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A retrospective analysis of mature T-and NK-cell lymphomas

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Cancer Biology & Medicine 2024年第3期21卷 223-229页

作者： Junlei Jia Xiaohui Wang Zheng Song Shen meng Yue Fei Jingwei Yu Xia Liu Xue Han Lanfang Li Lihua Qiu Zhengzi Qian Shiyong Zhou Wenchen Gong bin meng Xiubao Ren Xianhuo Wang Huilai Zhang National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine and Department of LymphomaTianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinThe Sino-US Center for Lymphoma and Leukemia ResearchTianjin 300060China Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China Department of Pathology Department of Immunology/Biotherapy Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin 300060China

Mature T-and natural killer(NK)-cell lymphomas are heterogeneous groups of malignant lymphoid neoplasms arising from T and NK cells. The incidence of mature T-and NK-cell lymphomas is 2.1 per 100,000 people, according... 详细信息

关键词： lymphoma neoplasms killer

Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu bin meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimot

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

Synergistic effect of Zr and Mo on precipitation and high-temperature properties of Al-Si-Cu-Mg alloys

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China Foundry 2024年第1期21卷 71-81页

作者： Chao Gao bing-rong Zhang Yin-ming Li Zhi-ming Wang Xiang-bin meng Faculty of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Hebei Ounai Machinery Mould Co.Ltd. Xingtai 054500HebeiChina

This study focuses on finding a solution to the sharp decline in mechanical properties of Al-Si-Cu-Mg alloys due to rapid coarsening of traditional intermediate phases at high temperature.A new type of modified al oy,to be used in automobile engines at high temperatures,was prepared by adding Zr and Mo into Al-Si-Cu-Mg alloy.The synergistic effects of Zr and Mo on the microstructure evolution and high-temperature mechanical properties were studied.Results show that the addition of Zr and Mo generates a series of intermetallic phases dispersed in the alloy.They can improve the strength of the alloy by hindering dislocation movement and crack propagation.In addition,some nano-strengthened phases show coherent interfaces with the matrix and improve grain refinement.The addition of Mo greatly improves the heat resistance of the alloy.The extremely low diffusivity of Mo enables it to improve the thermal stability of the intermetallic phases,inhibit precipitation during aging,reduce the size of the precipitates,and improve the heat resistance of the alloy.

关键词： Al-Si-Cu-Mg alloy high-temperature properties Zr-Mo-rich intermetallics nano-strengthening phases

Acceptor-acceptor-type Organoboron Conjugated Polymers:Effect of Backbone Configuration on Thermoelectric Performance

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Chinese Journal of Polymer Science 2023年第1期41卷 108-116页

作者： Chang-Shuai Dong bin meng Jun Liu Li-Xiang Wang State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China

The development of n-type polymer thermoelectrics lags far behind that of p-type ones in view of material diversity and performance.New structural insights into the thermoelectric performance are needed for efficient n-type polymer thermoelectric materials.Herein,we developed three acceptor-acceptor type organoboron polymers and investigated the effect of backbone configuration on thermoelectric performance.The three polymers are designed based on double B←N bridged bipyridine(BNBP)unit with monomeric thieno[3,4-c]pyrrole-4,6-dione(TPD),TPD dimer and TPD trimer as the copolymerizing units,respectively.The three polymers show similar low LUMO energy levels but different backbone configuration.Compared with the wavy backbone configuration,the pseudo-straight backbone configuration imparts the polymer with much enhanced crystallinity and electron mobility.As a result,after n-doping,the polymer with pseudo-straight configuration shows much higher electronic conductivity and power factor.We think these findings could serve as important guidelines for molecular design toward efficient n-type polymer thermoelectric materials.

关键词： Organoboron polymers Acceptor-acceptor type conjugated polymers n-Type polymer thermoelectrics n-Doping

Theoretical and experimental investigation on the efficiency of a novel roller piston pump

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浙江大学学报(英文版)A辑:应用物理与工程 2023年第9期24卷 762-781页

作者： Chenchen ZHANG Yiren ZANG Heyuan WANG bin meng Sheng LI Jian RUAN College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China

This study presents a novel roller piston pump,in which a cam guide-roller type rolling support is adopted to replace the sliding pair support of the swash plate-slipper pair to achieve the oil suction and discharge of the piston cavity.In addition,the shaft distribution is used to replace the original valve plate distribution and the driving shaft is used as the distribution shaft to remove the valve plate structure,which greatly simplifies the design of the axial piston pump.Such a configuration largely reduces the number of sliding friction pairs of the pump,and avoids the influence of the sliding friction pair on it under high-speed and variable-speed conditions.Firstly,mathematical models of the mechanical and volumetric efficiencies of the roller pump are deduced respectively through force analysis and the compressibility equation.Based on the numerical simulation of MATLAB and AMESim,the effects of load pressure and rotational speed on mechanical and volumetric efficiencies are studied respectively,and it is verified that the roller pump has no structural flow pulsation.The prototype pump is then designed and built,along with a special test rig.The outlet pressure,outlet flow,and torque of the pump under different load pressures and rotational speeds are measured,and the mechanical and volumetric efficiencies of the prototype pump under various load pressures and rotational speeds are obtained.The experimental results are in good agreement with the simulated analysis.When the load pressure is 8 MPa and the speed is 5000 r/min,the mechanical and the volumetric efficiencies are 85.5% and 96.8%,respectively.When the speed is increased to 10000 r/min,the mechanical and the volumetric efficiencies are 66.7% and 95.6%,respectively.The experimental results show that the proposed roller piston pump has excellent efficiency under wide-speed and high-speed conditions and can be a potential solution as a fuel pump in aerospace fuel systems.

