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Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca cidonio Richard O.c.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK center for Life Nano-and Neuro-Science(cLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-EcM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMScs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-EcM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMScs viability upon *** composite of human bone-EcM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(cAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMScs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-EcM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

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High-temperature tribological performance of functionally graded Stellite 6/Wc metal matrix composite coatings manufactured by laser-directed energy deposition

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Friction 2024年第3期12卷 522-538页

作者： marta OSTOLAZA Alaitz ZABALA Jon Inaki ARRIZUBIETA Iñigo LLAVORI Nagore OTEGI Aitzol LAMIKIZ Department of Mechanical Engineering University of the Basque Country UPV/EHUPlaza Torres Quevedo 1Bilbo 48013Spain Faculty of Engineering Mechanics and Industrial ProductionMondragon UnibertsitateaLoramendi 4Mondragon 20500Spain

Wear-driven tool failure is one of the main hurdles in the *** issue can be addressed through surface coating with ceramic-reinforced metal matrix ***,the maximum ceramic content is limited by *** this work,the tribological behaviour of the functionally graded Wc-ceramic-particlereinforced Stellite 6 coatings is *** that end,the wear resistance at room temperature and 400°c is ***,the tribological analysis is supported by crack sensitivity and hardness evaluation,which is of utmost importance in the processing of composite materials with *** indicate that functionally graded materials can be employed to increase the maximum admissible Wc content,hence improving the tribological behaviour,most notably at high ***,a shift from abrasive to oxidative wear is observed in high-temperature wear testing.

关键词： friction coating metal matrix composite functionally graded materials high temperature laserdirected energy deposition

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Phenazines:Natural products for microbial growth control

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hLife 2024年第3期2卷 100-112页

作者： cátia A Sousa marta Ribeiro Francisca Vale Manuel Simões ISEP/P.PORTO School of EngineeringPolytechnic of PortoPortoPortugal LEPABE-Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoPortoPortugal ALicE-Associate Laboratory in chemical Engineering Faculty of EngineeringUniversity of PortoPortoPortugal

The unprecedented problem of antibiotic resistance has become a major challenge for public health,which has contributed to an increase in infections caused by such *** microbial infections,typically biofilm-related,are alsocoupled to an increase in human mortality and ***,the demand for new antimicrobial agents hasincreased along with the evolution of microbial resistance *** products produced by bacteria,such as phenazines,have been recognized as an important source for the development of new antimicrobial agents,through the exploitation of their capacity to increase oxidative stress in other *** are a large groupof nitrogen-containing heterocyclic compounds and are essential for several cellular processes including iron acquisition,signaling events,enzymatic processes,and biofilm ***-inspired antibiotics(i.e.,2-bromo-1-hydroxyphenazine,2,4-dibromo-1-hydroxyphenazine,bromophenazine-21,phenazine-13,and phenazine-14)are veryactive against a wide range of gram-positive and gram-negative bacteria,including those associated with severe *** this study,mechanisms of phenazine-inspired antibiotics in the cellular processes of planktonic and sessilebacteria are ***,the application of phenazine-inspired antibiotics for the eradication of multidrugresistant planktonic and biofilm bacterial infections is also reviewed.

关键词： antimicrobial agents biofilms multidrug-resistant natural products phenazines

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Does the provision of live black soldier fly and yellow mealworm larvae improve Muscovy duck welfare?

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Journal of Animal Science and Biotechnology 2024年第1期15卷 442-455页

作者： marta Gariglio Sihem Dabbou Manuela Renna Ilaria Biasato Sara Bellezza Oddon Marco Meneguz Raul Daniel Miazzo Stefania Bergagna Elena colombino Elisabetta Macchi Achille Schiavone Department of Veterinary Sciences University of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy center Agriculture Food Environment(c3A) University of TrentoVia Edmund Mach 1San Michele All’AdigeTrento(TN)38098Italy Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy BEF Biosystems s.r.l Via Tancredi Canonico 18/CTorino(TO)10156Italy Unidad de Investigacion Aviar Produccion AvicolaFac.Agr.y Vet.Universidad Nacional de Rio CuartoCordobaArgentina Veterinary Medical Research Institute for Piemonte Liguria and Valle d’AostaVia Bologna 148Torino(TO)10154Italy

