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Evaluation of Acute Toxicity, Antioxidant and Antibacterial Potential of Leaves Extracts from Two Anacardiaceae’s Species: Lannea microcarpa Engl. &K. Krause and Mangifera indica L.

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Journal of Biosciences and Medicines 2022年第10期10卷 125-134页

作者： Monique brigitte Ouattara Jean Hubert Bationo Martin Kiendrebeogo Odile Germaine Nacoulma Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Unité de formation et de recherche en sciences de la vie et de la terre Département de Biochimie-Microbiologie Ouagadougou Burkina Faso

Background: Leaves of Mangifera indica L or Lannea microcarpa Engl. & K. Krause are used in traditional medicine in Burkina Faso to treat bacterial, parasitic or metabolic diseases. Objective: The aim of this study is to evaluate the acute general toxicity, antioxidant potential and antibacterial activitiy of leave’s aqueous extracts from Lannea microcarpa Engl. and K. Krause and Mangifera indica L. The use of these plants in traditional medicine motivated our choice to lead scientific studies. Methods: The aqueous decoction of the leaves is the form of use recommended by traditional healers. We used the same type of extracts for studies. Acute toxicity was studied in NMRI strain mice, with the dose of 2000 mg/kg body weight, for each plant species. The antioxidant activity is evaluated by the method of reduction of radical DPPH. The phytochemical compounds were detected with specific reagent: Alcaloids with Dragendorff’s reagent, Flavonoids with ammonia (NH4OH), Polyphenols and tannins are revelated by ferric chloride (FeCl3). Saponosides were revelated by their foaming power property. Bacterial inhibiting activity is tested by measuring the diameters’ inhibition of extracts on reference strains. Results: The aqueous extracts were not toxic at the maximum dose of 2000 mg/kg body weight, for each plant species. The extracts showed an antioxidant activity with an IC50, 20 μg/ml for Lannea microcarpa and 18 μg/ml for Mangifera indica. The extracts showed no bacterial activity on three strains of bacteria tested: Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The phytochemicals we have identified are for L. microcarpa: tannins and phenolics compounds, triterpenes, saponosides. We identified in M. indica’s extracts: tannins and phenolics compounds, triterpenes, saponosides and flavonoids.

关键词： Lannea microcarpa Mangifera indica Toxicity Antioxidant Activity DPPH Antibacterial Activity Phytochemical Compounds

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Ultrastructural Characteristics of Sheep and Horse Mesenchymal Stem Cells (MSCs)

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Microscopy Research 2013年第3期1卷 17-23页

作者： Asuman Ozen Irem Gul Sancak brigitte Von Rechenberg Sabine Koch Competence Center for Applied Biotechnology and Molecular Medicine (CABMM) Vetsuisse Faculty University of Zurich Zurich Switzerland Department of Histology-Embryology Veterinary Faculty Ankara University Ankara Turkey Department of Surgery Veterinary Faculty Ankara University Ankara Turkey

In the present study, the morphological and ultrastructural characteristics of mesenchymal stem cells (MSCs) induced towards osteogenic, adipogenic, and chondrogenic lineages were investigated. The main objective of this paper was to focus on the differentiation capacity of ovine [oMSCs] and equine MSCs [eMSCs]. Bone marrow [BM] MSCs were isolated from ovine and equine patients, expanded in monolayer culture and induced into osteogenic, adipogenic and chondrogenic differentiation. For chondrogenic differentiation, cells were cultured in micromass culture. Also, their ultrastructural phenotypes were studied by transmission electron microscopy [TEM]. This study was aimed to provide an indepth morphological description of BM-derived ovine and equine MSCs induced towards three lineages, it demonstrated that TEM analysis is useful in elucidating detailed structural information.

关键词： Ultrastructure Mesenchymal Stem Cells (MSCs) TEM Differentiation Equine Ovine

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Left recurrent laryngeal nerve palsy following aortic arch stenting: A case report

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World Journal of Cardiology 2019年第12期11卷 316-321页

作者： Hannah Elisabeth Fürniss Johanna Hummel brigitte Stiller Jochen Grohmann Department of Congenital Heart Disease and Pediatric Cardiology University Heart Centre Freiburg-Bad Krozingen Medical Centre-University of Freiburg Faculty of Medicine University of Freiburg

BACKGROUND Aortic arch stenting is continuously emerging as a safe and effective option to alleviate aortic arch stenosis and arterial *** SUMMARY We present a 15-year-old girl with aortic arch hypoplasia who had undergone implantation of an uncovered 22 mm Cheatham-Platinum stent due to severe(native)aortic arch *** follow-up seven months later,she presented a significant re-stenosis of the aortic arch.A second stent(LD Max 26 mm)was implanted and both stents were dilated up to 16 *** an initially unremarkable post-interventional course,the patient presented with hoarseness five days after the *** and CT scans ruled out an intracranial pathology,as well as thoracic hematoma,arterial dissection,and aneurysm around the intervention *** confirmed left vocal fold paresis attributable to an injury to the left recurrent laryngeal nerve(LRLN)during aortic arch stenting,as the nerve loops around the aortic arch in close proximity to the area of the implanted *** a non-invasive therapeutic approach entailing regular speech therapy,the patient recovered and demonstrated no residual clinical symptoms of LRLN palsy after six *** Left recurrent laryngeal nerve palsy is a rare complication of aortic arch stenting not previously reported.

