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The History of HSCT in Korea -Lessons from the Experience of 2,500 cases of Hematopoietic Stem Cell Transplantation in CHSCTC-

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The History of HSCT in Korea -Lessons from the Experience of...

Big data in healthcare:Conceptual network structure,key challenges and opportunities

第十届亚太国际骨髓移植会议

作者： Chun-choo Kim Catholic Hemopoietic Stem Cell Transplantation Center St. Mary’s HospitalCatholic University of Korea College of MedicineSeoulKorea

＜正＞First successful allogeneic bone marrow transplantation （BMT） in Korea was performed at Catholic hematopoietic stem cell transplantation center （CHSCTC） for patient with acute lymphoblastic leukemia in 1983. First autologous and unrelated BMT in Korea was also performed in the CHSCTC in 1985 and 1995, respectively. There was a rapid increase in the allogeneic and autologous stem cell transplantation （SCT） from 1996. Nowadays CHSCTC usually performs more than 250 SCT in a year. We have achieved 2,500 cases of SCT until May 2005. Up to now, we performed 1,906 cases of ailogeneic SCT （72.3%）, 742 cases

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Digital Communications and Networks 2023年第4期9卷 856-868页

作者： Leonardo B.Furstenaua Pedro Leivas Michele Kremer Sott Michael S.Dohan Jose Ricardo Lopez-Robles Manuel J.Cobo Nicola Luigi Bragazzi Kim-Kwang Raymond choo Post-Graduate Program in Industrial Engineering Federal University of Rio Grande Do SulPorto Alegre90035-190Brazil University of Santa Cruz Do Sul Av.Independencia 2293Santa Cruz Do SulRSBrazil Business School Unisinos UniversityAv.Dr.Nilo Peçanha 160091330-002Porto AlegreBrazil Faculty of Business Administration Lakehead UniversityThunder BayOntarioCanada Autonomous University of Zacatecas Av.Ramon Lopez Velarde Col.CentroZacatecas98000Mexico Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain York University ON M3J 1P3Canada Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Big data is a concept that deals with large or complex data sets by using data analysis tools(e.g.,data mining,machine learning)to analyze information extracted from several sources *** data has attracted wide attention from academia,for example,in supporting patients and health professionals by improving the accuracy of decision-making,diagnosis and disease *** research aimed to perform a Bibliometric Performance and Network Analysis(BPNA)supported by a Scoping Review(SR)to depict the strategic themes,thematic evolution structure,main challenges and opportunities related to the concept of big data applied in the healthcare *** this goal in mind,4857 documents from the Web of Science covering the period between 2009 to June 2020 were analyzed with the support of SciMAT *** bibliometric performance showed the number of publications and citations over time,scientific productivity and the geographic distribution of publications and research *** strategic diagram yielded 20 clusters and their relative importance in terms of centrality and *** thematic evolution structure presented the most important themes and how it changes over ***,we presented the main challenges and future opportunities of big data in healthcare.

关键词： Big data Healthcare digitalization Bibliometric Strategic intelligence Co-word analysis SciMAT

The fibroblast growth factor receptor pathway in hepatocellular carcinoma

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Hepatoma Research 2018年第9期4卷 19-29页

作者： Joycelyn Jie Xin Lee Su Pin choo Division of Medical Oncology National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore

Hepatocellular carcinoma is the third most common cause of cancer-related death globally and portends a poor prognosis. The fibroblast growth factor receptor (FGFR) pathway is increasingly acknowledged to play a role in the pathogenesis of hepatocellular carcinoma (HCC) and is postulated to be upregulated as a mechanism of resistance to anti-VEGF treatment. We attempt to review the importance of the FGFR pathway in HCC oncogenesis, as well as the current clinical evidence on the efficacy and safety of FGFR pathway inhibitors in HCC.

