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Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population

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World Journal of Gastroenterology 2011年第42期17卷 4682-4688页

作者： Dana L Bruden m.chael G bruce Karen m.m.ernyk Julie m.rris Debby Hurlburt Thom.s W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J m.m.hon Arctic Investigations Program Division of Preparedness and Emerging InfectionsNational Center for Emerging Zoonoses and Infectious DiseasesCenters for Disease Control and Prevention Alaska Native Tribal Health Consortium Anchorage

AIm. TO evaluate the accuracy of two non-invasive tests in a population of Alaska Native persons. High rates of Helicobacter pylori （H. pylon] infection, H. pyIori treatm.nt failure, and gastric cancer in this population necessitate docum.ntation of infection status at m.ltiple tim. points over a patient＇s *** test, 13C urea breath test （UBT）, and im.unoglobulin G antibodies to H. pylori in serum. The perform.nces of 13C-UBT and antibody test were com.ared to a gold standard defined by a positive H. pylori test by culture or, in case of a negative culture result, by positive histology and a positive rapid urease test.RESULTS： The sensitivity and specificity of the 13C- UBT were 93% and 88%, respectively, relative to the gold standard. The antibody test had an equivalent sensitivity of 93% with a reduced specificity of 68%. The false positive results for the antibody test were associated with previous treatm.nt for an H. pylorlinfection [relative risk （RR） = 2.8]. High levels of antibodies to H. py/or/were associated with chronic gastritis and m.le gender, while high scores in the 13C-UBT test were associated with older age and with theH. pylori bacteria load on histological exam.nation （RR = 4.4）. CONCLUSION： The 13C-UBT outperform.d the antibody test for H. pylori and could be used when a noninvasive test is clinically necessary to docum.nt treatm.nt outcom. or when m.nitoring for reinfection.

关键词： Urea breath test Antibody test Sensitivity Specificity

Night-tim. Rise in Rat Pineal N-Acetyltransferase due to Carbaryl Adm.nistration Is Reduced by Propranolol Treatm.nt

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Biom.dical and Environm.ntal Sciences 1995年第1期8卷 45-53页

作者： AHm.D m. ATTIA m.STAFA H. m.STAFA bruce A. RICHARDSON AND RUSSEL J. REITER(Departm.nt of Environm.ntal Studies, Institute of Graduate Studies and Research, P.O.Box 832, Alexandria, Egypt Departm.nt of Cellular and Structural Biology, University of Texas, Departm.nt of Environm.ntal Studies Institute of Graduate Studies and Research Alexandria Egypt.

The purpose of the present study was to exam.ne the effects of adm.nistration of sublethal doses of carbaryl on nighttim. rat pineal m.latonin synthesis in the presence and absence of propranolol, a β-adrenergic receptor antagonist. Two groups of adult m.le albino rats were adm.nistered orally N-m.thyl-l-naphthylcarbam.te (carbaryl) (8. 33m./kg BW daily in corn oil) for six successive days; another two groups received corn oil *** the last day of carbaryl treatm.nt, half of the anim.ls received an intraperitoneal injection of propranolol (20 m./kg body weight, one hour before lights off). The other two groups were given a saline injection. Four hours after darkness onset, pineal N-acetyltransferase (NAT) and hydroxyindole-O-m.thyltransferase (HIOm.) activities as well as pineal concentrations of 5-hydroxytryptophan (5HTP), serotonin (5HT),5-hydroxyindole acetic acid (5HIAA) and pineal and serum.m.latonin levels were m.asured. Nocturnal NAT activity was increased due to carbaryl adm.nistration but the pesticide was ineffective in stim.lating NAT activity in rats treated with *** 5HT was decreased due to carbaryl adm.nistration but 5HTP and 5HIAA levels were unaffected. Pineal and serum.m.latonin levels were decreased due to propranolol treatm.nt. The results indicate that carbaryl m.y influence pineal NAT activity by a m.chanism.that involves β-adrenergic neural transm.ssion.

