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Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying fang Xiao-Rui Pan Xin-Xing Zeng Zheng-Zheng Li bo-fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

Effect of swirling flow on platelet concentration distribution in small-caliber artificial grafts and end-to-end anastomoses

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Acta Mechanica Sinica 2011年第5期27卷 833-839页

作者： fan Zhan Yu-bo fan Xiao-Yan Deng Key Laboratory for Biomechanics and Mechanobiologyof Ministry of Education School of Biological Science and Medical EngineeringBeihang University 100191 Beijing China

Platelet concentration near the blood vessel wall is one of the major factors in the adhesion of platelets to the *** our previous studies,it was found that swirling flows could suppress platelet adhesion in small-caliber artificial grafts and end-to-end *** order to better understand the beneficial effect of the swirling flow,we numerically analyzed the near-wall concentration distribution of platelets in a straight tube and a sudden tubular expansion tube under both swirling flow and normal flow *** numerical models were created based on our previous experimental *** simulation results revealed that when compared with the normal flow,the swirling flow could significantly reduce the near-wall concentration of platelets in both the straight tube and the expansion *** present numerical study therefore indicates that the reduction in platelet adhesion under swirling flow conditions in small-caliber arterial grafts,or in end-to-end anastomoses as observed in our previous experimental study,was possibly through a mechanism of platelet transport,in which the swirling flow reduced the near-wall concentration of platelets.

关键词： Platelet near-wall concentration · Swirling flow · Small-caliber arterial grafts · End-to-end anastomosis

Non-SPF routing algorithm based on ordered semi-group preference algebra

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The Journal of China Universities of Posts and Telecommunications 2017年第6期24卷 14-23页

作者： Zhang Yongtang fan bo Department of Computer Science and Technology Guangdong Neusoft Institute Foshan 528225 China Guangdong Key Laboratory of Big Data Analysis and Processing Guangzhou 510006 China

Layer 2 network technology is extending beyond its traditional local area implementation and finding wider acceptance in provider＇s metropolitan area networks and large-scale cloud data center networks. This is mainly due to its plug-and-play capability and native mobility support. Many efforts have been put to increase the bisection bandwidth in layer 2 network, which has been constrained by the spanning tree protocol （STP） that layer 2 network uses for preventing looping. The recent trend is to incorporate layer 3＇s routing approach into layer 2 network so that multiple paths can be used for forwarding traffic between any source-destination （S-D） node pair. Equal cost multipath （ECMP） is one such example. However, ECMP may still be limited in generating multiple paths due to its shortest path （lowest cost） requirement. In this paper, we consider a non-shortest-path routing approach, called equal preference multipath （EPMP） based on ordered semi group theory, which can generate more paths than ECMP. In EPMP routing, all the paths with different traditionally-defined costs, such as hops, bandwidth, etc., can be determined equally now and thus they become equal candidate paths. By the comparative tests with ECMP, EPMP routing not only generates more paths, provides 15% higher bisection bandwidth, but also identifies bottleneck links in a hierarchical network when different traffic patterns are applied EPMP is more flexible in controlling the number and length of multipath generation. Simulation results indicate the effectiveness of the proposed algorithm. It is a good reference for non-blocking running of big datacenter networks.

关键词： non-SPF routing algorithm algebraic routing equal preference multipath datacenter networks

Antibacterial and corrosive properties of copper implanted austenitic stainless steel

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 293-298页

作者： Juan Xiong bo-fan Xu Hong-wei Ni School of Physics and Electronic Technology Hubei University Wuhan 430062 China School of Material and Metallurgy Wuhan University of Science and Technology Wuhan 430081 China

Copper ions were implanted into austenitic stainless steel （SS） by metal vapor vacuum arc with a energy of 100 keV and an ions dose range of （0.5-8.0）× 10^17 cm^-2. The Cu-implanted SS was annealed in an Ar atmosphere furnace. Glancing X-ray diffraction （GXRD）, transmission electron microscopy （TEM） and Auger electron spectroscopy （AES） were used to reveal the phase compositions, microstructures, and concentration profiles of copper ions in the implanted layer. The results show that the antibacterial property of Cu-implanted SS is attributed to Cu9.9Fe0.1, which precipitated as needles. The depth of copper in Cu-implanted SS with annealing treatment is greater than that in Cu-implanted SS without annealing treatment, which improves the antibacterial property against S. aureus. The salt wetting-drying combined cyclic test was used to evaluate the corrosion-resistance of antibacterial SS, and the results reveal that the antibacterial SS has a level of corrosion-resistance equivalent to that of un-implanted SS.

