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Investigating ischemia and reperfusion-induced organ damage in severe cardiac arrest:A comprehensive proteomics perspective

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journal of Pharmaceutical Analysis 2024年第3期14卷 427-430页

作者： ju Yeon Lee Muhammad Shoaib jin-Woong Choi Rishabh C.Choudhary Tai Yin Nara Yoon Kei Hayashida Seunguk j.Baek Santiago j.Miyara Lance B.Becker junhwan kim Research Center of Bioconvergence Analysis Korea Basic Science InstituteCheongjuSouth Korea Bio-Analytical Science University of Science and TechnologyCheongjuSouth Korea Laboratory for Critical Care Physiology Feinstein Institutes for Medical ResearchManhassetNY11030USA Donald and Barbara Zucker School of Medicine at Hofstra/Northwell School of Medicine HempsteadNY11549USA Mathematics and Computer Science Adelphi UniversityGarden CityNY11530USA Department of Emergency Medicine North Shore University HospitalManhassetNY11030USA

Cardiac arrest(CA)is a life-threatening condition with complex pathophysiology and limited treatment *** gain deeper insights into the pathological state of vital organs,we employed a proteomics analysis in rodents to assess proteome alterations in the brain,heart,kidney,and liver using a rat model of *** brain displayed severe protein alterations in essential cellular pathways,including three major energy-generating pathways after CA,which worsened after resuscitation,resulting in the most significant overall protein changes among the ***,the liver,experiencing the most substantial protein alterations post-CA,demonstrated significant recovery,presenting the least protein changes post-resuscitation.

关键词： alterations organs damage

A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： june-Ha Shin Hwa-Ryeon kim jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

Recent developments in selective laser processes for wearable devices

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Bio-Design and Manufacturing 2024年第4期7卷 517-547页

作者： Youngchan kim Eunseung Hwang Chang Kai Kaichen Xu Heng Pan Sukjoon Hong Optical Nanoprocessing Lab Department of Mechanical EngineeringBK21 FOUR ERICA-ACE CenterHanyang University55 Hanyangdaehak-RoSangnok-GuAnsan 15588Republic of Korea Multiscale Manufacturing Lab J.Mike Walker’66 Department of Mechanical EngineeringTexas A&M UniversityCollege StationTX 77843USA State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China

Recently,the increasing interest in wearable technology for personal healthcare and smart virtual/augmented reality applications has led to the development of facile fabrication *** have long been used to develop original solutions to such challenging technological problems due to their remote,sterile,rapid,and site-selective processing of *** this review,recent developments in relevant laser processes are summarized under two separate ***,transformative approaches,such as for laser-induced graphene,are *** addition to design optimization and the alteration of a native substrate,the latest advances under a transformative approach now enable more complex material compositions and multilayer device configurations through the simultaneous transformation of heterogeneous precursors,or the sequential addition of functional layers coupled with other electronic *** addition,the more conventional laser techniques,such as ablation,sintering,and synthesis,can still be used to enhance the functionality of an entire system through the expansion of applicable materials and the adoption of new ***,various wearable device components developed through the corresponding laser processes are discussed,with an emphasis on chemical/physical sensors and energy *** addition,special attention is given to applications that use multiple laser sources or processes,which lay the foundation for the all-laser fabrication of wearable devices.

关键词： Selective laser process Wearable device Transformative approach Laser-induced graphene Ablation Sintering Synthesis

Modeling Ionic Polymer-Metal Composites with Space-Time Adaptive Multimesh hp-FEM

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Communications in Computational Physics 2012年第1期11卷 249-270页

作者： David Pugal Pavel Solin Kwang j.kim Alvo Aabloo Mechanical Engineering Department University of NevadaReno RenoNV 89557USA Department of Mathematics and Statistics University of NevadaReno RenoNV 89557USA Institute of Thermomechanics PragueCzech Republic Institute of Technology University of TartuNooruse St 150411 TartuEstonia

We are concerned with a model of ionic polymer-metal composite(IPMC)materials that consists of a coupled system of the Poisson and Nernst-Planck equations,discretized by means of the finite element method(FEM).We show that due to the transient character of the problem it is efficient to use adaptive algorithms that are capable of changing the mesh dynamically in *** also show that due to large qualitative and quantitative differences between the two solution components,it is efficient to approximate them on different meshes using a novel adaptive multimesh *** study is accompanied with numerous computations and comparisons of the adaptive multimesh hp-FEMwith several other adaptive FEM algorithms.

