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Luteolin alleviates sorafenib-induced ferroptosis of BRL-3A cells through modulation of the Nrf2/GPX4 signaling pathway

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Traditional Medicine Research 2024年第10期9卷 1-9页

作者： bo-wen zhang Di Yang Jin-Tao Li Mei-Hao Peng Jia-Qing Liao Qi Zhao Yi-Xi Yang Qiu-Xia Lu Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China

Background:Luteolin is a flavonoid chemical that exists in a variety of medicinal and edible plants and holds many biologically active properties in liver protection,anti-cancer,antioxidants,anti-inflammatory,neuroprotective,*** to its hepatoprotective properties,luteolin was selected to co-treat with sorafenib,one of the approved protein kinase inhibitors,to reduce sorafenib-induced normal liver cell ***:The BRL-3A cell line was treated with sorafenib to establish a liver injury model,followed by luteolin *** cell viability was detected,and the mechanism of action was detected by immunofluorescence,western blotting,and real-time quantitative ***:The research findings demonstrated that luteolin could increase cystine/glutamate transporter xCT(SLC7A11)and glutathione peroxidase 4(GPX4)expression and display a chelating effect on iron,which led to increased glutathione and decreased malondialdehyde,Fe^(2+) and lipid reactive oxygen species contents in BRL-3A cells,and the sorafenib-induced mitochondrial membrane potential decrease was also *** addition,when sorafenib caused the accumulation of lipid reactive oxygen species,luteolin could help release this oxidative stress by activating nuclear factor E2-related factor 2(Nrf2)and up-regulating the expression of the associated genes heme oxygenase 1(HO-1)and quinone oxidoreductase 1(NQO1).Conclusion:Therefore,luteolin may ameliorate sorafenib-induced ferroptosis by activating the Nrf2-associated pathway without any impact on sorafenib anti-cancer *** can be used as an adjuvant to sorafenib to reduce liver injury in patients with hepatocellular carcinoma.

关键词： luteolin sorafenib liver injury ferroptosis Nrf2/GPX4

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The flavonoids from Pentorum chinense *** ferroptosis to alleviate sorafenib-induced liver injury in BRL-3A cells

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Traditional Medicine Research 2024年第2期9卷 18-26页

作者： Di Yang bo-wen zhang Shan Lei Jin-Tao Li Mei-Hao Peng Jia-Qing Liao Xue Tang Qi Zhao Qiu-Xia Lu Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant Chengdu UniversityChengdu 610106China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China School of Pharmacy Chengdu UniversityChengdu 610106China Chengdu Analytical Applications Center Shimadzu(China)Co.Ltd.Chengdu 610023China

Background:Drug-induced liver damage is a severe medical issue that affects people all over the *** has some side effects that cause liver injury.A dietary medicinal plant called Penthorum chinense Pursh.(PCP)has hepatoprotective *** are currently few reports on PCP’s protective impact and mechanism against sorafenib-induced liver ***:To create a liver injury model,sorafenib was administered to BRL-3A *** viability assays,immunofluorescence tests,Western blotting,real-time quantitative PCR,and high-content imaging systems were utilized to examine PCP’s effect and ***:In this study,PCP treatment mitigated the liver damage caused by sorafenib by enhancing cell survival,lowering lipid reactive oxygen species and malondialdehyde levels,and elevating glutathione *** addition,PCP can enhance the protein expression of cystine/glutamate transporter xCT and glutathione peroxidase 4,reduce iron content and alleviate mitochondrial *** mechanism studies revealed that PCP inhibited ferroptosis by promoting the production of nuclear factor E2-related factor 2 nuclear translocation and subsequently affecting target genes(HO-1 and NQO1).Conclusion:Together,PCP regulates the nuclear factor E2-related factor 2 pathway,which helps to lessen ferroptosis brought on by sorafenib.