关键词： copper ion implantation stainless steel antibacterial property corrosion resistance

Structural optimization strategy of pipe isolation tool by dynamic plugging process analysis

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Petroleum Science 2021年第6期18卷 1829-1839页

作者： Ting-Ting Wu Hong Zhao bo-Xuan Gao fan-bo Meng College of Mechanical and Transportation Engineering China University of PetroleumBeijing102249China

During the pipeline plugging process,both the pipeline and the pipe isolation tool(PIT)will be greatly damaged,due to the violent vibration of the flow *** this study,it was proposed for the first time to reduce the vibration of the flow field during the plugging process by optimizing the surface structure of the ***,the central composite design(CCD)was used to obtain the optimization schemes,and the drag coefficient and pressure coefficient were proposed to evaluate the degree of flow field ***,a series of computational fluid dynamics(CFD)simulations were performed to obtain the drag coefficient and pressure coefficient during dynamic *** the mathematical model of drag coefficient and pressure coefficient with the surface structure of the PIT were established ***,a modified particle swarm optimization(PSO)was applied to predict the optimal value of the surface structure of the ***,an experimental rig was built to verify the effectiveness of the *** results showed that the improved method could reduce the flow field vibration by 49.56%.This study provides a reference for the design of the PIT surface structure for flow field vibration technology.

关键词： Pipe isolation tool Dynamic analysis Drag coefficient Pressure coefficient Modified particle swarm optimization algorithm

ORGANIC/INORGANIC HYBRID EPOXY NANOCOMPOSITES BASED ON OCTA(AMINOPHENYL)SILSESQUIOXANE

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Chinese Journal of Polymer Science 2013年第1期31卷 148-158页

作者： Hai-bo fan 杨荣杰 Xiang-mei Li School of Materials Science & Engineering Beijing Institute of Technology

Octa（aminophenyl）silsesquioxane （OAPS） was used as the curing agent of diglycidyl ether of bisphenol-A （DGEBA） epoxy resin. A study on comparison of DGEBA/OAPS with DGEBA/4,4＇-diaminodiphenyl sulfone （DDS） epoxy resins was achieved. Differential scanning calorimetry was used to investigate the curing reaction and its kinetics, and the glass transition of DGEBA/OAPS. Thermogravimetric analysis was used to investigate thermal decomposition of the two kinds of epoxy resins. The reactions between amino groups and epoxy groups were investigated using Fourier transform infrared spectroscopy. Scanning electron microscopy was used to observe morphology of the two epoxy resins. The results indicated that OAPS had very good compatibility with DGEBA in molecular level, and could form a transparent DGEBA/OAPS resin. The curing reaction of the DGEBA/OAPS prepolymer could occur under low temperatures compared with DGEBA/DDS. The DGEBA/OAPS resin didn＇t exhibit glass transition, but the DGEBA/DDS did, which meant that the large cage structure of OAPS limited the motion of chains between the cross-linking points. Measurements of the contact angle indicated that the DGEBA/OAPS showed larger angles with water than the DGEBA/DDS resin. Thermogravimetric analysis indicated that the incorporation of OAPS into epoxy system resulted in low mass loss rate and high char yield, but its initial decomposition temperature seemed to be lowered.

关键词： Organic-inorganic hybrid composites Nanostructures Epoxy resin Silsesquioxane Curing kinetics.