关键词： tim. Night-tim. Rise in Rat Pineal N-Acetyltransferase due to Carbaryl Adm.nistration Is Reduced by Propranolol Treatm.nt

Optim.zation of m.cropatterned poly(lactic-coglycolic acid) film. for enhancing dorsal root ganglion cell orientation and extension

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Neural Regeneration Research 2018年第1期13卷 105-111页

作者： Ching-Wen Li Brett Davis Jill Shea Him.nshu Sant bruce Kent Gale Jayant Agarwal Departm.nt of m.chanical Engineering National Chung Hsing University Departm.nt of Surgery School of Medicine University of Utah Departm.nt of m.chanical Engineering University of Utah

Nerve conduits have been a viable alternative to the ‘gold standard’ autograft for treating sm.ll peripheral nerve gap injuries. However, they often produce inadequate functional recovery outcom.s and are ineffective in large gap injuries. Ridge/groove surface m.cropatterning has been shown to prom.te neural cell orientation and guide growth. However, optim.zation of the ratio of ridge/groove param.ters to prom.te orientation and extension for dorsal root ganglion （DRG） cells on poly（lactic-co-glycolic acid）（PLGA） film. has not been previously conducted. Photolithography and m.cro-m.lding were used to define various com.inations of ridge/groove dim.nsions on PLGA film.. The DRG cells obtained from.chicken em.ryos were cultured on m.cropatterned PLGA film. for cell orientation and m.gration *** of the film. occurred during the test period, however, this did not cause deform.tion or distortion of the m.cropatterns. Results from.the DRG cell orientation test suggest that when the ridge/groove ratio equals 1 （ridge/groove width param.ters are equal, i.e., 10 μm.10 μm.（even））, the degree of alignm.nt depends on the size of the ridges and grooves, when the ratio is sm.ller than 1 （groove controlled） the alignm.nt increases as the ridge size decreases, and when the ratio is larger than 1 （ridge controlled）, the alignm.nt is reduced as the width of the grooves decreases. The m.gration rate and neurite extension of DRG neurons were greatest on 10 μm.10 μm.and 30 μm.30 μm.m.cropatterned PLGA film.. Based on the data, the 10 μm.10 μm.and 30 μm.30 μm.m.cropatterned PLGA film. are the optim.zed ridge/groove surface patterns for the construction of nerve repair devices.

关键词： nerve regeneration nerve repair neural cell m.gration neural cell alignm.nt m.cropattern dorsal root ganglion topological cues neural regeneration

Controlled release of FK506 from.m.cropatterned PLGA film.:potential for application in peripheral nerve repair

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Neural Regeneration Research 2018年第7期13卷 1247-1252页

作者： Brett Davis Susan Wojtalewicz Pratim. Labroo Jill Shea Him.nshu Sant bruce Gale Jayant Agarwal Departm.nt of Bioengineering University of Utah Departm.nt of Surgery University of Utah Departm.nt of m.chanical Engineering University of Utah

After decades of research,peripheral nerve injury and repair still frequently results in paralysis,chronic pain and neuropathies leading to severe disability in *** clinically available nerve conduits only provide crude guidance of regenerating axons across nerve gap without additional ***506（Tacrolim.s）,an FDA approved im.unosuppressant,has been shown to enhance peripheral nerve regeneration but carries harsh side-effects when delivered *** objective of this study was to develop and evaluate a bioresorbable drug delivery system.capable of local extended delivery of FK506 that also provides topological guidance cues to guide axon growth via *** was used to create m.cropatterned poly（lactide-co-glycolic acid）（PLGA） film. em.edded with ***-patterned,10/10 μm.ridge/groove width）,and 30/30 μm.patterned film. loaded with 0,1,and 3 μg/cm. FK506 were m.nufactured and *** vitro FK506 rate of release testing indicated that the film. are capable of an extended（at least 56 days）,controlled,and scalable release of *** extension bioactivity assay indicated that FK506 released from.the film.（concentration of sam.les tested ranged between 8.46–19.7 ng/m.L） m.intained its neural bioactivity and prom.ted neurite extension sim.lar to control FK506 dosages（10 ng/m.L FK506）.The m.lti-functional FK506 em.edded,m.cropatterned poly（lactide-co-glycolic acid） film. developed in this study have potential to be used in the construction of peripheral nerve repair devices.

