Injections of Substances Inducing Apoptosis to Cancer Cells but Stimulation of Normal Cells May Prevent Cancer

作     者：Birgit Elisabeth Swenson 

作者机构：Tegelformsgatan 4 Moelnda143136 Sweden 

出 版 物：《Journal of Chemistry and Chemical Engineering》 (化学与化工（英文版）)

年 卷 期：2011年第5卷第5期

页      面：393-403页

学科分类：0710[理学-生物学] 090601[农学-基础兽医学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0906[农学-兽医学] 

主　　题：正常细胞 诱导凋亡 癌细胞 癌症 物质 注射 硒缺乏症 氧杂蒽酮 

摘      要：Selenium(Se) compounds have prevented and Se-deficiency has induced the initiation of cancer. Se(0)-forming compounds and hydroxy-xanthones have killed cancer cells but shown beneficial effects to normal cells. They may together be effective in the treatment of cancer. Many enzymes which contain selenocysteine (Secys) can catalyze reactions with reducible oxygen (O2, O2 -, or H2O2). Experiments strongly support that Se-enzymes are activated by Se(0), from e. g. selenite, selenodiglutathione, binding to Se(-II) in Secys, forming an electron conducting Se-link to reducible oxygen as a protection against oxidations. Cancer cells, which are energy supported only from fermentation, are not dependent on Se which is why they are more sensitive to toxic effects of Se than normal cells. The energy from fermentation is insufficient for normal cell functions. High doses of Se(0)-containing compounds are toxic in that they form links with thiols (R?S?Se-) reducing their reaction rate. The reaction of an SH-enzyme, necessary in fermentation, is impaired. Mangostins (hydroxy-xanthones) induce apoptosis in human cancer cells but stimulate respiration. The OH-groups are responsible for the effects and the reduction of NADP+ into NADPH. Fermentation is inhibited as NADP+ is necessary for the process. Cancer may be treated by injections of Se(0)-forming compounds and hydroxy-xanthones into cancer cells in doses causing apoptosis. However, in diluted form, when meting normal cells, the substances promote the yield of energy by stimulating the electron transference to reducible oxygen. Se(0)-activated Se-links and hydrogen from hydroxy-xanthones hopefully prevent the initiation of cancer.