Background The provision of environmental enrichments to Muscovy ducks could reduce the expression of the aggressive *** aim of the present study was to evaluate the effects of black soldier fly(BSF)and yellow mealworm(YM)live larva provision on Muscovy duck performance,excreta corticosterone metabolites(EcM),behavior,and blood *** A total of 1263-day-old female Muscovy ducklings were allotted to 18 pens(6 replicates/treatment,7 birds/pen)and assigned to 3 experimental treatments:a control group fed commercial feed,and two experimental treatments fed commercial feed plus the 5%(based on the expected daily feed intake,as fed basis)of BSF and YM live larvae(BSF and YM groups,respectively).A two-phase feeding program was applied:starter(from 3 to 31 days of age)and grower-finisher(from 32 to 55 days of age).The live weight,average daily gain,average daily feed intake,and feed conversion ratio were *** consumption times were collected,and video recordings were performed during 3 periods(P)each day:the hour before(P1),during(P2),and after(P3)the larva *** were evaluated at 3,31,and ***,the total red and white blood cell counts,serum proteins,lipids,and liver and renal function serum enzymes were evaluated on 12 birds/*** The experimental treatment did not affect the growth performance of the birds(P>0.05).Larva consumption times were always similar between the two insect species,except at 14–18 days of age,were BSF larvae were consumed faster than YM larvae(Pctivity during P2,and preening behavior increased in YM birds during *** c birds increased the attack behavior over the weeks(Pced the attack frequency(P1>P3;Pcantly reduced the EcM at 55 days of age and the heterophil to lymphocyte ratio(Pconclusions Live BSF and YM larva supplementatio

关键词： Behavior cairina moschata Environmental enrichment Hermetia illucens Poultry Tenebrio molitor Welfare

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The first record of dermochelyid turtles in the Eocene of Tierra del Fuego:new insights on the evolution of the Weddellian faunas

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Advances in Polar Science 2024年第1期35卷 63-77页

作者： Paula BONA Juliana STERLI Marcelo Saúl de la FUENTE Eduardo OLIVERO marta S.FERNÁNDEZ Marcelo REGUERO División Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina consejo Nacional de Investigaciones científicas y Técnicas(cONIcET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Museo Paleontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina centro Austral de Investigaciones científicas-cONIcET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fossil record has been the key to reconstructing the evolution of the Weddellian Sea and final dismemberment of Southern *** this context,Eocene marine vertebrates from Seymour(Marambio)Island have provided valuable *** present the first Eocene record of marine reptiles from the southern Atlantic coast of South *** corresponds to several postcranial turtle remains represented by a proximal end of the right humerus,three caudal and one thoracic vertebrae,a fragment of the left pubis,and ten ossicles of the dorsal carapace,coming from the Leticia Formation(late-mid Eocene)at cabo Tiburones,Tierra del Fuego,*** materials show severalfeatures such as the size and general morphology of the humerus and vertebrae,and the presence of relatively small,irregular,smooth,and unkeeled ossicles,which allow us to assign them to Dermochelyidae *** are a cosmopolitan group ofcryptodiran turtles,registered from the late cretaceous up to the recent,with some physiological-biological peculiarities(e.g.,endothermy and an exclusive jellyfish-based diet)and characterized by the presence of an osseous carapace formed by *** new finding from the Leticia Formation is an addition to the scarce and extremely fragmentary record of Eocene dermochelyids from the southern seas like those from the La Meseta and Submeseta formations(Antarctica)and the Waihao and Burnside formations(New Zealand).This new information allows us to discuss the presence of these turtles in such high latitudes in the past and its implication in the evolution of the Weddellian fauna.

关键词： marine reptiles sea turtles Dermochelyidae Paleogene La Meseta Formation Submeseta Formation Leticia Formation

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor cilleros-Mañé Laia Just-Borràs marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal marta Tomàs carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and c(PKA and PKc)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKc activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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The effect of Laves phases and nano-precipitates on the electrochemical corrosion resistance of Mg-Al-ca alloys under alkaline conditions

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Journal of Magnesium and Alloys 2024年第6期12卷 2447-2461页

作者： Markus Felten Veronika chaineux Siyuan Zhang Ali Tehranchi Tilmann Hickel christina Scheu Joshua Spille marta Lipińska-chwałek Joachim Mayer Benjamin Berkels Marcus Hans Imke Greving Silja Flenner Sandra Sefa Daniela Zander chair of corrosion and corrosion Protection RWTH Aachen UniversityAachen 52072 Germany Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany central Facility for Electron Microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbHJülich 52428Germany Mathematical Image and Signal Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany Materials chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The electrochemical corrosion mechanisms of Mg alloys were extensively studied in previous investigations of different chemical com-positions,modified surface states and various electrolyte ***,recent research focused on the active state of Mg dissolution,leading to unresolved effects of secondary phases adjacent to a stableα-solid solution passive *** present study investigates the fundamental electrochemical corrosion mechanisms of three different Laves phases with varying phase morphologies and phase fractions in the passive state of Mg-Al-ca *** microstructure was characterized by(transmission-)electron microscopy and synchrotron-based transmission X-ray *** electrochemical corrosion resistance was determined with a standard three-electrode setup and advanced in-situ flow cell measurements.A new electrochemical activity sequence(c15>c36>α-Mg>c14)was obtained,as a result of a stable passive layer formation on theα-solid ***,nm-scale Mg-rich precipitates were identified within the Laves phases,which tend to inhibit the corrosion kinetics.

