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From foredeep to orogenic wedge-top: The Cretaceous Songliao retroforeland basin, China

Geoscience Frontiers 2023年第3期14卷 65-73页

作者： Zhiqiang Feng Stephan A.graham Petroleum Exploration and Production Research Institute SINOPECNo.197 Baisha Rd.Beijing 112206China Department of Geological Sciences Stanford UniversityStanfordCA 94305USA

Songliao Basin,the largest Mesozoic intracontinental nonmarine basin in eastern China,initiated during the latest Jurassic as a backarc extensional basin;rifting failed and thermal cooling controlled subsidence through the early Late *** 2-D and 3D reflection seismic and borehole data with regional geological studies,we interpret sedimentary sequence and structural patterns of the Coniacian-Maastrichtian fill of Songliao Basin as defining a retroforeland basin system developed after 88 Ma(marked by the T11 unconformity in the basin),including(1)significant increase in the thickness of the Nenjiang Formation eastward towards orogenic highlands of the Zhangguangcai Range and the convergent continental margin;(2)a shift of detrital provenance in the basin from north to southeast;and(3)propagation of E-W shortened structures,increasing eastward in amplitude,frequency,and degree of inversion toward the *** latest Cretaceous,foreland basin fill progressively deformed,as the foredeep evolved to a wedge-top tectonic setting,marked by the basin-wide T04 unconformity within the upper Nenjiang Formation at 81.6 *** of the basin was brought into the orogenic wedge and eroded by the end of the *** Jurassic/Early Cretaceous backarc rifting of uncratonized basement comprised of accreted terranes likely facilitated and localized the *** normal faults reactivated and extensively inverted as thrust faults are prominent in the eastern 1/3 of the basin,whereas folds developed above detachments in shaley early post-rift strata dominate the western 2/3 of the *** foreland development likely was driven by changing plate dynamics and collision along the Pacific margin after 88 Ma.

关键词： Retroforeland basin Intracontinental basin Seismic reflection and borehole data Lithospheric plate dynamics Songliao basin

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History of Helicobacter pylori,duodenal ulcer,gastric ulcer and gastric cancer

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World Journal of Gastroenterology 2014年第18期20卷 5191-5204页

作者： David Y graham Michael E DeBakey VA Medical Center Baylor College of MedicineHoustonTX 77030United States

Helicobacter pylori (H. pylori) infection underlies gastric ulcer disease, gastric cancer and duodenal ulcer disease. The disease expression reflects the pattern and extent of gastritis/gastric atrophy (i.e., duodenal ulcer with non-atrophic and gastric ulcer and gastric cancer with atrophic gastritis). Gastric and duodenal ulcers and gastric cancer have been known for thousands of years. Ulcers are generally non-fatal and until the 20th century were difficult to diagnose. However, the presence and pattern of gastritis in past civilizations can be deduced based on the diseases present. It has been suggested that gastric ulcer and duodenal ulcer both arose or became more frequent in Europe in the 19th century. Here, we show that gastric cancer and gastric ulcer were present throughout the 17th to 19th centuries consistent with atrophic gastritis being the predominant pattern, as it proved to be when it could be examined directly in the late 19th century. The environment before the 20th century favored acquisition of H. pylori infection and atrophic gastritis (e.g., poor sanitation and standards of living, seasonal diets poor in fresh fruits and vegetables, especially in winter, vitamin deficiencies, and frequent febrile infections in childhood). The latter part of the 19th century saw improvements in standards of living, sanitation, and diets with a corresponding decrease in rate of development of atrophic gastritis allowing duodenal ulcers to become more prominent. In the early 20th century physician’s believed they could diagnose ulcers clinically and that the diagnosis required hospitalization for “surgical disease” or for “Sippy” diets. We show that while H. pylori remained common and virulent in Europe and the United States, environmental changes resulted in changes of the pattern of gastritis producing a change in the manifestations of

关键词： Helicobacter pylori Duodenal ulcer Gastric ulcer Gastric cancer Medical history Ulcer surgery Epidemiology Gastritis Atrophic gastritis Antiquity

