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mmunomodulatory properties of silver nanoparticles ontribute to anticancer strategy for murine fibrosarcoma

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Cellular & Molecular Immunology 2016年第2期13卷 191-205页

作者： Biswajit Chakraborty Ramkrishna pal Mohammed Ali Leichombam Mohindro singh Dewan Shahidur Rahman Sujit Kumar Ghosh Mahuya Sengupta Immunobiology Laboratory Department of Biotechnology Assam University Silchar India Department of Chemistry Assam University Silchar India

The use of nanotechnology in nanoparticle-based cancer therapeutics is gaining impetus due to the unique biophysical properties of nanoparticles at the quantum level. Silver nanoparticles （AgNPs） have been reported as one type of potent therapeutic nanoparticles. The present study is aimed to determine the effect of AgNPs in arresting the growth of a murine fibrosarcoma by a reductive mechanism. Initially, a bioavailability study showed that mouse serum albumin （MSA）-coated AgNPs have enhanced uptake; therefore, toxicity studies of AgNP-MSA at 10 different doses （1-10 mg/kg b.w.） were performed in LACA mice by measuring the complete blood count, lipid profile and histological parameters. The complete blood count, lipid profile and histological parameter results showed that the doses from 2 to 8 mg （IC50： 6.15 mg/kg b.w.） sequentially increased the count of leukocytes, lymphocytes and granulocytes, whereas the 9- and 10-mg doses showed conclusive toxicity. In an antitumor study, the incidence and size of fibrosarcoma were reduced or delayed when murine fibrosarcoma groups were treated by AgNP-MSA. Transmission electron micrographs showed that considerable uptake of AgNP-MSA by the sentinel immune cells associated with tumor tissue and a morphologically buckled structure of the immune cells containing AgNP-MSA. Because the toxicity studies revealed a relationship between AgNPs and immune function, the protumorigenic cytokines TNF-α, IL-6 and IL-1β were also assayed in AgNP-MSA-treated and non-treated fibrosarcoma groups, and these cytokines were found to be downregulated after treatment with AgNP-MSA.

关键词： AgNP-MSA fibrosarcoma IL-1β IL-6 immunomodulation nanoparticles TNF-α

Neglected reverse Essex-Lopresti injury with ulnar nerve compression

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Chinese Journal of Traumatology 2011年第2期14卷 111-113页

作者： Ajay pal singh Ish Kumar Dhammi Anil Kumar Jain Department of Orthopaedics UCMS & GTB Hospita Delhi 110095 India

A 45 year old woman was diagnosed as having anteromedial radial head dislocation and distal radius fracture five months after her injury on fight forearm. The radial head dislocation led to ulnar nerve compression. She had severe restriction of her elbow movements. She was treated with arthrolysis, decompression of the ulnar nerve and radial head resection. The reverse Essex Lopresti injury and radial head dislocation compressing the ulnarnerve has not been reported in English language literature to the best of our knowledge. A mechanism is proposed for the injury. In acute presentations, restoration of both the radioulnar joints should be done and neglected nature of such injury leads to suboptimal outcomes.

关键词： Radius fracture Unar nerve Elbow joint

Removal of chromium from water effluent by adsorption onto Vetiveria zizanioidesand Anabaenaspecies

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Natural Science 2013年第3期5卷 341-348页

作者： Manoj Kumar Abhradip pal Joginder singh Shashank Garg Madhu Bala Ashish Vyas Yogender pal Khasa Umesh C. Pachouri Aarupadai Veedu Institute of Technology Tamilnadu India Department of Biotechnology and Biosciences Lovely Professional University Phagwara India Department of Microbiology South Campus University of Delhi New Delhi-110021 India Institute of Nuclear Medicine & Allied Sciences Defence Research and Development Organisation New Delhi India

Bioadsorption phenomenon is more or less like a chemical reaction and several parameters are bound to affect the process. The pH, amount of adsorbent and agitation time influence the biosorptive potentiality. Hence, the present study on adsorption of Cr(VI) by activated Vetivera roots and Blue green algae Anabaena supports that it is an effective low cost adsorbent for the removal of Cr(VI) from plating effluent. Langmuir and Freundlich adsorption isotherm correlate the equilibrium adsorption data. In batch experiments both Vetiveria and Anabaena species were found to be cost effective biosorbent for the efficient removal of Cr(VI) from the effluent and comparatively Anabaena species was found to adsorb maximum Cr(VI) (88.86%) at a low contact time of 60 min. The data obtained from the experiments and modeling would prove useful in designing and fabricating an efficient treatment plant for Cr(VI) rich effluent.

关键词： Bioadsorption Vetiveria Anabaena Adsorption Isotherm Chromium

Rectangular Microstrip Patch Antenna Using Air as Substrate for S-Band Communication

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Journal of Electromagnetic Analysis and Applications 2014年第3期6卷 38-41页

作者： Manish Gupta Saurabh Sachdeva N. Kumar Swamy Inder pal singh Department of EECE ITM University Gurgaon India Departmentof Electrical and Electronics Engineering ITM University Gur- gaon & Raipur India Departmentof Mechanical Engineering Shinas College of Technology Shinas Oman.

