mmunomodulatory properties of silver nanoparticles ontribute to anticancer strategy for murine fibrosarcoma
mmunomodulatory properties of silver nanoparticles ontribute to anticancer strategy for murine fibrosarcoma作者机构：Immunobiology Laboratory Department of Biotechnology Assam University Silchar India Department of Chemistry Assam University Silchar India
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2016年第13卷第2期
页 面：191-205页
核心收录：
学科分类：090603[农学-临床兽医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 09[农学] 0906[农学-兽医学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：Leichombam Mohindro Singh and Dewan Shahidur Rahman University Grants Commission, UGC
主 题：AgNP-MSA fibrosarcoma IL-1β IL-6 immunomodulation nanoparticles TNF-α
摘 要：The use of nanotechnology in nanoparticle-based cancer therapeutics is gaining impetus due to the unique biophysical properties of nanoparticles at the quantum level. Silver nanoparticles （AgNPs） have been reported as one type of potent therapeutic nanoparticles. The present study is aimed to determine the effect of AgNPs in arresting the growth of a murine fibrosarcoma by a reductive mechanism. Initially, a bioavailability study showed that mouse serum albumin （MSA）-coated AgNPs have enhanced uptake; therefore, toxicity studies of AgNP-MSA at 10 different doses （1-10 mg/kg b.w.） were performed in LACA mice by measuring the complete blood count, lipid profile and histological parameters. The complete blood count, lipid profile and histological parameter results showed that the doses from 2 to 8 mg （IC50： 6.15 mg/kg b.w.） sequentially increased the count of leukocytes, lymphocytes and granulocytes, whereas the 9- and 10-mg doses showed conclusive toxicity. In an antitumor study, the incidence and size of fibrosarcoma were reduced or delayed when murine fibrosarcoma groups were treated by AgNP-MSA. Transmission electron micrographs showed that considerable uptake of AgNP-MSA by the sentinel immune cells associated with tumor tissue and a morphologically buckled structure of the immune cells containing AgNP-MSA. Because the toxicity studies revealed a relationship between AgNPs and immune function, the protumorigenic cytokines TNF-α, IL-6 and IL-1β were also assayed in AgNP-MSA-treated and non-treated fibrosarcoma groups, and these cytokines were found to be downregulated after treatment with AgNP-MSA.
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