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Consequences of metabolic syndrome on postoperative outcomes after pancreaticoduodenectomy

World Journal of Gastroenterology 2017年第17期23卷 3142-3149页

作者： Alban Zarzavadjian Le Bian David Fuks Sophie Chopinet Sébastien Gaujoux Manuela Cesaretti Renato Costi Ajay P Belgaumkar Claude Smadja brice gayet Department of Digestive Surgery Centre Hospitalier Simone Veil Laboratory of Medical Ethics and Legal Medicine University Paris Descartes Department of Digestive disease-Institut Mutualiste Montsouris UniversitéParis Descartes Department of Digestive Surgery Assistance PubliqueHopitaux de Paris Hopital Cochin Department of Digestive Surgery Assistance PubliqueHopitaux de Paris Hopital Antoine Béclère157 rue de la Porte Trivaux Boulevard Général Leclerc

AIM To analyze immediate postoperative outcomes after pancreaticoduodenectomy regarding metabolic *** In two academic centers, postoperative outcomes of patients undergoing pancreaticoduodenectomy from 2002 to 2014 were prospectively recorded. Patients presenting with metabolic syndrome [defined as at least three criteria among overweight(BMI ≥ 28 kg/m2), diabetes mellitus, arterial hypertension and dyslipidemia] were compared to patients without metabolic *** Among 270 consecutive patients, 29(11%) presented with metabolic syndrome. In univariable analysis, patients with metabolic syndrome were significantly older(69.4 years vs 62.5 years, P = 0.003) and presented more frequently with soft pancreas(72% vs 22%, P = 0.0001). In-hospital morbidity(83% vs 71%) and mortality(7% vs 6%) did not differ in the two groups so as pancreatic fistula rate(45% vs 30%, P = 0.079) and severity of pancreatic fistula(P = 0.257). In multivariable analysis, soft pancreas texture(P = 0.001), pancreatic duct diameter 30 kg/m2(P = 0.041) were identified as independent risk factors of pancreatic fistula after pancreaticoduodenectomy, but not metabolic *** In spite of logical reasoning and appropriate methodology, present series suggests that metabolic syndrome does not jeopardize postoperative outcomes after pancreaticoduodenectomy. Therefore, definition of metabolic syndrome seems to be inappropriate and fatty pancreas needs to be assessed with an international consensual histopathological classification.

关键词： Soft pancreas Postoperative outcomes Metabolic syndrome Pancreaticoduodenectomy

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Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity

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Cancer Communications 2022年第11期42卷 1212-1216页

作者： Nicolas Alejandro Fraunhoffer Analía Meilerman Abuelafia brice Chanez Martin Bigonnet Odile gayet Julie Roques Eduardo Chuluyan Nelson Dusetti Juan Iovanna Cancer Research Center of Marseille InsermPaoli-Calmettes InstitutAix-Marseille UniversityScientific and Technological Park of LuminyMarseille 13288France Buenos Aires University Center for Pharmacological and Botanical StudiesFaculty of MedicineNational Council for Scientific and Technical ResearchBuenos AiresC1121ABGArgentina Buenos Aires University Faculty of MedicineDepartment of MicrobiologyParasitology and ImmunologyBuenos Aires C1121ABGArgentina Predicting Med Scientific and Technological Park of LuminyMarseille 13288France

Dear Editor,Pancreatic ductal adenocarcinoma(PDAC)treatment is focused on two *** polychemotherapy,FOLFIRINOX(folinic acid,fluorouracil,irinotecan,oxali-platin),is used in patients with good health conditions[1],while gemcitabine,as monotherapy,in patients with poor health conditions[2–4].Gemcitabine resistance-associated pathways have been targeted to sensitize cancer cells,but the results were *** a transcrip-tomic bioinformatics analysis combined with biological validation,we showed that glucuronidation was associ-ated with the gemcitabine resistance in PDAC,and its inhibition could switch tumors from resistant to sensitive.

关键词： gemcitabine cancer chemotherapy

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Fast-track protocols in laparoscopic liver surgery:Applicability and correlation with difficulty scoring systems

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World Journal of Gastrointestinal Surgery 2022年第3期14卷 211-220页

作者： Ruben Ciria Ana Padial María Dolores Ayllón Carmen García-Gaitan Javier briceño Unit of Hepatobiliary Surgery and Liver Transplantation University Hospital Reina SofiaCordoba 14004Spain Unit of Anesthesiology University Hospital Reina SofiaCordoba 14004Spain

BACKGROUND Few series have reported the utility of fast-track protocols(FTP)in minimally invasive liver *** To report the applicability of FTP in minimally invasive liver surgery and to correlate with difficulty *** The series of patients undergoing minimally invasive liver surgery from 2014 was ***,Southampton and gayet’s scores were compared as predictors of FTP *** of FTP was considered within 24-h,48-h and *** models were performed to define dischargegayet’s scores achieved area under the receiver operating characteristic values for<24-h stay of 0.780,0.687 and 0.698,*** and specificity values for the best score(Iwate)were 87.7%and 66.7%,respectively(cutoff=5.5).In multivariate models,<72 h stay and complications revealed body mass index as a risk factor independent from difficulty *** The development of aggressive FTP is feasible and<24-h stay can be achieved even in moderate and advanced complexity *** scores,including body mass index value,may be useful to predict which cases may adhere to these protocols.

关键词： Liver Fast-track Enhanced recovery Laparoscopy

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FUNCTIONAL AND MORPHOLOGICAL ALTERATIONS IN ON BIPOLAR CELLS OF THE RD10 MOUSE RETINA

FUNCTIONAL AND MORPHOLOGICAL ALTERATIONS IN ON BIPOLAR CELLS...

