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Effect of growth hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3

World Journal of Gastroenterology 2009年第43期15卷 5418-5424页

作者： Betul Ersoy Kemal Ozbilgin Erhun Kasirga Sevinc Inan senol Coskun Ibrahim Tuglu Division of Pediatric Endocrinology Department of PediatricsFaculty of MedicineCelal Bayar University Manisa 45010Turkey Department of Histology and Embryology Faculty of MedicineCelal Bayar UniversityManisa 45010 Turkey Division of Pediatric Gastroenterology De- partment of PediatricsFaculty of MedicineCelal Bayar UniversityManisa 45010Turkey Department of Histology and Embryology Faculty of MedicineCelal Bayar University Manisa 45010Turkey Department of Pediatrics Faculty of Medicine Celal Bayar UniversityManisa 45010Turkey

AIM:To evaluate the effects of growth hormone(GH) on the histology of small intestines which might be related to the role of insulin like growth factor(IGF)-I, IGF-binding protein 3(IGFBP-3)and its receptors. METHODS:Twelve week-old adult male Wistar albino rats were divided into two *** study group(n =10),received recombinant human growth hormone (rGH)at a dose of 2 mg/kg per day subcutaneously for 14 d and the control group(n=10)received physiologic *** sections of jejunum were stained with periodic acid shift(PAS)and hematoxylin and eosin(HE) for light *** were also examined for IGF-I, IGFBP-3 and IGF-receptor *** intensity was graded semi-quantitatively using the HS- CORE. RESULTS:Goblet cells and the cells in crypt epitheliawere significantly increased in the study group compared to that of the control *** have demonstrated an increase of IGF-I and IGFBP-3 immunoreactivities in surface epithelium of the small intestine by GH ***-I receptor immunoreactivities of crypt,villous columnar cells,enteroendocrine cells and muscularis mucosae were also more strongly positive in the study group compared to those of in the control group. CONCLUSION:These findings confirm the important trophic and protective role of GH in the homeostasis of the small *** trophic effect is mediated by an increase in IGF-I synthesis in the small intestine, but the protective effect is not related to IGF-I.

关键词： Growth hormone Small intestine Like growth factor-I Insulin like growth factor binding protein 3

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Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-α treatment?

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World Journal of Gastroenterology 2005年第48期11卷 7688-7689页

作者： Mehmet Sahin Mehmet Isler Altug senol Mustafa Demirci Zeynep Dilek Aydin Department of Internal Medicine Department of Microbiology and Parasitology

Immunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus （HCV） infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome.

关键词： Hepatitis C Interferon Fasciola hepatica

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Multiple-solitons for generalized(2+1)-dimensional conformable Korteweg-de Vries-Kadomtsev-Petviashvili equation

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Journal of Ocean Engineering and Science 2022年第6期7卷 536-542页

作者： Lanre Akinyemi Mehmet senol Orkun Tasbozan Ali Kurt Department of Mathematics Lafayette CollegeEastonPennsylvaniaUSA Nevsehir HacıBektas Veli University Department of MathematicsNevsehirTurkey Mustafa Kemal University Department of MathematicsHatayTurkey Pamukkale University Department of MathematicsDenizliTurkey

This paper studied new class of integral equation called the Korteweg-de Vries-Kadomtsev-Petviashvili(KdV-KP)*** equation consist of the well-known fifth-order KdV equation in the context of the Kadomtsev-Petviashvili *** newly gathered class of sixth-order KdV-KP equation is studied using the sub-equation method to obtain several soliton-type solutions which consist of trigonometric,hyperbolic,and rational *** application of the sub-equation approach in this work draws attention to the outstanding characteristics of the suggested method and its ability to handle completely integrable ***,the obtained solutions have not been reported in the previous literature and might have significant impact on future research.

