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Prior transfusion of umbilical cord mesenchymal stem cells can effectively alleviate symptoms of motion sickness in mice through interleukin 10 secretion

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World Journal of Stem Cells 2021年第2期13卷 177-192页

作者： Hua-Su Zhu Dong li Cong li Jin-Xian Huang Shan-Shan Chen lan-bo li Qing Shi Xiu-li Ju Department of Pediatrics Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Stem Cell and Regenerative Medicine Research Center Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Animal Laboratory Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Pediatrics Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Motion sickness(MS)is a disease that occurs during unbalanced movement,characterized by gastrointestinal symptoms and autonomic nervous system *** clinical treatments for MS are *** evidence indicates that the levels of pro-inflammatory cytokines increase during MS and are associated with an inner ear immune *** the present study,mesenchymal stem cells(MSCs)have been shown to exert strong immunosuppressive *** To explore whether umbilical cord-derived mesenchymal stem cells(UC-MSCs)can prevent the occurrence of MS,and the underlying mechanism regulated by MSCs in a mouse model of *** A total of 144(equal numbers of males and females)5wkold BALB/c mice were randomly divided into five groups:Normal group(n=16),MS group(n=32),MSCs group(n=32),MS+MSCs group(n=32),and MS+AS101/MSCs group(n=32).The MSCs group(n=32),MS+MSCs group(n=32),and MS+AS101/MSCs group(n=32)were preventively transplanted with UC-MSCs or AS101-treated UC-MSCs(1×106 cells/mouse).Mice in the MS(n=32),MS+MSCs,and MS+AS101/MSCs groups were subjected to rotation on a centrifuge for 10 min at 8×g/min for MS model establishment on days 3,5,8,and 10 after UC-MSCs *** Morris water maze(MWM)test was used to observe the symptom of ***-linked immunosorbent assay(EliSA)and reverse transcription-quantitative polymerase chain reaction(RT-qPCR)were used to detect the levels of inflammatory cytokines in mice peripheral blood and the petrous part of the temporal bone *** blot analysis was performed to analyze the JAK2/STAT3 signaling pathway in the cochlear *** examination was performed by hematoxylin and eosin(HE)staining for conventional morphological evaluation in the petrous part of temporal bone *** The MWM test demonstrated that UC-MSCs improved the symptoms of *** MS+MSCs group was faster than the MS group on days 3 and 5(P=0.036 and P=0.002,respectively).EliSA and RT-qPCR showed that

关键词： Mesenchymal stem cell Motion sickness Inflammation Immune microenvironment Interleukin-10 JAK2/STAT3

Comparison on Two Different Instrumental Methods for Determination of Fat Content in Washed Cashmere

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Animal Husbandry and Feed Science 2011年第4期3卷 47-48页

作者： WANG Hong-bo CHANG Yu-lan li Wei-hong DU Tian-qing liANG li-na lanzhou Institute of Animal Science and Veterinary Pharmaceutics of CAAS Quality Supervising Inspecting and Testing Center for Animal Fi-ber Fur Leather and Products (Lanzhou) of MOA of P. R. China Lanzhou 730050China

The aim of this study was to compare two different instrumental methods for determination of fat content in washed cashmere. The fat content in washed cashmere was determined using Soxhlet fat extraction unit and fiber grease extractor quickly, respectively. The results show that no significant difference was found between these two instrumental methods, and reliability of fiber grease extractor quickly was confirmed for deter- mination of fat content in washed cashmere. Therefore, the fiber grease extractor quickly can meet current standard for determination of fat content in washed cashmere.

关键词： Cashmere Fat content Fiber grease extractor quickly Soxhlet fat extraction unit

Establishment of a high-resolution 2-D reference map of human spermatozoal proteins from 12 fertile sperm-bank donors

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Asian Journal of Andrology 2007年第3期9卷 321-329页

作者： ling-Wei li li-Qing Fan Wen-Bing Zhu Hong-Chuan Nie bo-lan Sun Ke-li Luo Ting-Ting liao Le Tang Guang-Xiu Lu Institute of Reproduction and Stem Cells Engineering Central-South University Changsha 410078 China

Aim： To extend the analysis of the proteome of human spermatozoa and establish a 2-D gel electrophoresis （2-DE） reference map of human spermatozoal proteins in a pH range of 3.5-9.0. Methods： In order to reveal more protein spots, immobilized pH gradient strips （24 cm） of broad range of pH 3-10 and the narrower range of pH 6-9, as well as different overlapping narrow range pH immobilized pH gradient （IPG） strips, including 3.5-4.5, 4.0-5.0, 4.5-5.5, 5.0-6.0 and 5.5-6.7, were used. After 2-DE, several visually identical spots between the different pH range 2-D gel pairs were cut from the gels and confirmed by mass spectrometry and used as landmarks for computer analysis. Results： The 2-D reference map with pH value from 3.5 to 9.0 was synthesized by using the ImageMaster analysis software. The overlapping spots were excluded, so that every spot was counted only once. A total of 3 872 different protein spots were identified from the reference map, an approximately 3-fold increase compared to the broad range pH 3-10 IPG strip （1 306 spots）. Conclusion： The present 2-D pattern is a high resolution 2-D reference map for human fertile spermatozoal protein spots. A comprehensive knowledge of the protein composition of human spermatozoa is very meaningful in studying dysregulation of male fertility.