关键词： Hepatocellular carcinoma targeted therapy fibroblast growth factor

热带石松科植物中石杉碱甲的含量差异(英文)

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中国天然药物 2012年第2期10卷 125-128页

作者： NorShahidah Sahidan Chee Yan choo A.Latiff Razali Jaman MedChem Herbal Research Group Faculty of Pharmacy Universiti Teknologi MARA 42300 Selangor Malaysia Faculty of Sciences and Technology Universiti Kebangsaan Malaysia Bangi Selangor Malaysia Faculty of Sciences and Technology Universiti Kebangsaan Malaysia Bangi Selangor Malaysia

(-) Huperzine A is a bioactive alkaloid from Huperzia serrata (Lycopodiaceae) used for the treatment of Alzheimer's disease. High yielding (-) huperzine A species is of interest for mass propagation since it grows slowly in temperate countries. The content of (-) huperzine A from temperate countries was reported but none reported from tropical species. The aim of this study was to evaluate the content of (-) huperzine A from tropical club mosses and further identify a high yielding species. Club mosses from Lycopodiaceae family were collected from Peninsular Malaysia. The collected club mosses were dried, pulverized and extracted with methanol. A gradient reverse phase HPLC-photodiode array detector method with increasing amount of methanol in 0.01 % trifluoroacetic acid was developed. The calibration curve was linear from 5 to 100 g·mL-1 with correlation coefficient, r2, of 0.998 1. The precision for both intra-and inter-day peak area were between 0.48% to 1.24 % and 0.95% to 3.85 %, respectively. The recovery of the method was between 99.8% to 103.8 %. Though geographically segregated, (-) huperzine A content in Huperzia phlegmaria and *** found in the tropics was highest and similar to species in Australasia. Both species may provide a good source of (-) huperzine A.

关键词： Lycopodiaceae (-) Huperzine A HPLC Tropics

Male metaplastic breast cancer with poor prognosis:A case report

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World Journal of Clinical Cases 2022年第15期10卷 4964-4970页

作者： Hyun Yul Kim Seungju Lee Dong-il Kim Chang Shin Jung Jee Yeon Kim Kyung Jin Nam Ki Seok choo Youn Joo Jung Department of Surgery Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Pathology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea Department of Radiology Pusan National University Yangsan HospitalPusan National University School of MedicineGyeongnam 50612South Korea

BACKGROUND Metaplastic breast cancer(MBC)is a rare subtype of breast *** constitute less than 1%of breast cancer cases and are much rarer in *** are few reports of MBC because of its ***,an aggressive type of cancer,is refractory to common treatment modalities of breast cancer and has a poor *** SUMMARY We report a case of MBC in a 78-year-old *** visited our clinic with a palpable mass on the left breast with no masses in the axillary *** had previously undergone robot-assisted laparoscopic radical prostatectomy for prostate cancer,but there was no family history of *** breast mass was visible on ultrasonography,mammography,and magnetic resonance imaging,and chest computed tomography revealed a lung mass in the posterior basal segment of the right lower *** patient was diagnosed with metaplastic carcinoma on core needle biopsy with lung *** mastectomy with sentinel lymph node biopsy and video-assisted segmentectomy of the right lung was ***,multiple metastases appeared 3 mo after surgery in the brain,chest,and abdomen,and the patient died 5 mo after the initial *** MBC is an aggressive and extremely rare breast cancer *** case reports are needed to determine the optimal treatment.

关键词： Breast neoplasm Male Triple-negative breast cancer Metaplastic breast cancer Adjuvant treatment Case report

Workplace Wellness,Mental Health Literacy,and Usage Intention of E-Mental Health amongst Digital Workers during the COVID-19

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International Journal of Mental Health Promotion 2023年第1期25卷 99-126页

作者： choon-Hong Tan Ah-choo Koo Hawa Rahmat Wei-Fern Siew Alexius Weng-Onn Cheang Elyna Amir Sharji Faculty of Creative Multimedia Multimedia UniversityCyberjaya63000Malaysia Faculty of Applied Communication Multimedia UniversityCyberjaya63000Malaysia International Medical University(IMU) Bukit Jalil57000Malaysia

