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Injections of Substances Inducing Apoptosis to Cancer Cells but Stimulation of Normal Cells May Prevent Cancer

Journal of Chemistry and Chemical Engineering 2011年第5期5卷 393-403页

作者： birgit Elisabeth Swenson Tegelformsgatan 4 Moelnda143136 Sweden

Selenium（Se） compounds have prevented and Se-deficiency has induced the initiation of cancer. Se（0）-forming compounds and hydroxy-xanthones have killed cancer ceils but shown beneficial effects to normal cells. They may together be effective in the treatment of cancer. Many enzymes which contain selenocysteine （Secys） can catalyze reactions with reducible oxygen （O2~ 02 or H202）. Experiments strongly support that Se-enzymes are activated by Se（0）, from e.g. selenite, selenodiglutathione, binding to Se（-II） in Secys, forming an electron conducting Se-link to reducible oxygen as a protection against oxidations. Cancer cells, which are energy supported only from fermentation, are not dependent on Se which is why they are more sensitive to toxic effects of Se than normal cells. The energy from fermentation is insufficient for normal cell functions. High doses of Se（0）-containing compounds are toxic in that they form links with thiols （R-S-Se） reducing their reaction rate. The reaction of an SH-enzyme, necessary in fermentation, is impaired. Mangostins （hydroxy-xanthones） induce apoptosis in human cancer ceils but stimulate respiration. The OH-groups are responsible for the effects and the reduction of NADP＋ into NADPH. Fermentation is inhibited as NADP＋ is necessary for the process. Cancer may be treated by injections of Se（0）-forming compounds and hydroxy-xanthones into cancer cells in doses causing apoptosis. However, in diluted form, when meting normal cells, the substances promote the yield of energy by stimulating the electron transference to reducible oxygen. Se（0）-activated Se-links and hydrogen from hydroxy-xanthones hopefully prevent the initiation of cancer.

关键词： Cancer prevention Se-enzymes Se-link selenite nicotine hydroxy-xanthones.

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Long-term follow-up after complete ablation of Barrett's esophagus with argon plasma coagulation

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World Journal of Gastroenterology 2005年第8期11卷 1182-1186页

作者： Ahmed Madisch Stephan Miehike Ekkehard Bayerdoerffer birgit Wiedemann David Antos Anke Sievert Michael Vieth Manfred Stolte Heinrich Schulz Medical Department Ⅰ Department of Hematology and Oncology Institute of Medical Statistics and Biometry Clinic for Pediatric Diseases Gastroenterologist in private practice Institute of Pathology

AIM: To report the long-term outcome of patients after complete ablation of non-neoplastic Barrett's esophagus (BE) with respect to BE relapse and development of intraepithelial neoplasia or esophageal adenocarcinoma. METHODS: In 70 patients with historically proven non neoplastic BE, complete BE ablation was achieved by argon plasma coagulation (APC) and high-dose proton pump inhibitor therapy (120 mg omeprazole daily). Sixty-six patients (94.4%) underwent further surveillance endoscopy. At each surveillance endoscopy four-quadrant biopsies were taken from the neo-squamous epithelium at 2 cm intervals depending on the pre-treatment length of BE mucosa beginning at the neo-Z-line, and from any endoscopically suspicious lesion. RESULTS: The median follow-up of 66 patients was 51 mo (range 9-85 mo) giving a total of 280.5 patient years. A mean of 6 biopsies were taken during surveillance endoscopies. In 13 patients (19.7%) tongues or islands suspicious for BE were found during endoscopy. In 8 of these patients (12.1%) non-neoplastic BE relapse was confirmed histologically giving a histological relapse rate of 3% per year. In none of the patients, intraepithelial neoplasia nor an esophageal adenocarcinoma was detected. Logistic regression analysis identified endoscopic detection of islands or tongues as the only positive predictor of BE relapse (P= 0.0004). CONCLUSION: The long-term relapse rate of non neoplastic BE following complete ablation with high-power APC is low (3% per year).