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Cooling History of Mesozoic Magmatism and Implications for Large-Scale Gold Mineralization in the Jiaodong Peninsula, East China: Constraints from T-t Paths Determined by U-Pb Thermochronology of Zircon and Apatite

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Journal of Earth Science 2024年第3期35卷 878-889页

作者： Guangyan Zhou Mingchun Song Long Li Yan Luo Dgraham Pearson Jianbo Zhou Zhengjiang Ding Xuefeng Yu Yingxin Song Jie Li Shiyong Li Faculty of Earth Sciences China University of GeosciencesWuhan 430074China Department of Earth&Atmospheric Sciences University of AlbertaEdmontonAlberta T6G 2E3Canada Hebei Key Laboratory of Strategic Critical Mineral Resources Hebei GEO UniversityShijiazhuang 050031China Shandong Provincial No.6 Exploration Institute of Geology and Mineral Resources Weihai 264209China College of Earth Sciences Jilin UniversityChangchun 130061China Ministry of Natural Resources Key Laboratory of Gold Mineralization Processes and Resources Utilization Key Laboratory of Metallogenic-Geologic Processes and Comprehensive Utilization of Minerals Resources in Shandong ProvinceShandong Institute of Geological SciencesJinan 250013China Shandong Nuclear Industry Geological Group 273 Yantai 264006China

The Mesozoic intrusions of the Jiaodong Peninsula,eastern China,host giant gold *** the genesis of these deposits requires the determination of the source of the parental auriferous fluid and the timing of gold mineralization,which are strongly influenced by the cooling/uplift histories of the hosting *** performed an integrated U-Pb geochronology study on both zircon and apatite from four major magmatic episodes of the Jiaodong *** zircon and apatite U-Pb ages are 156.9±1.2 and 137.2±2.4 Ma for the Linglong intrusion,129.9±1.0 and 125.0±3.8 Ma for the Qujia intrusion,119.5±0.7 and 117.2±1.8 Ma for the Liulinzhuang intrusion,118.6±1.0 and 111.6±1.6 Ma for the Nansu intrusion,*** coupled zircon and apatite data of these granitoids indicate a slow cooling rate(11.9°C/Ma)in the Late Jurassic,and rapid uplift and cooling(35.8-29.2°C/Ma)in the Early *** dramatically increased uplift and cooling period in the Early Cretaceous are contemporaneous with large-scale gold mineralization in the Jiaodong *** implies that thermal upwelling of asthenosphere and related tectonic extension played an important role in gold remobilization and precipitation.

关键词： magmatism geochronology zircon apatite gold deposits Jiaodong Peninsula

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Modification of ubiquitin C-terminal hydrolase L1 by reactive lipid species: role in neural regeneration and diseases of aging

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Neural Regeneration Research 2016年第6期11卷 908-909页

作者： Steven H.graham Geriatric Research Educational and Clinical Center V.A. Pittsburgh Healthcare System

Role of ubiquitin C-terminal hydrolase L1（UCHL1）in brain function：Ubiquitin is used by a variety of cellular systems to tag proteins for transport to various *** are a number of enzymes in the ubiquitin-proteasome ... 详细信息

关键词： ubiquitin proteasome regeneration Ubiquitin hydrolase Modification synaptic neuronal lipid enzymes

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Effect and mechanism of manganate preoxidation for organics removal

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Science China(Technological Sciences) 2014年第6期57卷 1160-1164页

作者： REN ZhiJun NIGEL graham College of Aerospace and Civil Engineering Harbin Engineering University Department of Civil and Environmental Engineering Imperial College LondonSouth Kensington Campus

The performance and mechanism of manganate preoxidation process for organics removal were investigated in the present *** results showed that manganate was a potentially powerful oxidizing agent and could make the natural organic matter(NOM)concentration of sample solution *** process of manganate in combination with ferrous sulphate(FeMnO)was effective for organics removal and with the highest removal rate of 89%when the FeMnO dose was 0.18 mmol/*** fluorescence analysis showed that the fluorescence intensity values related to hydrophobic acids and model humic acid polymers were the highest and the relative position of the main peak fluorescence intensity was shifted towards lower emission wavelengths,which indicated the reduction in the degree of aromaticity of residual organic matter fraction.

