Genetic Association Study of KCNB1 Gene with the Susceptibility of Hypertension Related LVH （Left Ventricular Hypertrophy） Patients in Malaysia
Genetic Association Study of KCNB1 Gene with the Susceptibility of Hypertension Related LVH （Left Ventricular Hypertrophy） Patients in Malaysia作者机构：Institute of Medical Molecular Biotechnology Faculty of Medicine Universiti Teknologi MARA Sungai Buloh 47000 Malaysia Faculty of Medicine Universiti Teknologi MARA Batu Caves 68100 Selangor Malaysia
出 版 物：《Journal of Life Sciences》 (生命科学（英文版）)
年 卷 期：2013年第7卷第4期
页 面：341-347页
学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 12[管理学] 120203[管理学-旅游管理] 1202[管理学-工商管理] 07[理学] 08[工学] 071007[理学-遗传学]
主 题：Left ventricular hypertrophy KCNBI SNP (single nucleotide polymorphism) Malaysia.
摘 要：LVH （Left ventricular hypertrophy） is an independent risk factor for the development of heart failure, cardiac arrhythmias and stroke. A recent genome-wide association study reported the involvement of a candidate gene namely KCNBI in mechanism for development of LVH in hypertension. This study aimed to replicate the finding by investigating the genetic association of KCNBI gene among the hypertensive LVH patients from Malaysia. We genotyped a SNP （single nucleotide polymorphism） located in KCNBI namely, rs6063397 among 200 subjects consisting of61 LVH and 139 non LVH patients using Sanger sequencing method. Statistical analysis revealed no significant association between the L VH susceptibility between the allele and genotype frequencies （P = 0.2719 and 0.4768, respectively）. This finding suggests that KCNBI may not playa role in LVH susceptibility in hypertensive patients in Southeast Asian populations.
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