Enzymatic and metabolic regulation of lysine succinylation

作     者：Annapoorna Sreedhar Elizabeth K.Wiese Taro Hitosugi 

作者机构：Department of Molecular Pharmacology and Experimental TherapeuticsMayo ClinicRochesterMNUSA Division of Oncology ResearchMayo ClinicRochesterMNUSA 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2020年第7卷第2期

页      面：166-171页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 0703[理学-化学] 10[医学] 

基　　金：We apologize to any authors whose work could not be included owing to space limitations.This work was supported in part by NIH R01 CA225680-01(T.H.) Research Scholar Grant(RSG-19-076-01-TBE)from the American Cancer Society(T.H.) Career Catalyst Research funding(CCR14300798)from the Susan G.Komen Foundation(T.H.),the Eagles Cancer Research Fund(T.H.),a Team Science Platform Award from the Mayo Clinic Center for Biomedical Discovery(T.H.),the Developmental Therapeutics Program from the Mayo Clinic Cancer Center(T.H.),and the Mayo Clinic Breast SPORE P50CA 116201-10(T.H.).E.K.W.was supported by a predoctoral fellowship from the Mayo Foundation for Education and Research 

主　　题：Lysine succinylation Metabolism Post-translational modification SIRT5 Succinyl-CoA 

摘      要：Lysine succinylation(Ksucc),defined as a transfer of a succinyl group to a lysine residue of a protein,is a newly identified protein post-translational modification^*** chemical modification is reversible,dynamic,and evolutionarily conserved^4 where it has been comprehensively studied in both bacterial and mammalian cells^*** proteins involved in the regulation of various cellular and biological processes have been shown to be heavily succinylated^*** clinical data provides evidence that dysregulation of Ksucc is correlated with the development of several diseases,including cardiovascular diseases and cancer^***,an in-depth understanding of Ksucc and its regulation is important not only for understanding its physiological function but also for developing drug therapies and targeted agents for these *** this review,we highlight some of the recent advances in understanding the role of Ksucc and desuccinylation under physiological and pathological conditions.