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Novel biomarkers GEP/ABCB5 regulate response to adjuvant transarterial chemoembolization after curative hepatectomy for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 524-530页

作者： Charing Ching-Ning Chong Siu Tim Cheung Yue-Sun Cheung Anthony Wing-Hung Chan Stephen Lam Chan Simon Chun-Ho Yu Paul bo-San lai Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong4/F Clinical Science Building30-32 Ngan Shing StreetShatinHong KongChina Department of Anatomical and Cellular Pathology State Key Laboratory in Oncology in South ChinaPrince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Clinical Oncology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Imaging and Interventional Radiology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina

Background: Transarterial chemoembolization(TACE) is the most commonly used adjuvant therapy for hepatocellular carcinoma(HCC) after curative resection. Responses to TACE are variable due to tumor and patient heterogeneity. We had previously demonstrated that expression of Granulin-epithelin precursor(GEP) and ATP-dependent binding cassette(ABC)B5 in liver cancer stem cells was associated with chemoresistance. The present study aimed to evaluate the association between GEP/ABCB5 expression and response to adjuvant TACE after curative resection for HCC. Methods: Patients received adjuvant TACE after curative resection for HCC and patients received curative resection alone were identified from a prospectively collected database. Clinical samples were retrieved for biomarker analysis. Patients were categorized into 3 risk groups according to their GEP/ABCB5 status for survival analysis: low(GEP-/ABCB5-), intermediate(either GEP +/ABCB5-or GEP-/ABCB5 +) and high(GEP +/ABCB5 +). Early recurrence(recurrence within 2 years after resection) and disease-free survival were analyzed. Results: Clinical samples from 44 patients who had followed-up for more than 2 years were retrieved for further biomarker analysis. Among them, 18 received adjuvant TACE and 26 received surgery alone. Patients with adjuvant TACE in the intermediate risk group was associated with significantly better overall survival and 2-year disease-free survival than those who had surgery alone( P = 0.036 and P = 0.011, respectively). Adjuvant TACE did not offer any significant differences in the early recurrence rate, 2-year disease-free survival and overall survival for patients in low and high risk groups. Conclusions: Adjuvant TACE can only provide survival benefits for patients in the intermediate risk group(either GEP +/ABCB5-or GEP-/ABCB5 +). A larger clinical study is warranted to confirm its role in patient selection for adjuvant TACE.

关键词： Adjuvant therapy Hepatocellular carcinoma Drug transporter Transarterial chemoembolisation Granulin-epithelin precursor

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Selection and application of four QTLs for grain protein content in modern wheat cultivars

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Journal of Integrative Agriculture 2024年第8期23卷 2557-2570页

作者： Zihui Liu Xiangjun lai Yijin Chen Peng Zhao Xiaoming Wang Wanquan Ji Shengbao Xu State Key Laboratory of Crop Stress Biology for Arid Areas/College of Agronomy Northwest A&F UniversityYangling 712100China

The grain protein content(GPC)is the key parameter for wheat grain nutritional *** study conducted a resampling GWAS analysis using 406 wheat accessions across eight environments,and identified four previously reported GPC *** analysis of 87 landraces and 259 modern cultivars revealed the loss of superior GPC haplotypes,especially in Chinese *** haplotypes were preferentially adopted in different agroecological zones and had broad effects on wheat yield and agronomic *** GPC QTLs did not significantly reduce yield,suggesting that high GPC can be achieved without a yield *** results of this study provide a reference for future GPC breeding in wheat using the four identified QTLs.