关键词： nerve regeneration FK506 controlled release m.cropatterns topological cues PLGA

Fundam.ntal m.vem.nt skills training to prom.te physical activity in children with and without disability： A pilot study

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Journal of Sport and Health Science 2015年第3期4卷 235-243页

作者： Catherine m. Capio Cindy H.R Sit Kathlynne F. Eguia bruce Abernethy Richard S.W. m.sters Institute of Hum.n Perform.nce The University of Hong Kong Hong Kong China Departm.nt of Sports Science and Physical Education The Chinese University of Hong Kong Hong Kong China Alternative Learning Resource School Quezon City 1113 Philippines Faculty of Health Sciences University of Queensland Brisbane Queensland 4072 Australia Sports and Leisure Studies Departm.nt The University of Waikato Hamilton 3240 New Zealand

Background： A positive association between fundam.ntal m.vem.nt skills （Fm.） and physical activity （PA） has been shown in previous research of children with and without disability. This pilot study explored a causal m.chanism.for such relationship, and hypothesized that when Fm. proficiency is im.roved, enhanced PA uptake will be found in children with and without disability. It was further hypothesized that im.roving Fm. proficiency will have a greater im.act on children with disability than those without disability. m.thods： Participants include typically developing （TD） children without disability and children with cerebral palsy （CP）, who were allocated to Fm. training groups （CP-Fm. n = 12, TD-Fm. n = 13） and control groups （CP-C n = 12, TD-C n = 13）. Training groups practiced five Fm. （run, jum., kick, throw, catch） in weekly 45-m.n sessions for 4 weeks. Control groups had their regular physiotherapy （CP） or physical education （TD） sessions. Fm. were evaluated using process- and product-oriented m.asures, and PA was m.asured using accelerom.ters, before and after training. Results： It was verified that training groups gained im.rovem.nts in Fm. while control groups did not. No significant changes in weekday PA were found. Increased weekend m.derate to vigorous physical activity （m.PA） was found in the CP-Fm. group, while decreased weekend sedentary tim. was found in the CP-Fm. and TD-Fm. groups. The percentages of participants who exceeded the m.nim.m.detectable change （m.C9o） in m.PA and sedentary tim. were larger in children with CP than in children without disability. Conclusion： The findings suggest that im.roved Fm. proficiency could potentially contribute to heightened PA and decreased sedentary tim. during weekends for children. Such effect of im.roved Fm. proficiency on PA appears to be greater in those with physical disability than in those without disability. It is recom.ended that the findings of this pilot study should be further exam.ned in future

关键词： Cerebral palsy Fundam.ntal m.vem.nt skills m.tor learning Physical activity Sedentary behavior

Resilience in a m.xican Pacific m.ngrove after Hurricanes: Im.lications for Conservation Restoration

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Journal of Environm.ntal Protection 2013年第12期4卷 1383-1391页

作者： m.teo D. m. Ruiz bruce Taylor José Luis Rangel-Salazar Bonifacio Cortés Hernández Departm.nt of Biodiversity Conservation El Colegio de la Frontera Sur San Cristóbal de Las Casas Campus Chiapas Mexico Reforestation Nursery Servicios Ecoturísticos La Ventanilla Cooperative Society Puchutla Mexico

High resilience is a m.ngrove trait that is com.atible with life in a dynam.c environm.nt, however, catastrophic disturbance can lead to the entire forest structure being re-defined. In the Pochutla district of Oaxaca, two hurricanes m.de landfall in 1997 and one m.re in 2012. Following the 1997 hurricanes, extensive m.ngrove restoration was carried out in the study area. A cohort of Rhizophora m.ngle saplings planted in 2007 showed 10% m.rtality during the first year after transplantation, an average growth of 39 cm. and a positive association between growth rate and the level of water in the lagoon. Following Hurricane Carlotta of 2012, m.asurem.nts of structural im.act and tree m.rtality were taken in restored R. m.ngle stands and in naturally regenerated patches of Laguncularia racem.sa. The role of tree girth in R. m.ngle susceptibility to wind dam.ge was also investigated. The stands of R. m.ngle suffered 80% reduction in stem.density and 86% loss of basal area, whereas the corresponding values for L. racem.sa were 26% and 15%, respectively. Within stands of R. m.ngle, m.rtality conserved a positive relationship with structural im.act categories and the frequency of snapped stem. was segregated across girth classes. The results suggest that L. racem.sa has greater resilience to hurricane dam.ge, which has som. consistency with previous research and im.lications for conservation restoration protocols. In order to prom.te a system.with higher resilience, we recom.end an on-going restoration effort with m.xed m.ngrove species.

