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gaAs-chip-based mid-infrared supercontinuum generation

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Light(Science & Applications) 2023年第11期12卷 2443-2450页

作者： geoffroy granger Myriam Bailly Hugo Delahaye Cristian Jimenez Idris Tiliouine Yann Leventoux Jean-Christophe Orlianges Vincent Couderc bruno gérard Rezki Becheker Said Idlahcen Thomas godin Ammar Hideur Arnaud grisard Eric Lallier Sébastien Février Universitéde Limoges XLIM UMR CNRS 7252 123 Av.A.Thomas87060 LimogesFrance Thales Research&Technology 1 Av.Augustin Fresnel91767 Palaiseau CedexFrance III-V Lab 1 Av.Augustin Fresnel91767 Palaiseau CedexFrance CORIA(UMR 6614) CNRS-INSA Rouen-Universitéde Rouen NormandieNormandie UniversitéSaint-Etienne du RouvrayFrance

The mid-infrared spectral region opens up new possibilities for applications such as molecular spectroscopy with high spatial and frequency *** example,the mid-infrared light provided by synchrotron sources has helped for early diagnosis of several ***,alternative light sources at the table-top scale would enable better access to these state-of-the-art characterizations,eventually speeding up research in biology and *** supercontinuum generation in highly nonlinear waveguides pumped by compact fiber lasers represents an appealing alternative to ***,we introduce orientation-patterned gallium arsenide waveguides as a new versatile platform for mid-infrared supercontinuum *** and fiber-based pump lasers are optimized in tandem to allow for the group velocities of the signal and the idler waves to match near the degeneracy *** configuration exacerbates supercontinuum generation from 4 to 9μm when waveguides are pumped at 2750 nm with few-nanojoule energy *** brightness of the novel mid-infrared source exceeds that of the thirdgeneration synchrotron source by a factor of *** also show that the nonlinear dynamics is strongly influenced by the choice of waveguide and laser parameters,thus offering an additional degree of freedom in tailoring the spectral profile of the generated *** an approach then opens new paths for high-brightness mid-infrared laser sources development for high-resolution spectroscopy and ***,thanks to the excellent mechanical and thermal properties of the waveguide material,further power scaling seems feasible,allowing for the generation of watt-level ultra-broad frequency combs in the mid-infrared.

关键词： waveguide pumped pump

Single-cell pan-omics, environmental neurology, and artificial intelligence:the time for holistic brain health research

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Neural Regeneration Research 2025年第6期20卷 1703-1704页

作者： Paolo Abondio Francesco bruno IRCCS Istituto delle Scienze Neurologiche di Bologna BolognaItaly Association for Neurogenetic Research(ARN) Lamezia TermeCatanzaroItaly

The brain,with its trillions of neural connections,different cellular types,and molecular complexities,presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural *** traditional methods have provided valuable insights,emerging technologies offer unprecedented opportunities to delve deeper into the underpinnings of brain *** the everevolving landscape of neuroscience,the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks.

关键词： function artificial landscape

Purines:From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury

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Neuroscience Bulletin 2020年第11期36卷 1315-1326页

作者： bruno g.Frenguelli Nicholas Dale School of Life Sciences The University WarwickCoventry CV47ALUK

The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological *** particular,adenosine triphosphate(ATP)and its metabolite and precursor,adenosine,regulate a wide variety of cellular and systems-level physiological processes extending from ATP acting as the cellular energy currency,to the adenosine arising from the depletion of cellular ATP and responding to reduce energy demand and hence to preserve ATP during times of metabolic *** inter-relationship provides opportunities for both the diagnosis of energy depletion during conditions such as stroke,and the replenishment of ATP after such *** this review we address these opportunities and the broad potential of purines as diagnostics and restorative agents.

关键词： Purines Adenosine ATP Biomarker Stroke Cerebral ischemia Traumatic brain injury Adenine D-ribose

Tweaking the acid-sensitivity of transiently thermoresponsive polyacrylamides with cyclic acetal repeating units

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Science China Chemistry 2020年第4期63卷 504-512页

作者： Simon Van Herck bruno g.De geest Department of Pharmaceutics Ghent UniversityGhentBelgium

Merging the characteristics of thermoresponsive and stimuli-degradable polymers yields so-called transiently thermoresponsive polymers, which can find application for the design of injectable gels, nanoparticles, etc. within a biomedical context. Among these polymers, only a limited number is reported which shows selective degradation under mild acidic conditions. However,extension of the library of transiently thermoresponsive polymers is desired to broadening the biomaterials toolbox to suit specific needs. Three monomers were developed by modification of 2-hydroxyethylacrylamide(HEAm) via tetrahydropyranylation or-furanylation with 3,4-dihydro-2 H-pyran(DHP), 2,3-dihydrofuran(DHF) or 2,3-dihydro-5-methylfuran(MeDHF). The presence of an acetal or ketal bond provided the monomers a pH-dependent hydrolysis behavior ranging from minutes to days. RAFT polymerisation allowed for the construction of homopolymers with temperature responsive behavior and pH-dependent hydrolysis which was strongly influenced by nature of the monomeric repeating units.

