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Air-Decking Technique in Bench Blasting

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Journal of China University of Mining and Technology 2006年第2期16卷 184-188页

作者： ZHU Hong-bing lu wen-bo WU Liang Key Laboratory of Water Resource and Hydropower Engineering Science Wuhan University Wuhan Hubei 430072 China

The mechanism and the design parameters of blasting with air-decking are studied. The theory of detonation waves is used to investigate the processes of the one-dimensional plane detonation wave within a borehole. The interac- tion of the rarefaction wave with an interface and reflection on a rigid wall is also analyzed. The same courses of the shock wave are also investigated. This decides the distribution of the pressure of the explosion products changing with time along the borehole. Based on the above theoretical analysis, two conditions should be met for a reasonable range of values of the air-decking ratio in blasting rock. First, the rarefaction wave from the contact interface between detonation products and air reaches the bottom earlier than that of the reflected shock wave from the end of the stemming. Second, the reflected shock wave reaches the contact interface between the detonation products and air earlier than that of the reflected rarefaction wave from the bottom of the borehole. Finally, the reasonable value of the air-decking ratio must be decided theoretically in air-decking blasting. For different explosives, the reasonable range of air-decking ratio varies from 0.15 to 0.4. This result is well consistent with what was obtained by previous researchers.

关键词： air-decking technique bench blasting detonation wave air-decking ratio

In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis:a narrative review

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1979-1985页

作者： bing-wen lu Guo-Jun Chao Gai-Ping Wu Li-Ke Xie Department of Ophthalmology Ophthalmology Hospital of China Academy of Traditional Chinese MedicineBeijing 100040China

Retinitis pigmentosa(RP)is the most recognized inherited retinal disorder involving progressive photoreceptors degeneration which eventually causes ***,the pathogenesis of RP is still unclear,making it difficult to establish satisfying *** have been found to support the theory that vascular dysfunction is associated with the progression of *** coherence tomography angiography(OCTA)is a newly developed technology that enables visualization as well as quantitative assessment of retinal and choroidal vasculature *** in OCTA have opened a window for indepth understanding of RP ***,we propose a hypothesis of RP pathogenesis based on the current OCTA findings in RP,which includes four stages and two important key factors,vascular dysfunction and microglia ***,we discuss the future animal experiments needed and how advanced OCTA technology can help to further verity the *** final goal is to explore potential treatment options with enhanced understanding of RP pathogenesis.

关键词： retinitis pigmentosa optical coherence tomography angiography vascular dysfunction microglia activation

More than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration

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Neural Regeneration Research 2019年第9期14卷 1494-1498页

作者： bing-wen lu Larry Baum Kwok-Fai So Kin Chiu Li-Ke Xie Department of Ophthalmology Eye HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administration RegionChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Genomic Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Li Ka Shing Faculty of MedicineHong Kong Special Administration RegionChina Department of Psychiatry Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Li Ka Shing Faculty of MedicineHong Kong Special Administration RegionChina GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina Funding:This

Artemisinin,also called qinghaosu,is originally derived from the sweet wormwood plant(Artemisia annua),which is used in traditional Chinese *** and its derivatives(artemisinins)have been widely used for many years as anti-malarial agents,with few adverse side ***,evidence has recently shown that artemisinins might have a therapeutic value for several other diseases beyond malaria,including cancers,inflammatory diseases,and autoimmune *** is a challenging age-associated neurological disorder characterized by deterioration of neuronal structures as well as functions,whereas neuroinflammation has been considered to be an underlying factor in the development of various neurodegenerative disorders,including Alzheimer’s *** discovered properties of artemisinins suggested that they might be used to treat neurodegenerative disorders by decreasing oxidation,inflammation,and amyloid beta protein(Aβ).In this review,we will introduce artemisinins and highlight the possible mechanisms of their neuroprotective activities,suggesting that artemisinins might have therapeutic potential in neurodegenerative disorders.

