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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-clermont Aisha Khan George Jimsheleishvili Patricia graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLc MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanc.d.amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a c.d.ver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanc.d.mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produc.d.an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Analysis of switching conditions of chalcogenide alloys during crystallization

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Journal of University of Science and Technology Beijing 2006年第5期13卷 446-449页

作者： Wanhua Yu c.d. Wright Materials Science and Engineering School University of Science and Technology Beijing Beijing 100083 China School of Engineering and computer Science University of Exeter Exeter EX4 4QF UK

To understand the principle and limitation of chalcogenide alloy Ge2Sb2Te5 （GST） in solid-state memory devices during crystallization, it was necessary to develop a physically realistic model that could reflect the electrical and thermal properties of these media. A novel comprehensive numerical model has been developed for simulating these memory devices, which describes the electrical and thermal behavior using the solution of the nonlinear, time-dependent electrical and heat conduction equation. The finite-difference-time-domain technique was adopted to compute the electrical field and heat distribution in the device. Several contributing factors that affect the crystallization switching process such as the geometry of the GST layer, temperature and electric field dependency of the electrical conductivity have been discussed. The results of the simulations were then used to provide critical guidelines for fabrication and optimization of the device performance.

关键词： chalcogenide alloy crystallization simulation modeling memory

Seismo-ionospheric anomalies and implications from recent GNSS observations in India and South-East Asia

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Geodesy and Geodynamics 2016年第1期7卷 11-18页

作者： c.d. Reddy Indian Institute of Geomagnetism Navi Mumbai India

The lithosphere and the atmosphere/ionosphere, continuously exchange energy through various coupling mechanisms. Earthquake creates waves of energy, e.g. direct shock acoustic waves （SAWs） and Rayleigh wave induc.d.acoustic waves （PAWs）. In the event of an earthquake occurring beneath the sea, atmospheric gravity waves {AGWs） are also generated. If the earthquake is large enough （Mw 〉 6）, SAWs, PAWs and AGWs induce detectable ionospheric plasma perturbations. Inferring the seismological information from these seismo-ionospheric manifestations is the subject that pertains to ionospheric seis- mology. Both ground and satellite based advanc.d.radio techniques are being used in monitoring ionospheric plasma perturbations. In this study, seismo-ionospheric anomalies and implications from recent GNSS observations in India and South-East Asia are dis- cussed, mainly pertaining to the following. （1） From the ionospheric plasma response to 2015 Nepal earthquake, the estimated group velocity for Andaman and Indian shield re- gions are 2100 ms i and 3900 ms-1 respectively and validated from ground measurements. （2） Atmospheric acoustic resonance at 4.0 mHz and a train of wave packet of TEc variation resulting from the beat phenomenon observed at the site ＇umlh＇ and （3） GNSS-based tsunami warning which is going to be promising tool in augmenting the existing tsunami warning systems.

关键词： Earthquake Tsunami Ionosphere GNSSTEc

METASTABLE PHASE SEPARATION OF Fe_(50)cu_(50) HYPOPERITEcTIc ALLOY UNdER SPAcE SIMULATION cONdITIONS

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Acta Metallurgica Sinica(English Letters) 1999年第2期12卷 198-204页

作者： Lu, X.Y. cao, c.d. Wei, B.B. Northwestern Polytechnical Univ Xi'an China

A 3m drop-tube was used to investigate the solidification of Fe50cu50 hypoperitectic alloy. The falling droplets solidified as spheres and splats. The obtained particles range from 1000μm to 80μm in diameter. It was found that the phase separation occurred if the Fe-cu liquid was undercooled to a certain extent before *** the big particles macroscopic separation of Fe-rich phase always appeared in the cented of the particles, and in the small ones the Fe-rich phase usually solidified as little spheres. In the flakes the Fe-rich and cu-rich layers alternatively displayed from top to bottom.

关键词： peritectic alloy phase separation dendrite growth drop tube

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： desmond A.Nunez Ru c.Guo division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induc.d.ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-c.d.ng RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEdLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

A review of friction stir welding of steels： Tool, material flow, microstructure, and properties

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Journal of Materials Science & Technology 2018年第1期34卷 39-57页

作者： F.c. Liu Y. Hovanski M.P. Miles c.d. Sorensen T.W. Nelson department of Mechanical Engineering Brigham Young University Provo UT 84602. USA Manufacturing Engineering Technology Brigham Young University Provo UT 84602 USA

considerable progress has been achieved in friction stir welding （FSW） of steels in every aspect of tool fab- rication, microstructure control and properties evaluation in the past two dec.d.s. With the development of reliable welding tools and precise control systems, FSW of steels has reached a new level of technical maturity. High-quality, long welds can be produc.d.in many engineering steels. compared to traditional fusion welding, FSW exhibits unique advantages producing joints with better properties. As a result of active control of the welding temperature and/or cooling rate, FSW has the capability of fabricating steel joints with excellent toughness and strength. For example, unfavorable phase transformations that usu- ally occur during traditional welding can be avoided and favorable phase fractions in advanc.d.steels can be maintained in the weld zone thus avoiding the typical property degradations associated with fusion welding. If phase transformations do occur during FSW of thick steels, optimization of microstructure and properties can be attained by controlling the heat input and post-weld cooling rate.

关键词： Joining Stainless steels carbon steels High strength low alloy (HSLA) steels Advanc.d.high strength steels (AHSS) Oxide dispersion strengthened (OdS) steels

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Fostering children’s Participation in disaster Risk Reduction Through Play:A case Study of LEGO and Minecraft

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International Journal of disaster Risk Science 2021年第6期12卷 867-878页

作者： Loïc Le dé Jc Gaillard Anthony Gampell Nickola Loodin graham Hinchliffe School of Public Health and Interdisciplinary Studies Auckland University of TechnologyManukauAuckland 2025New Zealand School of Environment The University of Auckland.Auckland 1142.New Zealand Unit for Environmental Sciences and Management North-West UniversityPotchefstroom 2520South Africa School of Science.Auckland University of Technology Auckland 1010New Zealand

This article focuses on children’s participation in disaster risk *** draws on a 2018 study done in New Zealand with 33 school children who conducted participatory mapping with LEGO and the video game Minecraft to assess disaster risk in their locality and identify ways to be more *** research involved participatory activities with the children actively involved in the co-design,implementation,and evaluation of the initiative.A focus group discussion was also conducted to assess the project from the viewpoint of the *** results indicate that LEGO and Minecraft are playful tools for children to participate in disaster risk *** research identifies four key elements of genuine children’s participation,including the Participants,Play,the Process,and Power(4 Ps).This framework emphasizes that fostering children’s participation in disaster risk reduction requires focusing on the process through which children gain power to influence decisions that matter to *** process,through play,is child-centered and fosters *** article concludes that Play is essential to ground participation within children’s worldviews and their networks of friends and relatives.

关键词： children's participation disaster risk reduction New Zealand Participatory game tools