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Application of novel constrained friction processing method to produce fine grained biomedical Mg-Zn-Ca alloy

Journal of Magnesium and Alloys 2024年第2期12卷 516-529页

作者： Ting Chen Banglong Fu Junjun Shen Uceu F.H.R.Suhuddin Björn wiese Yuanding Huang Min Wang Jorge F.dos Santos Jean Pierre Bergmann Benjamin Klusemann Solid State Materials Processing Institute of Material MechanicsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Functional Magnesium Materials Institute of Metallic BiomaterialsHelmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany Shanghai Key Laboratory of Materials Laser Processing and Modification Shanghai Jiao Tong UniversityDongchuan Road 800Shanghai 200240China Applied Materials and Manufacturing Energy and Environment DivisionPacific Northwest National LaboratoryPO Box 999RichlandWA 99352USA Production Technology Group Technisiche Universität IlmenauGustav-Kirchhoff-Platz 2Ilmenau 98693Germany Institute for Production Technology and Systems Leuphana University of LüneburgUniversitätsallee 1Lüneburg 21335Germany

In order to obtain Mg alloys with fine microstructures and high mechanical performances,a novel friction-based processing method,name as“constrained friction processing(CFP)”,was *** CFP,defect-free Mg-Zn-Ca rods with greatly refined grains and high mechanical properties were *** to the previous as-cast microstructure,the grain size was reduced from more than 1 mm to around 4μm within 3 s by a single process *** compressive yield strength was increased by 350%while the ultimate compressive strength by 53%.According to the established material flow behaviors by“tracer material”,the plastic material was transported by shear *** the base material to the rod,the material experienced three stages,*** by the tool,upward flow with additional tilt,followed by upward *** microstructural evolution was revealed by“stop-action”*** microstructural development at regions adjacent to the rod is mainly controlled by twinning,dynamic recrystallization(DRX)as well as particle stimulated nucleation,while that within the rod is related to DRX combined with grain growth.

关键词： Constrained friction processing Magnesium alloys Microstructure Mechanical properties Grain refinement Plastic deformation

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Lipid nanoparticles deliver mRNA to the blood-brain barrier

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Nano Research 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakked Randi Calkins Sebastian Rudden Camille Jones Jessie Doan Bora Jang Elisa Schrader Echeverri Ryan Zenhausern Liming Lian David Loughrey Hannah E.Peck Rachelle wiese Dorothy Koveal Philip J.Santangelo James E.Dahlman George C.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

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LDH sealing for PEO coated friction stir welded AZ31/AA5754 materials

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Nano Materials Science 2024年第4期6卷 428-442页

作者： Tatsiana Shulha Maria Serdechnova Ting Wu Thymoty Naacke Gert wiesea Carsten Blawert Mikhail L.Zheludkevich Institute of Surface Science Helmholtz-Zentrum Hereon Faculty of Engineering CAU Kiel University

The need to combine various metals in light-weight constructions requires the development of coatings that prevent galvanic corrosion. Layered double hydroxides(LDHs) can be an example of such coatings, which were previously successfully obtained in situ on individual materials. In addition, the possibility of LDH growth(including LDH growth in the presence of chelating agents) on the surface of plasma electrolytic oxidation(PEO)-coated metals was previously shown. This PEO + LDH combination could improve both corrosion and mechanical characteristics of the system. The possibility of LDHs formation in situ on the surface of PEO-coated friction stir welded(FSW) magnesium-aluminum materials(AZ31/AA5754 system was selected as a model one) was demonstrated in the presence of 1,3-diamino-2-hydroxypropane-N,N,N',N'-tetraacetic acid(DHPTA) as a chelating agent, which was selected based on analysis of respective metal-ligand compounds stability. LDHs growth was achieved under ambient pressure without addition of carbonates in the electrolyte. The effectiveness of the resulting coating is shown both for corrosion resistance and hardness.