关键词： breeding grain protein content haplotype selection and application wheat

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Model architecture level privacy leakage in neural networks

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Science China(Information Sciences) 2024年第3期67卷 20-32页

作者： Yan LI Hongyang YAN Teng HUANG Zijie PAN Jiewei lai Xiaoxue ZHANG Kongyang CHEN Jin LI Institute of Artificial Intelligent and Blockchain Guangzhou University Pazhou Lab

Privacy leakage is one of the most critical issues in machine learning and has attracted growing interest for tasks such as demonstrating potential threats in model attacks and creating model *** recent years, numerous studies have revealed various privacy leakage risks(e.g., data reconstruction attack, membership inference attack, backdoor attack, and adversarial attack) and several targeted defense approaches(e.g., data denoising, differential privacy, and data encryption). However, existing solutions generally focus on model parameter levels to disclose(or repair) privacy threats during the model training and/or model interference process, which are rarely applied at the model architecture level. Thus, in this paper, we aim to exploit the potential privacy leakage at the model architecture level through a pioneer study on neural architecture search(NAS) paradigms which serves as a powerful tool to automate a neural network *** investigating the NAS procedure, we discover two attack threats in the model architecture level called the architectural dataset reconstruction attack and the architectural membership inference attack. Our theoretical analysis and experimental evaluation reveal that an attacker may leverage the output architecture of an ongoing NAS paradigm to reconstruct its original training set, or accurately infer the memberships of its training set simply from the model architecture. In this work, we also propose several defense approaches related to these model architecture attacks. We hope our work can highlight the need for greater attention to privacy protection in model architecture levels(e.g., NAS paradigms).

关键词： neural architecture search data reconstruction attack membership inference attack

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源-荷-储协同优化的配电网平衡能力提升方法

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中国电机工程学报 2024年第13期44卷 5097-5108,I0007页

作者：顾光荣杨鹏汤波王丁来鑫上海电力大学电气工程学院上海市杨浦区200090 国网河南省电力公司信阳供电公司河南省信阳市464000 上海理工大学机械工程学院上海市杨浦区200092

在新型电力系统建设背景下,针对分布式新能源和柔性负荷大量接入导致配电网供需情况日益复杂、功率和能量平衡愈加困难等问题,该文提出一种源-荷-储协同优化的配电网平衡能力提升方法,从经济性与用能低碳性等方面提高配电网运行水平。首... 详细信息

在新型电力系统建设背景下,针对分布式新能源和柔性负荷大量接入导致配电网供需情况日益复杂、功率和能量平衡愈加困难等问题,该文提出一种源-荷-储协同优化的配电网平衡能力提升方法,从经济性与用能低碳性等方面提高配电网运行水平。首先,建立多场景下的源荷不确定性模型,在有效量化配电网源荷不确定性的基础上提取典型运行场景;其次,提出一种基于信息熵理论的源荷功率时序平衡度量化评估方法;最后,建立源-荷-储协同的两阶段优化模型,第1阶段通过事件驱动机制深入挖掘用户参与需求响应的潜力,第2阶段在储能系统建模时引入平衡度约束以促进新能源消纳,进而使配电网的平衡能力得到最大程度提升。通过浙江某地区电网实例验证所提方法对提升配电网平衡能力和新能源消纳能力的科学性和实用性。

关键词：源-荷-储协同配电网平衡能力源荷不确定性信息熵理论事件驱动

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Interpenetrating network-reinforced gel polymer electrolyte for ultra-stable lithium−iodine batteries

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Carbon Energy 2024年第6期6卷 234-247页

作者： Ying Jiang Peng Huang Minman Tong Bingxin Qi Tao Sun Zhongyun Xian Wen Yan Chao lai School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhouJiangsuChina

Li-I2 batteries have attracted much interest due to their high capacity,exceptional rate performance,and low *** so,the problems of unstable Li anode/electrolyte interface and severe polyiodide shuttle in Li-I2 batteries need to be ***,the interfacial reactions on the Li anode and I2 cathode have been effectively optimized by employing a well-designed gel polymer electrolyte strengthened by cross-linked Ti-O/Si-O(GPETS).The interpenetrating network-reinforced GPETS with high ionic conductivity(1.88×10^(-3)S cm^(-1)at 25℃)and high mechanical strength endows uniform Li deposition/stripping over 1800 h(at 1.0mA cm^(-2),with a plating capacity of 3.0mAh cm^(-2)).Moreover,the GPETS abundant in surface hydroxyls is capable of capturing soluble polyiodides at the interface and accelerating their conversion kinetics,thus synergistically mitigating the shuttle *** from these properties,the use of GPETS results in a high capacity of 207 mAh g^(-1)(1 C)and an ultra-low fading rate of 0.013%per cycle over 2000 cycles(5 C).The current study provides new insights into advanced electrolytes for Li-I2 batteries.

