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Admission Motor Strength Grade Predicts Mortality in Patients with Acute Ischemic Stroke Undergoing Mechanical Thrombectomy

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Neuroscience & Medicine 2013年第1期4卷 1-6页

作者： Vishnumurthy Shushrutha Hedna Aakash N. Bodhit Saeed Ansari Adam D Falchook latha G. Stead Sharathchandra Bidari brian l hoh Kenneth M Heilman Michael F Waters Department of Emergency Medicine University of Florida Gainesville USA Department of Neurology University of Florida Gainesville USA Department of Neuroradiology University of Florida Gainesville USA Department of Neurosciences University of Florida Gainesville USA. Department of Neurosurgery University of Florida Gainesville USA

Background: The mortality due to mechanical thrombectomy (MT) in the acute treatment of intracranial arterial occlu- sions can be up to 45%. The SWIFT (Solitaire FR with the Intention for Thrombectomy) and Multi MERCI (mechani- cal embolus removal in cerebral ischemia) trials have evaluated the safety and efficacy of MT. It may be important to determine pre-procedural factors that help predict post-intervention prognosis. We sought to determine if admission medical research council (MRC) motor strength grade along with other factors can be used as predictor of mortality after MT for acute ischemic stroke. Methods: Retrospective analysis of stroke database assessing outcomes in all 62 patients who underwent MT as an intervention for acute ischemic stroke, with or without concurrent intravenous thrombolysis was done. Five baseline variables were included in univariate and multivariate analyses to define the in- dependent predictors of mortality during current hospitalization. The medical research council (MRC) motor grade (0 - 5);modified collateral flow (CS) grading (0 - 3);age;acute and chronic co-morbidities were used as the baseline vari- ables. If motor strength grade were different in upper and lower extremities, then the lower grade was used. Age was analyzed independently as well as dichotomized using 80 as cut-off value. Relevant stroke related acute and chronic co-morbidities were given 1 point each and mean calculated. Results: In the univariate analysis, low (0 - 1) motor strength grade (OR, 0.11;95% CI, 0.021 - 0.33;p = 0.001) and age (OR, 1.06;95% CI, 1.02 - 1.12;p = 0.011) was sig- nificantly associated with mortality. The presence of collateral flow, acute and chronic co-morbidities were not signifi- cantly associated with mortality. In the multivariate analysis, motor grade retained its statistical significance for morta- lity (OR, 0.09;95% CI, 0.01 - 0.32;p = 0.003) along with chronic co-morbidity (OR, 1.52;95% CI 1.05 - 2.43;

关键词： Motor Grade Collaterals Ischemic Stroke Endovascular Intervention Outcome after Stroke Mortality after Stroke Acute Stroke Endovascular Treatment Mechanical Thrombectomy

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage Mark l.Dell’Acqua brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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动脉瘤性蛛网膜下腔出血患者的重症监护处理：神经危重症监护学会多学科共识会议的推荐意见

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国际脑血管病杂志 2013年第5期21卷 324-347页

作者： Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi brian l. hoh Giuseppe lanzino Peter le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿英英(译) From the Neurology/Neurosurgery Intensive Care Unit Washingion University St. Louis MO USA Rush Medical College Chicago IL USA University of California at San Francisco San Francisco CA USA University of Cambridge Cambridge UK University of Cincinnati Cincinnati OH USA University of California at los Angeles LOs Angeles CA USA Universit6 de la M.diterranae Marsedle France Columbia University New York NY USA San Gerardo Hospital Monza Italy University of Virginia Charlottesville VA USA Heinrich-Heine University Dttsseldorf Germany University of Florida Gainesville FL USA Mayo Clinic Rochester MN USA University of Pennsylvania Philadelphia PA USA University Hospital Innsbruck lnnsbruck Austria Fondazione IRCCS Ch Granda- Ospedale Policlinico Milan University Milan Italy University of Washington St. Louis MO USA Baylor College of Medicine Houston TX USA Nottingham University Hospitals Nottingham UK University of Utrecht Utrecht The Netherlands Freie Universitit Berlin Berlin Germany Washington University St. Louis MO USA 首都医科大学宣武医院神经内科北京100053