A Rectangular Microstrip Patch Antenna model is proposed using air as a substrate to study the characteristics of designed antenna. The dimensions of designed antenna are 17 mm × 16.66 mm with substrate at frequency 3.525 GHz. In this paper, the simulation is performed by using software Computer Simulation Technology (CST) Microwave studio based on finite difference time domain technique. The characterization of the designed antenna was analyzed in terms of return loss, bandwidth, directivity, gain, radiation pattern, VSWR.

关键词： Rectangular Microstrip Patch Antenna Air Substrate Directivity

Isolation and in vivo hep-atoprotective activity of Melothria heterophylla(Lour.) *** chemically induced liver injuries in rats

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Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 619-623页

作者： Arijit Mondal Tapan Kumar Maity Dilipkumar pal Santanu Sannigrahi Jagadish singh Department of Pharmaceutical Technology Jadavpur UniversityKolkata-700 032India School of Pharmaceutical Sciences IFTM UniversityMoradabad-244 001India NSHM College of Pharmaceutical Technology 124 B.L Saha RoadKolkata-700 053West BengalIndia

Objective:To investigate hepatoprotective activity of ethanol extract of Melothria heterophyila Lour Cogn.（EEMH） against CCl4-induced hepatic damage in ***:β-sitosterol was isolated by column chromatography and characterized *** different doses（200 and 400 mg/kg bw） of EEMH were administered orally in alternate *** hepatoprotective activity was studied in liver by measuring biochemical parameters such as serum aspartate amino transferase（AST）,alanine amino transferase（ALT）,alkaline phosphatase（ALP）,total protein and total *** peroxidation product and different antioxidant enzyme activities were assessed in liver ***:EEMH reduced all biochemical parameters and lipid peroxidation,as well as it increased the antioxidant enzyme activities in comparison with *** protective effect of the extract on CCl4 induced damage was confirmed by histopathological examination of the ***:This result strongly supports the protective effect of EEMH against acute liver injury,and may be attributed to its antioxidative activity.

关键词： Carbon tetrachloride Hepatoprotective activity Melothria helerophylla β-sitosterol Silymarin

Synergistic Influence of Pre-Harvest Calcium Sprays and Postharvest Hot Water Treatment on Fruit Firmness, Decay, Bitter Pit Incidence and Postharvest Quality of Royal Delicious Apples (Malus x domesticaBorkh)

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American Journal of Plant Sciences 2013年第1期4卷 153-159页

作者： R. R. Sharma D. singh R. K. pal Division of Plant Pathology Indian Agricultural Research Institute New Delhi India Division of Post Harvest Technology Indian Agricultural Research Institute New Delhi India

Experiments were conducted to observe the effect of pre-harvest calcium (Ca) applied as calcium chloride (1% W/V) and postharvest hot water treatment (HWT) on “Royal Delicious” apples. For this, apples were divided in 4 lots viz., untreated (neither Ca nor HWT), Ca alone (pre-harvest 3 sprays of CaCl2 (1.0% w/v) in the orchard), HWT (42℃ for 2 h). Apples of all four lots were stored in cold storage maintained at 0℃ ± 1℃ and 90% - 95% relative humidity for 6 months. After storage, fruits were removed to ambient conditions for 5 days, and then observations on decay area and incidence, bitter pit incidence, fruit Ca content, lipoxygenase (LOX) and antioxidant (AOX) activity, fruit firmness and fruit quality parameters were recorded. After 6 months in cold storage plus 5 day at 22℃ ± 2℃ and 70% + 4% RH, apples, which received Ca as pre-harvest spray or those which received postharvest hot water treatment or Ca + HWT had significantly lesser decay area (decay lesions) caused by Penicillium expansum or Botrytis cinerea than untreated ones (control). Ca + HWT treatment was significantly more effective on B. cinerea than P. expansum. Untreated apples exhibited higher incidence of bitter pit (18.2%) than those treated with Ca or HWT or both. Fruit Ca content (2.92% DM) were significantly lower and conversely the LOX activity (6.9 μmoles min–1×g–1FW) was higher in untreated apples. Similarly, total phenolics and AOX activity were also lower in the untreated apples than Ca or HWT treated. HWT or Ca treated apples have beneficial effects on fruit firmness, peel colour and quality parameters like TSS and ascorbic acid content. Thus, it is concluded that pre-harvest sprays of calcium chloride with postharvest HWT is highly useful for “Royal Delicious” for reducing decay loss, maintaining firmness, high levels of antioxidants and fruit quality.

