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Acta Geochimica 2017年第3期36卷 363-366页

作者： F.chabaux D.Viville Y.Lucas J.Ackerer c.ranchoux c.Bosia M.c.Pierret T.Labasque L.Aquilina R.Wyns c.Lerouge c.Dezaye P.Négreol Laboratoire D'Hydrologie et de Géochimie de Strasbourg (LHyGeS) CNRS Université de Strasbourg 1 Rue Blessig 67084 Strasbourg Cedex France cNRS Géosciences Rennes UMR 6118 Université de Rennesl Campus de Beaulieu 35042 Rennes Cedex France BRGM 3 Avenue Claude Guillemin 45060 Orléans France

From the study of the Strengbach and Ringelbach watersheds we propose to illustrate the interest of combining the geochemical tracing and geochemical modeling approaches on surface and deep borehole waters,to decipher the diversity of the water flow and the associated water–rock interactions in such elementary mountainous catchments. The results point to a clear geochemical typology of waters depending on the water circulations(deep vs. hypodermic) within the substratum.

关键词： Weathering Water pathways U activity ratios Sr isotope ratios Anthropogenic gases(cFc,SF6) cZO

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Spatial assessment of the areas sensitive to degradation in the rural area of the municipality (c)ukarica

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International Soil and Water conservation Research 2019年第1期7卷 71-80页

作者： Natalija Momirovi(c) Ratko Kadovi(c) Veljko Perovi(c) Milo(s)Marjanovi(c) Aleksandar Baumgertel Institute of Forestry Kneza Vi(s)eslava 311030 BelgradeSerbia Faculty of Forestry University of BelgradeKneza Vi(s)eslava 111030 BelgradeSerbia Institute for Biological Research'Sini(s)a Stankovi(c)' University of BelgradeBulevar despota Stefana 14211060 BelgradeSerbia Faculty of Mining and Geology University of BelgradeDu(s)ina 711000 BelgradeSerbia

In this paper,the assessment of the sensitivity of the soil in the rural area of (c)ukarica municipality to the processes of degradation is *** areas,especially in the vicinity of large cities,are exposed to numerous processes of degradation:soil erosion,urban and industrial zone expansion at the expense of fertile agricultural soils,activation of landslides and a number of other significant ecological *** on the characteristics of the research area,the MEDALUS (Mediterranean Desertification and Land Use) model was applied,and for the assessment of sensitivity to the processes of degradation the main quality indicators were considered:soil,climate,vegetation and *** each of the analyzed quality indicators,parameter groups were *** parameter is quantified according to the defined method by giving them a sensitivity coefficient between 1.0 and *** 10.0 has been applied to analyze and prepare layers of quality ***,the geometric mean for all four quality indicators was used to generate the map of environmental sensitivity to *** results obtained show that 41.54% of the study area is classified as critical;22.34% of the surface as fragile;8.47% of the areas are potentially endangered and 9.58% not threatened to degradation *** results have also shown that MEDALUS model is a functional tool for simulations which support sustainable land management in the areas prone to degradation.

关键词： MEDALUS Land degradation Landslides Human pressures GIS mapping

Important step towards an understanding of the exotic Z_(c)(3900)

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Science china(Physics,Mechanics & Astronomy) 2024年第9期67卷 199-200页

作者： c.Hanhart Institute for Advanced Simulation Forschungszentrum JulichJilich D-52425Germany

The Standard Model of particle physics,which contains the field theories for the electro-weak interaction(QED)and the strong interaction(QcD),is an extremely successful theory describing a huge variety of phenomena at... 详细信息

关键词： interaction atomic describing

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Hepatitis c Virus, Insulin Resistance, and Steatosis

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Journal of clinical and Translational Hepatology 2016年第1期4卷 66-75页

作者： Dominik Kralj Lucija Virovi(c) Juki(c) Sanja Stojsavljevi(c) Marko Duvnjak Martina Smoli(c) Ines Bili(c) (c)ur(c)i(c) Department of Gastroenterology and Hepatology Sisters of Charity University Hospital Center Zagreb Croatia Department of Pharmacology Faculty of Medicine University of Osijek Osijek Croatia Department of Pharmacology Faculty of MedicineUniversity of Osijek Department of Endocrinology and metabolism disorders University Hospital Center Osijek Osijek Croatia

