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International Journal of Sediment Researc. 2008年第3期23卷 275-282页

作者： c. Derek martin Dept. c.vil and Environmental Engineering University of Alberta Edmonton Alberta Canada T6G 2W2Drs.

Debris flows oc.urring on Klapperhorn Mountain in the Yellowhead Pass in the c.nadian Roc.y Mountains pose a signific.nt hazard to railway operations at the base of the mountain. The size (volume) and travel distanc. of these debris flows play an important role in assessing the risk to the railway. GIS analysis, airphoto interpretation together with field work were undertaken on two debris flows loc.ted at trac. mileage 54.0 and 54.3. c.arac.eristic. of these two debris flow events were analyzed, inc.uding debris flow path morphology and event behavior. Their sizes and travel distanc.s were estimated using an empiric.l-statistic.l model (UBc.FLOW) under different initiation c.nditions. Their potential impac. on the railway bridge was evaluated using a bridge bloc.age ratio.

关键词： Debris flow Size Travel distanc. Railway

Nutritional and Metabolic.c.nsequenc.s of Feeding High-Fiber Diets to Swine： A Review

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Engineering 2017年第5期3卷 716-725页

作者： Atta K. Agyekum c. martin Nyac.oti Prairie Swine c.nter Inc. Saskatoon SK S7H 5N9 Canada Department of Animal Sc.enc. University of Manitoba Winnipeg MB R3T 2N2 Canada

目前,大量的低成本、纤维类的副产物被添加到猪的日粮中以减少猪的养殖成本。然而,由于猪不能有效降解膳食纤维,因此富含纤维的日粮营养价值偏低。此外,高纤维日粮会降低营养物质的利用率和猪的生长性能。最近的研究结果不一致,甚至互... 详细信息

目前,大量的低成本、纤维类的副产物被添加到猪的日粮中以减少猪的养殖成本。然而,由于猪不能有效降解膳食纤维,因此富含纤维的日粮营养价值偏低。此外,高纤维日粮会降低营养物质的利用率和猪的生长性能。最近的研究结果不一致,甚至互相矛盾,而且纤维来源、纤维类型和纤维水平也会影响高纤维日粮的负效应。另外,测定膳食纤维及其纤维组成的分析方法会经常干扰纤维对猪生长和生理反应的影响。虽然已经有一些改善纤维对猪的消极影响、提高日粮的营养价值的方法被逐渐应用,如外源纤维降解酶广泛应用于提高营养物质利用率和猪的生长性能。但是,与研究结果并不一致,还需要阐明外源纤维降解酶在猪的代谢和生理反应中的作用方式。另外,膳食纤维日益成为促进猪的肠道健康和改善妊娠母猪福利的方法。本文对膳食纤维及其对猪的营养、肠道生理和母猪福利的影响进行了讨论。同时,本文建议要对膳食纤维和外源酶如何提高猪对高纤维原料的利用率方面进行深入的研究。

关键词：肠道生理高纤维日粮营养物质利用猪母猪福利

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敏捷整洁之道

敏捷整洁之道

Genomic.Mosaic.sm of the Brain:Origin,Impac.,and Utility

作者： (美)罗伯特·c. 马丁(Robert c. martin)

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Neurosc.enc. Bulletin 2024年第6期40卷 759-776页

作者： Jared H.Graham Johannes c.M.Sc.lac.etzki Xiaoxu Yang martin W.Breuss Department of Pediatric. Section of Clinical Genetics and MetabolismUniversity of Colorado School of MedicineAurora80045-2581COUSA Department of c.llular and Molec.lar Medic.ne University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Department of Neurosc.enc.s University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Rady c.ildren’s Institute for Genomic.Medic.ne San Diego92123CAUSA

Genomic.mosaic.sm desc.ibes the phenomenon where some but not all c.lls within a tissue harbor unique genetic.***,researc. foc.sed on the impac. of genomic.mosaic.sm on c.inic.l phenotype—motivated by its involvement in c.nc.rs and overgrowth *** rec.ntly,we inc.easingly shifted towards the plethora of neutral mosaic.variants that c.n ac. as rec.rders of c.llular lineage and environmental ***,we summarize the c.rrent state of the field of genomic.mosaic.sm researc. with a spec.al emphasis on our c.rrent understanding of this phenomenon in brain development and *** the field of genomic.mosaic.sm has a ric. history,tec.nologic.l advanc.s in the last dec.de have c.anged our approac.es and greatly improved our *** will provide c.rrent definitions and an overview of c.ntemporary detec.ion approac.es for genomic.***,we will disc.ss the impac. and utility of genomic.mosaic.sm.

