Effect of swirling flow on platelet concentration distribution in small-caliber artificial grafts and end-to-end anastomoses

作     者：Fan Zhan Yu-Bo Fan Xiao-Yan Deng 

作者机构：Key Laboratory for Biomechanics and Mechanobiologyof Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang University 100191 Beijing China 

出 版 物：《Acta Mechanica Sinica》 (力学学报（英文版）)

年 卷 期：2011年第27卷第5期

页      面：833-839页

核心收录：

学科分类：0710[理学-生物学] 080706[工学-化工过程机械] 07[理学] 08[工学] 0807[工学-动力工程及工程热物理] 0802[工学-机械工程] 0701[理学-数学] 0801[工学-力学（可授工学、理学学位）] 0702[理学-物理学] 071003[理学-生理学] 

基　　金：supported by Grant-in-Aid from the National Natural Science Foundation of China (10632010 11072023) 

主　　题：Platelet near wall concentration · Swirling flow · Small caliber arterial grafts · End to end anastomosis 

摘      要：Platelet concentration near the blood vessel wall is one of the major factors in the adhesion of platelets to the *** our previous studies,it was found that swirling flows could suppress platelet adhesion in small-caliber artificial grafts and end-to-end *** order to better understand the beneficial effect of the swirling flow,we numerically analyzed the near-wall concentration distribution of platelets in a straight tube and a sudden tubular expansion tube under both swirling flow and normal flow *** numerical models were created based on our previous experimental *** simulation results revealed that when compared with the normal flow,the swirling flow could significantly reduce the near-wall concentration of platelets in both the straight tube and the expansion *** present numerical study therefore indicates that the reduction in platelet adhesion under swirling flow conditions in small-caliber arterial grafts,or in end-to-end anastomoses as observed in our previous experimental study,was possibly through a mechanism of platelet transport,in which the swirling flow reduced the near-wall concentration of platelets.