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Factors influencing COVID-19 vaccination intention among university students:A cross-sectional study in Malaysia

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Biosafety and Health 2023年第1期5卷 37-44页

作者： Chee Yin Wong Jen Sern Tham Chai Nien Foo Foong Leng Ng Saleha Shahar Mohd Nizam Zahary Mohd Nazri Ismail Cheng Siang Tan boon peng hoh Subbiah Vijay Kumar Yang Mooi Lim Center for Cancer Research Universiti Tunku Abdul RahmanKajang 43000Malaysia M.Kandiah Faculty of Medicine&Health Sciences Universiti Tunku Abdul RahmanKajang 43000Malaysia Department of Communication Faculty of Modern Languages and CommunicationUniversiti Putra MalaysiaSerdang 43400Malaysia UPM-UNICEF C4D Faculty of Modern Languages and CommunicationUniversiti Putra MalaysiaSerdang 43400Malaysia Faculty of Science Universiti Teknologi MalaysiaJohor Bahru 81310Malaysia Faculty of Health Sciences Universiti Sultan Zainal AbidinKuala Nerus 21300Malaysia Analytical Biochemistry Research Centre Universiti Sains MalaysiaBayan Lepas 11900Malaysia Faculty of Medicine and Health Sciences Universiti Malaysia SarawakKota Samarahan 94300Malaysia Faculty of Medicine and Health Sciences UCSI UniversityCheras 56000Malaysia Biotechnology Research Institute Universiti Malaysia SabahKota Kinabalu 88400Malaysia

Vaccination is crucial in controlling the spread of the coronavirus disease 2019(COVID-19)that triggered the pandemic,but herd immunity can only work with high vaccination coverage in the *** study aims to measure the COVID-19 knowledge level and determine the factors influencing COVID-19 vaccination intention among university students in Malaysia.A cross-sectional online survey was carried out with 1,274 Malaysian university students in July *** and multivariate analyses were employed to examine the relationships between the study *** showed that the majority of university students had an acceptable level of knowledge of *** knowledge,risk perception of COVID-19,social norms,and perceived benefit of COVID-19 vaccination were positively associated with vaccination ***,perceived trust in information sources of COVID-19 vaccination and the government's response to COVID-19 did not affect the university students’desire to receive the *** findings are essential for health policymakers and healthcare providers to implement evidence-based interventions to increase COVID-19 vaccination uptake among university students.

关键词： Behavioral intention COVID-19 Influencing factor SARS-CoV-2 University student Vaccination

Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique

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National Science Review 2023年第4期10卷 19-21页

作者： Yanan Cao Lingling Chen Hua Chen Yupeng Cun Xiaofeng Dai Hongli Du Feng Gao Fengbiao Guo Yalong Guo Pei Hao Shunmin He Shunping He XiongLei He Zheng Hu boon-peng hoh Xin Jin Qian Jiang Qinghua Jiang Asifullah Khan Hong-Zhi Kong Jinchen Li Shuai Cheng Li Ying Li Qiang Lin Jianquan Liu Qi Liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi Xiaofeng Song Jianzhong Su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-Dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu Yu Xue Wenjun Yang Zhaohui Yang Kai Ye Yuan-Nong Ye Li Yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan Zhang Liye Zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping Zhang Ruijin Hospital Shanghai Jiao Tong University College of Life Science and Technology Guangxi University Beijing Institute of Genomics Chinese Academy of Sciences Children's Hospital of Chongqing Medical University Wuxi School of Medicine Jiangnan University School of Biology and Biological Engineering South China University of Technology Department of Physics School of ScienceTianjin University School of Pharmaceutical Sciences Wuhan University Institute of Botany Chinese Academy of Sciences Institut Pasteur of Shanghai Chinese Academy of Sciences Institute of Biophysics Chinese Academy of Sciences Institute of Hydrobiology Chinese Academy of Sciences School of Life Sciences Sun Yat-sen University Institute of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Faculty of Medicine and Health Sciences University College Sedaya International School of Medicine South China University of Technology Department of Medical Genetics Capital Institute of Pediatrics School of Life Science and Technology Harbin Institute of Technology Department of Biochemistry Abdul Wali Khan University Xiangya Hospital Central South University Department of Computer Science City University of Hong Kong College of Life Science and Technology Foshan University South China Sea Institute of Oceanology Chinese Academy of Sciences College of Ecology Lanzhou University School of Life Sciences and Technology Tongji University School of Life Sciences Peking University Kunming Institute of Zoology Chinese Academy of Sciences College of Animal Science South China Agricultural University Institute of Neuroscience Chinese Academy of Sciences School of Life Sciences East China Normal University Nanjing University of Aeronautics and Astronautics Wenzhou Institute University of Chinese Academy of Sciences Institute of Systems Biomedicine Shanghai Jiao Tong University Tongji Medical College Huazhong University of Science and Technology School of Life Sciences Xiamen University Division of Life Science and Department of

Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic’ that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19.

关键词： SARS-COV-2 ORIGIN

High-speed GaN-based laser diode with modulation bandwidth exceeding 5 GHz for 20 Gbps visible light communication

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Photonics Research 2024年第6期12卷 1186-1193页

作者： JUNFEI WANG JUNHUI HU CHAOWEN GUAN YUQI HOU ZENGYI XU LEIHAO SUN YUE WANG YUNING ZHOU boon S.OOI JIANYANG SHI ZIWEI LI JUNWEN ZHANG NAN CHI SHAOHUA YU CHAO SHEN School of Information Science and Technology Fudan UniversityShanghai 200433China peng Cheng Laboratory Shenzhen 518000China ZGC Institute of Ubiquitous-X Innovation and Applications Beijing 100876China Photonics Laboratory King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

Visible light communication(VLC)based on laser diodes demonstrates great potential for high data rate maritime,terrestrial,and aerial wireless data ***,we design and fabricate high-speed blue laser diodes(LDs)grown on c-plane gallium nitride(GaN)*** was achieved through active region design and miniaturization toward a narrow ridge waveguide,short cavity length,and single longitudinal mode Fabry–Perot laser *** fabricated mini-LD has a low threshold current of 31 mA and slope efficiency of 1.02 W/A.A record modulation bandwidth of 5.9 GHz(−3dB)was measured from the *** the developed mini-LD as a transmitter,the VLC link exhibits a high data transmission rate of 20.06 Gbps adopting the bit and power loading discrete multitone(DMT)modulation *** corresponding bit error rate is 0.003,satisfying the forward error correction *** demonstrated GaN-based mini-LD has significantly enhanced data transmission rates,paving the path for energy-efficient VLC systems and integrated photonics in the visible regime.

关键词： communication diode waveguide

广西歧舌苔属植物研究及一中国新记录种毛缘歧舌苔

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西北植物学报 2024年第8期44卷 1338-1344页

作者：王顺莉韦玉梅唐启明何文钏彭涛贵州师范大学生命科学学院贵阳550025 广西壮族自治区中国科学院广西植物研究所广西喀斯特植物保育与恢复生态学重点实验室广西桂林541006 国家公园局新加坡植物园新加坡259569

【目的】了解歧舌苔属植物在广西的实际分布情况,为广西苔藓植物研究增加新资料的同时,也为中国苔藓植物多样性保护添加必要的基础数据。【方法】通过野外调查结合广西植物标本馆(IBK)馆藏标本的核查,获得歧舌苔属植物研究材料,经室内... 详细信息

【目的】了解歧舌苔属植物在广西的实际分布情况,为广西苔藓植物研究增加新资料的同时,也为中国苔藓植物多样性保护添加必要的基础数据。【方法】通过野外调查结合广西植物标本馆(IBK)馆藏标本的核查,获得歧舌苔属植物研究材料,经室内形态观察及查阅相关文献,确定其物种多样性。【结果】发现广西歧舌苔属植物标本10份,最终确认广西歧舌苔属植物3种,分别为毛缘歧舌苔[Schistochila sciurea(Nees)Schiffn.]、大歧舌苔[***(Nees&Blume)***&Steph.]、阔叶歧舌苔[***(Nees)Trevis.]。【结论】歧舌苔科以及歧舌苔属均为首次在广西记录的科属,其中毛缘歧舌苔是中国新记录种。文章对毛缘歧舌苔的形态特征进行详细描述,对另外2个种主要形态特征进行归纳,并提供各个种的引证标本信息、地理分布以及彩色图版。