关键词： Hot Water Treatment Lipoxygenase Activity Antioxidant Activity Bitter Pit Fruit Quality

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高速加工双收缩丝的新概念

纺织导报 2007年第1期 75-76,78-79页

作者： Suprit pal singh B. Markus Reichwein Rajiv Padhye Barmag公司

合成纤维约占全部纤维消费量的一半,并广泛应用于纤维和纺织技术的各个领域.尽管许多种以合成聚合物加工的纤维都被认为是有潜在价值的商品,但聚酯纤维是市场的主宰.聚酯纤维方面的一项新的、非常重要的进展是将其用于加工'有美感'的织... 详细信息

合成纤维约占全部纤维消费量的一半,并广泛应用于纤维和纺织技术的各个领域.尽管许多种以合成聚合物加工的纤维都被认为是有潜在价值的商品,但聚酯纤维是市场的主宰.聚酯纤维方面的一项新的、非常重要的进展是将其用于加工'有美感'的织物.这类纤维被称作'新合纤'.这一名称源自最初开发出这种丝的日本发明者.加工这种丝的工艺大都采用低速技术,所加工的双收缩长丝是2根或2根以上具有不同沸水收缩性长丝的机械组合.这种机械组合是通过沿长丝长度方向进行以空气诱导的、重复和连续的网络组合、加捻组合或合股组合来实现的.

关键词：聚合物加工合成纤维收缩纺织技术潜在价值聚酯纤维消费量

In Pursuitof Porcine Pluripotent Stem Cells for Autologous Cell Therapy

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Stem Cell Discovery 2014年第4期4卷 107-124页

作者： Vinod Verma Ashish Mehta Sanjay pal Manoj Kumar Birbal singh Ashok Kumar Sanjeev Gautam Centre of Biotechnology Nehru Science Complex University of Allahabad Allahabad India National Heart Research Institute Singapore National Heart Centre Singapore Department of Microbiology & Immunology National Institute of Nutrition Hyderabad India Indian Veterinary Research Institute Regional Station Palampur India Department of Zoology MLK Post Graduate College Balrampur India Department of Biotechnology Kurukshetra University Kurukshetra India

Treatments to repair the human heart following regenerative diseases remain a challenge for medical science. Unlike lower vertebrate species the human heart lacks a regenerative pathway meaning that research has to be focused on cell transplantation. Porcines (Sus scrofa) are excellent models for cardiovascular disease and pluripotent stem cells (PSCs) generated from porcines will provide important clinical insights for cardiac cell therapy. This could open a new avenue of research into degenerative conditions as porcine is a more effective human proxy to work with. However, bona fide PSCs are currently available onlyin rodents (mouse, rat) and primates (monkey, human). Attempts to derivepluripotent stem cells (PSCs) from porcine have been going on for more than two decades with slow progress. Despite the fact that the porcine stem cells are under increasing glare of publicity due to milestone achievements in this area of research. Advances in stem cell technology, especially the genetic engineering, innovative cell culturing and induced pluripotency to generate stem cells has dramatically revolutionized the basic and applied investigations and applications of porcine stem cells. This review attempts to summarize the major signaling pathways involved in maintenance of pluripotency and the state of the art conceptual and technical progress for generating bona fide porcine PSCs.

关键词： Porcine Model Signaling Pathways Stem Cells Induced Pluripotent Stem Cells Pluripotency Regenerative Medicine Cell Therapy Epigenetics

Use of Isoproturon Imprinted Polymer Membranes as a Selective Recognition Platform in a Resistance Based Electrochemical Sensor

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Open Journal of Applied Biosensor 2013年第1期2卷 20-28页

作者： Krishna pal singh Ramesh Kumar Prajapati Saurabh Ahlawat Sweeti Ahlawat Manjul Mungali Satish Kumar Clay Product Environment Study Technology Division CSIR-Central Building Research Institute Roorkee India Membrane Biophysics & Nanobiosensor Research Laboratory CBSH G.B. Pant University of Agriculture & Technology Pantnagar India Membrane Biophysics & Nanobiosensor Research Laboratory CBSH G.B. Pant University of Agriculture & TechnologyPantnagar India

Methacrylic acid with isoproturon has been utilized to prepare molecularly imprinted polymeric (MIP) membrane on Whatman filter paper no. 5 for selective electrochemical estimation of isoproturon pesticide. MIP membrane was prepared by radical polymerization and characterized using Ultra Violet spectrophotometer, Fourier Transform Infra Red (FTIR) spectroscopy and Scanning Electron Microscopy (SEM). Contact angle study was used to determine the surface energy of the MIP membrane and electrical conductivity measurements were performed by applying a small-amplitude alternating voltage (20 mV) with frequencies varying from 20 Hz to 80 kHz generated by a low-frequency wave form generator. Different isoproturon concentrations in samples were tested and analyzed. Results indicate linear increase in membrane resistance with increasing isoproturon in 10-3 to 10-6 M range. The selectivity of the electrochemical sensor was confirmed by testing isoproturon in presence of the structurally related compounds monouran and diuran. Results reveal highly selective and sensitive sensor, which can be employed for regular estimation of isoproturon in fields.

关键词： Sensor Isoproturon Molecular Imprinting Monouran Diuran