关键词： Barrett's esophagus Argon plasma coagulation Esophageal adenocarcinoma

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Automatic Visual Leakage Detection and Localization from Pipelines in Chemical Process Plants Using Machine Vision Techniques

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Engineering 2021年第6期7卷 758-776页

作者： Mina Fahimipirehgalin Emanuel Trunzer Matthias Odenweller birgit Vogel-Heuser Institute of Automation and Information Systems Technical University of MunichGarching 85748Germany Evonik Technology and Infrastructure GmbH Hanau 63450Germany

Liquid leakage from pipelines is a critical issue in large-scale process *** in pipelines affects the normal operation of the plant and increases maintenance ***,it causes unsafe and hazardous situations for ***,the detection and localization of leakages is a crucial task for maintenance and condition ***,the use of infrared(IR)cameras was found to be a promising approach for leakage detection in large-scale *** cameras can capture leaking liquid if it has a higher(or lower)temperature than its *** this paper,a method based on IR video data and machine vision techniques is proposed to detect and localize liquid leakages in a chemical process *** the proposed method is a vision-based method and does not consider the physical properties of the leaking liquid,it is applicable for any type of liquid leakage(i.e.,water,oil,etc.).In this method,subsequent frames are subtracted and divided into ***,principle component analysis is performed in each block to extract features from the *** subtracted frames within the blocks are individually transferred to feature vectors,which are used as a basis for classifying the *** k-nearest neighbor algorithm is used to classify the blocks as normal(without leakage)or anomalous(with leakage).Finally,the positions of the leakages are determined in each anomalous *** order to evaluate the approach,two datasets with two different formats,consisting of video footage of a laboratory demonstrator plant captured by an IR camera,are *** results show that the proposed method is a promising approach to detect and localize leakages from pipelines using IR *** proposed method has high accuracy and a reasonable detection time for leakage *** possibility of extending the proposed method to a real industrial plant and the limitations of this method are discussed at the end.

关键词： Leakage detection and localization Image analysis Image pre-processing Principle component analysis k-nearest neighbor classification

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Deletion of a Stay-Green Gene Associates with Adaptive Selection in Brassica napus

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Molecular Plant 2016年第12期9卷 1559-1569页

作者： Lunwen Qian Kai Voss-Fels Yixin Cui Habib U. Jan birgit Samans Christian Obermeier Wei Qian Rod J. Snowdon Department of Plant Breeding IFZ Research Centre for Biosystems Land Use and Nutrition Justus Liebig University Heinrich-Buff-Ring 26-32 35392 Giessen Germany College of Agronomy and Biotechnology Southwest University 400716 Chongqing China

Chlorophyll levels provide important imrormation about plant growth and physiological plasticity in response to changing environments. The stay-green gene NON-YELLOWING 1 （NYE1） is believed to regu-late chlorophyll degradation during senescence, concomitantly affecting the disassembly of the light- harvesting complex and hence indirectly influencing photosynthesis. We identified Brassica napus acces- sions carrying an NYE1 deletion associated with increased chlorophyll content, and with upregulated expression of light-harvesting complex and photosynthetic reaction center （PSI and PSII） genes. Compar- ative analysis of the seed oil content of accessions with related genetic backgrounds revealed that the B. napus NYE1 gene deletion （bnnyel） affected oil accumulation, and linkage disequilibrium signatures suggested that the locus has been subject to artificial selection by breeding in oilseed B. napus forms. Comparative analysis of haplotype diversity groups （haplogroups） between three different ecotypes of the allopolyploid B. napus and its A-subgenome diploid progenitor, Brassica rapa, indicated that introgres- sion of the bnnyel deletion from Asian B. rapa into winter-type B. napus may have simultaneously improved its adaptation to cooler environments experienced by autumn-sown rapeseed.

关键词： rapeseed breeding chlorophyll photosynthesis presence-absence variation PAV

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Protein supplementation intake for bodybuilding and resista nee training may impact sperm quality of subfertile men undergoing fertility treatment:a pilot study

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Asian Journal of Andrology 2019年第2期21卷 208-211页

作者： Shathmigha Ketheeswaran Thor Haahr Betina Povlsen Rita Laursen birgit Alsbjerg Helle Elbaek Sandro C Esteves Peter Humaidan The Fertility Clinic Skive Regional Hospital Resenvej 25Skive 7800Denmark Faculty of Health Aarhus UniversityAarhus C 8000Denmark ANDROFERT Center for Male ReproductionCampinas 13075-460Brazil Department of Surgery Division of UrologyUniversity of Campinas(UNICAMP)Campinas 13083-887Brazil

Dear Editor,During the last decade,there has been an increase in the usage of dietary protein supplements for bodybuilding,especially among young men who work out in commercial gyms.1 Recently,it was shown that 23 of 24 dietary supplements available in fitness equipment and online shops contained anabolic steroids.2 However,these supposedly pro-androgenic supplements presumably differ from the more commonly used whey and soy protein supplements.3,4 Notwithstanding,both products are listed as dietary supplements rather than medical drugs;thus,they are not rigorously tested,5 do not necessarily list all contents,2 and consequently might contain known and unknown active components3,6.

