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Infectious Diseases of Poverty 2021年第1期10卷 36-45页

作者： Karla Y.Ganley Marta Wilson-Barthes Andrew R.Zullo Sandra G.Sosa-Rubi carlos J.conde-Glez Santa Garcia-cisneros Mark N.Lurie brandon D.L.Marshall Don Operario Kenneth H.Mayer Omar Galarraga Department of Narrative Medicine Columbia UniversityNew YorkNYUSA Department of Epidemiology School of Public HealthBrown UniversityProvide neeRlUSA Department of Health Services Policyand PracticeSchool of Public HealthBrown University121 South Main StreetBox G-121S-2ProvidenceRl 02912USA National Institute of Public Health(INSP) CuernavacaMorelosMexico Department of Behavioral and Social Science School of Public HealthBrown UniversityProvidenceRlUSA Fenway Health and Harvard University BostonMAUSA.

Background:Male sex workers are at high-risk for acquisition of sexually transmitted infections(STIs),including human immunodeficiency virus(HIV).We quantified incidence rates of STIs and identified their time-varying predictors among male sex workers in Mexico ***:From January 2012 to May 2014,male sex workers recruited from the largest HIV clinic and community sites in Mexico city were tested for chlamydia,gonorrhea,syphilis,hepatitis,and HIV at baseline,6-months,and *** nee rates with 95%bootstrapped confide nee limits were *** examined potential timevarying predictors using generalized estimating equations for a population averaged ***:Among 227 male sex workers,median age was 24 and baseline HIV prevalence was 32%.Incidence rates(per 100 person-years)were as follows:HIV[5.23;95%confidence interval(cI):2.15-10.31],chlamydia(5.15;95%cI:2.58-9.34),gonorrhea(3.93;95%cI:1.88-7.83),syphilis(13.04;95%cI:8.24-19.94),hepatitis B(2.11;95%cI:0.53-4.89),hepatitis c(0.95;95%cI:0.00-3.16),any STI except HIV(30.99;95%cI:21.73-40.26),and any STI including HIV(50.08;95%cI:37.6062.55).In the multivariable-adjusted model,incident STI(excluding HIV)were lower among those who reported consistently using condoms during anal and vaginal intercourse(odds ratio=0.03,95%cI:0.00-0.68)compared to those who reported inconsistently using condoms during anal and vaginal ***:Incidence of STIs is high among male sex workers in Mexico *** condom use is an important protective factor for STIs,and should be an important comp on ent of interventions to prevent incide nt infect i ons.

关键词： Male sex worker Men who have sex with men HIV Sexually transmitted infection Transmission Risk factor Mexico

RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： Zheng Zhang Keren Zhou Li Han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su brandon Tan chao Shen Wei Li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung Mark Boldin chun-Wei chen David Ann Zhijian Qian Xiaolan Deng Jianjun chen Zhenhua chen Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family center for Leukemia Research City of HopeDuarteCA 91010USA Sun Yat-sen University cancer center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou Laboratory GuangzhouGuangdong 510005China Bioland Laboratory GuangzhouGuangdong 51005China Department of Liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China School of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

中低速率输注瑞芬太尼不改变脑电双频指数监测下维持麻醉所需靶控输注丙泊酚的浓度

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麻醉与镇痛 2008年第2期4卷 46-52页

作者： Lars P. Wang Peter McLoughlin Michael J. Paech Irina Kurowski Emma L. brandon 包睿(译) 邓小明(校) Department of Anaesthesia and Pain Medidne Royal Perth Hospital Perth Western AustraliaAustralia Pharmacology and Anaesthesiology Unit School of Medicine and PharmacologyUniversity. of Western Australia Perth Western Australia Australia 不详

背景本文旨在观察不同速率输注瑞芬太尼是否会降低使脑电双频指数（bispectral index，BIS）≤50的丙泊酚Ec50（半数有效浓度）值。方法将72例ASA分级Ⅰ或Ⅱ级拟行气管内插管并靶控输注（TcI）丙泊酚维持麻醉的成人患者，随机分为6组。... 详细信息