关键词： Laves phase STEM Magnesium corrosion Passive layer

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Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： christian Bracco marta Gallarate Marco Badinella Martini corrado Magnino Salvatore D'Agnano Roberta canta Giulia Racca Remo Melchio cristina Serraino Valentina Polla Mattiot Giovanni Gollè Luigi Fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BAcKGROUND Hepatocellular carcinoma(Hcc)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of Hcc patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of Hcc recorded at"Santa croce e carle"Hospital in cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in Hcc patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 Hcc patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** c virus infection was the most common Hcc risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The child-Pugh score distribution of the patients was:class A 75%,class B 21%and class c 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the Hcc was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodulec stage of the *** Barcelona clinic Liver cancer(BcLc)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BcLc stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis Etiology Treatment

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EDTA间接滴定法快速检测cO_(2)吸收液中碳酸氢根与碳酸根总量的研究

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低碳化学与化工 2024年第2期49卷 89-95页

作者：李取超殷国栋姚国栋朱宁正 marta Sibhat 周仰原赵建夫同济大学环境科学与工程学院上海200092 上海洗霸气候科学技术有限公司上海200091

碳捕集、利用与封存(ccUS)技术是减少二氧化碳(cO_(2))排放的有效措施之一,其中化学吸收法应用广泛且技术成熟。在化学吸收法中,用碱性溶液吸收cO_(2)后,cO_(2)吸收液中存在一定量的碳酸氢根和碳酸根,准确测定cO_(2)吸收液中碳酸氢根和... 详细信息

碳捕集、利用与封存(ccUS)技术是减少二氧化碳(cO_(2))排放的有效措施之一,其中化学吸收法应用广泛且技术成熟。在化学吸收法中,用碱性溶液吸收cO_(2)后,cO_(2)吸收液中存在一定量的碳酸氢根和碳酸根,准确测定cO_(2)吸收液中碳酸氢根和碳酸根的总量,可确定cO_(2)吸收液的cO_(2)吸收量。根据脱硫废水(作为cO_(2)吸收液)的水质组分及其复杂性提出了采用EDTA间接滴定法快速测定cO_(2)吸收液中碳酸氢根和碳酸根的总量(以碳酸根计,下同)。对碳酸氢根和碳酸根系列标准溶液的测定结果表明,系列标准溶液的标准曲线线性拟合系数均大于0.9993,线性拟合范围为100~2500 mg/L,因此EDTA间接滴定法测定碳酸氢根和碳酸根总量的检测范围为100~2500 mg/L。对实际工程水样的测定结果显示,测定结果的相对标准偏差为0.92%~1.28%(n=5),准确性较好,EDTA间接滴定法测定碳酸氢根和碳酸根总量具有现实可行性。

关键词： cO_(2)化学吸收定量检测间接滴定脱硫废水

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EDTA间接滴定法快速检测cO吸收液中碳酸氢根与碳酸根总量的研究

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低碳化学与化工 2024年

作者：李取超殷国栋姚国栋朱宁正 marta Sibhat 周仰原赵建夫同济大学环境科学与工程学院上海洗霸气候科学技术有限公司

碳捕集、封存与利用(ccUS)技术是当前减少二氧化碳(cO2)排放的有效措施之一，其中化学吸收法应用广泛且技术成熟。在化学吸收法中，用碱性溶液吸收cO2后，cO2吸收液中存在一定量的碳酸氢根和碳酸根，准确测定cO2吸收液中碳酸氢根和碳酸... 详细信息

碳捕集、封存与利用(ccUS)技术是当前减少二氧化碳(cO2)排放的有效措施之一，其中化学吸收法应用广泛且技术成熟。在化学吸收法中，用碱性溶液吸收cO2后，cO2吸收液中存在一定量的碳酸氢根和碳酸根，准确测定cO2吸收液中碳酸氢根和碳酸根的总量，可确定cO2吸收液的cO2吸收量。本研究根据脱硫废水(作为cO2吸收液)的水质组分及其复杂性提出采用EDTA间接滴定法快速测定cO2吸收液中碳酸氢根和碳酸根的总量(以碳酸根计，下同)。对碳酸氢根和碳酸根系列标准溶液的测定结果表明，系列标准溶液的标准曲线线性拟合系数均大于0.9993，线性拟合范围为100～2500 mg/L，因此EDTA间接滴定法测定碳酸氢根和碳酸根总量的检测范围为100～2500 mg/L。对实际工程水样的测定结果显示，测定结果的相对标准偏差为0.92%～1.28%(n=5)，准确性较好，因此EDTA间接滴定法测定碳酸氢根和碳酸根总量具有现实可行性。

关键词： cO 化学吸收定量检测间接滴定脱硫废水

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