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Adapt.ve Design of Fluorescence Imaging Syst.ms for Cust.m Resolut.on, Fields of View, and Geomet.ies

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Biomedical Engineering Front.ers 2023年第1期4卷 260-273页

作者： Roujia Wang Riley J.Deut.ch Enakshi D.Sunassee brian t.Crouch Nirmala Ramanujam Depart.ent.of Biomedical Engineering Duke UniversityDurhamNCUSA Depart.ent.of Pharmacology and Cancer Biology Duke University Medical CenterDurhamNCUSA

Object.ve and Impact.St.t.ment.We developed a generalized comput.t.onal approach t. design uniform,high-int.nsit. excit.t.on light.for low-cost.quant.t.t.ve fluorescence imaging of in vit.o,ex vivo,and in vivo samples wit. a single ***:Fluorescence imaging is a ubiquit.us t.ol for biomedical *** ext.nsively modify exist.ng syst.ms for t.ssue imaging,increasing t.e t.me and effort.needed for t.anslat.onal research and t.ick t.ssue *** modificat.ons are applicat.onspecific,requiring new designs t. scale across sample ***:We implement.d a comput.t.onal model t. simulat. light.propagat.on from mult.ple *** a global opt.mizat.on algorit.m and a cust.m cost.funct.on,we det.rmined t.e spat.al posit.oning of opt.cal fibers t. generat. 2 illuminat.on *** result. were implement.d t. image core needle biopsies,preclinical mammary t.mors,or t.mor-derived *** were st.ined wit. molecular probes and imaged wit. uniform and nonuniform ***:Simulat.on result. were fait.fully t.anslat.d t. bencht.p *** demonst.at.d t.at.uniform illuminat.on increased t.e reliabilit. of int.aimage analysis compared t. nonuniform illuminat.on and was concordant.wit. t.adit.onal hist.logical *** comput.t.onal approach was used t. opt.mize t.e illuminat.on geomet.y for t.e purposes of imaging 3 different.fluorophores t.rough a mammary window chamber *** specifically designed for int.avit.l t.mor imaging generat.d higher image cont.ast.compared t. t.e case in which illuminat.on originally opt.mized for biopsy images was ***:We demonst.at. t.e significance of using a comput.t.onally designed illuminat.on for in vit.o,ex vivo,and in vivo fluorescence *** illuminat.on increased t.e reliabilit. of int.aimage analysis and enhanced t.e local cont.ast.of biological *** approach is generalizable across light.sources,biological appl

关键词： illuminat.on Fluorescence image

Mice lacking perforin have improved regenerat.on of t.e injured femoral nerve

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Neural Regenerat.on Research 2022年第8期17卷 1802-1808页

作者： Igor Jakovčevski Monika von Düring David Lut. Maja Vulović Mohammad Hamad Gebhard reiss Eckart.Först.r Melit.a Schachner Inst.t.t.für Anat.mie und Klinische Morphologie Universität Witten/HerdeckeWittenGermany Depart.ent.of Neuroanat.my and Molecular Brain Research Ruhr University BochumBochumGermany Depart.ent.of Anat.my Faculty of Medical SciencesUniversity of KragujevacKragujevacSerbia Keck Cent.r for Collaborat.ve Neuroscience and Depart.ent.of Cell Biology and Neuroscience Rutgers UniversityPiscatawayNJUSA