关键词： acetals polyacrylamides stimuli-responsive

Control of light emission of quantum emitters coupled to silicon nanoantenna using cylindrical vector beams

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Light(Science & Applications) 2023年第10期12卷 2248-2255页

作者： Martin Montagnac Yoann Brûlé Aurélien Cuche Jean-Marie Poumirol Sébastien J.Weber Jonas Müller guilhem Larrieu Vincent Larrey Franck Fournel Olivier Boisron bruno Masenelli gérard Colas des Francs gonzague Agez Vincent Paillard CEMES-CNRS Universitéde ToulouseToulouseFrance ICB Universitéde BourgogneCNRSDijonFrance LAAS-CNRS Universitéde ToulouseToulouseFrance CEA-LETI UniversitéGrenoble-AlpesGrenobleFrance Universitéde Lyon UniversitéLyon 1CNRS UMR 5510ILMVilleurbanneFrance Universitéde Lyon INSA LyonCNRSEcole Centrale de LyonUniversitéLyon 1CPEUMR 5270INLVilleurbanneFrance Bruno Masenelli

Light emission of europium(Eu^(3+))ions placed in the vicinity of optically resonant nanoantennas is usually controlled by tailoring the local density of photon states(LDOS).We show that the polarization and shape of the excitation beam can also be used to manipulate light emission,as azimuthally or radially polarized cylindrical vector beam offers to spatially shape the electric and magnetic fields,in addition to the effect of silicon nanorings(Si-NRs)used as *** photoluminescence(PL)mappings of the Eu^(3+)transitions and the Si phonon mappings are strongly dependent of both the excitation beam and the Si-NR *** experimental results of Raman scattering and photoluminescence are confirmed by numerical simulations of the near-field intensity in the Si nanoantenna and in the Eu^(3+)-doped film,*** branching ratios obtained from the experimental PL maps also reveal a redistribution of the electric and magnetic emission *** results show that it could be possible to spatially control both electric and magnetic dipolar emission of Eu^(3+)ions by switching the laser beam polarization,hence the near field at the excitation wavelength,and the electric and magnetic LDOS at the emission *** paves the way for optimized geometries taking advantage of both excitation and emission processes.

关键词： excitation cylindrical spatially

Impact of the polymer backbone chemistry on interactions of amino-acid-derived zwitterionic polymers with cells

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Bioactive Materials 2023年第6期24卷 524-534页

作者： Meike N.Leiske bruno g.De geest Richard Hoogenboom Supramolecular Chemistry group Centre of Macromolecular Chemistry(CMaC)Department of Organic and Macromolecular ChemistryGhent UniversityKrijgslaan 281 S4B-9000GhentBelgium Department of Pharmaceutics and Cancer Research Institute ghent(CRIg) Ghent UniversityOttergemsesteenweg 460B-9000GhentBelgium Faculty of Biology Chemistry&Earth SciencesUniversity of BayreuthUniversitätsstraße 3095447 BayreuthGermany

Zwitterionic polymers are known to interact with cells and have been shown to reveal cancer cell *** this work,the importance of the chemistry of the polymer backbone for the cellular specificity of amino-acid-derived polyzwitterions is demonstrated.A series of glutamic acid(glu)-based vinyl monomers(i.e.,an acrylate,a methacrylate,an acrylamide,and a methacrylamide)were prepared and used for reversible addition-fragmentation chain-transfer(RAFT)polymerisation,yielding defined polymers with narrow size distribution(Ðglu-functionalised,zwitterionic polymers revealed high cytocompatibility;however,differences in cellular association and specificity were *** particular,the methacrylamide-derived polymers showed high association with both,breast cancer cells and non-cancerous dendritic cells and,consequently,lack *** contrast,high specificity to only breast cancer cells was observed for polyacrylates,-methacrylates,*** analysis of the polymers revealed differences in hydrophobicity,zeta potential,and potential side chain hydrolysis,which are impacted by the polymer backbone and might be responsible for the altered the cell association of these *** is shown that a slightly negative net charge is preferred over a neutral charge to retain cell *** was also confirmed by association experiments in the presence of competitive amino acid transporter *** affinity of slightly negatively charged glu-derived polymers to the xCT glu/cystine cell membrane antiporter was found to be higher than that of neutrally charged *** results emphasise the importance of the polymer backbone for the design of cell-specific *** study further highlights the potential to tailor amino-acid-derived zwitterionic materials beyond their side chain functionality.