关键词： Conformable derivative Sub-equation method KdV-KP equations Multiple-soliton solutions

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Proton magnetic resonance spectroscopy of the anterior cingulate gyrus and caudate nucleus in schizophrenia patients versus healthy controls

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Neural Regeneration Research 2011年第6期6卷 467-473页

作者： Lutfi Incesu Meral Baydin Kerim Aslan Baris Diren Huseyin Sahin Omer Boke senol Dane Department of Radiology Medical FacultyOndokuz Mayis University Department of Radiology Gazi State Hospital Department of Radiology Ataturk State Hospital Department of Radiology Medicana International Hospital Department of Psychiatry Medical FacultyOndokuz Mayis University Department of Physiology Medical FacultyFatih University

Proton magnetic resonance spectroscopy （^1 H-MRS） permits the assessment of cerebral neurometabolites, such as N-acetylaspartate, choline, and creatine, in vivo and has been used to study schizophrenia. The present study used ^1H-MRS to compare the spectroscopy change of N-acetylaspartate, creatine, and choline metabolite levels in the anterior cingulate and caudate nucleus of both schizophrenia patients and healthy controls, as well as between the left and right cerebral hemispheres in the schizophrenia patients. Results showed that N-acetylaspartate and creatine metabolite levels in the left anterior cingulate gyrus were significantly lower in the schizophrenia patients than in the healthy controls, indicating hypometabolism. In addition, choline concentration in the left caudate nucleus of schizophrenia patients was significantly lower than in the right caudate nucleus, indicating that it is necessary to study the cerebral lateralization of ^1H-MRS in schizophrenia patients.

关键词： schizophrenia magnetic resonance spectroscopy anterior cingulate gyrus caudate nucleus neurocognitive test

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Analytical and approximate solutions of nonlinear Schrödinger equation with higher dimension in the anomalous dispersion regime

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Journal of Ocean Engineering and Science 2022年第2期7卷 143-154页

作者： Lanre Akinyemi Mehmet senol M.S.Osman Department of Mathematics Lafayette CollegeEastonPAUSA Nev¸s ehir HacıBekta¸s Veli University Department of MathematicsNev¸s ehirTurkey Department of Mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt

The generalized Riccati equation mapping method(GREMM)is used in this paper to obtain different types of soliton solutions for nonlinear Schrödinger equation with higher dimension that existed in the regimes of anomalous ***,we use the q-homotopy analysis method combined with the Laplace transform(q-HATM)to obtain approximate solutions of the bright and dark optical *** q-HATM illustrates the solutions as a rapid convergent *** addition,to show the physical behavior of the solutions obtained by the proposed techniques,the graphical representation has been provided with some parameter *** findings demonstrate that the proposed techniques are useful,efficient and reliable mathematical method for the extraction of soliton solutions.

关键词： q-homotopy analysis method Generalized Riccati equation mapping method Laplace transform

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Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2?

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Natural Products and Bioprospecting 2020年第4期10卷 171-186页

作者： Ilkay Erdogan Orhan F.Sezer senol Deniz Department of Pharmacognosy Faculty of PharmacyGazi University06330 AnkaraTurkey

New coronavirus referred to SARS-CoV-2 has caused a worldwide pandemic(COVID-19)declared by *** disease 2019(COVID-19)is an infectious disease with severe acute respiratory syndrome caused by coronavirus-2(SARS-CoV-2).SARS-CoV-2 is akin to SARS-CoV,which was the causative agent of severe acute respiratory syndrome(SARS)in 2002 as well as to that of Middle East respiratory syndrome(MERS)in ***-CoV-2 has been revealed to belong to Coronaviridiae family as a member ofβ-*** has a positive-sense single-stranded RNA with the largest RNA *** its genomic sequence has a notable similarity to that of SARS-CoV,antiviral drugs used to treat SARS and MERS are now being also applied for COVID-19 *** order to combat SARS-CoV-2,many drug and vaccine development studies at experimental and clinical levels are currently conducted *** this sense,medicinal plants and the pure natural molecules isolated from plants have been reported to exhibit significant inhibitory antiviral activity against SARS-CoV and other types of *** the present review,plant extracts and natural molecules with the mentioned activity are discussed in order to give inspiration to researchers to take these molecules into consideration against SARS-CoV-2.