关键词： Roller piston pump Shaft distribution mechanism Mechanical efficiency Volumetric efficiency Aerospace pump

Analytical Modelling and Experiment of Novel Rotary Electro-Mechanical Converter with Negative Feedback Mechanism for 2D Valve

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Chinese Journal of Mechanical Engineering 2022年第5期35卷 162-182页

作者： bin meng Mingzhu Dai Chenhang Zhu Chenchen Zhang Chuan Ding Jian Ruan College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China

The manufacturing of spiral groove structure of two-dimensional valve(2D valve)feedback mechanism has shortcomings of both high cost and time-consuming.This paper presents a novel configuration of rotary electro-mechanical converter with negative feedback mechanism(REMC-NFM)in order to replace the feedback mechanism of spiral groove and thus reduce cost of valve manufacturing.In order to rapidly and quantitative evaluate the driving and feedback performance of the REMC-NFM,an analytical model taking leakage flux,edge effect and permeability nonlinearity into account is formulated based on the equivalent magnetic circuit approach.Then the model is properly simplified in order to obtain the optimal pitch angle.FEM simulation is used to study the influence of crucial parameters on the performance of REMC-NFM.A prototype of REMC-NFM is designed and machined,and an exclusive experimental platform is built.The torque-angle characteristics,torque-displacement characteristics,and magnetic flux density in the working air gap with different excitation currents are measured.The experimental results are in good agreement with the analytical and FEM simulated results,which verifies the correctness of the analytical model.For torque-angle characteristics,the overall torque increases with both current and rotation angle,which reaches about 0.48 N·m with 1.5 A and 1.5°.While for torque-displacement characteristics,the overall torque increases with current yet decrease with armature displacement due to the negative feedback mechanism,which is about 0.16 N·m with 1.5 A and 0.8 mm.Besides,experimental results of conventional torque motor are compared with counterparts of REMC-NFM in order to validate the simplified model.The research indicates that the REMC-NFM can be potentially used as the electro-mechanical converter for 2D valves in civil servo areas.

关键词： Electro-mechanical converter Magnetic circuit topology Analytical modeling 2D valve

DGMRES Method Augmented with Eigenvectors for Computing the Drazin-inverse Solution of Singular Linear Systems

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Acta Mathematicae Applicatae Sinica 2016年第2期32卷 549-558页

作者： bin meng College of Science Nanjing University of Aeronautics and Astronautics

The DGMRES method for solving Drazin-inverse solution of singular linear systems is generally used with restarting. But the restarting often slows down the convergence and DGMRES often stagnates. We show that adding some eigenvectors to the subspace can improve the convergence just like the method proposed by R. Morgan in [R. Morgan, A restarted GMRES method augmented with eigenvectors, SIAM J. Matrix Anal App1., 16： 1154-1171, 1995. We derive the implementation of this method and present some numerical examples to show the advantages of this method.

关键词： Drazin-inverse DGMRES Krylov subspace iterative method eigenvector

Recent development of n-type thermoelectric materials based on conjugated polymers

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Nano Materials Science 2021年第2期3卷 113-123页

作者： bin meng Jun Liu Lixiang Wang State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022PR China University of Science and Technology of China Hefei230026PR China

Thermoelectric(TE)materials based on conjugated polymers have received much attention due to their great advantages of solution processibility,light weight,flexibility,and low thermal conductivity.These advantages make them potential candidates for large-area,low-cost and low-power TE applications.Both efficient p-type and n-type conjugated polymers with high and comparable thermoelectric performance are required for practical TE applications.However,due to the inefficient n-doping efficiency and unstable electron transport of most n-type conjugated polymers,the TE performance of n-type polymers is much poorer than that of their p-type counterparts,impeding the development of polymer TE materials.Great efforts have been made to address the low ndoping efficiency and TE performance of n-type polymers,including the chemical modification of traditional ntype polymers,the design of new n-type conjugated polymers,and the development of more efficient n-dopants,as well as doping engineering.Nowadays,the TE performance of n-type polymers has been greatly improved,indicating a bright future for polymer TE materials.In this review,we summarize the recent progress made on ntype polymer TE materials,mainly focusing on the structure-performance relationships based on promising n-type polymers for TE applications.This review aims to provide some guidelines for future material design.

关键词： Polymer thermoelectrics n-type polymers n-doping Conductivity Power facto

Regulation Method for Torque-Angle Characteristics of Rotary Electric-Mechanical Converter Based on Hybrid Air Gap

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Chinese Journal of Mechanical Engineering 2020年第2期33卷 100-110页

作者： bin meng Yongjiang Lai Xinguo Qiu Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of EducationZhejiang University of TechnologyHangzhouChina

The torque-angle characteristics of electric-mechanical converters are important determinants of the quality of electrohydraulic proportional control systems.It is far more difficult for a rotary electric-mechanical converter(REMC)to obtain flat torque-angle characteristics than traditional proportional solenoid,greatly influencing the promotion and application of rotary valves for electrohydraulic proportional control systems.A simple and feasible regulation method for the torque-angle characteristics of REMCs based on a hybrid air gap is proposed.The regulation is performed by paralleling an additional axial air gap with the original radial air gap to obtain a flat torque-angle characteristic and increase output torque.For comparison,prototypes of REMCs based on hybrid and radial air gaps were manufactured,and a special test rig was built.The torque-angle characteristics under different excitation currents and step responses were studied by magnetic circuit analysis,finite element simulation,and experimental research.The experimental results were consistent with the theoretical analysis.It was shown that REMCs based on a hybrid air gap can obtain a flat torque-angle characteristic with further optimizing of key structural parameters and also increase output torque.This regulation method provides a new approach for the design of proportional rotary electromechanical converters.

关键词： Rotary valve Rotary electric-mechanical converter Torque-angle characteristic Hybrid air gap Axial air gap Radial air gap