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第十八届国际眼科研究大会

作者： T Puthussery J gayet R.M Duvoisin W.R Taylor Neurological Sciences Institute Oregon Health and Science UniversityBeavertonORU.S.A.

＜正＞The success of retinal prostheses and stem cell therapies as treatments for Retinitis Pigmentosa （RP） relies on the structural and functional integrity of the downstream neurons,particularly the second-order bipolar *** conducted a longitudinal study in the rd10 mouse,a model of human autosomal recessive RP,to evaluate the timing of

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Pseudodesulfovibrio indicus ***.,***.,a piezophilic sulfate-reducing bacterium from the Indian Ocean and reclassification of four Desulfovibrio spp.

Pseudodesulfovibrio indicus ***.,***.,a piezophilic sulfate-...

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福建省海洋学会2016年学术年会

作者： Junwei Cao Nicolas gayet Xiang Zeng Zongze Shao Mohamed Jebbar Karine Alain Universite de Bretagne Occidentale(UBO UEB)Institut Universitaire Europeen de la Mer(IUEM)-UMR 6197Laboratoire de Microbiologie des Environnements Extremes(LMEE)Place Nicolas Copemic CNRS IUEM-UMR 6197Laboratoire de Microbiologie des Environnements Extremes(LMEE)Place Nicolas Copernic Ifremer UMR 6197Laboratoire de Microbiologie des Environnements Extremes(LMEE)Technopole Pointe du diable School of Municipal and Environmental Engineering Harbin Institute of Technology State Key Laboratory Breeding Base of Marine Genetic Resources Key Laboratory of Marine Genetic ResourcesThe Third Institute of State Oceanic Administration

A novel sulfate-reducing bacterium,strain J2,was isolated from a serpentinized peridotite sample from the Indian *** analysis based on 16S rRNA gene sequences showed that strain J2 clustered with the genus Desulfovibrio within the family Desulfovibrionaceae,but it showed low similarity(87.95%)to the type species Desulfovibrio desulfuricans DSM *** was most closely related to *** MSL79(96.96%),followed by *** Aspo-2(96.11%),*** C1TLV30(96.04%)and *** DSM11384(95.17%).Other available sequences shared less than 93.33%16S rRNA gene sequence *** were Gram-negative,anaerobic,motile vibrios(2-6x0.4-0.6μm).Growth was observed at salinities ranging from 0.2 to 6%(optimum 2.5%),from pH 5 to 8(optimum 6.5-7),and at temperatures between 9 and 40℃(optimum 30-35℃).Strain J2 was piezophilic,growing optimally at 10 MPa(range 0-30 MP a).Strain J2 used lactate,malate,pyruvate,formate and hydrogen as energy ***,thiosulfate,sulfite,fumarate,and nitrate were used as terminal electron *** and pyruvate were *** main fatty acids were iso-C,anteiso-C,summed feature 9(iso-Cω9c and/or C10-methyl)and *** DNA G+C content of strain J2 was 63.5 mol%.The combined genotypic and phenotypic data show that strain J2 represents a novel species of a novel genus in the family Desulfovibrionaceae,for which the name Pseudodesulfovibrio indicus ***.,*** proposed,with the type strain J2(=MCCC 1A01867=DSM 101483).We also propose the reclassification of *** as Pseudodesulfovibrio piezophilus comb,nov.,*** as *** comb,nov.,*** as *** *** *** as *** ***.

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动脉粥样硬化血栓形成性疾病患者的预后:在院外机构进行的一项前瞻性调查

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 50-51页

作者： Ferrières J. Cambou J.-P. gayet J.-L. 刘少伟 INSERM U 558 Department of Epidemiology Toulouse France

背景和目的:缺血性脑卒中、心肌梗死和外周动脉疾病都是同一基础病变的临床表现。然而,动脉粥样硬化血栓形成性疾病常相互关联,对这些疾病作为一个整体的预后情况仍知之甚少。方法:本调查旨在评估动脉粥样硬化血栓形成性疾病患者中继发... 详细信息

背景和目的:缺血性脑卒中、心肌梗死和外周动脉疾病都是同一基础病变的临床表现。然而,动脉粥样硬化血栓形成性疾病常相互关联,对这些疾病作为一个整体的预后情况仍知之甚少。方法:本调查旨在评估动脉粥样硬化血栓形成性疾病患者中继发性血管事件的1年发生率。测定心肌梗死、缺血性脑卒中和心血管性死亡的发生率。

关键词：血栓形成性缺血性脑卒中基础病变前瞻性调查栓塞性心血管事件非致死性无事件生存率执业医师

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测量MDCT影像上的肝脏肿瘤体积:半自动法及手动法比较

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国际医学放射学杂志 2011年第4期 395-396页

作者： L.Dubus M.gayet M.Zappa L.Abaleo A.De Cooman G.Orieux 胡鹏 Source Assistance Publique des Hpitaux de Paris APHPDepartment of RadiologyHpital Beaujon

目的用商品化软件回顾性比较半自动法和手动法测量肝脏恶性肿瘤体积,以及观察者间和观察者自身的差异。方法本研究纳入连续60例病人,30例未经治疗的肝转移瘤,30例肝细胞肝癌,肝脏MDCT显示92个病灶(49个转移灶,43个肝细胞肝癌灶)。2名放... 详细信息

目的用商品化软件回顾性比较半自动法和手动法测量肝脏恶性肿瘤体积,以及观察者间和观察者自身的差异。方法本研究纳入连续60例病人,30例未经治疗的肝转移瘤,30例肝细胞肝癌,肝脏MDCT显示92个病灶(49个转移灶,43个肝细胞肝癌灶)。2名放射科医生独立对病灶体积

关键词：肝脏肿瘤 CT 肿瘤容积分析肿瘤分析半自动容量分析

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