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GIS-Based Methodology for Crash Prediction on Single-Lane Rural Highways

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Journal of Geographic Information System 2021年第2期13卷 98-121页

作者： Márcia Macedo Emilia Kohlman Rabbani maria Maia Marlos Macedo Bianca ferreira Post-Graduate Program in Civil Engineering UPE Recife Brazil Post-Graduate Program in Systems Engineering UPE Recife Brazil Graduate Program in Architecture and Urban Planning UNICAP Recife Brazil

Due to the need to update the current guidelines for highway design to focus on safety, this study sought to build an accident prediction model using a Geographic Information System (GIS) for single-lane rural highways, with a minimum of statistically significant variables, adequate to the Brazilian reality, and improve accident prediction for places with similar characteristics. A database was created to associate the accident records with the geometric parameters of the highway and to fill in the gaps left by the absence of geometric highway plans through geometric reconstitution or semi-automatic extraction of highways using satellite images. The Generalized Estimating Equation (GEE) method was applied to estimate the coefficients of the model, assuming negative distribution of the binomial error for the count of observed accidents. The accident frequency and annual average daily traffic (AADT) were analyzed, along with the spatial and geometric characteristics of 215 km of federal single-lane rural highways between 2007 and 2016. The GEE procedure was applied to two models having three variations of distinct homogeneous segmentation, two based on segments and one based on the kernel density estimator. To assess the effect of constant traffic, two more variations of the models using AADT as an offset variable were considered. The predominant correlation structure in the models was the exchangeable. The principal contributing factors for the occurrence of collisions were the radius of the horizontal curve, the grade, segment length, and the AADT. The study produced clear indicators for the design parameters of roadways that influence the safety performance of rural highways.

关键词： Roads GEE Single-Lane Rural Highways GIS Crash Prediction

Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress

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World Journal of Gastroenterology 2017年第28期23卷 5146-5157页

作者： Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia ferreira de Barros Camila Lima Carvalho Virgínia maria Barros de Lorena Vláudia maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira Centro de Pesquisas Aggeu Magalhaes Fundacao Oswaldo Cruz Immunopathogenesis Section Laboratory of Parasitic DiseasesNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthBethesdaMDUSA and Laboratório de Doencas Parasitárias e infecciosasFaculdade de MedicinaUniversidade Federal de Minas Gerais Departamento de Morfologia e Fisiologia Animal Universidade Federal Rural de Pernambuco Departamento de Biofísica e Radiobiologia Universidade Federal de Pernambuco Centro Acadêmico de Vitória Universidade Federal de Pernambuco Departamento de Medicina Tropical Universidade Federal de Pernambuco

To evaluate the therapeutic effects of bone marrow-derived CD11b+CD14+ monocytes in a murine model of chronic liver *** liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry, biochemical assessment, immunohistochemistry and enzyme-linked immunosorbent ***11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-6 and IL-1β, in addition to pro-fibrotic factors, such as IL-13, transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased, while IL-10 and matrix metalloproteinase-9 increased in the monocyte-treated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and *** therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation, as well as increasing anti-fibrogenic factors.

关键词： Monocytes Bone marrow mononuclear cells Cell therapy Macrophages Glutathione Liver fibrosis

Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model

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World Journal of Gastroenterology 2017年第8期23卷 1353-1366页

作者： Gedson Rodrigues de Morais Lima Flavia Danniele Frota MachadoLarissa Lucena Périco Felipe Meira de Faria Anderson Luiz-ferreira Alba Regina Monteiro Souza Brito Cláudia Helena Pellizzon Clélia Akiko Hiruma-Lima Josean Fechine Tavares Josémaria Barbosa Filho LeOnia maria Batista Departamento de Ciências Farmacêuticas Centro de Ciências da SaúdeLaboratório de Farmacologia do Trato GastrintestinalUniversidade Federal da Paraíba(UFPB)Cidade Universitária Departamento de Fisiologia Instituto de BiociênciasUniversidade Estadual Paulista Departamento de Biologia Estrutural e Funcional Instituto de BiologiaUniversidade Estadual de Campinas(UNICAMP Departamento de Ciencias Biológicas Instituto de BiotecnologiaUniversidade Federal de Goiás Departamento de Morfologia Instituto de BiociênciasUniversidade Estadual Paulista

To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of Combretum duarteanum (Cd).METHODSInflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were *** Cd-EtOHE and Cd-HexP caused significant reductions in macroscopic lesion scores and ulcerative lesion areas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-α and IL-1β. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide *** data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.