关键词： potassium manganate femno process oxidation organic matters

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Associations between NOD2/CARD15 genotype andphenotype in Crohn’s disease-Are we there yet?

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World Journal of Gastroenterology 2006年第44期12卷 7097-7103页

作者： graham Radford-Smith Nirmala Pandeya IBD Unit Department of Gastroenter-ology Royal Brisbane and Womens Hospital Brisbane Queensland 4029 Australia Cancer and Population studies group Queensland Institute of Medical Research Brisbane Australia

There have been multiple NOD2/CARD15 genotype- phenotype analyses undertaken in patients with Crohn’s disease since the gene’s discovery in 2001. This review focuses on the major published series based upon their size and on the presence of specific clinical and genetic information provided in the published material from 2001 to 2005. Twelve studies provided raw data to carry out comparisons of disease location while ten studies included analysis of NOD2/CARD15 genotypes. NOD2/CARD15 variant frequency in ileal disease did not differ significantly among studies, whereas a comparison of disease location demonstrated highly significant differences among studies. Meta-analysis confirmed significant associations between NOD2/CARD15 variants and both ileal and ileocolonic disease locations, and with both stricturing and penetrating forms of disease behavior. This review underlines the significant phenotypic differences that exist among populations, including similar ethnic groups, and has demonstrated the need for further studies of patients with long-term “inflammatory” Crohn’s disease.

关键词： Crohn's disease Phenotypic heterogeneity Genotype Inter-observer agreement Disease location Disease behavior

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Single-cell Analysis Technologies for Immuno-oncology Research:from Mechanistic Delineation to Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 191-207页

作者： Zhiliang Bai graham Su Rong Fan Department of Biomedical Engineering Yale UniversityNew HavenCT 06511USA State Key Laboratory of Precision Measurement Technology and Instrument Tianjin UniversityTianjin 300072China Yale Stem Cell Center and Yale Cancer Center Yale School of MedicineNew HavenCT 06511USA Human and Translational Immunology Yale School of MedicineNew HavenCT 06511USA

The successes with immune checkpoint blockade(ICB)and chimeric antigen receptor(CAR)-T-cell therapy in treating multiple cancer types have established immunotherapy as a powerful curative option for patients with advanced ***,many patients do not derive benefit or long-term responses,highlighting a pressing need to perform complete investigation of the underlying mechanisms and the immunotherapy-induced tumor regression or *** recent years,a large number of single-cell technologies have leveraged advances in characterizing immune system,profiling tumor microenvironment,and identifying cellular heterogeneity,which establish the foundations for lifting the veil on the comprehensive crosstalk between cancer and immune system during *** this review,we introduce the applications of the most widely used single-cell technologies in furthering our understanding of immunotherapies in terms of underlying mechanisms and their association with therapeutic *** also discuss how single-cell analyses help to deliver new insights into biomarker discovery to predict patient response rate,monitor acquired resistance,and support prophylactic strategy development for toxicity ***,we provide an overview of applying cutting-edge single-cell spatial-omics to point out the heterogeneity of tumor–immune interactions at higher level that can ultimately guide to the rational design of next-generation immunotherapies.

关键词： Single-cell analysis Immunotherapy Biomarker discovery Checkpoint blockade CAR-T

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Quantifying multiple-site compositional turnover in an Afrotemperate forest, using zeta diversity

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Forest Ecosystems 2018年第2期5卷 189-197页

作者： Cang Hui Wessel Vermeulen graham Durrheim Centre for Invasion Biology Department of Mathematical SciencesStellenbosch University Mathematical and Physical Biosciences African Institute for Mathematical Sciences Garden Route Scientific Services South African National Parks