The prevalence of mental health problems in both Malaysian and global workplaces has signiﬁcantly increased due to the presence of the coronavirus disease(COVID-19)pandemic,globalization,technology advancement in Industry 4.0,and other contributing *** pervasiveness of the issue poses a huge challenge to improving the occupational safety and health(OSH)of workers in various industries,especially in the digital *** emergence of the innovative industry is evident mainly due to the rapid development of Industry 4.0 and the rele-vant demands of multiple businesses in the digital ***,limited studies and academic dis-cussions were conducted on the OSH topic of digital ***,the current study serves toﬁll the existing gap and provide academic contributions by scrutinising the perceptions of digital workers regarding their work-place well-being,mental health literacy,and the impression of employing e-mental *** objectives of this study are:1)To examine the mental health literacy and workplace wellness of digital workers,2)to explore the e-mental health usage intention and actual e-mental health utilization,and 3)to identify digital workers’feedback on e-mental *** the current context,e-mental health focuses on three dimensions,namely,1)“health in our hand(HIOH)”,2)“interacting for health(IFH)”,and 3)“data enabling health(DEH)”.The present study employed an online cross-sectional survey and received 326 digital workers’completed ***,such as“mental health literacy(MHL)”,“workplace wellness(WW)”,and e-mental health intention and usage were explicated by analysing the data through descriptive *** study results indicated a moderate to a high level of the MHL and the *** than half of the workers possessed a high intention level to employ e-mental health,with the HIOH dimension being the most prevalent ***,the actual e-mental health usage was very low,owing to the online r

关键词： E-mental health intention digital workers digital industry workplace wellness mental health literacy

Therapeutic efficacy and stent patency of transhepatic portal vein stenting after surgery

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World Journal of Gastroenterology 2016年第44期22卷 9822-9828页

作者： Ung Bae Jeon Chang Won Kim Tae Un Kim Ki Seok choo Joo Yeon Jang Kyung Jin Nam Chong Woo Chu Je Ho Ryu Department of Radiology Pusan National University Yangsan Hospital Department of Radiology Medical Research Institute Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Hospital Department of Surgery Pusan National University Yangsan Hospital

AIM To evaluate portal vein(PV) stenosis and stent patency after hepatobiliary and pancreatic surgery, using abdominal computed tomography(CT).METHODS Percutaneous portal venous stenting was attempted in 22 patients with significant PV stenosis(> 50%)-after hepatobiliary or pancreatic surgery- diagnosed by abdominal CT. Stents were placed in various stenotic lesions after percutaneous transhepatic portography. Pressure gradient across the stenotic segment was measured in 14 patients. Stents were placed when the pressure gradient across the stenotic segment was > 5 mm Hg or PV stenosis was > 50%, as observed on transhepatic portography. Patients underwent followup abdominal CT and technical and clinical success, complications, and stent patency were *** Stent placement was successful in 21 patients(technical success rate: 95.5%). Stents were positioned through the main PV and superior mesenteric vein(n = 13), main PV(n = 2), right and main PV(n = 1), left and main PV(n = 4), or main PV and splenic vein(n = 1). Patients showed no complications after stent placement. The time between procedure and final follow-up CT was 41-761 d(mean: 374.5 d). Twenty stents remained patent during the entire follow-up. Stent obstruction-caused by invasion of the PV stent by a recurrent tumor- was observed in 1 patient in a follow-up CT performed after 155 d after the procedure. The cumulative stent patency rate was 95.7%. Small in-stent low-density areas were found in 11(55%) patients; however, during successive follow-up CT, the extent of these areas had *** Percutaneous transhepatic stent placement can be safe and effective in cases of PV stenosis after hepatobiliary and pancreatic surgery. Stents show excellent patency in follow-up abdominal CT, despite development of small in-stent low-density areas.

关键词： Liver Vein Stent Computed tomography Surveillance Efficace

马来西亚非华裔生识字教学研究 ——以新华学校二甲班为例

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马来西亚非华裔生识字教学研究 ——以新华学校二甲班为例

作者： choo YEE KOON（朱翊郡）华中师范大学

学位级别：硕士

马来西亚的非华裔入读华文小学,让人数不足的微型小学起死回生,逃过被关闭的厄运。非华裔生在华文小学不能掌握华文,难于在小学的评估考试中(Ujian Pencapaian Sekolah Rendah,简称UPSR)达致全科及格,而让全校及格率滑落也是不争的事实... 详细信息