t.e role t.at.t.e immune syst.m plays aft.r injury of t.e peripheral nervous syst.m is st.ll not.complet.ly ***,a nat.ral killer cell-and t.lymphocyt.-derived enzyme t.at.mediat.s cyt.t.xicit.,plays import.nt.roles in aut.immune diseases,infect.ons and cent.al nervous syst.m t.auma,such as spinal cord *** dissect.t.e roles of t.is single component.of t.e immune response t. injury,we t.st.d regenerat.on aft.r femoral nerve injury in perforin-deficient.Pfp^(-/-))and wild-t.pe cont.ol *** frame mot.on analysis showed bet.er mot.r recovery in Pfp^(-/-)mice compared wit. cont.ol mice at.4 and 8 weeks aft.r *** t.acing of t.e mot.neuron axons regrown int. t.e mot.r nerve branch demonst.at.d more correct.y project.ng mot.neurons in t.e spinal cord of Pfp^(-/-)mice compared wit. *** of regrown axons measured by g-rat.o was more ext.nsive in Pfp^(-/-)t.an in wild-t.pe mice in t.e mot.r branch of t.e femoral ***^(-/-)mice displayed more cholinergic synapt.c t.rminals around cell bodies of spinal mot.neurons aft.r injury t.an t.e injured *** hist.logically analyzed lymphocyt. infilt.at.on 10 days aft.r surgery and found t.at.in Pfp^(-/-)mice t.e number of lymphocyt.s in t.e regenerat.ng nerves was lower t.an in wild-t.pes,suggest.ng a closed blood-nerve barrier in Pfp^(-/-)*** conclude t.at.perforin rest.ict. mot.r recovery aft.r femoral nerve injury owing t. decreased survival of mot.neurons and reduced myelinat.on.

关键词： blood-nerve barrier femoral nerve injury locomot.r recovery lymphocyt.s myelinat.on NK-cells perforin reinnervat.on

Genet.c Diversit. among Geographically Separat.d &lt.i&gt.Cyperus rot.ndus&lt./i&gt.Accessions Based on RAPD Markers and Morphological Charact.rist.cs

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American Journal of Plant.Sciences 2019年第11期10卷 2034-2046页

作者： William t. Molin Richard R. Kronfol Jeffery D. Ray brian E. Scheffler Charles t. Bryson Crop Product.on Syst.ms Research Unit USDA-ARS Stoneville MS USA Virginia Mason Medical Cent.r Seattle WA USA Crop Genet.cs Research Unit USDA-ARS Stoneville MS USA Genet.cs and Bioinformat.cs Research Unit USDA-ARS Stoneville MS USA

t.e diversit. of globally dist.ibut.d populat.ons of purple nut.edge was assessed using molecular marker dat. and morphological t.ait.. Clust.r analysis of binary random amplified polymorphic DNA (RAPD) dat. and morphological t.ait. indicat.d t.at.t.e global populat.on of purple nut.edge consist.d of t.o clades. Clust.r analysis of t.e RAPD dat. support.d separat.on of t.e purple nut.edge accessions evaluat.d int. t.o dist.nct.clades of 11 and 33 accessions. Except.for accessions ident.fied as California* and Arizona, all USA accessions were clust.red wit. accessions from t.iwan, West.rn Samoa, New Zealand, Malaysia, Japan, El Salvador, Columbia, Aust.alia, t.ailand and West.Indies. A second clust.r included accessions from Sudan, Greece, Iran, California*, Arizona, Brazil, Argent.na, Maurit.us, Philippines, Indonesia and t.nzania. t.e accessions from Sudan, Greece, Iran, Maurit.us, and t.nzania were dist.ibut.d along a similar longit.dinal axis. Clust.r analysis based on morphological t.ait. t.ough not.ident.cal t. t.at.based on RAPD dat. also support.d separat.on int. t.o clades and perhaps a t.ird. t.e lack of genet.c diversit. among accessions support.d t.e hypot.esis t.at.spread and propagat.on int. new environment. were largely by t.bers which preserved genet.c ident.t.. t.e lack of diversit. part.cularly among New World and USA accessions may also reflect.a relat.vely recent.int.oduct.on of t.e species int. t.e Americas and a low level of out.rossing.

关键词： Purple Nut.edge RAPDs Genet.c Diversit.

Acoust.fluidic separat.on enables early diagnosis of t.aumat.c brain injury based on circulat.ng exosomes

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Microsyst.ms & Nanoengineering 2021年第2期7卷 59-69页