关键词： Amino-acid-functionalised polymer Zwitterionic polymer Cell-specific polymer Cancer-targeting RAFT-Polymerisation

Advancements,strategies,and prospects of solid oxide electrolysis cells(SOECs):Towards enhanced performance and large-scale sustainable hydrogen production

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Journal of Energy Chemistry 2024年第7期94卷 688-715页

作者： Amina Lahrichi Youness El Issmaeli Shankara S.Kalanur bruno g.Pollet green Hydrogen Lab(gH2Lab) Hydrogen Research Institute(HRI)Universitédu QuébecàTrois-Rivières(UQTR)3351 boulevard des ForgesTrois-RivièresQuébec G9A 5H7Canada

Solid oxide electrolysis cells(SOECs)represent a crucial stride toward sustainable hydrogen generation,and this review explores their current scientific challenges,significant advancements,and potential for large-scale hydrogen *** SOEC technology,the application of innovative fabrication tech-niques,doping strategies,and advanced materials has enhanced the performance and durability of these systems,although degradation challenges persist,implicating the prime focus for future *** we provide in-depth analysis of the recent developments in SOEC technology,including Oxygen-SOECs,Proton-SOECs,and ***,Hybrid-SOECs,with their mixed ionic conducting electrolytes,demonstrate superior efficiency and the concurrent production of hydrogen and *** with the capacity to harness waste heat,these advancements in SOEC technology present signif-icant promise for pilot-scale applications in *** review also highlights remarkable achieve-ments and potential reductions in capital expenditure for future SOEC systems,while elaborating on the micro and macro aspects of sOECs with an emphasis on ongoing research for optimization and *** concludes with the potential of SOEC technology to meet various industrial energy needs and its significant contribution considering the key research priorities to tackle the global energy demands,ful-fillment,and decarbonization efforts.

关键词： Solid oxide electrolysis cells Proton-SOECs Oxygen-SoECs Hybrid-SOECs Intermediate-high temperature electrolysers Hydrogenproduction

Engineered porous Ni2P-nanoparticle/Ni2P-nanosheet arrays via the Kirkendall effect and Ostwald ripening towards efficient overall water splitting

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Nano Research 2020年第8期13卷 2098-2105页

作者： Yutai Wu Hui Wang Shan Ji bruno g.Pollet Xuyun Wang Rongfang Wang State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China College of Biological Chemical Science and Chemical EngineeringJiaxing UniversityJiaxing314001China Department of Energy and Process Engineering Faculty of EngineeringNorwegian University of Science and Technology(NTNU)NO-7491TrondheimNorway

Transitional metal phosphides with array-like structure grown on conductive support materials are promising bifunctional catalysts for the oxygen evolution reaction(OER)and hydrogen evolution reaction(HER).In this study,a method was developed to synthesize directly porous Ni2P nanosheet arrays and Ni2P nanoparticles onto nickel foam via a hydrothermal reaction followed by a phosphorization *** studies revealed that the allomorphs of Ni2P nanosheets and Ni2P nanoparticles in the array-like structure were formed via the Kirkendall effect and Ostwald ripening.A fully functional water electrolyzer containing Ni2P as electrodes for the OER and HER exhibited promising activity and *** 10 mA·cm^−2,a Ni2P cell voltage of 1.63 V was obtained,which was only 0.05 V smaller than that found for Pt/C/NF||RuO2/NF *** enhanced electrocatalytic performance resulted from the favorable porosity of the Ni2P arrays and the synergistic effect between Ni2P nanosheets and Ni2P nanoparticles.

关键词： Ni2P catalysts arrays overall water splitting Kirkendall effect Ostwald ripening

Aging men-Challenges ahead

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Asian Journal of Andrology 2001年第3期3卷 161-168页

作者： bruno Lunenfeld Faculty of Life Sciences Bar-Ilan University Israel

The prolongation of life expectancy and the drastic reduction of fertility rate are the primary cause of an agingworld. It is projected that the elderly (above 65) will increase within the next 25 years by 82% , whereas the new bornonly by 3% . Despite the enormous medical progress during the past few decades, the last years of life are still accom-panied by increasing ill health and disability. The ability to maintain active and independent living for as long as possi-ble is a crucial factor for aging in health and dignity. Therefore, the promotion of healthy aging and the prevention ofdisability in men, must assume a central role in medical research and medical practice as well as in the formulation ofnational health and social policies. Effective programs promoting health and aging will ensure a more efficient use ofhealth and social services and improve the quality of life in older persons by enabling them to remain independent andproductive. The most important and drastic gender differences in aging are related to organs and or systems dependantor influenced by reproductive hormones. In distinction to the course of reproductive aging in women, with the rapid de-cline in sex hormones and expressed by the cessation of menses, aging men experience a slow and continuous decline ofhormones. This decline in endocrine function involves; A decrease of testosterone, dehydroepiandrosterone (DHEA),oestrogens, thyroid stimulating hormone (TSH), growth hormone (gH), insulin-like growth factor-1 (IgF-1), andmelatonin. This decrease is concomitant with an increase of LH and FSH. In addition sex hormone binding globulin's(SHBg) increase with age resulting in further lowering the concentrations of free biologically active androgens. Inter-ventions such as hormone replacement therapy may prevent, delay or alleviate the debilitating conditions which may re-sult from secondary partial endocrine deficiency. Primary and secondary preventive strategies such as the promotion of asafe

关键词： aging life expectancy health expectancy fertility HRT(hormone replacement therapy) quality of life preventive strategies