关键词： sorafenib Pentorum chinense Pursh. ferroptosis oxidative stress Nrf2

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Low power LNA using the MOSFETs in moderate inversion

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The Journal of China Universities of Posts and Telecommunications 2011年第3期18卷 120-123页

作者： XIA wen-bo zhang Xiao-lin School of Electronic Information Engineering Beihang University Beijing 100191 China

This paper presents an integrated complementary metal oxide semiconductor （CMOS） low power low noise amplifier （LNA） for global positioning system （GPS） receivers. To achieve low power dissipation, the MOS transistors in the proposed LNA are biased in moderate inversion region. It is implemented by SMIC 180 nm 1P6M CMOS process. The experiment results show that a gain of 12.14 dB@l.57 GHz is achieved with low noise figure （NF） of 1.62 dB. The power consumption of the circuit is 1.5 mW at supply voltage of 1.8 V. The ratio of gain to dc power consumption is 8 dB/mW. The size of the LNA is only 980 μm ×720 μm including the pads.

关键词： CMOS GPS LNA moderate inversion radio frequency (RF)

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Apollo: Rapidly Picking the Optimal Cloud Configurations for Big Data Analytics Using a Data-Driven Approach

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Journal of Computer Science & Technology 2021年第5期36卷 1184-1199页

作者： Yue-wen Wu Yuan-Jia Xu Heng Wu Lin-Gang Su wen-bo zhang Hua Zhong University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China

Big data analytics applications are increasingly deployed on cloud computing infrastructures,and it is still a big challenge to pick the optimal cloud configurations in a cost-effective *** this paper,we address this problem with a high accuracy and a low *** propose Apollo,a data-driven approach that can rapidly pick the optimal cloud configurations by reusing data from similar *** first classify 12 typical workloads in BigDataBench by characterizing pairwise correlations in our offline *** a new workload comes,we run it with several small datasets to rank its key characteristics and get its similar *** on the rank,we then limit the search space of cloud configurations through a classification *** last,we leverage a hierarchical regression model to measure which cluster is more suitable and use a local search strategy to pick the optimal cloud configurations in a few extra *** evaluation on 12 typical workloads in HiBench shows that compared with state-of-the-art approaches,Apollo can improve up to 30%search accuracy,while reducing as much as 50%overhead for picking the optimal cloud configurations.

关键词： big data analytics cloud configuration data driven

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InAs/InAsSb type-Ⅱ superlattice with near room-temperature long-wave emission through interface engineering

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Rare Metals 2022年第3期41卷 982-991页

作者： bo-wen zhang Dan Fang Xuan Fang Hong-Bin Zhao Deng-Kui Wang Jin-Hua Li Xiao-Hua Wang Dong-bo Wang State Key Laboratory of High Power Semiconductor Lasers School of ScienceChangchun University of Science and TechnologyChangchun 130022China School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China State Key Laboratory of Advanced Materials for Smart Sensing General Research Institute for Nonferrous MetalsBeijing 100088China Department of Opto-electronic Information Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

Ga-free InAs/InAsSb type-Ⅱ superlattices(T2SL) have extensive application prospective in infrared photodetectors. Achieving higher operation temperature is critical to its commercial applications. Here, a fractional monolayer alloy method was used to grow InAsSb alloy with better controlled alloy composition. The as-grown T2SL gave eleven satellite peaks and a first satellite peak with a narrow full-width-half-maximum (FWHM) of 20.5arcsec (1 arcsec=0.01592°). Strain mapping results indicated limited Sb diffusion through the As-Sb exchange process at the interface. Moreover, unlike interface states caused by the As-Sb exchange effect, this relatively clear interface was distinctive with localized states with higher activation energies of the non-radiative recombination process ((18±1) meV and (84±12) meV at different temperature ranges), which means that this interface state introduced by fractional monolayer alloy growth method can effectively suppress Auger recombination process in T2SL. Through this interface engineering of InAs/InAsSb Type-Ⅱ superlattice, it achieved detective photoluminescence (PL) signal with the center wavelength of 9μm at 250K.