关键词： Cardiac catheterization Congenital heart defects Hypoplastic aortic arch Endovascular procedure Vocal cord paralysis Case report

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Using Boosted Regression Trees and Remotely Sensed Data to Drive Decision-Making

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Open Journal of Statistics 2017年第5期7卷 859-875页

作者： brigitte Colin Samuel Clifford Paul Wu Samuel Rathmanner Kerrie Mengersen School of Mathematical Sciences Queensland University of Technology Brisbane Australia

Challenges in Big Data analysis arise due to the way the data are recorded, maintained, processed and stored. We demonstrate that a hierarchical, multivariate, statistical machine learning algorithm, namely Boosted Regression Tree (BRT) can address Big Data challenges to drive decision making. The challenge of this study is lack of interoperability since the data, a collection of GIS shapefiles, remotely sensed imagery, and aggregated and interpolated spatio-temporal information, are stored in monolithic hardware components. For the modelling process, it was necessary to create one common input file. By merging the data sources together, a structured but noisy input file, showing inconsistencies and redundancies, was created. Here, it is shown that BRT can process different data granularities, heterogeneous data and missingness. In particular, BRT has the advantage of dealing with missing data by default by allowing a split on whether or not a value is missing as well as what the value is. Most importantly, the BRT offers a wide range of possibilities regarding the interpretation of results and variable selection is automatically performed by considering how frequently a variable is used to define a split in the tree. A comparison with two similar regression models (Random Forests and Least Absolute Shrinkage and Selection Operator, LASSO) shows that BRT outperforms these in this instance. BRT can also be a starting point for sophisticated hierarchical modelling in real world scenarios. For example, a single or ensemble approach of BRT could be tested with existing models in order to improve results for a wide range of data-driven decisions and applications.

关键词： Boosted Regression Trees Remotely Sensed Data Big Data Modelling Approach Missing Data

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Phytochemical Screening and Acute Toxicity Evaluation of Leaves Extract of Two Fabaceae’s Species: Sesbania pachycarpaDC. and Indigofera berhautianaGillett

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Journal of Biosciences and Medicines 2020年第7期8卷 28-34页

作者： Monique brigitte Ouattara Jean Hubert Bationo Martin Kiendrebeogo Odile Germaine Nacoulma Laboratoire de Biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Unité de Formation et de Recherche en Sciences de la Vie et de la Terre Département de Biochimie-Microbiologie Ouagadougou Burkina Faso

Objective: The aim of this study is to screen chemical composition and to evaluate the acute general toxicity of leaves aqueous extracts from Sesbania pachycarpa DC. (Fabaceae), used in traditional medicine in Burkina Faso to treat malaria, helminthiasis, and aqueous extracts of the leaves from Indigofera berhautiana Gillet (Fabaceae) used to treat hepatitis and typhoid fever. Methods: Aqueous decoction of leaves from Sesbania pachycarpa DC. or Indigofera berhautiana Gillett which are the form of use recommended by traditional health practitioners, were used for tests. Aqueous extracts used to evaluate the acute toxicity, were studied on mice of strain NMRI. For the toxicity study, the doses of the aqueous extracts were respectively 5 mg/kg, 50 mg/kg, 300 mg/kg and 2000 mg/kg of body weight. Phytochemical screening was done to identify the phytochemicals contained in extracts. Results: Aqueous extracts of two species: Sesbania pachycarpa DC., Indigofera berhautiana Gillet were not toxic at the maximum dose of 2000 mg/kg of body weight. Phytochemical screening, showed coumarins, flavonoids, tannins, polyphenols compounds, steroids and/or triterpenes and saponosides in the aqueous extracts of the two species. Alkaloids were identified in Sesbania pachycarpa aqueous extract.

关键词： Sesbania pachycarpa DC. Indigofera bergautiana Gillet Aqueous Extracts Acute General Toxicity NMRI Strain Phytochemicals Compounds

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Kulturdifferenz in Fachtextsortenkonventionen

Kulturdifferenz in Fachtextsortenkonventionen

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2007年

作者： Horn-Helf brigitte.

