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Transient expression of inactive RB in mesenchymal stem cells impairs their adipogenic potential and is associated with hypermethylation of the PPARγ2 promoter

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Genes & Diseases 2022年第1期9卷 165-175页

作者： Mikhail Baryshev Nikolai Petrov Vladimir Ryabov boris popov Institute of Cytology Russian Academy of Sciences St.Petersburg4Tikhoretsky Av.194064St.PetersburgRussia Institute of Microbiology and Virology Riga Stradins UniversityRatsupites 5LV-1067RigaLatvia Developmental Therapeutics Branch National Cancer InstituteNational Institutes of HealthBethesdaMaryland 20892USA

The retinoblastoma gene product(pRb)is a chromatin-associated protein that can either suppress or promote activity of key regulators of tissue-specific *** found that twelve weeks after transfection of the exogenous active(ΔB/X andΔр34)or inactive(ΔS/N)forms of RB into the 10T1/2 mesenchymal stem cells and clonal selection not a single cell line did contain exogenous RB,despite being G-418 ***,the consequences of the transient production of exogenous RB had different effects on the cell ***ΔB/X andΔр34 cells transfected with active form of RB showed elevated levels of inducible adipocyte differentiation(AD).On the contrary,theΔS/N cells transfected with inactive RB mutant were insensitive to induction of AD associated with abolishing of expression of the PPARγ***,the PPARγ2 promoter in undifferentiatedΔS/N cells was hypermethylated,but all except−60 position CpG became mostly demethylated after cells exposure to *** conclude that while transient expression of inactive exogenous RB induces long term epigenetic alterations that prevent adipogenesis,production of active exogenous RBs results in an AD-promoting epigenetic *** results indicate that pRb is involved in the establishment of hereditary epigenetic memory at least by creating a methylation pattern of PPARγ2.

关键词： Adipogenic differentiation DNA methyltransferase 1 Mesenchymal stem cells MSCs RB Retinoblastoma susceptibility gene

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pRb-E2F signaling in life of mesenchymal stem cells:Cell cycle,cell fate,and cell differentiation

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Genes & Diseases 2014年第2期1卷 174-187页

作者： boris popov Nikolay Petrov Institute of Cytology Russian Academy of SciencesSt.Petersburg4Tikhoretsky Av.194064Russia

Mesenchymal stem cells(MSCs)are multipotent cells that can differentiate into various mesodermal lines forming fat,muscle,bone,and other lineages of connective *** possess plasticity and under special metabolic conditions may transform into cells of unusual phenotypes originating from ecto-and *** transplantation,MSCs release the humoral factors promoting regeneration of the damaged *** last five years,the numbers of registered clinical trials of MSCs have increased about 10 *** gives evidence that MSCs present a new promising resource for cell therapy of the most dangerous *** efficacy of the MSCs therapy is limited by low possibilities to regulate their conversion into cells of damaged tissues that is implemented by the pRb-E2F *** widely accepted viewpoint addresses pRb as ubiquitous regulator of cell cycle and tumor ***,current publications suggest that basic function of the pRb-E2F signaling in development is to regulate cell fate and *** facultative and constitutive chromatin modifications,pRb-E2F signaling promotes transient and stable cells quiescence,cell fate choice to differentiate,to senesce,or to *** of pRb is associated with cancer cell *** regulates cell fate by retaining quiescence of one cell population in favor of commitment of another or by suppression of genes of different cell *** is the founder member of the“pocket protein”family possessing functional *** increase in the efficacy of the MSCs based cell therapy will depend on precise understanding of various aspects of the pRb-E2F signaling.

关键词： Cell cycle Cell differentiation Cell fate Mesenchymal stem cells pRb-E2F signaling

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Hepatobiliary system and intestinal injury in new coronavirus infection(COVID-19):A retrospective study

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World Journal of Clinical Cases 2023年第10期11卷 2226-2236页

作者： Konstantin V Kozlov Konstantin V Zhdanov Anna K Ratnikova Vyacheslav A Ratnikov Artem V Tishkov Vladimir Grinevich Yuriy A Kravchuk Panteley I Miklush Polina O Nikiforova Vera V Gordienko Alexander F popov boris G Andryukov Department of Infectious Disease Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia Department of Admission Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Roentgenology Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Physics Mathematics and InformaticsFSBEI HE IP.Pavlov SPbSMU MOH RussiaSaint-Petersburg 197022Russia 2nd Department of Therapy(Advanced Medical Education) Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia School of Medicine Far Eastern Federal UniversityVladivostok 690922Russia

BACKGROUND An important area of effective control of the coronavirus disease 19(COVID-19)pandemic is the study of the pathogenic features of severe acute respiratory syndrome coronavirus 2 infection,including those based on assessing the state of the intestinal microbiota and *** To study the clinical features of the new COVID-19 in patients with mild and moderate severity at the stage of hospitalization,to determine the role of hepatobiliary injury,intestinal permeability disorders,and changes in the qualitative and quantitative composition of the microbiota in the development of systemic inflammation in patients with *** The study was performed in 80 patients with COVID-19,with an average age of 45 years,19 of whom had mild disease,and 61 had moderate disease *** scope of the examination included traditional clinical,laboratory,biochemical,instrumental,and radiation studies,as well as original methods for studying microbiota and intestinal *** The clinical course of COVID-19 was studied,and the clinical and biochemical features,manifestations of systemic inflammation,and intestinal microbiome changes in patients with mild and moderate severity were *** permeability characteristics against the background of COVID-19 were evaluated by measuring levels of proinflammatory cytokines,insulin,faecal calprotectin,and *** This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COVID-19 severity.