关键词： bodybuilding Protein supplementation fertility treatment

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Zoonotic sources and the spread of antimicrobial resistance from the perspective of low and middle-income countries

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Infectious Diseases of Poverty 2023年第3期12卷 73-87页

作者： Ioana D.Olaru birgit Walther Frieder Schaumburg Institute of Medical Microbiology University of MünsterMünsterGermany Advanced Light and Electron Microscopy Robert Koch-InstituteBerlinGermany Department of Environmental Hygiene German Environment AgencyBerlinGermany

Background Antimicrobial resistance is an increasing challenge in low and middle-income countries as it is wide-spread in these countries and is linked to an increased *** from human and environmental factors,animal-related drivers of antimicrobial resistance in low-and middle-income countries have special features that differ from high-income *** aim of this narrative review is to address the zoonotic sources and the spread of antimicrobial resistance from the perspective of low-and middle-income *** body Contamination with extended-spectrum beta-lactamase(ESBL)-producingEscherichia coli is highest in poultry(Africa:8.9–60%,Asia:53–93%)and there is a risk to import *** through poultry meat in *** aquacultures,the proportion of ESBL-producers *** can be high(27%)but the overall low quality of published studies limit the general conclusion on the impact of aquacultures on human *** colonization of wildlife is 1–9%in bats or 2.5–63%*** most of them are migratory animals,they can disperse antimicrobial resistant bacteria over large ***-called‘filth flies’are a relevant vector not only of enteric pathogens but also of antimicrobial resistant bacteria in settings where sanitary systems are *** Africa,up to 72.5%of‘filth flies’are colonized with ***,mostly conferred by CTX-M(24.4–100%).While methicillin-resistantStaphylococcus aureus plays a minor role in livestock in Africa,it is frequently found in South America in poultry(27%)or pork(37.5–56.5%)but less common in Asia(poultry:3%,pork:1–16%).Conclusions Interventions to contain the spread of AMR should be tailored to the needs of low-and middle-income *** comprise capacity building of diagnostic facilities,surveillance,infection prevention and control in small-scale farming.

关键词： Antimicrobial resistance Extended-spectrum Beta-lactamase Methicillin-resistant Staphylococcus aureus

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哈斯马格推出Multigrind CU小型磨床

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工具技术 2017年第9期51卷 I0009-I0010页

作者： birgit Hummler

复杂几何形状工件的磨削加工正朝着整序加工发展。在整序加工趋势下。哈斯马格磨床有限公司推出了一款结构紧凑、占地面积小的CU型磨床，其刚性及柔性方面丝毫不逊色于哈斯马格其他大规格磨床。

关键词：磨床 CU 磨削加工几何形状结构紧凑占地面积整序

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Development of early gastric cancer 4 and 5 years after complete remission of Helicobacter pyloriassociated gastric low-grade marginal zone B-cell lymphoma of MALT type

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World Journal of Gastroenterology 2001年第2期7卷 248-253页

作者： Andrea Morgner Stephan Miehlke Manfred Stolte Andreas Neubauer birgit Alpen Christian Thiede Hermann Klann Franz-Xaver Hierlmeier Christian Ell Gerhard Ehninger Ekkehard Bayerdorffer Medical Department I Technical University HospitalFetscherstr.74Dresden Institute for Pathology Klinikum BayreuthPreuschwitzer Str.101Bayreuth Centre for Internal Medicine UniversityhospitalBaldingerstr.Marburg Private Gastroenterologist Exerzierplatz 12Passau Med.Dept. Krankenhaus KehlheimKehlheim Centre for Internal Medicine HSKLudwig-Erhard-Str.100WiesbadenGermany

