In depth understanding of retinitis pigmentosa pathogenesis through optical coherence tomography angiography analysis:a narrative review
作者机构：Department of OphthalmologyOphthalmology Hospital of China Academy of Traditional Chinese MedicineBeijing 100040China
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2021年第14卷第12期
页 面：1979-1985页
核心收录：
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
基 金：National Natural Science Foundation of China(No.82174445) China Post-doctoral Science Foundation in 2019(No.2019M650987) Natural Science Foundation of Beijing of China(No.7192235)
主 题：retinitis pigmentosa optical coherence tomography angiography vascular dysfunction microglia activation
摘 要：Retinitis pigmentosa(RP)is the most recognized inherited retinal disorder involving progressive photoreceptors degeneration which eventually causes ***,the pathogenesis of RP is still unclear,making it difficult to establish satisfying *** have been found to support the theory that vascular dysfunction is associated with the progression of *** coherence tomography angiography(OCTA)is a newly developed technology that enables visualization as well as quantitative assessment of retinal and choroidal vasculature *** in OCTA have opened a window for indepth understanding of RP ***,we propose a hypothesis of RP pathogenesis based on the current OCTA findings in RP,which includes four stages and two important key factors,vascular dysfunction and microglia ***,we discuss the future animal experiments needed and how advanced OCTA technology can help to further verity the *** final goal is to explore potential treatment options with enhanced understanding of RP pathogenesis.
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