Background： Species turnover is typically measured by partitioning diversity components into alpha and pairwise beta diversity. However, alpha and beta components cannot express the full spectrum of multiple-site compositional turnover. To this end, zeta diversity has been proposed as an extended framework to allow complete biodiversity partitioning and to measure multiple-site species turnover. We use a zeta-diversity framework to explore the turnover and potential community assembly processes of an African Montane Forest. Methods： Using a 20 m grid, we explore the species turnover in a 4.55 ha forest plot located in the Garden Route National Park of South Africa, with 47 and 27 canopy and sub-canopy tree species in the regional poo We first calculate how zeta diversity declines and how the probability of retention of species with particular occupancies changes with increasing zeta orders （i.e. the number of sites [grid cells] involved in the calculation）. Using null models with row sums and column sums constrained respectively, we explore whether species turnover is driven by mechanisms of ecological differences （species-specific occupancies） or habitat heterogeneity （site-specific alpha diversity and thus environmental filters）. Results： The decline of zeta diversity with zeta order followed a power law; that is, the probability of retention increased with species occupancies, suggesting common species being more likely to be discovered in extra sites. The null model retaining row sums （species＇ occupancy） of the species-by-site matrix recreated perfectly the decline of zeta diversity, while the null model of habitat heterogeneity （retaining column sums） was rejected. This suggests that mechanisms driving species-specific occupancies （i.e. ecological differences between species） dictate the multi-site species turnover in the community. The spatial patterns of zeta diversity revealed little spatial structuring forces, supporting a fine-grain structure in these sou

关键词： Species turnover Diversity partitioning Zeta diversity Community assembly Southern cape forest Afromontane forest

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Immunotherapy in gastric cancer

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World Journal of Gastroenterology 2014年第7期20卷 1657-1666页

作者： Satoko Matsueda David Y graham Cancer Vaccine Development Division Research Center for Innovative Cancer TherapyKurume UniversityKurumeFukuoka 830-0011Japan Michael E DeBakey VA Medical Center Baylor College of MedicineHoustonTX 77030United States

Gastric cancer is the second most common of cancerrelated deaths *** the majority of cases gastric cancer is advanced at diagnosis and although medical and surgical treatments have improved,survival rates remain *** immunotherapy has emerged as a powerful and promising clinical approach for treatment of cancer and has shown major success in breast cancer,prostate cancer and ***,we provide an overview of concepts of modern cancer immunotherapy including the theory,current approaches,remaining hurdles to be overcome,and the future prospect of cancer immunotherapy in the treatment of gastric *** cell therapies,cancer vaccines,gene therapies,monoclonal antibody therapies have all been used with some initial successes in gastric ***,to date the results in gastric cancer have been disappointing as current approaches often do not stimulate immunity efficiently allowing tumors continue to grow despite the presence of a measurable immune ***,we discuss the identification of targets for immunotherapy and the role of biomarkers in prospectively identifying appropriate subjects or *** also discuss the molecular mechanisms by which tumor cells escape host immunosurveillance and produce an immunosuppressive tumor *** show how advances have provided tools for overcoming the mechanisms of immunosuppression including the use of monoclonal antibodies to block negative regulators normally expressed on the surface of T cells which limit activation and proliferation of cytotoxic T *** has greatly improved and is becoming an important factor in such fields as medical care and welfare for human *** has been rapid ensuring that the future of immunotherapy for gastric cancer is bright.

关键词： Gastric cancer Immune checkpoint Immune escape Adoptive cell therapy Cancer vaccine Antibody therapy Predictive biomarker

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The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 （StarD3/MLN64）, in BRIN-BD11 insulinoma cells

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Protein & Cell 2016年第11期7卷 833-838页

作者： Joana Borges Pinto Annette graham Department of Life Sciences School of Health and Life Sciences Glasgow Caledonian University Glasgow G4 0BA UK WolfsonWohl Cancer Research Centre Institute of Cancer Sciences University of Glasgow Switchback Road Bearsden Glasgow G61 1QH UK

Dear Editor, Insulin secretion by pancreatic β-cells is modulated by altering the cellular content and distribution of cholesterol, which is tightly regulated by a network of transcription factors, enzymes, receptors, transporters and cholesterol trafficking proteins. Inhibition of cellular biosynthesis by ＇statin＇ drugs, or depletion of plasma membrane cholesterol by methyl-β-cyclodextrin （MCD）, reduce glucose-stimulated insulin secretion （GSIS） and content in β-cells and islets;

关键词： Cholesterol Lutein Insulin Release Cholesterol Efflux Cholesterol Depletion

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