关键词： Layered double hydroxides (LDHs) Plasma electrolytic oxidation (PEO) Chelating agent Welded magnesium-aluminum materials Functional coatings

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肿瘤患者血清中组织多肽抗原（TPA）的研究

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中华医学检验杂志 1990年第6期13卷 359-361页

作者：李春海 bjor.,B 100850，军事医学科学院基础医学研究所 00850，军事医学科学院基础医学研究所解放军总医院临床医学基础研究所军事医学科学院附属医院瑞典国家细菌研究所肿瘤免疫室

组织多肽抗原(Tissue Polypeptide Antigen简称TPA)是从各种癌组织混合物中分离纯化后得到的抗原蛋白。经放免测定表明,血清中86例正常人的平均值为70.35±30.75U／L, 105例乳腺癌平均值为131.76±213.19 U／L, 26例肝癌患者的平均值879... 详细信息

组织多肽抗原(Tissue Polypeptide Antigen简称TPA)是从各种癌组织混合物中分离纯化后得到的抗原蛋白。经放免测定表明,血清中86例正常人的平均值为70.35±30.75U／L, 105例乳腺癌平均值为131.76±213.19 U／L, 26例肝癌患者的平均值879.27±1161.68U／L,乳腺癌和肝癌患者的阳性率分别为23.8％和84.6％。本实验采用双抗体夹心法(固相双位点法),方法比较简单,快速,仅在4小时内完成全部测量过程。

关键词：组织多肽抗原放射免疫测定肿瘤

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钻井及试验室用烃分析仪

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国外分析仪器技术与应用 1989年第1期 11-19页

作者： bjor.,Ma 张爱琴

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Alloying effect of silver in magnesium on the development of microstructure and mechanical properties by indirect extrusion

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Journal of Magnesium and Alloys 2021年第1期9卷 112-122页

作者： bjor. wiese Regine Willumeit-Römer Dietmar Letzig Jan Bohlen Division Metallic Biomaterials Institute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany Magnesium Innovation Center(MagIC) Institute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany

The effect of Ag in solid solution on the microstructure,texture and the deformation behaviour of indirectly extruded Mg was *** as a solid solution strengthener affects the behaviour during extrusion,resulting in enhanced deformation related heating and corresponding coarser grained *** substantial effect on the texture development is *** mechanical properties simultaneously increase in stress and strain levels with increasing Ag content,especially in tension as a result of the changing impact of the slip modes which can be associated with a decrease of the lattice parameters as well as the c/a ratio of the hcp lattice *** compression tests with twin dominated flow,the impact is much smaller on the compressive yield stress but higher with respect to the twinning related strain hardening *** solution strength functions for Fleischer and Labusch were determined,also confirming the anisotropic behaviour of the extruded Mg alloys.

关键词： Mg-Ag-alloys Lattice parameters Indirect extrusion Microstructure Mechanical properties

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Enzymatic and metabolic regulation of lysine succinylation

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Genes & Diseases 2020年第2期7卷 166-171页

作者： Annapoorna Sreedhar Elizabeth K.wiese Taro Hitosugi Department of Molecular Pharmacology and Experimental Therapeutics Mayo ClinicRochesterMNUSA Division of Oncology Research Mayo ClinicRochesterMNUSA

Lysine succinylation(Ksucc),defined as a transfer of a succinyl group to a lysine residue of a protein,is a newly identified protein post-translational modification^*** chemical modification is reversible,dynamic,and evolutionarily conserved^4 where it has been comprehensively studied in both bacterial and mammalian cells^*** proteins involved in the regulation of various cellular and biological processes have been shown to be heavily succinylated^*** clinical data provides evidence that dysregulation of Ksucc is correlated with the development of several diseases,including cardiovascular diseases and cancer^***,an in-depth understanding of Ksucc and its regulation is important not only for understanding its physiological function but also for developing drug therapies and targeted agents for these *** this review,we highlight some of the recent advances in understanding the role of Ksucc and desuccinylation under physiological and pathological conditions.