蛛网膜下腔出血（subarachnoidhemorrhage，SAH）是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏，使得治疗方法... 详细信息

蛛网膜下腔出血（subarachnoidhemorrhage，SAH）是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏，使得治疗方法各异，可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防，很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域，此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验，选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价（GradesofRecommendationsAssessment，DevelopmentandEvaluation，GRADE）系统进行文献回顾，结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见，其制定原则不仅强调研究资料的质量，而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见，即使缺乏高质量的证据。

关键词：蛛网膜下腔出血重症监护动脉瘤血管痉挛抗惊厥药低钠血症血管内发热

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2015年美国心脏协会／美国卒中协会对2013年急性缺血性卒中患者早期处理指南关于血管内治疗的局部更新

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国际脑血管病杂志 2015年第11期23卷 801-814页

作者：蔡必扬李华代齐良徐格林南京军区南京总医院神经内科 210002

目的本指南旨在对急性缺血性卒中血管内治疗的现有推荐意见提供局部更新。如相关内容与上一版指南重叠，则以本指南的推荐意见为准。方法此次局部更新对2013年以来发表的8项有关血管内治疗的临床随机试验结果和其他相关资料进行了分析... 详细信息

目的本指南旨在对急性缺血性卒中血管内治疗的现有推荐意见提供局部更新。如相关内容与上一版指南重叠，则以本指南的推荐意见为准。方法此次局部更新对2013年以来发表的8项有关血管内治疗的临床随机试验结果和其他相关资料进行了分析。本文并未对上一版指南发布后的所有文献进行全面回顾，而仅仅纳入了支持对现有推荐意见进行修改的关键性新证据。指南撰写委员会成员由美国心脏协会（American Heart Association，AHA）／美国卒中协会（American Stroke Association，ASA）卒中委员会下属的科学声明监督委员会以及AHA／ASA文稿监督委员会任命。整个指南制定过程严格遵守AHA的利益冲突政策。采用美国心脏协会，美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6名同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本循证指南介绍了急性缺血性卒中血管内治疗的患者选择、操作规程以及促进血管内治疗的医疗体系。结论某些血管内介入操作被证明能够为经过选择的急性缺血性卒中患者提供临床益处，应组建相应的医疗体系以促进血管内治疗的开展。

关键词： AHA科学声明血管内介入治疗动脉内输注神经影像学支架卒中治疗学

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Novel Heat Transfer Issues Associated with the Design and Safe Operation of the MEGAPIE Spallation Source Target

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Journal of Thermal Science 2007年第1期16卷 63-78页

作者： brian l.Smith Thermal Hydraulics laboratory Paul Scherrer InstituteSwitzerland

Critical heat transfer problems are discussed in the context of the operation of a spallation source target, which represents a first demonstration of the feasibility of an innovative concept for generating energy using a particle accelerator. Within the framework of the umbrella project MEGAPIE, an R＆D support group was organized to take responsibility for target cooling. This involved the use of advanced numerical methods - Computational Fluid Dynamics （CFD） and Finite Element Method （FEM） - validated against suitable experimental data, and by means of appropriate benchmarking exercises. The design studies using CFD resulted in an optimum flow configuration being defined for the coolant circulation. Flow visualization tests were undertaken using a glass/water test section, with the velocity field mapped using optical and ultrasonic measuring techniques. These were followed by heat transfer tests, using the actual target materials （lead-bismuth-eutectic coolant and steel confinement）. Further CFD/FEM work to analyze operational transients and accident sequences was also carded out, and is described in the paper.

