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Tweaking the acid-sensitivity of transiently thermoresponsive polyacrylamides with cyclic acetal repeating units

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Science China Chemistry 2020年第4期63卷 504-512页

作者： Simon Van Herck bruno G.De Geest Department of Pharmaceutics Ghent UniversityGhentBelgium

Merging the characteristics of thermoresponsive and stimuli-degradable polymers yields so-called transiently thermoresponsive polymers, which can find application for the design of injectable gels, nanoparticles, etc. within a biomedical context. Among these polymers, only a limited number is reported which shows selective degradation under mild acidic conditions. However,extension of the library of transiently thermoresponsive polymers is desired to broadening the biomaterials toolbox to suit specific needs. Three monomers were developed by modification of 2-hydroxyethylacrylamide(HEAm) via tetrahydropyranylation or-furanylation with 3,4-dihydro-2 H-pyran(DHP), 2,3-dihydrofuran(DHF) or 2,3-dihydro-5-methylfuran(MeDHF). The presence of an acetal or ketal bond provided the monomers a pH-dependent hydrolysis behavior ranging from minutes to days. RAFT polymerisation allowed for the construction of homopolymers with temperature responsive behavior and pH-dependent hydrolysis which was strongly influenced by nature of the monomeric repeating units.

关键词： acetals polyacrylamides stimuli-responsive

The bottlenose dolphin Tursiops truncatus foraging around a fish farm:Effects of prey abundance on dolphins' behavior

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Current Zoology 2009年第4期55卷 243-248页

作者： bruno A■DZ LóPEZ The Bottlenose Dolphin Research Institute BDRI

The extent to which prey abundance influences both bottlenose dolphin foraging behavior and group size in the presence of human activities has not previously been *** primary aim of this study was to identify and quantify how wild bottlenose dolphins respond,individually and as groups,to the relative abundance of prey around a fish *** views of dolphins' behavior were obtained by focal following individual animals whilst simultaneously collecting surface and underwater behavioral data.A total of 2150 dive intervals were analyzed,corresponding to 342 focal samples,lasting over 34 *** dolphins remained submerged for a mean duration of 46.4 seconds and a maximum of 249 *** study provides the first quantified data on bottlenose dolphin diving behavior in a marine fin-fish farm *** study's results indicate that within a fish farm area used intensively by bottlenose dolphins for feeding,dolphins did not modify dive ***,underwater observations confirmed that dolphins find it easier to exploit a concentrated food source and it appears that hunting tactic and not group size plays an important role during feeding ***,bottlenose dolphins appear capable of modifying their hunting tactics according to the abundance of *** top predators display behavioral responses to activities not directed at them,the task of studying all possible effects of human activities can become even more challenging.

关键词： Bottlenose dolphin Tursiops truncatus Diving behavior Foraging behavior Prey abundance Human activities,Hunting tactics Aquaculture

Wave Propagation Across Acoustic/Biot’s Media:A Finite-Difference Method

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Communications in Computational Physics 2013年第4期13卷 985-1012页

作者： Guillaume Chiavassa bruno Lombard Centrale Marseille Laboratoire de Mecanique Modelisation et Procedes PropresUMR 7340 CNRSTechnopole de Chateau-Gombert38 rue Frederic Joliot-Curie13451 MarseilleFrance Laboratoire de Mecanique et d’Acoustique UPR 7051 CNRS31 chemin Joseph Aiguier13402 MarseilleFrance

Numerical methods are developed to simulate the wave propagation in heterogeneous 2D fluid/poroelastic *** propagation is described by the usual acoustics equations(in the fluid medium)and by the low-frequency Biot’s equations(in the porous medium).Interface conditions are introduced to model various hydraulic contacts between the two media:open pores,sealed pores,and imperfect ***-posedness of the initial-boundary value problem is *** grid numerical methods previously developed in porous heterogeneous media are adapted to the present context:a fourth-order ADER scheme with Strang splitting for timemarching;a space-time mesh-refinement to capture the slow compressional wave predicted by Biot’s theory;and an immersed interface method to discretize the interface conditions and to introduce a subcell *** experiments and comparisons with exact solutions are proposed for the three types of interface conditions,demonstrating the accuracy of the approach.