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Effects of Ginkgo Biloba Special Extract EGb 761^(█) in Very Mild Cognitive Impairment(vMCI)

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Neuroscience & Medicine 2011年第1期2卷 48-56页

作者： brigitte Grass-Kapanke Arija Busmane Andris Lasmanis Robert Hoerr Reiner Kaschel Alexian Hospital Krefeld KrefeldGermany Adoria Clinic RigaLatvia Alma Clinic RigaLatvia Dr.Willmar Schwabe GmbH&Co.KG Pharmaceuticals KarlsruheGermany University of Osnabrueck OsnabrueckGermany

Objective: To assess effects of EGb 761? on cognition and quality of life in subjects with very mild cognitive impair-ment. Methods: We randomized 300 subjects aged 45 to 65 with cognitive complaints and low functioning (more than one standard deviation below appropriate norm) in at least one cognitive test to double-blind treatment with once daily 240 mg EGb 761? or placebo for 12 weeks. Results: The exploratory intention-to-treat analysis showed significant im-provement (p < 0.025, one-sided) beyond practice effects for EGb 761? in a measure of attention (Vienna Test System - Work Performance Series) and trends in favour of EGb 761? in measures of memory (Wechsler Memory Scale III - Faces I, Appointments Test – delayed recall), and perceived physical health (SF36 - factor score Physical Health). Cognitive effects were more pronounced and more consistent (p < 0.025 in 4 of 5 tests) in subjects with lower memory function at baseline. Specifically, practice effects in the more demanding tests were attenuated or absent in these sub-jects. Conclusion: Ginkgo biloba extract EGb 761? improved cognitive functioning and aspects of quality of life in sub-jects with very mild cognitive impairment.

关键词： Ginkgo Biloba EGb 761^(█) Mild Cognitive Impairment Memory Concentration Randomised Controlled Trial

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Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 and 2 in Rheumatoid Arthritis

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International Journal of Clinical Medicine 2012年第4期3卷 254-262页

作者： Christine Beyeler Bernhard Dick Howard A. Bird brigitte M. Frey Academic Department of Musculoskeletal Medicine University of Leeds United Kingdom Departments of Nephrology and Hypertension and Clinical Research University Hospital of Berne Switzerland Institute of Medical Education Department of Rheumatology Clinical Immunology and Allergology

Objective. The sequential activities of the 11β-hydroxysteroid dehydrogenase enzymes type 1 and 2 have not been investigated so far in patients suffering from rheumatoid arthritis before and after starting treatment though the enzymes balancing cortisol and cortisone levels are involved in regulating various inflammatory diseases. Methods. In a retrospective study, a panel of 41 urinary steroid metabolites has been analysed in a group of 18 patients with active rheumatoid arthritis (RA) as they were brought under control with disease modifying drugs. Results. No major changes were found in a variety of androgen, oestrogen and progesterone metabolites, however the ratio of THF + 5αTHF/THE as an index of 11β-HSD1 oxidative activity demonstrated down-regulation with modification correlating significantly with change in acute phase reactants as the disease came under control. These findings were supported by a tendency of a reduced ratio of F/E, an index of 11β-HSD2 oxidative activity, resulting in a significant correlation of the two ratios (p < 0.001). This parallelism of the two enzymes with functions of clinical laboratory parameters during drug-induced improvement of the disease is novel. Conclusions. Urinary steroid metabolites, which alter with disease activity, may provide further insight into the mechanisms by which stress can modify arthritis through hormones.

关键词： Rheumatoid Arthritis Basic Clinical Scienc Hormones Inflammation Biomarkers

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Neural Model-Based Self-Tuning PID Strategy Applied to PEMFC

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Engineering（科研） 2014年第4期6卷 159-168页

作者： Cédric Damour Michel Benne brigitte Grondin-Perez Jean-Pierre Chabriat Physics Department University of La Reunion Saint-Denis France

This paper illustrates the benefits of a self-tuning PID strategy applied to a proton exchange membrane fuel cell system. Controller parameters are updated on-line, at each sampling time, based on an instantaneous linearization of an artificial neural network model of the process and a General Minimum Variance control law. The self-tuning PID scheme allows managing nonlinear behaviors of the system while avoiding heavy computations. The applicability, efficiency and robustness of the proposed control strategy are experimentally confirmed using varying control scenarios. In this aim, the original built-in controller is overridden and the self-tuning PID controller is implemented externally and executed on-line. Experimental results show good performance in setpoint tracking accuracy and robustness against plant/model mismatch. The proposed strategy appears to be a promising alternative to heavy computation nonlinear control strategies and not optimal linear control strategies.

关键词： Self-Tuning PID Controller Artificial Neural Network Model Proton Exchange Membrane Fuel Cell Real-Time Control Scheme Experimental Implementation

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Effect of marker genes on the consumption of transgenic potatoes by Leptinotarsa decemlineata,the Colorado potato beetle

Effect of marker genes on the consumption of transgenic pota...

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International Conference:Technology Transfer in Biological Control:From Research to Practice

作者： Anne LECARDONNEL Geneviève PREVOST brigitte SANGWAN Laboratoire de Biologie des Entomophages UPJV33 rue St Leu80039 AmiensFrance Laboratoire Androgenese et Biotechnologie UPJV33 rue St Leu80039 AmiensFrance

Rapid advances in recombinant DNA technologies opened new opportunities of crop *** techniques now available allow us to introduce genes of interest in agronomical *** most widespread technic using Agrobacterium-mediated gene transfer already gave rise to many transgenic ***,the possible occurrence of genetically modified

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