关键词： Combretum duarteanum Medicinal plants Combretaceae Inflammatory bowel disease Anti-inflammatory intestinal activity

Heterologous Bovine Tunica Albuginea Graft Conserved in Honey as Abdominal Wall Reinforcement in Rats

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Open Journal of Veterinary Medicine 2020年第8期10卷 139-153页

作者： Fellipe ferreira Lemos de Medeiros Natasha Nogueira ferreira Cecília Ribeiro Castañon Tábata Maués Carla ferreira Farias Lancetta Viviane Alexandre Nunes Degani maria de Lourdes Gonçalves ferreira Department of Pathology and Veterinary Clinic Faculty of Veterinary Universidade Federal Fluminense Rio de Janeiro Brazil Department of Morfology Universidade Castelo Branco Rio de Janeiro Brazil Professor Firmino Mársico Filho Veterinary Teaching Hospital (HUVET) Universidade Federal Fluminense Rio de Janeiro Brazil Department of Morfology Universidade Federal Fluminense Rio de Janeiro Brazil

Complex abdominal wall defects might be challenging for human and veterinary surgeons worldwide. Defects from trauma or congenital causes may lead to hernias development. The introduction of meshes to reinforce hernia repairs has improved surgical outcomes and several synthetic and biologic materials have been used. In this context, biomaterial prosthesis seems to be a satisfactory solution when managing great abdominal wall defects. The aim of the current study is to evaluate the bovine tunica albuginea (BTA) preserved in honey as graft material for rats’ abdominal wall reinforcement in incisional herniorrhaphy surgery as well as its viability, cicatrization and integration into the host tissue. Wistar rats were assigned to two main groups: 1) animals (n = 20) underwent median longitudinal laparotomy followed by laparorraphy with suture of the bovine tunica albuginea (BTA) graft as abdominal wall reinforcement;and 2) animals (n = 20) underwent only laparotomy and subsequent laparorrhaphy. Rats were clinically evaluated until euthanasia at post-surgical day 7, 14, 21 and 28. Necropsy and histopathological analysis of abdominal wall fragments were performed to compare groups and subgroups findings. BTA promoted abundant fibrosis, providing resistance and low postoperative complication rates. Besides, animals did not show rejection signs to the implant. In conclusion, BTA preserved in honey is an affordable, easy collection and handling biomaterial for graft, demanding simple surgical implantation technique for abdominal wall repair in rats.

关键词： Biomaterial Hernia Reconstructive Surgery Xenograft

Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding:A systematic review

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World Journal of Gastroenterology 2020年第45期26卷 7242-7257页

作者： Jose Cotter Cilenia Baldaia Manuela ferreira Guilherme Macedo Isabel Pedroto Department of Gastroenterology Hospital da Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal Department of Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBraga 4710-057Portugal Department of Life and Health Sciences Research Institute(ICVS)/3B’s PT Government Associate LaboratoryBraga 4710-057Portugal Department of Gastroenterology Hospital de Santa MariaCentro Hospitalar Lisboa NorteLisbon 1649-035Portugal Department of University Clinic of Medicine II Faculty of MedicineUniversity of LisbonLisbon 1649-028Portugal Department of Gastroenterology Centro Hospitalar e Universitário de CoimbraCoimbra 3000-075Portugal Department of Faculty of Medicine University of CoimbraCoimbra 3004-504Portugal Department of Gastroenterology Centro Hospitalar de São JoãoPorto 4200-319Portugal Department of Gastroenterology Faculty of MedicineUniversity of PortoPorto 4200-319Portugal Department of Gastroenterology and Hepatology Training Center World Gastroenterology OrganizationPorto 4200-319Portugal Department of Gastroenterology Centro Hospitalar do PortoPorto 4099-001Portugal Department of Institute of Biomedical Sciences Abel Salazar University of PortoPorto 4050-313Portugal