作者： Zeyu Wang Haichen Wang Ryan Becker Joseph Rufo Shujie Yang brian E.Mace Mengxi Wu Jun Zou Daniel t.Laskowit. t.ny Jun Huang Depart.ent.of Mechanical Engineering and Mat.rials Science Duke UniversityDurhamNC27708USA Depart.ent.of Neurology Duke UniversityDurhamNC27708USA Depart.ent.of Biomedical Engineering Duke UniversityDurhamNC27708USA Depart.ent.of Geriat.ics Duke UniversityDurhamNC27708USA Depart.ent.of Elect.ical&Comput.r Engineering Texas A&M UniversityCollege StationTX77840USA

t.aumat.c brain injury(t.I)is a global cause of morbidit. and *** management.and risk st.at.ficat.on of pat.ent. wit. t.I is made difficult.by t.e relat.ve insensit.vit. of screening radiographic st.dies as well as by t.e absence of a widely available,noninvasive diagnost.c *** part.cular,a blood-based biomarker assay could provide a quick and minimally invasive process t. st.at.fy risk and guide early management.st.at.gies in pat.ent. wit. mild t.I(mt.I).Analysis of circulat.ng exosomes allows t.e pot.nt.al for rapid and specific ident.ficat.on of t.ssue *** applying acoust.fluidic exosome separat.on—which uses a combinat.on of microfluidics and acoust.cs t. separat. biopart.cles based on differences in size and acoust.c propert.es—we successfully isolat.d exosomes from plasma samples obt.ined from mice aft.r *** isolat.on eliminat.d int.rference from ot.er blood component.,making it.possible t. det.ct.exosomal biomarkers for t.I via flow *** cyt.met.y analysis indicat.d t.at.exosomal biomarkers for t.I increase in t.e first.24 h following head t.auma,indicat.ng t.e pot.nt.al of using circulat.ng exosomes for t.e rapid diagnosis of *** levels of t.I biomarkers were only det.ct.d in t.e samples separat.d via acoust.fluidics;no changes were observed in t.e analysis of t.e raw plasma *** finding demonst.at.d t.e necessit. of sample purificat.on prior t. exosomal biomarker *** acoust.fluidic exosome separat.on can easily be int.grat.d wit. downst.eam analysis met.ods,it.shows great.pot.nt.al for improving early diagnosis and t.eat.ent.decisions associat.d wit. t.I.

关键词： diagnosis separat.on injury

Log-behavior of t.o Sequences Relat.d t. t.e Ellipt.c Int.grals

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Act. Mat.emat.cae Applicat.e Sinica 2020年第3期36卷 590-602页

作者： brian Yi SUN James Jing-Yu ZHAO Depart.ent.of Mat.emat.cs and Syst.m Science Xinjiang UniversityUrumqi 830046China School of Mat.emat.cs Tianjin UniversityTianjin 300350China

t.o int.rest.ng sequences arose in t.e st.dy of t.e series expansions of t.e complet. ellipt.c int.grals,which are called t.e Cat.lan-Larcombe-French sequence{Pn}n≥0 and t.e Fennessey-Larcombe-French sequence{Vn}n≥0 *** t.is paper,we first.est.blish some crit.ria for det.rmining log-behavior of a sequence based on it. t.ree-t.rm *** we prove t.e log-convexit. of{Vn^2-V(n-1)V(n+1)}n≥2 and{n!Vn}n≥1,t.e rat.o log-concavit. of{Pn}n≥0 and t.e sequence{An}n≥0 of Apéry numbers,and t.e rat.o log-convexit. of{Vn}n≥1.

关键词： t.e Cat.lan-Larcombe-French sequence t.e Fennessey-Larcombe-French sequence Apéry numbers log-concave log-convex t.ree-t.rm recurrence

Diet.ry nano chromium picolinat. can ameliorat. some of t.e impact. of heat.st.ess in cross-bred sheep

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Animal Nut.it.on 2021年第1期7卷 198-205页

作者： Alex t.Hung brian J.Leury Mat.hew A.Sabin Fahri Fahri Krist. DiGiacomo t.-Fa Lien Frank R.Dunshea Facult. of Vet.rinary and Agricult.ral Sciences The University of MelbourneParkvilleVIC3010Australia Murdoch Children's Research Inst.t.t. The University of MelbourneParkvilleVIC3010Australia Depart.ent.of Animal Science National Chiayi UniversityChina Facult. of Biological Sciences The University of LeedsLeeds LS29JTUnited Kingdom

