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Small-cell carcinoma of the prostate with negative CD56,NSE,Syn,and CgA indicators:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1630-1638页

作者： Hong-Jin Shi Zhi-Nan Fan Jin-Song Zhang bo-bo xiong Hai-Feng Wang Jian-Song Wang Department of Urology The Second Affiliated HospitalKunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Small-cell carcinoma of the prostate(SCCP)is a clinically rare malignant tumor,accounting for<1%of all prostate ***,negativity for all SCCP neuroendocrine markers is ***,we report a case of SCCP with comple... 详细信息

BACKGROUND Small-cell carcinoma of the prostate(SCCP)is a clinically rare malignant tumor,accounting forbody bone scan suggested an abnormally active multiple bone metabolism and possible bone *** and lungs computed tomography revealed no significant nodal *** a pathological diagnosis of SCCP after a prostate puncture,with negative indicators of common sensitive neuroendocrine staining,chemotherapy was administered;the patient died 4-5 mo after SCCP *** SCCP is a rare disease characterized by atypical clinical symptoms,limited treatment options,a short survival period,and a poor prognosis.

关键词： Prostate cancer Small cell carcinoma Neuroendocrine tumor Therapeutics Diagnosis Case report

A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-bo Deng Ji xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang xiong-Ying Ji Feng-Ying Zhang Ping Zhang bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

窄带光谱成像膀胱软镜联合钬激光治疗非肌层膀胱癌的疗效观察

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中国现代医学杂志 2021年第2期31卷 72-76页

作者：熊波波张劲松李宁王海峰左毅刚昆明医科大学第二附属医院泌尿外科(云南省泌尿外科研究所) 云南昆明650101

目的探讨窄带光谱成像膀胱软镜联合钬激光在非肌层浸润性膀胱癌(NMIBC)患者中的疗效。方法选取2017年6月—2018年6月于昆明医科大学第二附属医院泌尿外科收治的NMIBC患者60例。根据不同治疗方法随机分为窄带光谱成像组和白光成像组,各3... 详细信息

目的探讨窄带光谱成像膀胱软镜联合钬激光在非肌层浸润性膀胱癌(NMIBC)患者中的疗效。方法选取2017年6月—2018年6月于昆明医科大学第二附属医院泌尿外科收治的NMIBC患者60例。根据不同治疗方法随机分为窄带光谱成像组和白光成像组,各30例。比较两组手术相关指标和并发症情况,比较两组患者术后1个月、3个月、6个月及12个月的复发率,以及原位、异位肿瘤复发情况。结果窄带光谱成像组术后总复发率较白光成像组低(P0.05)。两组术后1个月、3个月、6个月及12个月的复发率比较,差异无统计学意义(P>0.05)。结论窄带光谱成像膀胱软镜联合钬激光治疗NMIBC具有较好的疗效,安全性高,能够降低NMIBC患者术后复发率,具有临床应用的价值。

关键词：膀胱肿瘤膀胱镜肿瘤复发,局部

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浅谈高速公路改扩建交通组织技术实施方案

西部交通科技 2017年第8期 18-21页

作者：赵伊博杨传波熊伟磊江西赣粤高速公路工程公司江西南昌330013

高速公路改扩建工程交通组织方案主要包括施工组织、交通组织、安全组织三个方面,文章对比国内有代表性的高速公路改扩建工程,以昌九改扩建工程为例,研究了改扩建工程交通组织关键技术,提出了交通组织的原则以及路基、路面交通组织方案... 详细信息

高速公路改扩建工程交通组织方案主要包括施工组织、交通组织、安全组织三个方面,文章对比国内有代表性的高速公路改扩建工程,以昌九改扩建工程为例,研究了改扩建工程交通组织关键技术,提出了交通组织的原则以及路基、路面交通组织方案,为今后的改扩建工程交通组织方案制定提供参考。

关键词：高速公路改扩建交通组织技术方案

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He Pan Chen Ming Zhou bo Xiang Wei xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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Optimal Neuro-Control Strategy for Nonlinear Systems With Asymmetric Input Constraints

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 575-583页

作者： xiong Yang bo Zhao School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China School of Systems Science Beijing Normal UniversityBeijing 100875China

In this paper,we present an optimal neuro-control scheme for continuous-time(CT)nonlinear systems with asymmetric input ***,we introduce a discounted cost function for the CT nonlinear systems in order to handle the asymmetric input ***,we develop a Hamilton-Jacobi-Bellman equation(HJBE),which arises in the discounted cost optimal control *** obtain the optimal neurocontroller,we utilize a critic neural network(CNN)to solve the HJBE under the framework of reinforcement *** CNN's weight vector is tuned via the gradient descent *** on the Lyapunov method,we prove that uniform ultimate boundedness of the CNN's weight vector and the closed-loop system is ***,we verify the effectiveness of the present optimal neuro-control strategy through performing simulations of two examples.

关键词： Adaptive critic designs(ACDs) asymmetric input constraint critic neural network(CNN),nonlinear systems optimal control reinforcement learning(RL)

A robust and efficient structural reliability method combining radial-based importance sampling and Kriging

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Science China(Technological Sciences) 2018年第5期61卷 724-734页

作者： xiong bo TAN HuiFeng Center for Composite Materialsa nd Structures Harbin Institute of Technology

Simulation based structural reliability analysis suffers from a heavy computational burden, as each sample needs to be evaluated on the performance function, where structural analysis is performed. To alleviate the computational burden, related research focuses mainly on reduction of samples and application of surrogate model, which substitutes the performance function. However,the reduction of samples is achieved commonly at the expense of loss of robustness, and the construction of surrogate model is computationally expensive. In view of this, this paper presents a robust and efficient method in the same direction. The present method uses radial-based importance sampling (RBIS) to reduce samples without loss of robustness. Importantly, Kriging is fully used to efficiently implement RBIS. It not only serves as a surrogate to classify samples as we all know, but also guides the procedure to determine the optimal radius, with which RBIS would reduce samples to the highest degree. When used as a surrogate, Kriging is established through active learning, where the previously evaluated points to determine the optimal radius are reused. The robustness and efficiency of the present method are validated by five representative examples, where the present method is compared mainly with two fundamental reliability methods based on active learning Kriging.

关键词： structural reliability simulation radial-based importance sampling Kriging active learning

Localized Asymmetric Atomic Matter Waves in Two-Component bose-Einstein Condensates Coupled with Two-Photon Microwave Field

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Communications in Theoretical Physics 2008年第5期49卷 1225-1228页

作者： xiong bo Beijing National Laboratory for Condensed Matter Physics Institute of Physics the Chinese Academy of SciencesBeijing 100080 China

We investigate localized atomic matter waves in the two-photon microwave field. Interestingly, the oscillations two-component bose-Einstein condensates coupled by of localized atomic matter waves will gradually decay and finally become non-oscillating behavior even if existing coupling field. In particular, atom numbers occupied in two different hyperfine spin states will appear asymmetric occupations after some time evolution.

关键词： bose Einstein condensate Feshbach resonance soliton Josephson effect