关键词： electrode/electrolyte interface gel polymer electrolytes lithium dendrites lithium−iodine batteries polyiodide shuttle

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Revealing the role of CCoAOMT1: fine-tuning bHLH transcription factors for optimal anther development

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Science China(Life Sciences) 2024年第3期67卷 565-578页

作者： Zesen lai Jianzheng Wang Ying Fu Menghan Wang Hong Ma Shiqing Peng Fang Chang State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological Engineering and Institute of Biodiversity SciencesInstitute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China School of Tropical Agriculture and Forestry Agriculture-Rural Affairs and Rural RevitalizationHainan UniversityHaikou 570228China Key Laboratory of Biology and Genetic Resources of Tropical Crops Ministry of AgricultureInstitute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikou 571101China Department of Biology Huck Institutes of the Life SciencesPennsylvania State UniversityUniversity ParkPA 16802USA

The tapetum,a crucial innermost layer encompassing male reproductive cells within the anther wall,plays a pivotal role in normal pollen *** transcription factors (TFs) bHLH010/089/091 redundantly facilitate the rapid nuclear accumulation of DYSFUNCTIONAL TAPETUM 1,a gatekeeper TF in the ***,the regulatory mechanisms governing the activity of bHLH010/089/091 remain *** this study,we reveal that caffeoyl coenzyme A O-methyltransferase 1 (CCoAOMT1) is a negative regulator affecting the nuclear localization and function of bHLH010 and bHLH089,probably through their K259 *** findings underscore that CCoAOMT1 promotes the nuclear export and degradation of bHLH010 and ***,elevated CCoAOMT1 expression resulted in defective pollen development,mirroring the phenotype observed in bhlh010 bhlh089 ***,our investigation revealed that the K259A mutation in the bHLH089 protein disrupted its translocation from the nucleus to the cytosol and impeded its degradation induced by ***,transgenic plants with the probHLH089::bHLH089^(K259A)construct failed to rescue proper pollen development or gene expression in bhlh010 bhlh089 ***,these findings emphasize the need to maintain balanced TF homeostasis for male *** firmly establish CCoAOMT1 as a pivotal regulator that is instrumental in achieving equilibrium between the induction of the tapetum transcriptional network and ensuring appropriate anther development.

关键词： anther development nuclear localization bHLH O-methyltransferase transcription factor homeostasis

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New Frontiers on Intracellular cGAS Activation:Molecular Mechanisms,Cellular Signaling,and Therapeutic Strategies

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Chemical Research in Chinese Universities 2024年第4期40卷 632-645页

作者： SONG Xingrui LING Xiaoting LIU Hailong ZHAO Qiang LI Xiangjun lai Weiyi WANG Hailin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing10085P.R.China School of Chemical Sciences University of Chinese Academy of SciencesBeijing101408P.R.China

Cyclic GMP-AMP(cGAMP)synthase(cGAS)plays a pivotal role in the innate immune *** the primary DNA sensor in cells,cGAS binds to dsDNA in the cytoplasm and forms cGAS-DNA liquid-liquid phase separation(LLPS)and activates its catalytic *** activation triggers the cGAS-stimulator of interferon genes(STING)signaling pathway,establishing an efficient system for pathogen *** pathogen surveillance,cGAS performs a diverse range of roles,involved in inflammatory response,metabolic homeostasis,DNA damage repair,and cell *** biological functions regulate cellular physiological homeostasis and influence the occurrence and development of *** review provides an overview of the structure,localization,and intracellular biological functions of the cGAS-STING signaling pathway and cGAS-DNA ***,we discuss their contribution to the development of tumors,autoimmune diseases,and inflammatory diseases and highlight the innovative strategies in modulating cGAS activity,either through activation or inhibition,as a promising therapeutic approach.