关键词： human spermatozoal proteins ImageMaster mass spectrometry overlapping narrow range 2-D gel electrophoresis

Effects of anode slime removing by Fe^(2+)dissolution method on electrochemical properties of Pb−0.6%Ag anode and zinc electrowinning

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Transactions of Nonferrous Metals Society of China 2024年第11期34卷 3777-3788页

作者： Wen-jun WANG lan-bo li Xu liU Tie-chui YUAN He-xin GAO State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Zhejiang libo Industrial Co. Ltd.Shaoxing 312000China College of Mechanical and Energy Engineering Shaoyang UniversityShaoyang 422000China Zhuzhou Smelter Group Co. Ltd.Zhuzhou 412000China

Fe^(2+)dissolution method and manual method were used to remove the anode slime and their effects on properties of cast Pb−0.6wt.%Ag anode and zinc electrowinning were *** results reveal that the Fe^(2+)dissolution method can avoid mechanical damage to the oxide film layer on the anode surface,which cannot be achieved by traditional manual *** can lower the anode corrosion rate by 57.14%,thus reducing Pb contamination in electrolyte and zinc ***,compared with manual method,Fe^(2+)dissolution method can significantly improve the electrocatalytic activity of the anode and lower the initial power consumption of zinc electrowinning to 2720 kW·h/t after removing anode slime.

关键词： Pb−Ag anode zinc electrowinning anode slime removing electrochemical properties

The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian li Jun WANG Xianhui CAO Laifu GONG Jian li bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

Targets capture by distributed active swarms via bio-inspired reinforcement learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 210-221页

作者： Kun Xu Yue li Jun Sun Shuyuan Du Xinpeng Di Yuguang Yang bo li Institute of Biomechanics and Medical Engineering Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua University Institute of Nuclear and New Energy Technology Tsinghua University Shanghai Aerospace Control Technology Institute Shanghai Key Laboratory of Aerospace Intelligent Control Technology College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals. Learning from nature may provide new strategies for controlling collective dynamics of synthetic swarms to accomplish specific functions. Here, we present a bioinspired computational framework that steers distributed active swarms to collectively capture and merge targets via reinforcement learning. We exploit collective milling structures of natural herds to cage the targets, and adopt a switching control policy inspired by sperms' chiral dynamics to optimize the trajectories of individuals, through which the active swarms can selforganize to enclose single or multiple distant targets in a dynamical, adaptive and scalable manner. There exists a critical swarm size, beyond which the excessive competition between agents would generate large mechanical forces, leading to capture instability but enabling the transition from short-distance to long-distance merging capture of multiple targets. This work provides physical insights into distributed active swarms and could offer a multilevel, decentralized strategy toward controlling swarm robotics in wide applications such as bio-medical devices, machine immunity, and target clearance.

关键词： swarm intelligence robotics multi-tasks artificial intelligence bionics

中空介孔碳球修饰的丝网印刷碳电极用于尼古丁的电化学检测

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分析测试学报 2017年第8期36卷 998-1003页

作者：赵红莉李小庆施立波刘莉蓝闽波张乾华东理工大学化学与分子工程学院上海200237 上海烟草集团有限责任公司上海200082

将一步法合成的中空介孔碳球(HMCS)修饰在丝网印刷碳电极(SPCE)上,得到了用于尼古丁电化学检测的新型电极(HMCS/SPCE)。通过扫描电子显微镜(SEM)、透射电子显微镜(TEM)、粉末X射线衍射(XRD)、X射线光电子能谱(XPS)以及拉曼光谱等方法对H... 详细信息

将一步法合成的中空介孔碳球(HMCS)修饰在丝网印刷碳电极(SPCE)上,得到了用于尼古丁电化学检测的新型电极(HMCS/SPCE)。通过扫描电子显微镜(SEM)、透射电子显微镜(TEM)、粉末X射线衍射(XRD)、X射线光电子能谱(XPS)以及拉曼光谱等方法对HMCS及修饰电极HMCS/SPCE进行表征。由于HMCS具有较大的电化学活性面积和良好的导电性,修饰电极HMCS/SPCE对尼古丁表现出良好的电催化活性。在优化实验条件下,电极HMCS/SPCE对尼古丁的检测线性范围为0~500μmol/L,灵敏度为0.850 m A/(cm^2·mmol·L^(-1)),检出限为0.058μmol/L。制备的传感器具有重复性好、稳定性高等特点,可用于实际烟草样品中尼古丁的检测。

关键词：中空介孔碳球丝网印刷碳电极尼古丁电化学传感器

High-dimensional large-scale mixed-type data imputation under missing at random

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Science China Mathematics 2025年

作者： Wei liu Guizhen li ling Zhou lan Luo School of Mathematics Sichuan University Center of Statistical Research and School of Statistics Southwestern University of Finance and Economics Department of Statistics and Actuarial Science University of Iowa

Missingness in mixed-type variables is commonly encountered in a variety of areas. The requirement of complete observations necessities data imputation when a moderate or large proportion of data is ***, inappropriate imputation would downgrade the performance of machine learning algorithms, leading to bad predictions and unreliable statistical inference. For high-dimensional large-scale mixed-type missing data, we develop a computationally efficient imputation method, missing value imputation via generalized factor models（MIG）, under missing at random. The proposed MIG method allows missing variables to be of different types,including continuous, binary, and count variables, and are scalable to both data size n and variable dimension p while existing imputation methods rely on restrictive assumptions such as the same type of missing variables,the low dimensionality of variables, and a limited sample size. We explicitly show that the imputation error of the proposed MIG method diminishes to zero with the rate Op(max{n-1/2, p-1/2}) as both n and p tend to infinity. Five real datasets demonstrate the superior empirical performance of the proposed MIG method over existing methods that the average normalized absolute imputation error is reduced by 5.3%–34.1%.

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： lan Zhang Jingge Wei Xilei liu Dai li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease