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Cortical activity in patients with high-functioning ischemic stroke during the Purdue Pegboard Test:insights into bimanual coordinated fine motor skills with functional near-infrared spectroscopy

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Neural Regeneration Research 2024年第5期19卷 1098-1104页

作者： Siyun Chen Mengchai Mao Guangyue Zhu Yufeng Chen Yuqi Qiu bin ye Dongsheng Xu The Second Rehabilitation Hospital of Shanghai ShanghaiChina College of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina School of Statistics East China Normal UniversityShanghaiChina The Third Rehabilitation Hospital of Shanghai ShanghaiChina Tongji University ShanghaiChina Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine ShanghaiChina

After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional *** arm training has been proposed as a promising intervention to address these ***,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted *** address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and ***-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand *** found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly ***,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test ***,the observed neural response patterns varied depending on the specific *** the unaffected hand task,the differences were primarily observed in the ipsilesional *** contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,*** significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual *** study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural resp

关键词： bilateral arm training bimanual coordination cortical activity fine motor dexterity functional near-infrared spectroscopy(fNIRS) high-functioning Purdue Pegboard Test stroke

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Endoscopic retrograde appendicitis treatment for periappendiceal abscess: A case report

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World Journal of Clinical Cases 2024年第4期12卷 801-805页

作者： Qiao-Mei Li bin ye Jun-Wei Liu Shang-Wen Yang Department of Gastroenterology Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Acute appendicitis is the most common abdominal *** present,the main treatments for periappendiceal abscess include antibiotics and ***,the complications and mortality of emergency surgery are *** preferred therapy is conservative treatment with antibiotics first,ultrasound-guided puncture drainage or surgical treatment is followed when *** retrograde appendicitis therapy(ERAT)for acute uncomplicated appendicitis have been proved clinically effective,but it is rarely used in periap-pendiceal *** SUMMARY We report a patient admitted to hospital because of“right lower abdominal pain for six days”.The computerized tomography(CT)of patient showed that appendicitis with fecaliths and abscess in the *** patient was treated by CT-guided puncture and drainage of abdominal abscess combined with ERAT to remove appendiceal fecaliths,irrigation and stent *** The patient did not receive surgery because of impoverished *** pain did not recur during the follow-up *** case confirms the value of ERAT in the treatment of periappendiceal abscess.

关键词： Transparent cap Colonoscopy Endoscopic retrograde appendicitis therapy Periappendiceal abscess Case report

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Sorafenib plus transarterial chemoembolization vs sorafenib alone for patients with advanced hepatocellular carcinoma: A systematic review and meta-analysis

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World Journal of Hepatology 2024年第1期16卷 91-102页

作者： Hong-Jie Yang bin ye Jia-Xu Liao Lei Lei Kai Chen Department of Radiology The Sixth People's Hospital of ChengduChengdu 610000Sichuan ProvinceChina Department of Oncology The Sixth People's Hospital of ChengduChengdu 610000Sichuan ProvinceChina Department of Pharmacy The Affiliated Taizhou People's Hospital of Nanjing Medical UniversityTaizhou 225300Jiangsu ProvinceChina

BACKGROUND Although the past decade has seen remarkable advances in treatment options for hepatocellular carcinoma(HCC),the dismal overall prognosis still envelops HCC *** comparative trials have been conducted to study whether transarterial chemoembolization(TACE)could improve clinical outcomes in patients receiving sorafenib for advanced HCC;however,the findings have been *** To study the potential synergies and safety of sorafenib plus TACE vs sorafenib alone for treating advanced HCC,by performing a systematic review and *** This study was conducted following the PRISMA statement.A systematic literature search was conducted using the Cochrane Library,Embase,PubMed,and Web of Science *** included in the present work were collected from patients diagnosed with advanced HCC receiving sorafenib plus TACE or sorafenib *** synthesis and meta-analysis were conducted using Review Manager *** The present study included 2780 patients from five comparative clinical trials(1 was randomized control trial and 4 were retrospective studies).It was found that patients receiving sorafenib plus TACE had better prognoses in terms of overall survival(OS),with a combined hazard ratio(HR)of 0.65[95%confidence interval(95%CI):0.46–0.93,P=0.02,n=2780].Consistently,progression free survival(PFS)and time to progression(TTP)differed significantly between the sorafenib plus TACE arm and sorafenib arm(PFS:HR=0.62,95%CI:0.40–0.96,P=0.03,n=443;TTP:HR=0.73,95%CI:0.64-0.83,Pbination therapy(risk ratio=1.36,95%CI:1.02-1.81,P=0.04,n=641).Regarding safety,the incidence of any adverse event(AE)was increased due to the addition of TACE;however,no significant difference was found in grade≥3 *** The combination of sorafenib with TACE has superior efficacy to sorafenib monotherapy,as evidenced by prolonged OS,PFS,and TTP,as well as increase

关键词： Hepatocellular carcinoma Sorafenib Transarterial chemoembolization Systematic review Meta-analysis

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Liu-Jun-Zi decoction alleviates chemotherapy-induced anorexia by regulating gut microbiota and TLR4/MyD88/NF-κB p65 signaling pathway

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Traditional Medicine Research 2024年第8期9卷 47-58页

作者： Yu-Jie Gao Xi-Pei Wu bin-bin ye Yong-Zhao Dai Yao-Zhong Zhao Xiu-Xiu Liao Ke Nie School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Liu-Jun-Zi decoction(LJZD),a classical nourishing formula in China,has been proven to be effective in treating chemotherapy-induced *** this study,the mechanism of LJZD in alleviating chemotherapy-induced anorexia was discussed from the aspects of regulating gut microbiota,repairing intestinal barrier injury and inhibiting inflammatory ***:A rat model of chemotherapy-induced anorexia was established using *** study evaluated the therapeutic effects of LJZD by observing the weight,food intake,and intestinal pathology of *** impact of LJZD on gut microbiota and metabolites,specifically short-chain fatty acids,was investigated through gut microbiota analysis and targeted *** anti-inflammatory and intestinal protective effects of LJZD were assessed by examining the expression of intestinal tight junction proteins associated with the inflammatory ***:LJZD alleviated cisplatin-induced inflammation and intestinal barrier disruption,as evidenced by upregulated expression of tight junction protein 1(TJ-1)and occludin,along with reduced serum levels of interleukin 6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and ***,LJZD alleviated microbiota imbalance and regulated the levels of short-chain fatty acids,especially increased the relative abundance of Coriobacteriales Incertae Sedis,Lactabacillus johnsonii F19785,Parasutterella,and reduced the *** the hypothalamus,LJZD exerts suppressive effects on the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)p65 signaling pathway,leading to a downregulation in the transcriptional activity of IL-6 and IL-1β,as well as Interleukin 6 receptors(IL-6R)and Interleukin-1βreceptors(IL-1R1)mRNA expression ***:In summary,LJZD alleviate chemotherapy-induced anorexia by modulating the gut microbiota,repairing the intestinal mechanical barriers,and suppressing the TLR4

关键词： Liu-Jun-Zi decoction chemotherapy-induced anorexia cisplatin TLR4/MyD818/NF-κB p65 gut microbiota rat

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冲击荷载引起的颗粒破碎对钙质砂液化特性的影响

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工程地质学报 2024年第2期32卷 410-419页

作者：叶斌毛盘叶冠林同济大学土木工程学院上海200092 上海交通大学船舶海洋与建筑工程学院上海200240

钙质砂具有孔隙率高、强度低、易破碎的特点。同时,钙质砂在波浪和地震等振动荷载的作用下,也具有发生液化的可能性。为探究钙质砂颗粒破碎与抗液化强度的关系,对南海永兴岛的钙质砂开展了三轴试验研究工作。首先,利用小型手动冲击装置... 详细信息

钙质砂具有孔隙率高、强度低、易破碎的特点。同时,钙质砂在波浪和地震等振动荷载的作用下,也具有发生液化的可能性。为探究钙质砂颗粒破碎与抗液化强度的关系,对南海永兴岛的钙质砂开展了三轴试验研究工作。首先,利用小型手动冲击装置对钙质砂进行破碎处理,获取了不同相对破碎率(Br)的试样,然后利用多功能动三轴仪分别对原始试样和不同破碎程度的试样进行了液化试验。结果表明:在相同围压和密实度条件下,钙质砂的抗液化强度(CRR)随着Br的增大而降低,但降低速率会随着Br的增大而减小。另一方面,相对密实度的增大会削弱颗粒破碎对钙质砂抗液化能力的影响。最后,为了定量评价颗粒破碎对钙质砂抗液化强度的影响,建立了Br-CRR的数学关系。

关键词：钙质砂颗粒破碎液化特性三轴试验

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紧密型协同立法的理论特征与实践逻辑

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哈尔滨工业大学学报（社会科学版） 2024年第2期26卷 43-50页

作者：韩业斌浙江农林大学文法学院杭州311300

根据立法合作的紧密程度不同,可以将区域协同立法模式分为紧密型协同立法和松散型协同立法。立法项目的重要程度是区分紧密型协同立法和松散型协同立法的重要依据,设立协同立法工作机构是紧密型协同立法的重要标志。随着中国区域一体化... 详细信息

根据立法合作的紧密程度不同,可以将区域协同立法模式分为紧密型协同立法和松散型协同立法。立法项目的重要程度是区分紧密型协同立法和松散型协同立法的重要依据,设立协同立法工作机构是紧密型协同立法的重要标志。随着中国区域一体化的不断推进,由松散型协同立法向紧密型协同立法过渡是区域协同立法实践的必然趋势。在紧密型协同立法模式中,还可以将其进一步细分为共同起草模式、征询意见模式和事后协调模式,同时需要发挥区域协同立法工作机构的作用,适当引入区域示范法,促进紧密型协同立法向纵深发展,以加速区域一体化进程。

关键词：区域协同立法区域一体化紧密型协同立法协同立法工作机构

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福建省儿童医院景观设计策略探析

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福建建筑 2024年第5期311卷 14-18页

作者：叶彬福建省建筑设计研究院有限公司福建福州350001

介绍福建省儿童医院项目的景观设计概况,同时分析五项景观设计的重点、难点问题,包括使用人群分析、景观设计原则、景观总体布局、景观分区设计以及景观绿化配置策略。通过系统化的景观设计,打破了人们原先的刻板印象,使病患能在轻松愉... 详细信息

介绍福建省儿童医院项目的景观设计概况,同时分析五项景观设计的重点、难点问题,包括使用人群分析、景观设计原则、景观总体布局、景观分区设计以及景观绿化配置策略。通过系统化的景观设计,打破了人们原先的刻板印象,使病患能在轻松愉悦的氛围中接受治疗。

关键词：医院景观庭院景观屋顶花园古树保护设计策略

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铁路单价承包模式审价工作探讨

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铁道建筑技术 2024年第5期 215-217页

作者：叶斌中铁第五勘察设计院集团有限公司北京102600

单价承包合同管理模式虽然在铁路合同管理中已经成为趋势,且在某铁路项目中全面应用,但目前该模式下的审价工作没有太多经验可参考。本文结合某铁路单价承包模式项目的特点,剖析了铁路项目在建设过程中工程变更审价、价差审价、验工计... 详细信息

单价承包合同管理模式虽然在铁路合同管理中已经成为趋势,且在某铁路项目中全面应用,但目前该模式下的审价工作没有太多经验可参考。本文结合某铁路单价承包模式项目的特点,剖析了铁路项目在建设过程中工程变更审价、价差审价、验工计价审价等工作重点,为铁路项目单价承包合同管理模式下的审价工作提供参考,避免铁路项目新合同模式下投资把控不严,投资不可控的情况发生。这些重点综合考虑,有助于确保铁路单价承包模式审价工作的全面性和实用性,为项目的顺利进行提供可靠的支持。

关键词：铁路单价承包审价

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Structure,ferroelectric,and enhanced fatigue properties of sol–gel-processed new Bi-based perovskite thin films of Bi(Cu_(1/2)Ti_(1/2))O_(3)–PbTiO_(3)

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Chinese Physics B 2024年第5期33卷 608-615页

作者：宋伟宾席国强潘昭刘锦叶旭斌刘哲宏王潇单鹏飞张林兴鲁年鹏樊龙龙秦晓梅龙有文 Department of Physics Shanghai Normal UniversityShanghai 200234China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute for Advanced Materials Technology University of Science and Technology BeijingBeijing 100083China Songshan Lake Materials Laboratory Dongguan 523808China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Bi-based perovskite ferroelectric thin films have wide applications in electronic devices due to their excellent ferroelectric *** Bi-based perovskite thin films Bi(Cu_(1/2)Ti_(1/2))O_(3)–PbTiO_(3)(BCT–PT) are deposited on Pt(111)/Ti/SiO_(2)/Si substrates in the present study by the traditional sol–gel *** structures and related ferroelectric and fatigue characteristics are studied *** BCT–PT thin films exhibit good crystallization within the phase-pure perovskite structure,besides,they have a predominant(100) orientation together with a dense and homogeneous *** remnant polarization(2P_(r)) values at 30 μC/cm^(2) and 16 μC/cm^(2) are observed in 0.1BCT–0.9PT and 0.2BCT–0.8PT thin films,*** intriguingly,although the polarization values are not so high,0.2BCT–0.8PT thin films show outstanding polarization fatigue properties,with a high switchable polarization of 93.6% of the starting values after 10^(8) cycles,indicating promising applications in ferroelectric memories.

关键词： ferroelectric thin films perovskite PbTiO_(3)-BiMeO_(3)

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深部脑刺激中同一性问题的混合定义路径

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自然辩证法通讯 2024年第1期46卷 29-37页

作者：孙晓宇吕凌峰叶斌中国科学技术大学科技哲学系安徽合肥230026 中山大学哲学系(珠海) 广东珠海519082

近年来围绕深部脑刺激(DBS)是否会威胁个人同一性这一问题产生了诸多争论,其根源主要是针对同一性概念认知上的分歧,因而解决该问题的关键不仅需要重新审视DBS与个人同一性的关系,更需要规范同一性概念。现有的同一性概念多是采用自上... 详细信息

近年来围绕深部脑刺激(DBS)是否会威胁个人同一性这一问题产生了诸多争论,其根源主要是针对同一性概念认知上的分歧,因而解决该问题的关键不仅需要重新审视DBS与个人同一性的关系,更需要规范同一性概念。现有的同一性概念多是采用自上而下或自下而上的单一的定义方式,具有一定的局限性且不适用于由DBS产生的问题。本文借助分析DBS在技术层面存在的问题,结合自上而下路径与自下而上路径,提出了解决DBS中同一性问题的混合式路径,即不仅要重新规范同一性定义,还要考虑到DBS技术的成熟性和安全性。

关键词：深部脑刺激同一性自上而下自下而上混合定义

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