关键词：歧苔类植物歧舌苔属广西新分布

Genetic Association Study of KCNB1 Gene with the Susceptibility of Hypertension Related LVH （Left Ventricular Hypertrophy） Patients in Malaysia

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Journal of Life Sciences 2013年第4期7卷 341-347页

作者： Julia Ashazila Mat Jusoh Norlaila Danuri Fadhlina Abdul Majid hoh boon peng Khalid Yusoff Institute of Medical Molecular Biotechnology Faculty of Medicine Universiti Teknologi MARA Sungai Buloh 47000 Malaysia Faculty of Medicine Universiti Teknologi MARA Batu Caves 68100 Selangor Malaysia

LVH （Left ventricular hypertrophy） is an independent risk factor for the development of heart failure, cardiac arrhythmias and stroke. A recent genome-wide association study reported the involvement of a candidate gene namely KCNBI in mechanism for development of LVH in hypertension. This study aimed to replicate the finding by investigating the genetic association of KCNBI gene among the hypertensive LVH patients from Malaysia. We genotyped a SNP （single nucleotide polymorphism） located in KCNBI namely, rs6063397 among 200 subjects consisting of61 LVH and 139 non LVH patients using Sanger sequencing method. Statistical analysis revealed no significant association between the L VH susceptibility between the allele and genotype frequencies （P = 0.2719 and 0.4768, respectively）. This finding suggests that KCNBI may not playa role in LVH susceptibility in hypertensive patients in Southeast Asian populations.

关键词： Left ventricular hypertrophy KCNBI SNP (single nucleotide polymorphism) Malaysia.

Demonstration of a low‐complexity memory‐polynomial‐aided neural network equalizer for CAP visible‐light communication with superluminescent diode

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Opto-Electronic Advances 2020年第8期3卷 1-11页

作者： Fangchen Hu Jorge A.Holguin-Lerma Yuan Mao peng Zou Chao Shen Tien Khee Ng boon S.Ooi Nan Chi Key Laboratory for Information Science of Electromagnetic Waves(MoE) Fudan UniversityShanghai 200433China Photonics Laboratory King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

Visible-light communication(VLC)stands as a promising component of the future communication network by providing high-capacity,low-latency,and high-security wireless *** diode(SLD)is proposed as a new light emitter in the VLC system due to its properties of droop-free emission,high optical power density,and low *** this paper,we analyze a VLC system based on SLD,demonstrating effective implementation of carrierless amplitude and phase modulation(CAP).We create a low-complexity memory-polynomial-aided neural network(MPANN)to replace the traditional finite impulse response(FIR)post-equalization filters of CAP,leading to significant mitigation of the linear and nonlinear distortion of the VLC *** MPANN shows a gain in Q factor of up to 2.7 dB higher than other equalizers,and more than four times lower complexity than a standard deep neural network(DNN),hence,the proposed MPANN opens a pathway for the next generation of robust and efficient neural network equalizers in *** experimentally demonstrate a proof-of-concept 2.95-Gbit/s transmission using MPANN-aided CAP with 16-quadrature amplitude modulation(16-QAM)through a 30-cm channel based on the 442-nm blue SLD emitter.

关键词： superluminescent diode visible-light communication neural network

Thiol-stabilized atomically precise, superatomic silver nanoparticles for catalysing cycloisomerization of alkynyl amines

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National Science Review 2018年第5期5卷 694-702页

作者： Juanzhu Yan Jun Zhang Xumao Chen Sami Malola Bo Zhou Elli Selenius Xiaomin Zhang peng Yuan Guocheng Deng Kunlong Liu Haifeng Su boon K.Teo Hannu Hkkinen Lansun Zheng Nanfeng Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsand Engineering Research Center for Nano-Preparation Technology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen University School of Materials and Chemical Engineering Anhui Jianzhu University Departments of Physics and Chemistry Nanoscience CenterUniversity of Jyvskyl