关键词： computational fluid dynamics finite element method liquid-metal coolant spallation source target

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Respiratory plasticity following spinal cord injury:perspectives from mouse to man

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Neural Regeneration Research 2022年第10期17卷 2141-2148页

作者： Katherine C.locke Margo l.Randelman Daniel J.hoh lyandysha V.Zholudeva Michael A.lane Department of Neurobiology&Anatomy Drexel UniversityPhiladelphiaPAUSA Marion Murray Spinal Cord Research Center PhiladelphiaPAUSA lillian S.Wells Department of Neurosurgery University of FloridaGainesvilleFLUSA Cardiovascular Disease Gladstone InstitutesSan FranciscoCAUSA

The study of respiratory plasticity in animal models spans *** the bench,researchers use an array of techniques aimed at harnessing the power of plasticity within the central nervous system to restore respiration following spinal cord *** field of research is highly clinically *** living with cervical spinal cord injury at or above the level of the phrenic motoneuron pool at spinal levels C3-C5 typically have significant impairments in breathing which may require assisted *** who are ventilator dependent are at an increased risk of ventilator-associated co-morbidities and have a drastically reduced life ***-clinical research examining respiratory plasticity in animal models has laid the groundwork for clinical *** how widely researched this injury is in animal models,relatively few treatments have broken through the preclinical *** three goals of this present review are to define plasticity as it pertains to respiratory function post-spinal cord injury,discuss plasticity models of spinal cord injury used in research,and explore the shift from preclinical to clinical *** investigating current targets of respiratory plasticity research,we hope to illuminate preclinical work that can influence future clinical investigations and the advancement of treatments for spinal cord injury.

关键词： breathing phrenic plasticity rehabilitation respiration spinal cord injury translation

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Effects of temperature change on mussel,Mytilus

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Integrative Zoology 2012年第3期7卷 312-327页

作者： Mackenzie l.ZIPPAY brian HElMUTH Environment and Sustainability Program Department of Biological SciencesUniversity of South CarolinaColumbiaSouth CarolinaUSA

An increasing body of research has demonstrated the often idiosyncratic responses of organisms to climate-related factors,such as increases in air,sea and land surface temperatures,especially when coupled with non-climatic *** argues that sweeping generalizations about the likely impacts of climate change on organisms and ecosystems are likely less valuable than process-based explorations that focus on key species and *** in the genus Mytilus have been studied for centuries,and much is known of their physiology and *** other intertidal organisms,these animals may serve as early indicators of climate change *** structuring species,their survival has cascading impacts on many other species,making them ecologically important,in addition to their economic value as a food ***,we briefly review the categories of information available on the effects of temperature change on mussels within this *** a considerable body of information exists about the genus in general,knowledge gaps still exist,specifically in our ability to predict how specific populations are likely to respond to the effects of multiple stressors,both climate and non-climate related,and how these changes are likely to result in ecosystem-level *** this genus provides an excellent model for exploring the effects of climate change on natural and human-managed ecosystems,much work remains if we are to make predictions of likely impacts of environmental change on scales that are relevant to climate adaptation.

关键词： climate change mussels Mytilus organismal responses temperature

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Geological cycling of potassium and the K isotopic response:insights from loess and shales

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Acta Geochimica 2019年第4期38卷 508-516页

作者： Weiqiang li Shilei li brian l.Beard State Key laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing 210046People's Republic of China MOE Key laboratory of Surficial Geochemistry School of Earth Sciences and EngineeringNanjing UniversityNanjing 210046People's Republic of China Department of Geoscience University of Wisconsin- Madison1215W Dayton StreetMadisonWI 53706USA NASA Astrobiology Institute University of Wisconsin- MadisonMadisonWI 53706USA