BACKGROUND Anemia is considered a public health issue and is often caused by iron ***-deficiency anemia(IDA)often originates from blood loss from lesions in the gastrointestinal tract in men and postmenopausal women,and its prevalence among patients with gastrointestinal bleeding has been estimated to be 61%.However,few guidelines regarding the appropriate investigation of patients with IDA due to gastrointestinal bleeding have been *** To review current evidence and guidelines concerning IDA management in gastrointestinal bleeding patients to develop recommendations for its diagnosis and *** Five gastroenterology experts formed the Digestive Bleeding and Anemia Workgroup and conducted a systematic literature search in PubMed and professional association ***(via PubMed)searches combined medical subject headings(MeSH)terms and the keywords“gastrointestinal bleeding”with“iron-deficiency anemia”and“diagnosis”or“treatment”or“management”or“prognosis”or“prevalence”or“safety”or“iron”or“transfusion”or“quality of life”,or other terms to identify relevant articles reporting the management of IDA in patients over the age of 18 years with gastrointestinal bleeding;retrieved studies were published in English between January 2003 and April *** professional association websites were searched for clinical practice *** lists from guidelines were reviewed to identify additional relevant *** recommendations were developed by consensus during two meetings and were supported by the published literature identified during the systematic *** From 494 Literature citations found during the initial literature search,17 original articles,one meta-analysis,and 13 clinical practice guidelines were *** on the published evidence and clinical experience,the workgroup developed the following ten recommendations for the management of IDA in patients with gastrointestinal bleeding:(1)Evaluation of

关键词： Anemia iron-deficiency Erythrocyte transfusion Ferric carboxymaltose Gastrointestinal hemorrhage Iron Practice guidelines as topic

Spatial Statistics and Age Structure of Leaf Cutting Ant Nests

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Open Journal of Statistics 2019年第2期9卷 196-217页

作者： Debora maria ferreira Canuto Sergio Furtado dos Reis Wesley Augusto Conde Godoy Departamento de Entomologia e Acarologia Escola Superior de Agricultura Luiz de Queiroz Universidade de Sao Paulo Piracicaba Brazil Departamento de Biologia Animal Universidade Estadual de Campinas Campinas Brazil

In this study, we investigated the spatial aggregation of old and incipient nests of Atta sexdens rubropilosa by fitting Poisson and Negative binomial models to nest abundance data. Our aim is to analyse the distribution of ant nests in eucalypt regrowth, Cerrado and native forest fragment. We also investigated the correlation between nest abundance and climatic factors, as well as different nest ages. When comparing nests of different ages we observed an aggregated pattern for both old and incipient nests. On the other hand, analysing the distribution of nests separately, only taking into account the different areas and respective borders, old nests exhibited an aggregated pattern and incipient nests showed a random pattern, except for native forest with ants exhibiting only an aggregated pattern. The levels of aggregation changed in response to different areas and border gradients, with more external borders showing higher aggregation than more internal borders. Temperature was the variable showing the highest correlation with nest abundance and the correlation between nests of different ages was totally depending on the different areas.

关键词： Spatial Statistics Leaf Cutting Ant Nest Aggregation Nest Age Forest Landscapes

The Role of Physical and Political Factors on the Conservation of Native Vegetation in the Brazilian Forest-Savanna Ecotone

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Open Journal of Forestry 2013年第1期3卷 49-56页

作者： Henrique O.Sawakuchi maria Victoria R.Ballester Manuel Eduardo ferreira Center of Nuclear Energy in Agriculture University of Sao PauloPiracicabaBrazil Social-Environmental Studies Institute/LAPIG Federal University of GoiásGoianiaBrazil