关键词： InAs/InAsSb Superlattice Interface states High operation temperature emission

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Therapeutic efficiency of tissue-engineered human corneal endothelium transplants on rabbit primary corneal endotheliopathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 492-498页

作者： Ting-jun FAN Jun ZHAO Xiu-zhong HU Xi-ya MA wen-bo zhang Chao-zhong YANG Key Laboratory for Corneal Tissue Engineering College of Marine Life Sciences Ocean University of China Qingdao 266003 China Qingdao Dongfang Eye Hospital Qingdao 266110 China

To evaluate the therapeutic efficiency of tissue-engineered human corneal endothelia (TE-HCEs) on rabbit primary corneal endotheliopathy (PCEP),TE-HCEs reconstructed with monoclonal human corneal endothelial cells (mcHCECs) and modified denuded amniotic membranes (mdAMs) were transplanted into PCEP models of New Zealand white rabbits using penetrating *** TE-HCEs were examined using diverse techniques including slit-lamp biomicroscopy observation and pachymeter and tonometer measurements in vivo,and fluorescent microscopy,alizarin red staining,paraffin sectioning,scanning and transmission electron microscopy observations in *** corneas of transplanted eyes maintained transparency for as long as 200 d without obvious edema or immune *** corneal thickness of transplanted eyes decreased gradually after transplanting,reaching almost the thickness of normal eyes after 156 d,while the TE-HCE non-transplanted eyes were turbid and showed obvious corneal *** polygonal corneal endothelial cells in the transplanted area originated from the TE-HCE *** intact monolayer corneal endothelium had been reconstructed with the morphology,cell density and structure similar to those of normal rabbit corneal *** conclusion,the transplanted TE-HCE can reconstruct the integrality of corneal endothelium and restore corneal transparency and thickness in PCEP *** TE-HCE functions normally as an endothelial barrier and pump and promises to be an equivalent of HCE for clinical therapy of human PCEP.

关键词： Tissue-engineered human corneal endothelium New Zealand white rabbits Penetrating keratoplasty Primary corneal endotheliopathy Transparency

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Validity and reliability testing of the Chinese (mainland) version of the 39-item Parkinson's Disease Questionnaire (PDQ-39)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 531-538页

作者： Wei LUO Xiao-hong GUI bo WANG wen-ying zhang Zhi-yuan OUYANG Yi GUO Bao-rong zhang Mei-ping DING Department of Neurology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

The 39-item Parkinson's Disease Questionnaire (PDQ-39) has been tested in many languages, but not in Chinese mainland. We aimed to assess the Chinese (mainland) version of the PDQ-39. Seventy-one subjects with Parkinson's disease (PD) completed the PDQ-39 and the Medical Outcomes Study 36-item Short Form Health Survey (SF-36). All subjects were retested with the PDQ-39 a week later. The united Parkinson's disease rating scale (UPDRS) and the Hoehn and Yahr (H & Y) scale were also used to evaluate the subjects. Reliability was assessed by Cron- bach's α and intra-class correlation coefficient (ICC). Validity was examined in terms of agreement with SF-36, UPDRS, and H & Y scales. The Chinese (mainland) version of the PDQ-39 demonstrated acceptable reliability (Cronbach's α: 0.84-0.88; ICC: 0.56-0.82). The item-total correlations (0.33-0.88) and scaling success rates (77.56%) indicated satisfactory convergent and discriminant validity of the PDQ-39 items. The correlations between related constructs of the PDQ-39 and UPDRS (r=0.44-0.68) and between those of the PDQ-39 and SF-36 (r=(-0.46)-(-0.69)) were all statistically significant (Pbodily discomfort, all other dimensions of the PDQ-39 significantly discriminated patients at different H & Y stages indicated by the H & Y scale. Although our observations indicate that some problematic subscales of this version of the PDQ-39 could be improved upon, this study suggests acceptable reliability and validity of the Chinese (mainland) version of the PDQ-39.