关键词： Biot’s model poroelastic waves jump conditions imperfect hydraulic contact highorder finite differences immersed interface method

Greasy hair against obesity

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Signal Transduction and Targeted Therapy 2022年第1期7卷 11-12页

作者： Sandra Nickel bruno Christ Department of General Visceral and Vascular SurgeryJena University Hospital07740 JenaGermany Cell Transplantation/Molecular Hepatology Lab Department of VisceralTransplantThoracic and Vascular SurgeryUniversity of Leipzig Medical Center04103 LeipzigGermany

In their article,Choa et *** the perspective to loose fat by in creasing seboge *** a T cell-depe ndent mechanism,they suggest that stimulation of sebum production by thymic stromal lymphopeietin(TSLP)"pulls"lipids out of the adipose tissue.^(1) The World Population Review(***/)ranks obesity rates to one third of the global *** co-morbidities comprise diabetes type 2,ischemic stroke and cardiovascular complications render this epidemic disease the number 1 cause of deaths worldwide(***/).

关键词： obesity al stimulation

Anti-fibrotic and anti-inflammatory effect of mesenchymal stromal cell-derived extracellular vesicles in chronic kidney disease

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BIOCELL 2023年第7期47卷 1499-1508页

作者： GIULIA CHIABOTTO STEFANIA bruno Department of Medical Sciences University of TorinoTorino10126Italy Molecular Biotechnology Center University of TorinoTorino10126Italy

Renal fibrosis and inflammation are common pathological features of chronic kidney disease(CKD).Since currently available treatments can only delay the progression of CKD,the outcome of patients with CKD is still *** therapeutic option for the prevention of CKD-related complications could be the use of mesenchymal stromal cells(MSCs),which have shown beneficial effects in tissue fibrosis and regeneration after ***,safety issues,such as cellular rejection and carcinogenicity,limit their clinical *** the bioactive factors secreted by MSCs,extracellular vesicles(EVs)have shown the same beneficial effect of MSCs,without any notable side *** heterogeneous population of membranous nano-sized particles can deliver genetic material and functional proteins to injured cells,prompting tissue *** we describe the anti-fibrotic and antiinflammatory properties of MSC-derived EVs in CKD preclinical models and summarize the potential molecular mechanisms involved in the regulation of renal fibrosis and inflammation.

关键词： Chronic kidney disease Renal fibrosis Epithelial-to-mesenchymal transition Mesenchymal stromal cell Extracellular vesicles

Systemic therapy of hepatocellular carcinoma:Current status and future perspectives

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World Journal of Gastroenterology 2014年第12期20卷 3087-3099页

作者： Domenico Germano bruno Daniele Oncology Unit A.O. "G.Rummo"

The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades, the introduction of novel therapies (such as sorafenib) have improved patient survival. Nevertheless, HCC remains the third most common cause of cancer-related deaths worldwide. Decision-making largely relies on evidence-based criteria, as showed in the US and European clinical practice guidelines, which endorse five therapeutic recommendations:resection; transplantation; radiofrequency ablation; chemoembolization; and sorafenib. Many molecularly targeted agents that inhibit angiogenesis, epidermal growth factor receptor, and mammalian target of rapamycin are at different stages of clinical development in advanced HCC. Future research should continue to unravel the mechanism of hepatocarcinogenesis and to identify key relevant molecular targets for therapeutic intervention. Identification and validation of potential surrogate and predictive biomarkers hold promise to individualize patient’s treatment to maximize clinical benefit and minimize the toxicity and cost of targeted agents.

关键词： Hepatocellular Carcinoma Molecular agents Targheted therapy Sorafenib

Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri bruno M.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard L.Voegels Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

A Recursive Basis for Primitive Forms in Symplectic Spaces and Applications to Heisenberg Groups

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Acta Mathematica Sinica,English Series 2016年第3期32卷 265-285页

作者： Annalisa BALDI Marilena BARNABEI bruno FRANCHI Dipartimento di Matematica Piazza di Porta S.Donato 540126 BolognaItaly

This paper is divided in two parts： in Section 2, we define recursively a privileged basis of the primitive forms in a symplectic space（V^（2n）, ω）. Successively, in Section 3, we apply our construction in the setting of Heisenberg groups H^n, n ≥ 1, to write in coordinates the exterior differential of the so-called Rumin＇s complex of differential forms in H^n.

关键词： Symplectic manifolds differential forms Heisenberg groups combinatorial functions

L^1-Poincaré and Sobolev inequalities for differential forms in Euclidean spaces Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

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Science China Mathematics 2019年第6期62卷 1029-1040页

作者： Annalisa Baldi bruno Franchi Pierre Pansu Dipartimento di Matematica Università di Bologna Laboratoire de Mathématiques d'Orsay Université Paris-Sud CNRSUniversité Paris-Saclay

In this paper, we prove Poincaré and Sobolev inequalities for differential forms in L^1(R^n). The singular integral estimates that it is possible to use for L^p, p > 1, are replaced here with inequalities which go ba... 详细信息

关键词： differential forms Sobolev-Poincaré inequalities homotopy formula