The AraguaiaRiver Basincovers a considerable extent of Brazilian Savanna (locally called Cerrado) and part of Amazon Tropical Rainforest, embracing high biodiversity and a vast flooding area. This region has been converted to agricultural lands since 1970s, for the past four decades, leading to a fragmented landscape that holds one of the few large remaining blocks of Cerrado primary vegetation. Therefore, to assess the degree of preservation of this area a 2007 primary vegetation map was derived through Boolean operations using land use and land cover maps from 1975, 1985, 1996 and 2007, from digital classification of Landsat MSS and TM images. To evaluate the role of driving factors on the presence of pristine vegetation, a logistic regression analyses was performed. Tested factors were: distance from roads and cities, terrain slope, land tenure, soil fertility and flooding. We found statistical significant values (p nous lands, wetlands and areas with low fertility have positive influence on the presence and maintenance of these pristine areas. The occurrence of original vegetation in many cases is associated with environmental constraints that difficult or do not allow agricultural use. Analysis of physical and political factors, which may have direct or indirect influence on the conservation and degradation of native vegetation are very important for the comprehension of the dynamics of regional land use, and provide supporting information for a more efficient and sustainable regional landscape planning.

关键词： Amazon-Cerrado Transition Pristine Vegetation Driving Factors Deforestation Araguaia River Basin Regional Planning

Brazil After Lula and Dilma Administrations： The Bolsa Familia and Implantation of a Basic Income

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Sociology Study 2017年第4期7卷 179-194页

作者： maria Ozanira da Silva e Silva Valeria ferreira Santos de Almada Lima Federal University of Maranhao State Brazil

The Family Stipend Program （Bolsa Famflia--BF） has been implemented since 2003 as the main strategy to face poverty in Brazil. Its benefit is the transfer of income to poor and extremely poor families as well as to articulate the monetary income transfer with some structural policies, mainly education, health, and work. The BF has already reached almost 14 million of families and is implemented in all the 5,545 Brazilian municipalities, i.e. about ~ of the Brazilian population. The program requires the fulfillment of some conditionalities in the field of education and health, such as： enrollment and attendance of the children and adolescents in school; children must get basic health care; and pregnant women must receive prenatal care. The BF is considered in Brazil, according to Eduardo Suplicy＇s Law Bill 266/2001 sanctioned by President Lula on ]anuary 8 of 2004, as the first step towards creating a Citizenship Basic Income. The goal of this proposal is to present and to problematize the recent political and economic post Lula and Dilma Administrations situation in order to demonstrate the climate of regression in the social protection programs and the dismantling of the same social rights already conquered by the worker class and the poor population. Among the programs to be mentioned is the BF. The intention is to highlight the economic situation of a long recession and rise in unemployment rates besides the decrease of the workers＇ income and the repression of social movements, in order to develop an analysis of the BF in this context.

关键词： Family stipend income transfer programs Brazil

Projecting Health Outcomes for Portuguese Ageing Population: Challenges and Opportunities

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Health 2014年第14期6卷 1874-1882页

作者： maria do Rosário Oliveira Martins Inês Campos Rodrigues Teresa ferreira Rodrigues CEPESE—Centro de Estudos da Populaç ã o Economia e Sociedade Universidade do Porto Porto Portugal Unidade de Saúde Pública Internacional e Bioestatística Instituto de Higiene e Medicina Tropical Universidade Nova de Lisboa Lisboa Portugal

Objectives: To project health outcomes for the period 2011-2031, in the Portuguese population aged 65 years and over, considering the expected changes in its demographic and educational structure. Methods: Demographic projections were produced using the multistate cohort component method. Logistic regression models were fitted to estimate current differences in health outcomes, using data from the Portuguese Health Survey. Such differences were applied to the projection results, in order to project the prevalence of “poor” self-reported health status, functional limitations and disability. Results: Our results point to a future improvement in the considered health outcomes. The prevalence of “poor” self-reported health status, functional limitations and disability will decrease in both genders, but will continue to be higher among women than men. Discussion: Beyond age and gender, other determinants of health, like education, should be considered when studying the possible evolution of health outcomes in an ageing population.

关键词： Projections Aging Educational Level Self-Reported Health Status Functional Limitations and Disability