关键词： artemisinin inflammation neuroinflammation neurodegeneration Alzheimer’s disease Parkinson’s disease Aβ anti-oxidation neuroprotection neural regeneration

MODELING UNCONFINED SEEPAGE FLOW USING THREE-DIMENSIONAL NUMERICAL MANIFOLD METHOD

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Journal of Hydrodynamics 2010年第4期22卷 554-561页

作者： JIANG Qing-hui DENG Shu-shen ZHOU Chuang-bing lu wen-bo School of Civil Engineering Wuhan University Wuhan 430072 China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan 430072 China

Three-dimensional numerical manifold method for unconfined seepage analysis is proposed in this *** constructing hydraulic potential functions of the manifold element,the element conductivity matrix and the global simultaneous equations for unconfined seepage analysis are derived in *** algorithm of locating the free surface and the formula for seepage forces are also ***-dimensional manifold method employs the tetrahedral mathematical meshes to cover the whole material *** the iterative process for locating the free surface,the manifold method can achieve an accurate seepage analysis of the saturated domain below the free surface with mathematical meshes *** the shape of manifold elements can be arbitrary,the disadvantage of changing the permeability of transitional elements cut by the free surface in the conventional Finite Element Method（FEM） is removed,and the accuracy of locating the free surface can be ***,the seepage force acting on the transitional elements can be accurately calculated by the simplex *** results for a typical example demonstrate the validity of the proposed method.

关键词： three-dimensional seepage numerical manifold method free surface mathematical mesh manifold element

Combined central retinal artery and vein occlusion associated with primary antiphospholipid syndrome treated by injection of dexamethasone intravitreal implant and anticoagulant therapy: a case report

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 1027-1029页

作者： bing-wen lu Li-Ke Xie Xiao-Feng Hao Xiao-Yan Zhang Jie luo Department of Ophthalmology Ophthalmology Hospital of China Academy of Traditional Chinese MedicineBeijing 100040China

Dear Editor,We present a case of combined central retinal artery and vein occlusion associated with primary antiphospholipid syndrome(APS) treated by injection of dexamethasone intravitreal implant(Ozurdex;) and anticoagulant therapy. Written informed consent was obtained by the patient to allow publication of this case. The study was conducted in accordance with the tenets of the Declaration of Helsinki.

关键词： injection occlusion implant

Retinal safety and toxicity study of artesunate in vitro and in vivo

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Advances in Ophthalmology Practice and Research 2023年第2期3卷 47-54页

作者： bing-wen lu Yu-Xiang Liang Jin-Feng Liu Zhong-Qing Sun Kwok-Fai So Kin Chiu Department of Ophthalmology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong KongChina Department of Psychology Faculty of Social SciencesThe University of Hong KongHong KongChina Guangdong-Hongkong-Macao(GHM)Institute of CNS Regeneration Ministry of EducationCNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouChina

Background:Artesunate(ART),a member of the artemisinin family,possesses multi-properties,including antiinflammation,anti-oxidation,and *** was recently reported to show anti-neovascularization effect on the cornea,iris,and *** to the expensive anti-VEGF treatment,this versatile,economical treatment option is attractive in the ophthalmic *** safety and toxicity profile of ART intravitreal application are in utmost ***:In this study,immortalized microglial(IMG)cells were treated with ART to determine the safe concentrations without inducing overt inflammatory *** transcription-polymerase chain reaction analysis was used to detect the cytokine expressions in IMG cells in response to ART *** doses of ART were intravitreally injected into the right eyes of C57BL/6 *** function was tested by electroretinogram,and retinal ganglion cell(RGC)survival was evaluated by counting Brn3a stained cells in flat-mounted retinas at 7 days after ART ***:ART below 5μM was safe for IMG cells in *** 2.5 and 5μM ART treatment increased IL-10 gene expression in IMG cells while not changing IL-1β,IL-6,TNF-α,and *** the in vivo study,intravitreal injection of ART below 100μM did not cause deterioration in the retinal function and RGC survival of the mouse eyes,while 1 mM ART treatment significantly attenuated both the scotopic and photopic b-wave amplitudes and impaired RGC *** addition,treatment with ART of 25,50,and 100μM significantly decreased TNF-αgene expression while ART of 100μM significantly increased IL-10 in the mouse ***:Intravitreal injection of 100μM ART could downregulate TNF-αwhile upregulate IL-10 in the mouse retina without causing retinal functional deterioration and RGC *** might be used as anti-inflammatory agent for retinal disorders.