Distributed Periodic Event-Triggered Optimal Control of DC Microgrids Based on Virtual Incremental Cost

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IEEE/CAA Journal of Automatica Sinica 2022年第4期9卷 624-634页

作者： Jiangkai Peng bo fan Zhenghong Tu Wei Zhang Wenxin Liu IEEE the Smart Microgrids and Renewable Technology(SMRT)Research Laboratory Department of Electrical and Computer EngineeringLehigh University the Department of Energy(AAU Energy) Aalborg University

This article presents a distributed periodic eventtriggered(PET)optimal control scheme to achieve generation cost minimization and average bus voltage regulation in DC *** order to accommodate the generation constraints of the distributed generators(DGs),a virtual incremental cost is firstly designed,based on which an optimality condition is derived to facilitate the control *** meet the discrete-time(DT)nature of modern control systems,the optimal controller is directly developed in the DT ***,to reduce the communication requirement among the controllers,a distributed event-triggered mechanism is introduced for the DT optimal *** event-triggered condition is detected periodically and therefore naturally avoids the Zeno *** closed-loop system stability is proved by the Lyapunov synthesis for switched *** generation cost minimization and average bus voltage regulation are obtained at the equilibrium ***,switch-level microgrid simulations validate the performance of the proposed optimal controller.

关键词： Bus voltage regulation DC microgrids event-triggered control distributed optimal control generation cost minimization

Distributed Control of Multiple-Bus Microgrid With Paralleled Distributed Generators

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 676-684页

作者： bo fan Jiangkai Peng Jiajun Duan Qinmin Yang Wenxin Liu IEEE the State Key Laboratory of Industrial Control Technology College of Control Science and Engineering Zhejiang University the Smart Microgrid and Renewable Technology (SMRT) Research Laboratory Department of Electrical and Computer Engineering Lehigh University the Global Energy Interconnection Research Institute North America (GEIRINA)

A microgrid is hard to control due to its reduced inertia and increased uncertainties. To overcome the challenges of microgrid control, advanced controllers need to be *** this paper, a distributed, two-level, communication-economic control scheme is presented for multiple-bus microgrids with each bus having multiple distributed generators(DGs) connected in parallel. The control objective of the upper level is to calculate the voltage references for one-bus subsystems. The objectives of the lower control level are to make the subsystems' bus voltages track the voltage references and to enhance load current sharing accuracy among the local DGs. Firstly, a distributed consensusbased power sharing algorithm is introduced to determine the power generations of the subsystems. Secondly, a discrete-time droop equation is used to adjust subsystem frequencies for voltage reference calculations. Finally, a Lyapunov-based decentralized control algorithm is designed for bus voltage regulation and proportional load current sharing. Extensive simulation studies with microgrid models of different levels of detail are performed to demonstrate the merits of the proposed control scheme.

关键词： Coordinate control decentralized control multiple-bus microgrid paralleled distributed generations power sharing algorithm

Adaptive Decentralized Output-Constrained Control of Single-Bus DC Microgrids

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IEEE/CAA Journal of Automatica Sinica 2019年第2期6卷 424-432页

作者： Jiangkai Peng bo fan Jiajun Duan Qinmin Yang Wenxin Liu the Smart Microgrid and Renewable Technology (SMRT) Research Laboratory Department of Electrical and Computer Engineering Lehigh University the State Key Laboratory of Industrial Control Technology College of Control Science and EngineeringZhejiang University the GEIRI North America

A single-bus DC microgrid can represent a wide range of applications. Control objectives of such systems include high-performance bus voltage regulation and proper load sharing among multiple distributed generators(DGs) under various operating conditions. This paper presents a novel decentralized control algorithm that can guarantee both the transient voltage control performance and realize the predefined load sharing percentages. First, the output-constrained control problem is transformed into an equivalent unconstrained one. Second, a two-step backstepping control algorithm is designed based on the transformed model for bus-voltage regulation. Since the overall control effort can be split proportionally and calculated with locally-measurable signals, decentralized load sharing can be realized. The control design requires neither accurate parameters of the output filters nor load measurement. The stability of the transformed systems under the proposed control algorithm can indirectly guarantee the transient bus voltage performance of the original system. Additionally, the high-performance control design is robust, flexible, and reliable. Switch-level simulations under both normal and fault operating conditions demonstrate the effectiveness of the proposed algorithm.

关键词： DC microgrids decentralized control paralleled converters output constraint