Both the electronic and surface structures of metal nanomaterials play critical roles in determining their chemical properties. However, the non-molecular nature of conventional nanoparticles makes it extremely challenging to understand the molecular mechanism behind many of their unique electronic and surface properties. In this work, we report the synthesis, molecular and electronic structures of an atomically precise nanoparticle, [Ag206 L72]~q(L = thiolate, halide; q = charge). With a four-shell Ag7@Ag32@Ag77@Ag90 Ino-decahedral structure having a nearly perfect D5hsymmetry, the metal core of the nanoparticle is co-stabilized by 68 thiolate and 4 halide ligands. Both electrochemistry and plasmonic absorption reveal the metallic nature of the nanoparticles, which is explained by density functional theory ***, the nanoparticle can be considered as a superatom, just short of a major electron shell closing of 138 electrons(q = –4). More importantly, many of ligands capping on the nanoparticle are labile due to their low-coordination modes, leading to high surface reactivity for catalysing the synthesis of indoles from 2-ethynylaniline derivatives. The results exemplify the power of the atomic-precision nanocluster approach to catalysis in probing reaction mechanisms and in revealing the interplay of heterogeneous reactivities,electronic and surface structural dynamics, thereby providing ways for optimization.

关键词： metal nanoclusters atomically precise nanoparticles nobel metal superatom nanocatalysis

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过渡金属银配体簇化合物的质谱分析

分析化学 2001年第3期29卷 280-282页

作者：胡长风欧阳荔彭嘉柔 Yihui Xu boon.K.Teo Department of Chemistry!University of Illinoisat Chicago IL 60607.USA 北京大学医药卫生分析中心!北京100083

用基质辅助激光解吸电离飞行时间质谱 (MALDI TOF MS)测定含有过渡金属银配位的簇类化合物苯乙炔基银的结构及其聚合度 ,比较了线性 (linear)和反射 (reflectron)飞行时间质谱各自的特点 ,探讨了银10 7Ag、10 9Ag两种同位素在质谱中的... 详细信息

用基质辅助激光解吸电离飞行时间质谱 (MALDI TOF MS)测定含有过渡金属银配位的簇类化合物苯乙炔基银的结构及其聚合度 ,比较了线性 (linear)和反射 (reflectron)飞行时间质谱各自的特点 ,探讨了银10 7Ag、10 9Ag两种同位素在质谱中的贡献及其表现。

关键词：基质辅助激光解吸电离飞行时间质谱簇类化合物银同位素

Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs

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Protein & Cell 2018年第3期9卷 283-297页

作者： Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan Key Laboratory for Major Obstetric Diseases of Guangdong Province Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150 China Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine South China Institute for Stem Cell Biology and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou 510530 China Center of Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology Kunming 650500 China Disease Modeling and Therapeutics Laboratory A'STAR Institute of Molecular and Cell Biology 61 Biopolis Drive Proteos Singapore 138673 Singapore Department of Biological Sciences National University of Singapore Singapore 117543 Singapore

Mitochondrial diseases are maternally inherited hetero- geneous disorders that are primarily caused by mitochondrial DNA （mtDNA） mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, mitochondrial defects can result in a wide spectrum of clinical manifestations. Mitochondria-targeted endonucleases provide an alternative avenue for treating mitochondrial disorders via targeted destruc- tion of the mutant mtDNA and induction of heteroplasmic shifting. Here, we generated mitochondrial disease patient-specific induced pluripotent stem cells （MiPSCs） that harbored a high proportion of m.3243A〉G mtDNA mutations and caused mitochondrial encephalomyopathy and stroke-like episodes （MELAS）. We engineered mitochondrial-targeted transcription activator-like effector nucleases （mitoTALENs） and successfully eliminated the m.3243A〉G mutation in MiPSCs. Off-target mutagenesis was not detected in the targeted MiPSC clones. Utilizing a dual fluorescence iPSC reporter cell line expressing a 3243G mutant mtDNA sequence in the nuclear genome, mitoTALENs displayed a significantly limited ability to target the nuclear genome compared with nuclear-localized TALENs. Moreover, genetically rescued MiPSCs displayed normal mitochondrial respiration and energy production. Moreover, neuronal progenitor cells differentiated from the rescued MiPSCs also demonstrated normal metabolic profiles. Further- more, we successfully achieved reduction in the human m.3243A〉G mtDNA mutation in porcine oocytes via injection of mitoTALEN mRNA. Our study shows the great potential for using mitoTALENs for specific targeting of mutant mtDNA both in iPSCs and mammalian oocytes, which not only provides a new avenue for studying mitochondrial biology and disease but also suggests a potential therapeutic approach for the treatment of mitochondrial disease, as well as the prevention of germline transmission of mutant mtDNA.

关键词： mitochondria iPSCs TALEN MELAS