关键词： Lysine succinylation Metabolism Post-translational modification SIRT5 Succinyl-CoA

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Factors influencing the spinal motoneurons in development

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Neural Regeneration Research 2015年第11期10卷 1773-1776页

作者： Stefan wiese Faculty for Biology and Biotechnology Group for Molecular Cell Biology Universitaetsstr.150 Ruhr University Bochum

The development of the spinal cord needs a concerted interaction of transcription factors activating diverse genes and signals from outside acting on the specification of the different cells. Signals have to act on the segments of the embryo as well as on the cranial-caudal axis and the dorso-ventral axis. Additionally the axons of the motoneurons have to cross the central nervous system barrier to connect to the periphery. Intensive anatomical studies have been followed by molecular characterization of the different subsets of transcription factors that are expressed by cells of the developing spinal cord. Here, intensive studies for the most important appearing cells, the motoneurons, have resulted in a good knowledge on the expression patterns of these proteins. Nonetheless motoneurons are by far not the only important cells and the concert activity of all cells besides them is necessary for the correct function and integrity of motoneurons within the spinal cord. This article will briefly summarize the different aspects on spinal cord development and focuses on the differentiation as well as the functionalization of motoneurons.

关键词： axon neurite synapse muscle extracellular matrix transcription factors

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全油正烷烃和类异戊二烯碳中同位素的变化

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地质地球化学 1994年第3期22卷 29-33页

作者： M.bjor.y 邵敏中科院地质新技术研究所

油样和源岩中沥青的碳同位素分析，主要是根据馏分法或全馏分法（即饱和烃、芳烃和NSO化合物）完成的。直到最近，前人对单个碳氢化合物中联同位素组成的研究受到了下列两个问题的限制：（1）使单个化合物的分辨率平衡；（2）为获得完... 详细信息

油样和源岩中沥青的碳同位素分析，主要是根据馏分法或全馏分法（即饱和烃、芳烃和NSO化合物）完成的。直到最近，前人对单个碳氢化合物中联同位素组成的研究受到了下列两个问题的限制：（1）使单个化合物的分辨率平衡；（2）为获得完善的分析结果而取得足够的分析原料。前人对单个碳氢化合物中欢同位素组成变化的研究，是利用填充柱气相色谱法收集用于分析的足够量的单个化合物；或者在最近，联合利用填充柱气相色谱仪和质谱仪，在分离单个碳氢化合物后立即分析其碳同位素组成。但这两种技术的分辨率还不足以获得精确的测量结果，而且前一种技术还很耗费时间。随着一种新的同位素比值－气相色谱法（使毛细管柱提高分辨率）的发展，这两个分析问题都已得到解决。利用这种仪器（VGIsogasIsochromⅢ）获得的实验结果表明，油件中的正烷烃与无环类异戊二烯在碳同位素组成上有着明显的差别。另外，这些类型化合物的同位素组成的差别似乎与源岩和成熟度的变化有关。本文介绍并讨论了一些精选的油样例子。

关键词：石油正烷烃碳同位素二烯碳

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Surface modification of biomedical Mg-Ca and Mg-Zn-Ca alloys using selective laser melting: Corrosion behaviour, microhardness and biocompatibility

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Journal of Magnesium and Alloys 2021年第6期9卷 2155-2168页

作者： Xiyu Yao Jincheng Tang Yinghao Zhou Andrej Atrens Matthew S.Dargusch Bjoern wiese Thomas Ebel Ming Yan School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China The University of Queensland School of Mechanical and Mining EngineeringCentre for Advanced Materials Processing and Manufacturing(AMPAM)QLD 4072 Australia Institute of Materials Research Helmholtz-Zentrum GeesthachtGeesthacht 21502Germany

Magnesium alloys such as Mg–Ca and Mg–Zn–Ca are good orthopaedic materials;however their tendency to corrode is *** we utilize selective laser melting(SLM)to modify the surface of these Mg alloys to simultaneously improve the corrosion behaviour and *** corrosion rate decreased from 2.1±0.2 mm/y to 1.0±0.1 mm/y for the laser-processed Mg–0.6Ca,and from 1.6±0.1 mm/y to 0.7±0.2 mm/y for laser-processed Mg–0.5Zn–*** microhardness increased from 46±1 HV to 56±1 HV for Mg–0.6Ca,and from 47±3 HV to 55±3 HV for Mg–0.5Zn–*** addition,good biocompatibility remained in the laser processed Mg *** improved properties are attributed to laser-induced grain refinement,confined impurity elements,residual stress,and modified surface *** results demonstrated the potential of SLM as a surface engineering approach for developing advanced biomedical Mg alloys.

关键词： Mg alloys Selective laser melting Surface modification Corrosion behaviour Microhardness

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