关键词： 39-item Parkinson’s Disease Questionnaire (PDQ-39) Quality of life Validity Reliability

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Reversibly sensitizing-storing-releasing ^(1)O_(2) within a single platinum(Ⅱ)-acetylide-based metallacycle molecule via laser power modulation

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Science China Chemistry 2024年第2期67卷 604-611页

作者： Ruyi Zhou wen Lv bo Li bo Yu Sudi zhang Yucheng Zhou Shujuan Liu Qiang Zhao State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology)Nanjing University of Posts and Telecommunications(NUPT)Nanjing210023China College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and DevicesNanjing University of Posts and Telecommunications(NUPT)Nanjing210023China

Tumor hypoxia severely limits the therapeutic efficacy of photodynamic therapy(PDT) for solid tumors,which is highly dependent on tissue oxygen *** this study,we developed a platinum(Ⅱ)-acetylide-based metallacycle compound bearing six 1,4-dimethylnaphthalenes(DMN) groups,and controlled the photodynamic and photothermal effects of the compound by adjusting the power of 730 nm laser to achieve reversible sensitization,storage and release of 1~O_(2) within a single *** compound formed nanoparticles by self-assembly and exhibited good water solubility and *** laser irradiation,the strong spin-orbit coupling of platinum atoms in the metallacycle facilitated 1~O_(2) *** produced 1~O_(2) was captured by the DMN carriers and transported into the hypoxic tumor,where 1~O_(2) release was triggered owing to the good photothermal effect of the extended conjugation of the *** therapy,the metallacycle serving as a photosensitizer,1~O_(2) carrier,and photothermal reagent,achieved the synergistic therapy of PDT/PTT,demonstrating the versatility of the *** study proposes a new strategy to develop phototherapy agents that are suitable for hypoxic tumors.

关键词： metallacycles singlet oxygen endoperoxides near-infrared absorption synergistic treatment

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Sclerosing odontogenic carcinoma of maxilla:A case report

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World Journal of Clinical Cases 2023年第8期11卷 1878-1887页

作者： Hui Yuh Soh wen-bo zhang Yao Yu Ran zhang Yan Chen Yan Gao Xin Peng Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery Faculty of DentistryUniversity Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Department of Oral Pathology Peking University School of StomatologyBeijing 100081China

BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only 14 cases published to *** biological characteristics of sclerosing odontogenic carcinoma remain indistinct because of its rarity;however,it appears to be locally aggressive,with no regional or distant metastasis reported to *** SUMMARY We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman,who presented with an indolent right palatal swelling,which progressively increased in size over 7 *** subtotal maxillectomy with surgical margins of approximately 1.5 cm was *** patient remained disease free for 4 years following the ablation *** workups,treatment,and therapeutic outcomes were *** More cases are needed to further characterize this entity,understand its biological behavior,and justify the treatment *** with wide margins of approximately 1.0 to 1.5 cm is proposed,while neck dissection,post-operative radiotherapy,or chemotherapy are deemed unnecessary.

关键词： Odontogenic tumor Sclerosing odontogenic carcinoma Head and neck

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Asian Journal of Andrology 2023年第1期25卷 132-136页

作者： Wei-Hao Shao Cai-Fang Zheng Yong-Chao Ge Xiao-Rui Chen bo-wen zhang Gai-Li Wang Wei-Dong zhang Department of Epidemiology School of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Urology The Third People's Hospital of ZhengzhouZhengzhou 450000China

A cross-sectional study was conducted to estimate the age-stratified normal levels and age-related changes in the risk predictors of benign prostatic hyperplasia(BPH)progression.A total of 4706 male participants aged 40 years or older in Zhengzhou(China)were *** values of the International Prostate Symptom Score(IPSS),prostate-specific antigen(PSA),prostate volume(PV),and postvoid residual urine volume(PVR)significantly increased with *** relationships between age and IPSS scores≥8(P for nonlinearity=0.046),PSA level≥1.6 ng ml^(-1),PV≥31 ml,or PVR≥39 ml(all P for nonlinearity1),regardless of the predictors of the IPSS score,PSA level,PV,or PVR;and the OR values increased ***,after the age of 61 years,the risk predictors related to BPH progression were positively correlated with age.

关键词： aging lower urinary tract symptoms postvoid residual urine volume prostate-specific antigen prostate volume

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