t.o st.dies were conduct.d t. evaluat. t.e effect.of nano chromium picolinat.(nCrPic)during heat.st.ess(HS)in *** t.e init.al st.dy,36 Merino×Poll cross-bred sheep were individually penned and allocat.d t. 3 diet.ry t.eat.ent.(0,400 and 800μg/kg nCrPic)for 8 *** composit.on was det.rmined at.t.e beginning and end of t.e experiment.using dual energy X-ray *** sheep remained in t.eir diet.ry groups but.were t.en placed in met.bolic cages and randomly allocat.d wit.in t.e diet.ry group t. differing ambient.t.mperat.re regimes,i.e.,t.ermo-neut.al(t.)(n=18)and HS(n=18),for 3 *** nCrPic had no effect.on growt. performance and body composit.on during t.e init.al st.dy conduct.d under t. *** st.ess decreased average daily feed int.ke(ADFI)(P=0.002)whereas sheep under HS had reduced average daily gain(ADG)and indeed lost.weight.Pt.ry nCrPic increased bot. ADFI(P=0.041)and ADG(P=0.049)under bot. t. and HS condit.ons such t.at.t.e performance of sheep receiving supplement.l nCrPic and exposed t. HS was similar t. t.at.of cont.ol sheep maint.ined under t. *** st.ess increased rect.l t.mperat.re(Pt.on rat.(Pt.cularly during t.e hot.est.part. of t.e day as indicat.d by int.ract.ons(Pt.een t.me of day and t.ermal *** t.mperat.re was lower in sheep fed nCrPic(P=0.050),part.cularly under peak HS condit.ons during t.e aft.rnoon as indicat.d by t.e int.ract.ons bet.een diet.ry nCrPic and t.me of day(Pt.ry nCrPic,t.ermal t.eat.ment.and t.me of day(P=0.010).Similarly,respirat.on rat. was lower in sheep fed nCrPic under peak HS condit.ons during t.e aft.rnoon as indicat.d by t.e int.ract.ons bet.een diet.ry nCrPic and t.ermal t.eat.ent.Pt.ry nCrPic and t.me of day(P=0.030).In conclusion,diet.ry nCrPic can part.ally ameliorat. t.e negat.ve effect. of HS as indicat.d by t.e maint.nance of ADFI and decreased physiological responses,such as elevat.o

关键词： Chromium picolinat. Sheep Heat.st.ess Nanot.chnology Physiology

IRX14 and IRX14-LIKE, t.o Glycosyl t.ansferases Involved in Glucuronoxylan Biosynt.esis and Drought.t.lerance in Arabidopsis

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Molecular Plant 2010年第5期3卷 834-841页

作者： brian D. Keppler Allan M. Showalt.r Depart.ent.of Environment.l and Plant.Biology Molecular and Cellular Biology Program Ohio University 315 Porter Hall Athens OH 45701-2979 USA

IRX14 and IRX14-LIKE （IRX14L） are t.o closely relat.d glycosyl t.ansferases in t.e glycosyl t.ansferase 43 （Gt.3） family of Arabidopsis. A t.DNA insert.on mut.nt.for IRX14 result. in comparat.vely minor changes, such as irregular xylem, while a mut.t.on for IRX14L result. in no changes. However, an irx14 and irx14L double mut.nt.severely affect. growt. and development. wit. t.e dwarf plant. failing t. produce an inflorescence st.m. Plant. t.at.are homozygous for IRX14 but.het.rozygous for IRX14L （irx14 irx14L（±）） exhibit.an int.rmediat. phenot.pe, including not.ceably smaller leaves, st.ms, and underdeveloped siliques. Addit.onally, t.e t.DNA insert.on mut.nt.for IRX14 was found t. result.in a drought.t.lerant.phenot.pe. Carbohydrat. analysis of t.t.l cell wall ext.act. revealed a reduct.on in xylose for t.e irx14 and irx14 irx14L（±） mut.nt., consist.nt.wit. a defect.in glucuronoxylan biosynt.esis. Immunolocalizat.on of xylan wit. t.e LM10 ant.body revealed a loss of xylan in irx14 mut.nt. and a furt.er reduct.on in t.e irx14 irx14L（±） mut.nt.. IRX14L likely funct.ons redundant.y wit. IRX14 in glucuronoxylan biosynt.esis, wit. IRX14 having a more import.nt.role in t.e process.

关键词： Abiot.c/environment.l st.ess cell walls genet.cs Arabidopsis irregular xylem xylan.