Hepatitis c virus (HcV) is one of the main causes of liver disease *** steatosis is a common finding in many hepatic and extrahepatic disorders,the most common being metabolic syndrome (MS).Overtime,it has been shown that the frequent coexistence of these two conditions is not coincidental,since many epidemiological,clinical,and experimental studies have indicated HcV to be strongly associated with liver steatosis and numerous metabolic ***,we present an overview of publications that provide clinical evidence of the metabolic effects of HcV and summarize the available data on the pathogenetic mechanisms of this *** has been shown that HcV infection can induce insulin resistance (IR) in the liver and peripheral tissues through multiple *** research has suggested that HcV interferes with insulin signaling both directly and indirectly,inducing the production of several proinflammatory *** replication,assembly,and release from hepatocytes require close interactions with lipid droplets and host *** modulation of lipid metabolism in host cells can induce hepatic steatosis,which is more pronounced in patients with HcV genotype *** risk of steatosis depends on several viral factors (including genotype,viral load,and gene mutations) and host features (visceral obesity,type 2 diabetes mellitus,genetic predisposition,medication use,and alcohol consumption).HcV-related IR and steatosis have been shown to have a remarkable clinical impact on the prognosis of HcV infection and quality of life,due to their association with resistance to antiviral therapy,progression of hepatic fibrosis,and development of hepatocellular ***,HcV-induced IR,oxidative stress,and changes in lipid and iron metabolism lead to glucose intolerance,arterial hypertension,hyperuricemia,and atherosclerosis,resulting in increased cardiovascular mortality.

关键词： Hepatitis c virus Metabolic syndrome Insulin resistance Steatosis

Influence of B4c and ZrB2 reinforcements on microstructural,mechanical and wear behaviour of AA 2014 aluminium matrix hybrid composites

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Defence Technology（防务技术） 2024年第10期40卷 242-254页

作者： Ramesh Babu R Rajendran c Saiyathibrahim A Rajkumar Velu Department of Mechanical Engineering Karpagam Institute of TechnologyCoimbatore 641105India Department of Mechanical Engineering Sri Krishna College of Engineering and TechnologyCoimbatore 641008India Department of Mechanical Engineering Indian Institute of Technology JammuJammu and Kashmir 181221India

considering their affordability and high strength-to-weight ratio,lightweight aluminium alloys are the subject of intensive research aimed at improving their properties for use in the aerospace *** research effort aims to develop novel hybrid composites based on AA 2014 alloy through the use of liquid metallurgy stir casting to reinforce dual ceramic particles of Zirconium Diboride(ZrB_(2))and Boron carbide(B4c).The weight percentage(wt%)of ZrB_(2) was varied(0,5,10,and 15),while a constant 5 wt%of B4c was maintained during this *** as-cast samples have been assessed using an Optical Microscope(OM)and a Scanning Electron Microscope(SEM)with Energy Dispersive Spectroscopy(EDS).The properties such as hardness,tensile strength,and wear characteristics of stir cast specimens were assessed to examine the impact of varying weight percentages of reinforcements in AA 2014 *** particular,dry sliding wear behaviour was evaluated considering varied loads using a pin-on-disc *** the weight%of ZrB_(2) grew and B4c was incorporated,hybrid composites showed higher hardness,tensile strength,and wear ***,the incorporation of a cumulative reinforcement consisting of 15 wt%ZrB_(2) and 5 wt%B4c resulted in a significant 31.86%increase in hardness and a 44.1%increase in tensile strength compared to AA 2014 *** addition,it has been detected that wear resistance of hybrid composite pin(containing 20 wt%cumulative reinforcement)is higher than that of other stir cast wear test pins during the whole range of applied *** surfaces of tensile specimens showed ductile fracture in the AA 2014 matrix and mixed mode for hybrid *** surfaces obtained employing higher applied load indicated abrasive wear with little plastic deformation for hybrid composites and dominant adhesive wear for matrix ***,the superior mechanical and tribological performance of hybrid composites can be attributed to dual reinforcement pa

关键词： AA 2014 alloy Stir casting Hybrid composite Hardness Tensile strength Specific wear rate