关键词： Artesunate Safety Retina Microglia

Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第1期68卷 89-136页

作者： wen Huang Zeng Lian Kening lu Department of Mathematics University of Science and Technology of ChinaHefei 230026China School of Mathematics Sichuan UniversityChengdu 610065China

Consider C^(2)Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering(i.e.,every point in the phase space is nonwandering),we prove a set of results:(1)the existence of abundance of random periodic points;(2)a random Livsic theorem;(3)a random Mañé-Bousch-Conze-Guivarc'h lemma;(4)the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

关键词： random Anosov systems Anosov system on bers entropy random periodic orbit random horseshoe cohomological equation random Livsic theorem random Bousch-Mañécohomology lemma

Advanced dielectrics for 2D devices

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Science Bulletin 2025年第3期70卷 295-296页

作者： Hao Zhang Zhiwen lu Zhenhai wen Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Chemistry University of OxfordOxford OX13TAUK CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Provincial Key Laboratory of Materials and Techniques toward Hydrogen EnergyFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

As the application potential of two-dimensional(2D)materials in fields such as nanoelectronics,optoelectronics,and quantum computing continues to grow,the challenge of fabricating high-quality dielectric layers has be... 详细信息

关键词： computing continue devices

Zhongfeng Xingnao Liquid ameliorates post-stroke cognitive impairment through sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1) pathway

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Chinese Journal of Natural Medicines 2025年第1期23卷 77-89页

作者： wenqin Yang wen wen Hao Chen Haijun Zhang Yun lu Ping Wang Shijun Xu State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine Institute of Material Medica Integration and Transformation for Brain Disorders Chengdu University of Traditional Chinese Medicine School of Pharmacy Chengdu University of Traditional Chinese Medicine Emergency Department Hospital of Chengdu University of Traditional Chinese Medicine

The activation of the sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1) pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing reactive oxygen species(ROS) levels. Clinical trials have demonstrated that Zhongfeng Xingnao Liquid(ZFXN) ameliorates post-stroke cognitive impairment(PSCI). However, the underlying mechanism, particularly whether it involves protecting mitochondria and inhibiting apoptosis through the SIRT1/Nrf2/HO-1 pathway, remains unclear. This study employed an oxygen-glucose deprivation(OGD) cell model using SHSY5Y cells and induced PSCI in rats through modified bilateral carotid artery ligation(2VO).The effects of ZFXN on learning and memory, neuroprotective activity, mitochondrial function, oxidative stress, and the SIRT1/Nrf2/HO-1 pathway were evaluated both in vivo and in vitro. Results indicated that ZFXN significantly increased the B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax) ratio, reduced terminal deoxynucleotidyl transferase-mediated d UTP nickend-labeling(TUNEL)+ cells, and markedly improved cognition, synaptic plasticity, and neuronal function in the hippocampus and cortex. Furthermore, ZFXN exhibited potent antioxidant activity, evidenced by decreased ROS and malondialdehyde(MDA) content and increased superoxide dismutase(SOD), catalase(CAT), and glutathione(GSH) levels. ZFXN also demonstrated considerable enhancement of mitochondrial membrane potential(MMP), Tom 20 fluorescence intensity, adenosine triphosphate(ATP) and energy charge(EC) levels, and mitochondrial complex Ⅰ and Ⅲ activity, thereby inhibiting mitochondrial damage. Additionally,ZFXN significantly increased SIRT1 activity and elevated SIRT1, nuclear Nrf2, and HO-1 ***, these effects were substantially counteracted when SIRT1 was suppressed by the inhibitor EX-527 in vitro. In conclusion, ZFXN alleviates PSCI by activating the SIRT1/Nrf2/HO-1 pathway and preventing mitochond

关键词： Apoptosis Mitochondrial function Oxidative stress Post-stroke cognitive impairment Sirtuin1/nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway Zhongfeng Xingnao Liquid