马来西亚的非华裔入读华文小学,让人数不足的微型小学起死回生,逃过被关闭的厄运。非华裔生在华文小学不能掌握华文,难于在小学的评估考试中(Ujian Pencapaian Sekolah Rendah,简称UPSR)达致全科及格,而让全校及格率滑落也是不争的事实。华小的成败,非华裔生扮演着极重要的角色。论文通过对非华裔生的识字教学进行研究,探索以教导华文为第二语文为原则下,寻求一套适合非华裔生在华小的教材与教学法。研究的目的在于让非华裔生先掌握基本的识字量,在评估试中华文科顺利过关,提升整体及格率,致非华裔生既是华小的“救命恩人”也不拖垮成绩的双赢局面。论文由以下基本的部分组成:第一部分,分析了马来西亚当前非华裔生在华小的学习情况问题及其研究意义,在梳理国内外研究文献的基础上,对研究对象与核心概念进行界定,论述了研究目标与研究内容、研究思路与方法。第二部分,简介了当代代表性的识字教学方法。借鉴其他国家教导非华裔生学习华文的方法,取长补短,作为设计研究教材和教学法的参照。第三部分,马来西亚华文小学非华裔生识字教学研究方案。在确定课题研究对象、选材准则、教学设计、教学原则的基础上,从教材排列、教学效果等方面对马来西亚华文小学非华裔生识字教学进行了探索。第四部分,马来西亚华文小学非华裔生识字教学存在的问题及原因。在对马来西亚华文小学非华裔生识字教学现状进行调查的基础上,分析了存在的问题及原因。第五部分,马来西亚华文小学非华裔生识字教学策略及效果。针对非华裔生的问题,提出了相应的教学策略,并分析了教学效果。

关键词：识字教学非华裔生华文小学马来西亚

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娘惹传统服饰在当代服装设计中的创新应用

娘惹传统服饰在当代服装设计中的创新应用

作者： Shannon choo Sher Ning 浙江科技学院

学位级别：硕士

娘惹是马来西亚的传统服饰,历史悠久积累丰厚。从史料来看,娘惹服饰的源起可追溯到15世纪,由峇峇和娘惹人组成的土生华人,结合了东方和西方融合的审美风格,形成了马来西亚独特的峇峇娘惹文化艺术。历史上,从中国南下到马来西亚的侨民和... 详细信息

娘惹是马来西亚的传统服饰,历史悠久积累丰厚。从史料来看,娘惹服饰的源起可追溯到15世纪,由峇峇和娘惹人组成的土生华人,结合了东方和西方融合的审美风格,形成了马来西亚独特的峇峇娘惹文化艺术。历史上,从中国南下到马来西亚的侨民和当地原住民通婚,带动了中马两国传统文化、生活习俗和手工技艺的融合,在服装、美食、建筑、手工艺等方面逐渐发展,演变形成了土生华人独特的风格。娘惹文化是娘惹自幼研习特殊的家政及纺织工艺品技艺所形成的文化,传承至今,并被纳入为马来西亚非物质遗产之一。近年,由于西方时尚风潮的影响,以及当代生活方式的变迁,峇峇娘惹文化及传统服装逐渐淡出生活,凸显了与当代时尚生活的距离,呈现衰落的迹象。究其原因,主要在于峇峇娘惹文化及传统服装缺乏与时俱进的发展和创新,不能适应当下消费者的穿着需求和审美需求。藉此,本文以娘惹服饰发展及衰落的文化因素研究为出发点,剖析娘惹服饰文化精神、服饰审美和传统技艺,梳理了马来西亚土生华人服饰类别的审美和特征,结合马来西亚时尚产业对娘惹服饰的需求分析,从服装设计的构成要素廓形、面料、工艺及色彩风方面着手,开展创新实践。设计实践以东方审美文化与西方时尚设计、传统服饰传承与当代生活需求相融合为基础设计理念,笔者践行主题构思、服装设计、传统工艺和成衣制作等环节,最终呈现当代娘惹创新设计系列服装,以促进传统与当代转变,打造兼具艺术价值和商业价值的创新娘惹服装。本文的研究通过对娘惹服饰在当代时装设计中的创新应用,提供传承文化创新实践,有助于弘扬国家及民族精神,满足当代审美需求,传承和保护马来西亚传统服装的文化遗产,重新唤起人们对土生华人文化的关注与兴趣,以防土生华人文化的衰落,实现传统服饰全球化和多元化的发展。

关键词：土生华人娘惹服装文化遗产当代服装设计创新