Shales are a major sink for K into seawater delivered from continental weathering,and are potential recorders of K *** precision K isotope analyses reveal a[0.6%variation in δ^41K values(41K/39K relative to NIST SRM 3141a)from a set of well characterized postArchean Australian shale(PAAS)*** contrast,loess samples have relatively homogenous δ^41K values(-0.5±0.1%),which may represent the average K composition of upper continental *** of the shales analyzed in this study have experienced K enrichment relative to average continental crust,and the majority of them define a trend of decreasing δ^41K value(from-0.5to-0.7%)with increasing K content and K/Na ratio,indicating cation exchange in clays minerals is accompanied by K isotope *** shale samples do not follow the trend and have elevated δ^41K values up to-0.1%,and these samples are characterized by variable Fe isotope compositions,which reflect post-depositional *** K isotope variability observed in shales,in combination with recent findings about K isotope fractionation during continental weathering,indicates that K isotopes fractionate during cycling of K between different reservoirs,and K isotopes in sediments may be used to trace geological cycling of K.

关键词： K isotopes loess Shale K cycle

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local and global methods in representations of Hecke algebras

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Science China Mathematics 2018年第2期61卷 207-226页

作者： Jie Du brian J.Parshall leonard l.Scott School of Mathematics and Statistics University of New South Wales(UNSW) Department of Mathematics University of Virginia

This paper aims at developing a "local-global" approach for various types of finite dimensional algebras, especially those related to Hecke algebras. The eventual intention is to apply the methods and applications developed here to the cross-characteristic representation theory of finite groups of lie type. We first review the notions of quasi-hereditary and stratified algebras over a Noetherian commutative ring. We prove that many global properties of these algebras hold if and only if they hold locally at every prime ideal. When the commutative ring is sufficiently good, it is often sufficient to check just the prime ideals of height at most one. These methods are applied to construct certain generalized q-Schur algebras, proving they are often quasi-hereditary(the "good" prime case) but always stratified. Finally, these results are used to prove a triangular decomposition matrix theorem for the modular representations of Hecke algebras at good primes. In the bad prime case, the generalized q-Schur algebras are at least stratified, and a block triangular analogue of the good prime case is proved, where the blocks correspond to Kazhdan-lusztig cells.

关键词： quasi-hereditary algebra stratified algebra Hecke algebra Schur algebra left cell endomorphism algebra exact category height one prime

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Behavior modeling and verification of movement authority scenario of Chinese Train Control System using AADl

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Science China(Information Sciences) 2015年第11期58卷 125-144页

作者： AHMAD Ehsan DONG YunWei lARSON brian lü JiDong TANG Tao ZHAN NaiJun School of Computer Science Northwestern Polytechnical University State Key laboratory of Computer Science Institute of Software Chinese Academy of Sciences Computing and Information Systems Kansas State University State Key laboratory of Rail Traffic Control and Safety Beijing Jiaotong University

Train control systems like most digital controllers are, by definition, hybrid systems as they interact with or try to control some aspects of the physical world. Detailed behavior modeling with constraints specification and formal verification, required for reliability prediction, is a great challenge for hybrid system *** control systems further intensify this challenge with extensive interaction between computing units and their physical environment and their mutual dependence on each other. In this paper, we investigate behavior modeling and formal verification of Chinese Train Control System level 3(CTCS-3) using Architectural Analysis & Design language(AADl) to cope with this challenge. AADl is an architecture description language for embedded systems and is based on model-based engineering paradigm. Along with structural modeling of embedded systems using the core language constructs, AADl also provides support for language extension through annex sublanguages. In system requirements specification document, the behavior of the CTCS-3 is specified as a set of basic operation scenarios that cooperate with each other to achieve safe and secure functionality of *** Authority(MA) scenario, explored in this paper, is considered as a basic and most crucial scenario to prevent trains from colliding with each other. The detailed discrete behavior of control system is modeled and verified using the Behavior language for Embedded Systems with Software(BlESS) annex sublanguage of AADl, and the continuous behavior of train with the cyber–physical interaction(communication between train and control system) is modeled using the Hybrid annex sublanguage. The behavior of the MA scenario at system level is verified using the Hybrid Hoare logic theorem prover. Behavior constraints are specified as assertions using first-order logic formulas augmented with a simple temporal operator.

关键词： AADl behavior modeling BlESS annex CTCS hybrid annex train control system

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