AIM: To report 3 of 120 patients on the German MALT lymphoma trial with H. pylori associated gastric MALT lymphoma who developed early gastric cancer 4 and 5 years, after complete lymphoma remission following cure of H. pylori infection. PATIENTS AND RESULTS: Three patients (two men, 74 and 70 years; one women, 77 years) with H. pylori-associated low-grade MALT lymphoma achieved complete lymphoma remission after being cured. Surveillance endoscopies were performed twice a year in accordance to the protocol. Four years after complete lymphoma remission in two patients, and after 5 years in the other, early gastric adenocarcinoma of the mucosa-type, type IIa and type IIc, respectively, was detected, which were completely removed by endoscopic mucosa resection. In one patient, the gastric cancer was diagnosed at the same location as the previous MALT lymphoma, in the other patients it was detected at different sites of the stomach distant from location of the previous MALT lymphoma. The patients were H. pylori negative during the whole follow-up time. CONCLUSION: These findings strengthen the importance of regular Long-term follow-up endoscopies in patients with complete remission of gastric MALT lymphoma after cure of H. pylori infection. Furthermore, gastric adenocarcinoma may develop despite eradication of H. pylori.

关键词： Helicobacter pylori Adenocarcinoma Aged Disease Susceptibility Female Helicobacter Infections Humans Lymphoma, Mucosa-Associated Lymphoid Tissue Male Remission Induction Stomach Neoplasms

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北京夏季高温高湿和降水过程对大气颗粒物谱分布的影响

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环境科学 2006年第11期27卷 2293-2298页

作者：胡敏刘尚吴志军张静赵云良 birgit Wehner Alfred Wiedensohler 北京大学环境学院环境模拟与污染控制国家联合重点实验室北京100871 德国莱比锡对流层研究所莱比锡04318

2004—07—13～2004—08—23使用TDMPS-APS系统在线测量颗粒物的数浓度谱分布，并于07—16～07—18选取了高温闷热夜晚、日间高温高湿和雨后晴朗干洁3种天气条件，使用多级串联撞击式采样器（MOUDI）测量颗粒物的质量浓度谱分布，结果... 详细信息

2004—07—13～2004—08—23使用TDMPS-APS系统在线测量颗粒物的数浓度谱分布，并于07—16～07—18选取了高温闷热夜晚、日间高温高湿和雨后晴朗干洁3种天气条件，使用多级串联撞击式采样器（MOUDI）测量颗粒物的质量浓度谱分布，结果表明，高温高湿天气条件下颗粒物的污染、尤其细粒子污染严重，导致很低的能见度（2．5km）；PM1．8和PM10的质量浓度分别为170．68μg／m^3和249．35μg／m^3，细粒子质量浓度占PM10的68％；粒径为50～100nm颗粒物的数浓度最高，为2×10^4～3×10^4个／cm^3；降雨过程对粗粒子和细粒子均有去除作用，对细粒子的去除作用尤为明显；降雨后PM10和PM1．8浓度分别比降雨前降低3倍和6倍；降雨过后的晴朗干洁天气有利于新粒子（3～20nm）的生成，生成的新粒子快速长大到50～100nm；随着污染物的累积，以后几天内又变为污染天气．

关键词：颗粒物质量浓度谱分布数浓度谱分布高温高湿降雨

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You Need to Know More to Understand My Scoring on the Survey: Free-Text Comments as Part of a PROM-Survey of Men with Prostate Cancer

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Open Journal of Nursing 2016年第5期6卷 365-375页

作者： Senada Hajdarevic birgit H. Rasmussen Per Fransson Department of Nursing Ume&aring University Ume&aring Sweden Department of Health Sciences Lund University Lund Sweden

Prostate cancer and its treatment have long-term implications for men’s lives. We aimed to describe the content, extent, and frequency of written comments to the open-ended question, “Further comments?” in the patient-reported outcome measures questionnaire. During the study period, 897 men participated;372 wrote 747 free-text comments in the questionnaire. These comments were analysed using qualitative content analysis and were grouped into four categories: 1) prostate cancer’s influence on health;2) clarifications of answers to the survey;3) descriptions of well-being despite the cancer;and 4) experiences of care and the need for contact with health care. The distribution of the comments shifted over time. The open-ended question not only allowed the participants to explain their other responses and describe important aspects of their lives during and after treatment, something not normally covered by a questionnaire, but it also indicated their experiences of health care services along the patients’ PC-trajectory. This further raises the issue of including an open-ended item in a forced-choice survey into the ethical realm to ensure that proper care is taken of participants’ answers and thoughts.

关键词： Prostate Cancer Questionnaire Open-Ended Question Information Feedback Quality of Life Nursing

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