关键词： Coronavirus SARS-CoV Medicinal plants Natural products Antiviral

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Hernia Repair during Cesarean Section—Compliance Matters: Tension-Free Tissue Repair

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International Journal of Clinical Medicine 2015年第1期6卷 1-6页

作者： senol Carilli General Surgery Department American Hospital Istanbul Turkey

Purpose: Simultaneous surgeries are increasingly applied in all surgical fields. They bring cost and health advantages to the patient and the economy. Pregnancy is one of the risk factors of hernia in females. We conducted a study for simultaneous tissue repairs of inguinal and umbilical hernias during cesarean section. Methods: Between January 1997 and August 2013 we have operated 42 patients with 45 hernias either umbilical or inguinal. We performed the repairs from the Pfannenstiel incision. Data about maternal age, parity, cause of cesarean section, length of operation, length of stay, complications and patient satisfaction were collected. Results: Within this period there were 19,904 deliveries in total. Incidence of umbilical hernia was found 0.2% and it was 0.1% for the inguinal hernia. Simultaneous hernia repairs significantly prolonged the operative time. There was no recurrence and complication. Conclusions: Our results showed that hernia repair can be performed without any additional risks during cesarean section. We believe that if there is an indication for cesarean section in a pregnancy complicated by an abdominal wall hernia, patients should be informed that it would be safe and effective to repair these hernias during cesarean section. This approach also enables tension-free pure tissue repairs.

关键词： Cesarean Section Hernia Repair Simultaneous Surgery Tissue Repair Abdominal Compliance

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Estimation of Number Of Small Cattle Through ARIMA Models in Turkey

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Journal of Mathematics and System Science 2015年第11期5卷 464-473页

作者： senol CELIK Bingol University Of Faculty Of Agriculture Department Of Animal Science Bingol Turkey.

In this study, the number of sheep and goats in Turkey were analysed by time series analysis method, and the number of great cattle for next years predicted through the most appropriate time series *** series was formed using the data on the number of sheep and goats belonging to the period between 1930 and 2014 in Turkey It was determined through autocorrelation function graphic that the series weren＇t stationary at first, but they became stationary after their first difference were calculated. A stagnancy test was performed through extended Dickey-Fuller test. So as to determine the suitability of the model, it was reviewed if autocorrelation and partial autocorrelation graphs were white noise series and also the results of Box-Ljung test were reviwed. Through the ＂tested models, the model estimations, of which parameter estimates were significant and Akaike information criterion （AIC） was the smallest, were performed. The most appropriate model in terms of both the number of sheep and goats is first-level integrated moving average model stated as ARIMA（0,1,1）. In this model, it was estimated that there would be an increase in the number of sheep and goats in Turkey between the years of 2015 and 2020, however, the increase in the number of sheep would be more than the increase in the number of goats.

关键词： ARIMA Models autocorrelation the number of sheep the number of goats.

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Two effective approaches for solving fractional generalized Hirota-Satsuma coupled KdV system arising in interaction of long waves

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Journal of Ocean Engineering and Science 2019年第1期4卷 24-32页

作者： Ali Kurt Hadi Rezazadeh Mehmet senol Ahmad Neirameh Orkun Tasbozan Mostafa Eslami Mohammad Mirzazadeh Department of Mathematics Mustafa Kemal UniversityHatayTurkey Faculty of Engineering Technology Amol University of Special Modern TechnologiesAmolIran Department of Mathematics Nevsehir Haci Bektas Veli UniversityNevsehirTurkey Department of Mathematics Faculty of SciencesGonbad Kavous UniversityGonbadIran Department of Mathematics Faculty of Mathematical SciencesUniversity of MazandaranBabolsarIran Department of Engineering Sciences Faculty of Technology and EngineeringEast of GuilanUniversity of GuilanRudsar-VajargahIran

In this article,two different methods,namely sub-equation method and residual power series method,have been used to obtain new exact and approximate solutions of the generalized Hirota-Satsuma system of equations,which is a coupled KdV *** fractional derivative is taken in the conformable *** of the obtained exact solutions were checked by substituting them into the corresponding system with the help of Maple symbolic computation *** results indicate that both methods are easy to implement,effective and *** are therefore ready to apply for various partial fractional differential equations.

关键词： Hirota-Satsuma coupled KdV system Sub-equation method Power series method Conformable fractional derivative

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Solution-Focused School Leadership Scale： A Validity and Reliability Study

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Psychology Research 2017年第2期7卷 95-103页

作者： senol Sezer Ordu University Ordu Turkey

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