Vibrioharveyi: a serious pat.ogen offish and invert.brat.s in maricult.re

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Marine Life Science & t.chnology 2020年第3期2卷 231-245页

作者： Xiao-Hua Zhang Xinxin He brian Aust.n MOE Key Laborat.ry of Marine Genet.cs and Breeding College of Marine Lite Sciences.Ocean University of ChinaQingdao 266003China Laborat.ry for Marine Ecology and Environment.l Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Front.ers Science Cent.r for Deep Ocean Mult.spheres and Eart. Syst.m Ocean University of ChinaQingdao 266100China Inst.t.t. of Aquacult.re University of StirlingStirling FK94LAScotlandUK

Vibrio harveyi,which belongs t. family Vibrionaceae of class G cunmap rot. obact. ria,includes t.e species *** char iae and *** as it. junior *** organism is a well-recognized and serious bact.rial pat.ogen of marine fish and invert.brat.s,including penaeid shrimp,in *** fish may exhibit.a range of lesions,including eye lesions/blindness,gast.o-ent.rit.s,muscle necrosis,skin ulcers,and t.il rot.*** shrimp,*** is regarded as t.e et.ological agent.of luminous vibriosis in which affect.d animals glow in t.e *** is a second condit.on of shrimp known as Bolit.s negricans where t.e digest.ve t.act.is filled wit. spheres of sloughed-off *** is recognized t.at.t.e pat.ogenicit. mechanisms of *** may be different.in fish and penaeid *** shrimp,t.e pat.ogenicit. mechanisms involved t.e endot.xin lipopolysaccharide,and ext.acellular prot.ases,and int.ract.on wit. *** fish,t.e pat.ogenicit. mechanisms involved ext.acellular hemolysin(encoded by duplicat. hemolysin genes),which was ident.fied as a phospholipase B and could inact.vat. fish cells by apopt.sis,via t.e caspase act.vat.on *** may ent.r t.e so-called viable but.noncult.rable(VBNC)st.t.,and resuscit.t.on of t.e VBNC cells may be an import.nt.reason for vibriosis out.reaks in *** cont.ol measures cent.r on diet.ry supplement.(including probiot.cs),nonspecific immunost.mulant.,and vaccines and t. a lesser ext.nt.ant.biot.cs and ot.er ant.microbial compounds.

关键词： Vibrio harveyi Pat.ogen Fish Invert.brat.s Aquacult.re

Hist.rical review of t.e causes of cancer

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World Journal of Clinical Oncology 2016年第1期7卷 54-86页

作者： Clarke brian Blackadar Depart.ent.of Food Science Ontario Agricultural College University of Guelph

In t.e early 1900 s, numerous seminal publicat.ons report.d t.at.high rat.s of cancer occurred in cert.in occupat.ons. During t.is period, work wit. infect.ous agent. produced only meager result. which seemed irrelevant.t. humans. t.en in t.e 1980 s ground breaking evidence began t. emerge t.at.a variet. of viruses also cause cancer in humans. t.ere is now sufficient.evidence of carcinogenicit. in humans for human t.cell lymphot.ophic virus, human immunodeficiency virus, hepat.t.s B virus, hepat.t.s C virus, human papillomavirus, Epst.in-Barr virus, and human herpes virus 8 according t. t.e Int.rnat.onal Agency for Research on Cancer(IARC). Many ot.er causes of cancer have also been ident.fied by t.e IARC, which include: Sunlight. t.bacco, pharmaceut.cals, hormones, alcohol, parasit.s, fungi, bact.ria, salt.d fish, wood dust. and herbs. t.e World Cancer Research Fund and t.e American Inst.t.t. for Cancer Research have det.rmined addit.onal causes of cancer, which include bet. carot.ne, red meat. processed meat., low fibre diet., not.breast.feeding, obesit., increased adult.height.and sedent.ry lifest.les. In brief, a hist.rical review of t.e discoveries of t.e causes of human cancer is present.d wit. ext.nded discussions of t.e difficult.es encount.red in ident.fying viral causes of cancer.

关键词： Infect.ons Causes Cancer Carcinogens Hist.rical Et.ology Int.rnat.onal agency for research on cancer