关键词： Cyclic GMP-AMP(cGAMP)synthase(cGAS)-stimulator of interferon genes(cGAS-STING) Liquid-liquid phase separation(LLPS) Biological function Disease

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A deep convolutional neural network for diabetic retinopathy detection via mining local and long-range dependence

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 153-166页

作者： Xiaoling Luo Wei Wang Yong Xu Zhihui lai Xiaopeng Jin bob Zhang David Zhang Shenzhen Key Laboratory of Visual Object Detection and Recognition Harbin Institute of TechnologyShenzhenChina Peng Cheng Laboratory ShenzhenChina Shenzhen Institute of Artificial Intelligence and Robotics for Society ShenzhenChina College of Big Data and Internet Shenzhen Technology UniversityShenzhenChina The Department of Computer and Information Science University of MacaoMacaoMacaoChina The Chinese University of Hong Kong(Shenzhen) ShenzhenChina

Diabetic retinopathy(DR),the main cause of irreversible blindness,is one of the most common complications of *** present,deep convolutional neural networks have achieved promising performance in automatic DR detection *** convolution operation of methods is a local cross-correlation operation,whose receptive field de-termines the size of the local neighbourhood for ***,for retinal fundus photographs,there is not only the local information but also long-distance dependence between the lesion features(*** and exudates)scattered throughout the whole *** proposed method incorporates correlations between long-range patches into the deep learning framework to improve DR ***-wise re-lationships are used to enhance the local patch features since lesions of DR usually appear as *** Long-Range unit in the proposed network with a residual structure can be flexibly embedded into other trained *** experimental results demon-strate that the proposed approach can achieve higher accuracy than existing state-of-the-art models on Messidor and EyePACS datasets.

关键词： image classification medical image processing pattern recognition

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Interpersonal psychotherapy-based psychological intervention for patient suffering from COVID-19:A case report

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World Journal of Clinical Cases 2020年第23期8卷 6064-6070页

作者： Chan-Chan Hu Jin-Wen Huang Ning Wei Shao-Hua Hu Jian-bo Hu Shu-Guang Li Jian-bo lai Man-Li Huang Dan-Dan Wang Jing-Kai Chen Xiao-Yi Zhou Zhong Wang Yi Xu Department of Mental Health The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Psychiatry The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Novel coronavirus disease 2019(COVID-19)was first found in Wuhan,China,and it has rapidly spread worldwide since the end of *** is an urgent need to treat the physical and psychological aspects of *** psychotherapy(IPT)-based psychological intervention is an evidence-based therapy for depression and post-traumatic stress *** SUMMARY This report describes a case of COVID-19 in a patient who transmitted the disease to his entire *** patient received four sessions of IPT-based psychological *** used the Hamilton Rating Scale for Depression and Patient Health Questionnaire to measure depression level,and the Hamilton Anxiety Scale and Generalized Anxiety Disorder to measure anxiety among the *** This case shows that IPT-based therapy can reduce COVID-19 patient depression and anxiety and the advantage of IPT-based therapy.

关键词： COVID-19 Psychological intervention Interpersonal therapy Interpersonal disputes Case report

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Pharmacological Effects of botanical Drugs on Myocardial Metabolism in Chronic Heart Failure

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Chinese Journal of Integrative Medicine 2024年第5期30卷 458-467页

作者： HU Yu-xuan QIU Sheng-lei SHANG Ju-ju WANG Zi lai Xiao-lei Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China

Although there have been significant advances in the treatment of heart failure in recent years,chronic heart failure remains a leading cause of cardiovascular disease-related *** studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart ***,most of the drugs that increase cardiac energy are still in the theoretical or testing *** research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate *** this review,we summarized the mechanisms by which botanical drugs(the active ingredients/formulas/Chinese patent medicines)improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptors(PPARs)and other related *** the same time,some potential protective effects of botanical drugs on myocardium,such as alleviating oxidative stress and dysbiosis signaling,caused by metabolic disorders,were briefly discussed.

关键词： botanical drugs chronic heart failure myocardial metabolism pharmacological effects review

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