背景本文旨在观察不同速率输注瑞芬太尼是否会降低使脑电双频指数（bispectral index，BIS）≤50的丙泊酚Ec50（半数有效浓度）值。方法将72例ASA分级Ⅰ或Ⅱ级拟行气管内插管并靶控输注（TcI）丙泊酚维持麻醉的成人患者，随机分为6组。瑞芬太尼输注速率分别为：B组0．1μg·kg^-1·min^-1,c组0．15μg·kg^-1·min^-1,D组0．2μg·kg^-1·min^-1,E组0．3μg·kg^-1·min^-1,F组0．4μg·kg^-1·min^-1,A组作为对照组不使用瑞芬太尼。在同一浓度瑞芬太尼组中，以第1例患者对TcI4μg/ml丙泊酚的反应决定岳一例患者的效应室浓度（Dixon的“序贯法”）。如果BIS〉50，后一例患者TcI丙泊酚的效应室浓度增加，如果BIS≤50，后一例患者TcI丙泊酚的效应室浓度则减少。同时研究了联合用药的血流动力学效应。结果Ec50变化范围为2．4-2．9μg/ml.未发现瑞芬太毫对丙泊酚Ec50的累加效应。但是未使用瑞芬太尼的空白对照组对丙泊酚的反应差异较大。使用瑞芬太尼组患者心率下降。结论瑞芬太昆输注不会减少无刺激麻醉患者丙泊酚需求量。在联合输注瑞芬太尼时不应当降低丙泊酚TcI浓度．

关键词：脑电双频指数监测半数有效浓度瑞芬太尼靶控输注维持麻醉丙泊酚低速率效应室浓度

*** chen's hand replant:An accomplishment of confucian teaching and action

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*** Chen's hand replant:An accomplishment of Confucian teach...

creatine and strength training in older adults:an update

中华医学会第10届全国显微外科学术会议暨世界首例断肢再植成功50周年庆典

作者： William c.Lineaweaver M.D.FAcS JMS Burn and Reconstructive center brandon MississippiUSA

Any teaching or action is unique in its *** accomplished,teachings and actions can he understood as examples of principles or ***’s hand replantation illustrates specific confucian principles. I have selected citations from The Analects to generalize aspects of ***’ s accomplishments. 2:11.A man who revies the old so as to find the new is qualified to teach others. ***’s medical training included detailed anatomic studies,thorough orthopedic residency,

关键词：

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Translational Exercise Biomedicine 2024年第3期1卷 212-222页

作者： Scott c.Forbes Darren G.candow Department of Physical Education Studies Brandon UniversityBrandonMBCanada Faculty of Kinesiology and Health Studies University of ReginaReginaSKCanada

Aging is associated with numerous physiological,musculoskeletal,and neurological impairments including a loss of muscle,strength,function,bone mineral,and *** training is an effective intervention to counter these age-associated *** addition,creatine supplementation is purported to enhance strength training gains in lean tissue mass,muscular strength,and *** is emerging evidence that creatine combined with strength training can alter bone geometry and cognitive *** purpose of this review is to update previous meta-analyses examining creatine combined with strength training on lean tissue mass and bone density compared to strength training and placebo.A secondary purpose was to explore the effects of creatine and strength training on *** meta-analyses revealed that creatine enhances lean tissue mass(mean difference[MD]:1.18 kg,95%cI:0.70–1.67;pcular strength(standard mean difference[SMD]:0.24,95%cI:0.05–0.43;p=0.02)compared to strength training and *** combined with strength training had no greater effects compared to strength training and placebo on lower body muscular strength(SMD:0.17,95%cI:−0.03–0.38;p=0.09),whole-body(MD:−0.00 g cm−2;95%cI:−0.01–0.00,p=0.32),femoral neck(MD:−0.00 g cm−2;95%cI:−0.01–0.00,p=1.00),or lumbar bone mineral density(MD:0.00 g cm−2,95%cI:−0.01–0.01;p=045).There is preliminary evidence that combining strength training and creatine is an effective strategy to improve bone geometry in postmenopausal females and cognitive function in older ***,the combination of creatine and strength training has favorable effects on lean tissue mass and upper body *** contrast,creatine combined with strength training does not enhance lower-body strength or bone mineral.

关键词： aging bone muscle strength brain health

近端指间关节掌腱膜挛缩治疗中早期的软组织分离术与筋膜切除术之后的马缰韧带松解术

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中国美容整形外科杂志 2013年第1期24卷 I0018-I0018页

作者： Randall O. croft Anthony A. smith brandon cofalde Wdliam J. casey Ⅲ Manna M. Rebecca Scott F. M. Duncan 吕梦竹(译) 郭澍(译) 孙强(译) 魏峰(译) 高景恒(译) 美国亚利桑那州斯科茨代尔梅约诊所整形再造外科中心外科部及骨科中国医科大学附属第一医院整形外科《中国美容整形外科杂志》编辑部

背景与目的用马缰韧带松解术来治疗近端指间关节掌腱膜挛缩并不能解决手指动脉短缩及皮肤不足的问题，DigitWidget应用软组织分离的方法成功克服了这些问题。本研究将先行筋膜切除术再行马缰韧带松解术，与先行软组织分离术再行有效松... 详细信息

