测外,还要现场测试新拌混凝土中氯离子和水分的含量,因为这两项指标可能会对混凝土结构的强度和耐久性产生影响;三是建立全国统一的预拌混凝土质量控制的核查系统。本文对这三种保证预拌混凝土质量的手段进行简单的介绍。

关键词：预拌混凝土质量控制现场检测核查系统

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Effects of long-term preservation on amphibian body conditio...

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

第十三届全国野生动物生态与资源保护学术研讨会暨第六届中国西部动物学学术研讨会

作者： Guocheng Shu Yuzhou Gong Feng Xie Nicholas c.wu cheng Li chengdu Institute of Biology Chinese Academy of Sciences University of chinese Academy of Sciences School of Biological Sciences University of Queensland

Measurements of historical specimens are widely applied in studies of taxonomy,systematics,and ecology,but biologists often assume that the effects of preservative chemicals on the morphology of amphibian specimens are minimal in their *** compared the body length and body mass of 182 samples of 13 live and preserved

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chinese Physics c 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.c.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.cai X.cai A.calcaterra G.F.cao N.cao S.A.cetin J.F.chang W.L.chang G.R.che G.chelkov c.chen c.H.chen chao chen G.chen H.S.chen M.L.chen S.J.chen S.L.chen S.M.chen T.chen X.R.chen X.T.chen Y.B.chen Y.Q.chen Z.J.chen Z.Y.chen S.K.choi X.chu G.cibinetto F.cossio J.J.cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich c.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici c.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch c.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge c.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.c.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu c.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius c.H.Heinz Y.K.Heng c.Herold T.Holtmann P.c.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.c.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.c.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz c.Li c.Li c.H.Li cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia carnegie Mellon University PittsburghPennsylvania 15213USA central china Normal University Wuhan 430079China central South University Changsha 410083China china center of Advanced Science and Technology Beijing 100190China china University of Geosciences Wuhan 430074China chung-Ang University Seoul06974Republic of Korea cOMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan college Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the cP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the cKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis cP-even fraction