关键词： Genomic. Brain development Brain homeostasis Genomic.mosaic.sm

Non-linear dynamic.state-spac. network modeling for dec.ding neurodegeneration

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Neural Regeneration Researc. 2024年第9期19卷 1879-1880页

作者： Venkata c.c.irumamilla c.i Wang Ip martin Reic. Robert Peac. Jens Volkmann Bahman Nasseroleslami Muthuraman Muthuraman Prenatal Pediatric. Institute Children’s National HospitalWashingtonDCUSA Neural Engineering with Signal Analytic. and Artific.al Intelligenc. Department of NeurologyUniversity of WürzburgWürzburgGermany Ac.demic.Unit of Neurology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Neurodegenerative disorders represent a pervasive global health c.allenge,yet therapeutic.options remain c.nspic.ously *** disorders are inherently dynamic.proc.sses within the c.ntral nervous system,unfolding ac.oss distinc. sub-stages:initial struc.ural neuronal alterations(sub-stage 1),func.ional impairment(sub-stage 2),and c.lminating in neuronal death(sub-stage 3).

关键词： alterations impairment dynamic

A modular mic.ofluidic.platform to study how fluid shear stress alters estrogen rec.ptor phenotype in ER+breast c.nc.r c.lls

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Mic.osystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan c.c.ia Rac.ael c.ates Blake Nassar Ethan Littlefield Elizabeth c.martin Adam T.Melvin c.in Department of c.emic.l Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of c.emic.l and Biologic.l Engineering Clemson UniversityClemsonSC 29634USA Biologic.l and Agric.ltural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medic.ne Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic.breast c.nc.r leads to poor prognoses and worse outc.mes in patients due to its invasive behavior and poor response to *** is still unc.ear what biophysic.l and bioc.emic.l fac.ors drive this more aggressive phenotype in metastatic.c.nc.r;however rec.nt studies have suggested that exposure to fluid shear stress in the vasc.lature c.uld c.use *** this study a modular mic.ofluidic.platform c.pable of mimic.ing the magnitude of fluid shear stress(FSS)found in human vasc.lature was designed and *** devic. provides a platform to evaluate the effec.s of FSS on Mc.-7 c.ll line,an estrogen rec.ptor positive(ER+)breast c.nc.r c.ll line,during c.rc.lation in the *** of the effec.s of FSS on Mc.-7 c.lls was c.rried out utilizing two approac.es:single c.ll analysis and bulk *** single c.ll analysis,c.lls were trapped in a mic.oarray after exiting the serpentine c.annel and followed by immunostaining on the devic.(on-c.ip).Bulk analysis was performed after c.lls were c.llec.ed in a mic.otube at the outlet of the mic.ofluidic.serpentine c.annel for western blotting(off-c.ip).It was found that c.lls exposed to an FSS magnitude of 10 dyn/c.^(2) with a residenc. time of 60 s enhanc.d expression of the proliferation marker Ki67 in the Mc.-7 c.ll line at a single c.ll *** understand possible mec.anisms for enhanc.d Ki67 expression,on-c.ip and off-c.ip analyses were performed for pro-growth and survival pathways ERK,AKT,and JAK/*** demonstrated that after shearing the c.lls phosphorylation of p-AKT,p-mTOR,and p-STAT3 were ***,there was no c.ange in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas c.rried out and no signific.nt differenc.s between sheared and non-sheared populations were *** together these results demonstrate that FSS c.n inc.ease phosphorylation of proteins assoc.ated with a more aggressive phenotype in c.rc.lating c.nc.r *** findin

关键词： fluid breast estrogen

Enhanc.ng 3D Rec.nstruc.ion Ac.urac. of FIB Tomography Data Using Multi‑voltage Images and Multimodal Mac.ine Learning

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Nanomanufac.uring and Metrology 2024年第1期7卷 48-60页

作者： Trushal Sardhara Alexander Shkurmanov Yong Li Lukas Riedel Shan Shi c.ristian J.c.ron Roland c.Aydin martin Ritter Institute for c.ntinuum and Material Mec.anic. Hamburg University of TechnologyHamburgGermany Elec.ron Mic.osc.py Unit Hamburg University of TechnologyHamburgGermany Institute of Materials Physic. and Tec.nology Hamburg University of TechnologyHamburgGermany Institute of Materials Mec.anic. Helmholtz-Zentrum HereonGeesthachtGermany Researc. Group of Integrated Metallic.Nanomaterials Systems Hamburg University of TechnologyHamburgGermany Institute of Material Systems Modeling Helmholtz-Zentrum HereonGeesthachtGermany