关键词： Coastal Lagoon Disturbance Hurricane m.ngrove Restoration Resilience

Sm.king influences outcom. in patients who had throm.olysed ischaem.c stroke:the ENCHANTED study

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Stroke & Vascular Neurology 2021年第3期6卷 395-401,I0033,I0034页

作者： Lingli Sun Lili Song Jie Yang Richard I Lindley Thom.son Robinson Pablo m.Lavados Candice Delcourt Hisatom. Arim. bruce Ovbiagele John Chalm.rs Craig S Anderson Xia Wang The George Institute for Global Health Peking University Health Science CentreBeijingChina The George Institute for Global Health University of New South WalesSydneyNSWAustralia Departm.nt of Neurology The First Affiliated Hospital of Chengdu Medical CollegeChengduChina Faculty of m.dicine University of SydneySydneyNSWAustralia Departm.nt of Cardiovascular Sciences and NIHR Biom.dical Research Unit for Cardiovascular Sciences University of LeicesterLeicesterUK Clínica Alem.na de Santiago Universidad del DesarrolloSantiago de ChileRegion Metropolitana de SChile Departm.nt of Preventive m.dicine and Public Health Faculty of MedicineFukuoka UniversityFukuokaJapan San Francisco VA Healthcare System University of CaliforniaSan FranciscoCaliforniaUSA

Background and purpose As studies vary in defining the prognostic significance of sm.king in acute ischaem.c stroke(AIS),we aim.d to determ.ne the relation of sm.king and key outcom.s in patient participants who had throm.olysed AIS of the international quasi-factorial random.sed Enhanced Control of Hypertension and Throm.olysis Stroke Study(ENCHANTED).m.thods Post-hoc analyses of ENCHANTED,an international quasi-factorial random.sed evaluation of intravenous alteplase-dose com.arison and levels of blood pressure control in patients who had throm.olysed *** logistic regression m.dels with inverse probability of treatm.nt weighting(IPTW)propensity scores were used to determ.ne associations of self-reported sm.king status and clinical outcom.s,according to 90-day m.dified Rankin Scale(m.S)scores and sym.tom.tic intracerebral haem.rrhage(sICH).Results Of 4540 patients who had an AIS,there were 1008(22.2%)current sm.kers who were younger and predom.nantly m.le,with m.re com.rbidities of hypertension,coronary artery disease,atrial fibrillation and diabetes m.llitus,and greater baseline neurological im.airm.nt,com.ared with *** univariate analysis,current sm.kers had a higher likelihood of a favourable shift in m.S scores(OR 0.88,95%CI 0.77 to 0.99;p=0.038)but this association reversed in a fully adjusted m.del with IPTW(adjusted OR 1.15,95%CI 1.04 to 1.28;p=0.009).A sim.lar trend was also apparent for dichotom.sed poor outcom.(m.S scores 2–6:OR 1.18,95%CI 1.05 to 1.33;p=0.007),but not with the risk of sICH across standard *** Sm.king predicts poor functional recovery in patients who had throm.olysed *** registration num.er NCT01422616.

关键词： patients sm.ke acute

Berne &am.; Levy生理学原理

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丛书名：国外优秀生命科学教材译丛

2008年

作者：（美）m.tthew N.Levy bruce A.Stanton bruce m.Koeppen

本书人体生理学的导论性读物，全书共分八篇，内容包括：细胞生理学、神经系统、肌肉、心血管系统、呼吸系统、肾系统、内分泌系统。

ISBN: (纸本)9787894898906;9787040231274

本书人体生理学的导论性读物，全书共分八篇，内容包括：细胞生理学、神经系统、肌肉、心血管系统、呼吸系统、肾系统、内分泌系统。

关键词：人体生理学

来源：畅想之星图书光盘版（南... 评论

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青光眼彩色图谱第三版