背景与目的用马缰韧带松解术来治疗近端指间关节掌腱膜挛缩并不能解决手指动脉短缩及皮肤不足的问题，DigitWidget应用软组织分离的方法成功克服了这些问题。本研究将先行筋膜切除术再行马缰韧带松解术，与先行软组织分离术再行有效松解，这两种方法在治疗近端指间关节掌腱膜挛缩的效果上进行了对比。方法作者在2001—2008年间比较了应用筋膜切除术联合马缰韧带松解与DigitWidget软组织分离术的治疗效果。

关键词：近端指间关节韧带松解术掌腱膜挛缩治疗效果膜切除术分离术软组织中早期

保持耕作土壤体系中肥料氮的行为及氮的有效管理的探讨

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土壤学进展 1995年第2期23卷 1-11页

作者：王小彬 L.D.Bailey c.A.Grant 中国农科院土肥所 100081 Agriculture canada brandon Rcsearch Station

N 肥的有效性及其去向自60年代初起就开始受到关注.当今的持续农业中,减少 N 肥的经济损失以及 N 肥对环境污染的影响已经引起了广泛的重视.随着农业持续发展的需要,保持耕作的面积正在不断扩大.然而由于保持耕作体系下的土壤环境条件... 详细信息

N 肥的有效性及其去向自60年代初起就开始受到关注.当今的持续农业中,减少 N 肥的经济损失以及 N 肥对环境污染的影响已经引起了广泛的重视.随着农业持续发展的需要,保持耕作的面积正在不断扩大.然而由于保持耕作体系下的土壤环境条件更有利于N的固定、反硝化和 N 的淋溶过程,而不利于 N 的矿化和硝化过程,因此 N 的管理显得更为重要.本文就保持耕作体系下,特别是加拿大草原地区土壤中,肥料 N 的行为及其有效管理的若干问题进行了探讨.

关键词：耕作制度保持耕作土壤肥料氮管理行为

收获前施用阿魏酸对深色烤烟TSNA含量的影响

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中国烟草学报 2007年第4期13卷 49-49页

作者： BAILEY A THOMAS T brandon J 吴晓芸（翻译）曹建平（校译）康婧（校译）赵百东（校译）肯塔基大学Princeton KY42445 美国 Swisher International Jacksonville FL and Hopkinsville KY美国不详

摘要: 阿魏酸(c 10H 10O 4),也称4-hydroxy-3-methoxy苯乙烯酸,是一种存在于许多植物叶片和种子中,尤其是谷类如糙米、全麦和燕麦中的酚类植物化学物质。阿魏酸具有抗氧化剂特性,实验室试验显示阿魏酸可有效抑制降烟碱与亚硝酸盐之... 详细信息

摘要: 阿魏酸(c 10H 10O 4),也称4-hydroxy-3-methoxy苯乙烯酸,是一种存在于许多植物叶片和种子中,尤其是谷类如糙米、全麦和燕麦中的酚类植物化学物质。阿魏酸具有抗氧化剂特性,实验室试验显示阿魏酸可有效抑制降烟碱与亚硝酸盐之间形成TSNA的反应。

关键词： TSNA 阿魏酸收获前烤烟深色施用植物化学物质实验室试验

nBTPT在改进尿素氮肥施用技术中的作用初探

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土壤肥料 1996年第6期 6-9页

作者：王小彬辛景峰 c.A.crant L.D.Bailey 中国农科院土肥所河北省农科院土肥所 AgricultureandAgri-fodcanada brandonResearchcentre

尿素直接随种子施用或在地表施用的方法几乎不再为人们所采用。然而，随着少耕、免耕的继续推广，一种尽量不使土壤扰动，又不造成伤苗或ＮＨ３挥发的尿素施用技术引起人们的关注。加拿大Ｂｒａｎｄｏｎ研究站近年正尝试着将一种脲酶抑... 详细信息

尿素直接随种子施用或在地表施用的方法几乎不再为人们所采用。然而，随着少耕、免耕的继续推广，一种尽量不使土壤扰动，又不造成伤苗或ＮＨ３挥发的尿素施用技术引起人们的关注。加拿大Ｂｒａｎｄｏｎ研究站近年正尝试着将一种脲酶抑制剂ｎＢＴＰＴ引进尿素可能随种子或在地表施用的少耕免耕的施肥技术中。生长调控室的研究表明。

关键词：脲酶抑制剂尿素氮肥施肥