关键词： Ionic polymer-metal composites IPMC Nernst-Planck equation Poisson equation finite element method FEM adaptive multi-mesh hp-FEM

A novel nonsense mutation of GPR143 gene in a Korean kindred with X-linked congenital nystagmus

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International journal of Ophthalmology(English edition) 2016年第9期9卷 1367-1370页

作者： Ungsoo Samuel kim Eunhae Cho Hyon j.kim Department of Ophthalmology Kim's Eye Hospital Seoul 07301 Korea Department of Ophthalmology Konyang University College of Medicine Daejeon 35365 Korea Green Cross Genome Yongin Kyunggi-do16903 Korea Department of Medicine Genetics Konyang University College of Medicine Daejeon 35365 Korea

Dear Editor,I am *** Samuel *** kim＇s Eye Hospital,Konyang University,Seoul,Korea.I write to present a novel mutation of GPR143 in Korean patients with X-linked congenital nystagmus by using exome *** nystagmus is an... 详细信息

关键词： GPR A novel nonsense mutation of GPR143 gene in a Korean kindred with X-linked congenital nystagmus gene

Effect of 1Al addition on deformation behavior of Mg

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journal of Magnesium and Alloys 2021年第2期9卷 489-498页

作者： ji Hyun Hwang A.Zargaran Gyeongbae Park O.Lee B.-j.Lee Nack j.kim Center for Advanced Aerospace Materials Pohang University of Science and Technology(POSTECH)PohangSouth Korea

Deformation behavior of 1 Al containing Mg alloy has been investigated in the present *** annealing,the Mg-1 Al alloy shows a typical basal *** compared to the pure Mg having a similar texture and grain size,the Mg-1 Al alloy shows much higher strength and larger *** trace analyses of the tensile strained specimens show that non-basal slips such as pyramidal I and II slips can be easily activated at an early stage of deformation in the Mg-1 Al alloy and the grains in the Mg-1 Al alloy are seen to accommodate a larger degree of deformation than those in the pure Mg at a given *** increasing tensile strain,however,there is a strain localization along the initially formed slip lines of non-basal slips,forming surface steps without activating multiple slip lines.

关键词： Deformation behavior Slip trace analysis Non-basal slip Strain localization Ductility

Understanding of the Relationship between the Properties of Cu(In,Ga)Se2 Solar Cells and the Structure of Ag Network Electrodes

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ENERGY & ENVIRONMENTAL MATERIALS 2024年第6期7卷 246-253页

作者： Yoo, Hyesun Quy, Hoang Van Lee, Inpyo jo, Seung Taek Hong, Tae Ei kim, junho Yoo, Dae-Hwang Shin, jinwook Commerell, Walter kim, Dae-Hwan Roh, jong Wook Kyungpook Natl Univ Reg Leading Res Ctr RLRC Smart Energy Syst Daegu 37224 Gyeongsangbug D South Korea Kyungpook Natl Univ Dept Hydrogen & Renewable Energy Daegu 47922 South Korea Kyungpook Natl Univ Dept Nano & Adv Mat Sci & Engn Daegu 37224 Gyeongsangbug D South Korea Daegu Gyeongbuk Inst Sci & Technol DGIST Div Energy Technol Daegu 42988 South Korea Incheon Natl Univ Dept Phys Nano Photoelect Device Lab Incheon 22012 South Korea TH Ulm THU Prittwitzstr 10 D-89081 Ulm Germany