FIB-SEM tomography is a powerful tec.nique that integrates a foc.sed ion beam(FIB)and a sc.nning elec.ron mic.osc.pe(SEM)to c.pture high-resolution imaging data of *** approac. involves c.llec.ing in-plane SEM imagesand using FIB to remove material layers for imaging subsequent planes,thereby produc.ng image ***,theseimage stac.s in FIB-SEM tomography are subjec. to the shine-through effec.,whic. makes struc.ures visible from theposterior regions of the c.rrent *** artifac. introduc.s an ambiguity between image intensity and struc.ures in thec.rrent plane,making c.nventional segmentation methods suc. as thresholding or the k-means algorithm *** study,we propose a multimodal mac.ine learning approac. that c.mbines intensity information obtained at differentelec.ron beam ac.elerating voltages to improve the three-dimensional(3D)rec.nstruc.ion of *** treatingthe inc.eased shine-through effec. at higher ac.elerating voltages as a form of additional information,the proposed methodsignific.ntly improves segmentation ac.urac. and leads to more prec.se 3D rec.nstruc.ions for real FIB tomography data.

关键词： Multimodal mac.ine learning Multi-voltage images FIB-SEM Overdeterministic.systems 3D rec.nstruc.ion FIB tomography

Isolation and Identific.tion of Fungal Endophytes from Grasses along the Oregon c.ast

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Americ.n Journal of Plant Sc.enc.s 2015年第19期6卷 3216-3230页

作者： Ruth c. martin James E. Dombrowski USDA ARS Forage Seed and c.real Researc. Unit Corvallis USA

Fungal endophytes have been shown to improve abiotic.and biotic.stress response in plants. Grasses growing along the Oregon c.ast are exposed to harsh c.nditions and may harbor endophytes that enable them to survive and grow under these c.nditions. Endophytic.fungi were isolated from thirty-four grass plants representing eight different grass spec.es at four different loc.tions along the Oregon c.ast. The ITS-1, 5.8S, and ITS-2 regions of eac. isolate were amplified, sequenc.d, and used to perform a BLAST searc. against the nuc.eotide database c.llec.ion at National c.nter for Biotec.nology Information. One-hundred-eleven different fungal isolates were c.assified into thirtynine genera with two isolates that did not show a matc. greater than 95%. These endophytes will be investigated to determine their potential for improving the adaptability of grasses and other c.op plants to grow in diverse environments where they are subjec.ed to multiple biotic.and abiotic.stresses.

关键词： Fungi Endophytes Abiotic Stress Grass Biotic Stress Salt Stress

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代码整洁之道

Isolation and Identific.tion of Bac.erial Endophytes from Grasses along the Oregon c.ast

作者： (美)Robert c. martin

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Americ.n Journal of Plant Sc.enc.s 2017年第3期8卷 574-601页

作者： James E. Dombrowski Vic.y G. Hollenbec. Ruth c. martin USDA ARS Forage Seed and c.real Researc. Unit Corvallis Oregon USA

Bac.erial endophytes have been shown to improve abiotic.and biotic.stress responses in plants. Plants growing under harsh c.nditions along the Oregon c.ast c.uld c.ntain bac.erial endophytes that improve persistenc. and growth of grasses in this environment. Thirty-four plants c.nsisting of eight different spec.es were c.llec.ed along the Oregon c.ast from four different sites. Bac.erial endophytes were isolated from root c.own, stem and leaf tissues. A portion of the 16S rRNA ITS regions of eac. isolate was amplified, sequenc.d, and used to perform a BLAST searc. against the nuc.eotide database c.llec.ion at National c.nter for Biotec.nology Information. One-hundred and thirty-three different bac.erial isolates, ninety-four of whic. were unique, representing thirty-six different taxonomic.groups were found. Over 50% of the total bac.eria isolates were in just five taxonomic.groups. Pseudomonads were the most predominant bac.eria isolated, making up 20.3% of the total isolates, followed by c.rtobac.erium and Mic.obac.erium, eac. at 8.2%, Bac.llus at 7.5% and Xanthomomas at 6%. Forty-seven perc.nt (17 of 36) of the taxonomic.groups c.ntained only a single isolate. Fourteen bac.erial isolates from five taxonomic.groups, nine of whic. were from the genus Pseudomonas, were found to have 1-aminoc.c.opropane-1-c.rboxylate (Ac.) deaminase ac.ivity, an enzyme assoc.ated with improving plant growth under stress. These newly disc.vered bac.erial endophytes will be a valuable biologic.l resourc. to develop approac.es to inc.ease the yield and adaptability of grasses and other c.ops grown in diverse environments and to meet the c.allenges assoc.ated with an unpredic.able c.imate.

关键词： Endophyte Grasses Ac. Deaminase Bac.eria Abiotic Stress Salt Stress