关键词： Novel coronavirus infection COVID-19 SARS-CoV-2 Zonulin Faecal calprotectin Microbiota

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Pyroptosis is a drug target for prevention of adverse cardiac remodeling: The crosstalk between pyroptosis, apoptosis, and autophagy

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The Journal of Biomedical Research 2022年第6期36卷 375-389页

作者： Natalia V.Naryzhnaya Leonid N.Maslov Sergey V.popov Alexandr V.Mukhomezyanov Vyacheslav V.Ryabov boris K.Kurbatov Alexandra E.Gombozhapova Nirmal Singh Feng Fu Jian-Ming Pei Sergey V.Logvinov Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Pharmaceutical Sciences and Drug Research Punjabi UniversityPatiala 147002India Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic MedicineFourth Military Medical UniversityXi'anShaanxi 710032China Department of Histology Embryology and CytologySiberian State Medical UniversityTomskTomsk Region 634055Russia

Acute myocardial infarction(AMI)is one of the main reasons of cardiovascular disease-related *** introduction of percutaneous coronary intervention to clinical practice dramatically decreased the mortality rate in *** cardiac remodeling is a serious problem in *** increase in the effectiveness of AMI treatment and prevention of adverse cardiac remodeling is difficult to achieve without understanding the mechanisms of reperfusion cardiac injury and cardiac *** of pyroptosis prevents the development of postinfarction and pressure overload-induced cardiac remodeling,and mitigates cardiomyopathy induced by diabetes and metabolic ***,it is reasonable to hypothesize that the pyroptosis inhibitors may find a role in clinical practice for treatment of AMI and prevention of cardiac remodeling,diabetes and metabolic syndrome-triggered *** was demonstrated that pyroptosis interacts closely with apoptosis and *** could be inhibited by nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 inhibitors,caspase-1 inhibitors,microRNA,angiotensin-converting enzyme inhibitors,angiotensinⅡreceptor blockers,and traditional Chinese herbal medicines.

关键词： pyroptosis apoptosis autophagy cardiac remodeling diabetes metabolic syndrome

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Habitat requirements of Boreal Owl(Aegolius funereus)and Pygmy Owl(Glaucidium passerinum)in rear edge montane populations on the Balkan Peninsula

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Avian Research 2022年第2期13卷 175-182页

作者： boris P.Nikolov Tzvetan Zlatanov Thomas Groen Stoyan Stoyanov Iva Hristova-Nikolova Manfred J.Lexer Institute of Biodiversity and Ecosystem Research Bulgarian Academy of Sciences 2 Yuri Gagarin Str.SfiaBulgaria Faculty of Geo-Information Science and Earth Observation(ITC)University of Twente Hengelosestraat 99 7514AEEnschedethe Netherlands University of Forestry 10Sv.Kliment Ohridski Blvd.SofiaBulgaria Biota Films Ltd. 51 Prof.Kiril Popov Str.SofiaBulgaria University of Natural Resources and Life Sciences Peter-Jordan-Str.82ViennaAustria

Rear-edge populations of montane species are known to be vulnerable to environmental change,which could affect them by habitat reduction and *** requirements of two cold-adapted boreo-alpine owl species—Boreal Owl(Aegolius funereus)and Pygmy Owl(Glaucidium passerinum)—have been studied in refugial montane populations in the western Rhodopes,South *** on owl presence and forest stand attributes recorded in situ have been used to identify significant predictors for owl *** results revealed Boreal Owl’s preference for comparatively dense forests(high canopy closure values),big trees(diameter at breast height≥50 cm)and large amount of fallen dead wood in penultimate stage of *** Pygmy Owl the only significant explanatory variable was the total amount of fallen dead *** suggest preference of both owl species for forests with structural elements typical of old-growth forests(i.e.,veteran trees,deadwood),the Pygmy Owl being less prone to inhabit managed *** at the rear edge of their Palearctic breeding range in Europe both Boreal and Pygmy Owls are of high conservation value on the Balkan ***,additional efforts are needed for their conservation in the light of climate change and resulting alteration of forest structural *** findings can be used for adjusting forest management practices in order to ensure both,sustainable profit from timber and continuous species survival.

关键词： Forest management Habitat requirements Owls Refugial populations

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A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： Leonid N.Maslov Natalia V.Naryzhnaya Sergey V.popov Alexandr V.Mukhomedzyanov Ivan A.Derkachev boris K.Kurbatov Andrey V.Krylatov Feng Fu Jianming Pei Vyacheslav V.Ryabov Evgenii V.Vyshlov Svetlana V.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MVO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MVO in patients with acute myocardial ***,the major events preceding the appearance of MVO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MVO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MVO,with L-type Ca2+channel blockers appearing the most effective in treating MVO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

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