The relation between the structure of the silver network electrodes and the properties of Cu(In,Ga)Se2 (CIGS) solar cells is systemically investigated. The Ag network electrode is deposited onto an Al:ZnO (AZO) thin film, employing a self-forming cracked template. Precise control over the cracked template's structure is achieved through careful adjustment of temperature and humidity. The Ag network electrodes with different coverage areas and network densities are systemically applied to the CIGS solar cells. It is revealed that predominant fill factor (FF) is influenced by the figure of merit of transparent conducting electrodes, rather than sheet resistance, particularly when the coverage area falls within the range of 1.3-5%. Furthermore, a higher network density corresponds to an enhanced FF when the coverage areas of the Ag networks are similar. When utilizing a thinner AZO film, CIGS solar cells with a surface area of 1.0609 cm2 exhibit a notable performance improvement, with efficiency increasing from 10.48% to 11.63%. This enhancement is primarily attributed to the increase in FF from 45% to 65%. These findings underscore the considerable potential for reducing the thickness of the transparent conductive oxide (TCO) in CIGS modules with implications for practical applications in photovoltaic technology.

关键词： CIGS large-area solar cell metal mesh metallic network transparent electrode

Effects of Cu addition on formability and surface delamination phenomenon in high-strength high-Mn steels

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journal of Materials Science & Technology 2020年第8期36卷 44-51页

作者： Min Chul jo jisung Yoo Min Cheol jo Alireza Zargaran Seok Su Sohn Nack j.kim Sunghak Lee Center for Advanced Aerospace Materials Pohang University of Science and TechnologyPohang 37673South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea

The formability of austenitic high-Mn steels is a critical issue in automotive applications under nonuniformly-deformed environments caused by dynamic strain *** austenite stabilizing alloying elements in those steels,Cu has been known as an effective element to enhance tensile properties via controlling the stacking fault energy and stability of *** effects of Cu addition on formability,however,have not been sufficiently reported *** this study,the Cu addition effects on formability and surface characteristics in the austenitic high-Mn TRIP steels were analyzed in consideration of inhomogeneous microstructures containing the segregation of Mn and *** reveal determining factors,various mechanical parameters such as total elongation,post elongation,strain hardening rate,normal anisotropy,and planar anisotropy were correlated to the hole-expansion and cup-drawing test *** respect to microstructural parameters,roles of(Mn,Cu)-segregation bands and resultant Cu-rich FCC precipitates on the formability and surface delamination were also discussed.

关键词： High-Mn steel Cu effects Cu-rich FCC phase Hole-expansion test Formability Stretch-flangeablity Surface delamination

Alloy design for laser powder bed fusion additive manufacturing:a critical review

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International journal of Extreme Manufacturing 2024年第2期6卷 29-63页

作者： Zhuangzhuang Liu Qihang Zhou Xiaokang Liang Xiebin Wang Guichuan Li kim Vanmeensel jianxin Xie Key Laboratory for Advanced Materials Processing(MOE) Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Capital Aerospace Machinery Corporation Limited Beijing 100076People’s Republic of China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJingshi Road 17923Jinan 250061People’s Republic of China Department of Materials Engineering KU LeuvenLeuven 3001Belgium

Metal additive manufacturing(AM)has been extensively studied in recent *** the significant progress achieved in manufacturing complex shapes and structures,challenges such as severe cracking when using existing alloys for laser powder bed fusion(L-PBF)AM have *** challenges arise because commercial alloys are primarily designed for conventional casting or forging processes,overlooking the fast cooling rates,steep temperature gradients and multiple thermal cycles of *** address this,there is an urgent need to develop novel alloys specifically tailored for L-PBF *** review provides a comprehensive summary of the strategies employed in alloy design for *** aims to guide future research on designing novel alloys dedicated to L-PBF instead of adapting existing *** review begins by discussing the features of the L-PBF processes,focusing on rapid solidification and intrinsic heat ***,the printability of the four main existing alloys(Fe-,Ni-,Al-and Ti-based alloys)is critically assessed,with a comparison of their conventional *** was found that the weldability criteria are not always applicable in estimating ***,the review presents recent advances in alloy development and associated strategies,categorizing them into crack mitigation-oriented,microstructure manipulation-oriented and machine learning-assisted ***,an outlook and suggestions are given to highlight the issues that need to be addressed in future work.

关键词： laser powder bed fusion alloy design printability crack mitigation