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A Formative History of Integrative Medicine in Hong Kong

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Chinese Journal of Integrative Medicine 2019年第6期25卷 403-408页

作者： YU Edwin Chau-leung bian zhao-xiang Hong Kong Association for Integration of Chinese-Western Medicine Hong Kong Baptist University

With Chinese medicine (CM) deeply rooted in Hong Kong's Chinese culture, empirical practice of CM has been the norm since the early days of Hong Kong, China. Western medicine (WM) had its humble beginnings in Hong Kong in the form of established services for colonial government staff;WM was subsequently extended to the Chinese population through missionary efforts. The scourge of the plague pestilenee in 1894 gave WM an advantage whence enforeed laws and regulations and the swing to scientific philosophy set a trend that snowballed WM dominance.

关键词： Formative History Integrative Medicine Hong Kong

Systematic Reviews/Meta-Analyses of Integrative Medicine in Chinese Need Regulation and Monitoring Urgently and Some Suggestions for Its Solutions

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Chinese Journal of Integrative Medicine 2018年第2期24卷 83-86页

作者： WANG Jia-ying TIAN Gui-hua LI You-ping WU Tai-xiang bian zhao-xiang DU Liang SHANG Hong-cai Department of Acupuncture and Moxibustion Wuxi People's Hospital Affiliated to Nanjing Medical University Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing City Dongzhimen HospitalBeijing University of Chinese Medicine the Chinese Cochrane Center Sichuan University School of Chinese Medicine Hong Kong Baptist University

With the introduction and development of evidence-based medicine in China, it has been spread rapidly in the area of integrative medicine（IM） and has become a new unique discipline. During almost 20 years, as one of the most important parts of evidence-based IM, systematic review（SR）/meta-analysis（MA） of IM have shown a good development momentum in the aspects of quantity, depth, breadth and influence, but also face the harsh situation of the uncontrolled quantity and quality, especially for SRs in Chinese. Therefore, how to supervise and standardize this area effectively becomes a problem to be solved. Based on the experience both at home and abroad, the authors put forward several kinds of solutions for laying the foundation for further development such as promoting the registration system of SR/MA of IM, effectively setting up the regulatory platform of quality and quantity, launching professional training for SR/MA reviewers, formingqualification registration, developing the data transfer and sharing platform to realize the transparency of evidence process.

关键词： integrative medicine systematic review in Chinese regulation and monitoring

Evidence-Based Chinese Medicine Clinical Practice Guideline for Stomach Pain in Hong Kong

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Chinese Journal of Integrative Medicine 2017年第10期23卷 793-800页

作者： ZHONG Linda LD SHI Nan-nan DAI Liang ZIEA Tat Chi NG Bacon TANG Xu-dong bian zhao-xiang LU Ai-ping Hong Kong Chinese Medicine Study Centre Hong Kong Baptist University Hong Kong SAR China School of Chinese Medicine Hong Kong Baptist University Hong Kong SAR China Institute of Basic Research in Clinical Medicine China Academy of Traditional Chinese Medicine Beijing (100091) China Department of Chinese Medicine Hong Kong Hospital Authority Hong Kong SAR China Department of Gastroenterology Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing (100091) China

Stomach pain in Chinese medicine（CM） is a very common disorder in clinical practice and it has been listed as one of the pilot three conditions in Hong Kong to develop evidence-based CM clinical practice guidelines（CM CPGs）. The aim of this stomach Pain CPG is to summarize the treatment methods of stomach pain with CM and evaluate reasonably, then to guide local licensed CM practitioners and provide beneficial reference for social medical decision makers and patients. In this manuscript, we defined stomach pain in CM and the category of chronic gastritis in Western medicine. The clinical manifestation, CM pattern classification, and CM intervention including herbal medicine treatment based on pattern differentiation, symptomatic treatment, acupuncture treatment, regulation and nursing were illustrated.

关键词： clinical practice guideline Chinese medicine pattern Chinese herbal medicine stomach pain

Standard Protocol Items for Clinical Trials with Traditional Chinese Medicine 2018: Recommendations, Explanation and Elaboration(SPIRIT-TCM Extension 2018)

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Chinese Journal of Integrative Medicine 2019年第1期25卷 71-79页

作者： DAI Liang CHENG Chung-wah TIAN Ran ZHONG Linda LD LI You-ping LYU Ai-ping CHAN An-wen SHANG Hong-cai bian zhao-xiang Hong Kong Chinese Medicine Clinical Study Centre School of Chinese Medicine Hong Kong Baptist University Institute of Digestive Diseases Longhua Hospital Shanghai University of Traditional Chinese Medicine Chinese Evidence-Based Medicine Centre Sichuan University Women's Col ege Research Institute Women's Col ege Hospital University of Toronto Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen Hospital Beijing University of Chinese Medicine

Traditional Chinese Medicine(TCM) is one of the oldest systems of medicine. More and more attention has been paid to TCM application, but the variable quality of clinical trials with TCM impedes its widespread acceptance. The Standard Protocol Items: Recommendations for Interventional Trials(SPIRIT) 2013 Statement has established guidelines for designing clinical trials to ensure that the trial results are accurate and reliable. However, there are difficulties when applying SPIRIT 2013 Statement to trials with TCM, due to the unique theory and the characteristic of TCM intervention. An Extension to the original SPIRIT was developed to ensure the quality of trial design with TCM. As Chinese herbal formulae, acupuncture and moxibustion are common and representative interventions in TCM practice, the executive working group determined that the SPIRIT-TCM Extension focus on these three interventions. Extension was developed through initiation, 3 rounds of Delphi consensus survey, and finalizing expert meeting. Seven items from the SPIRIT 2013 Statement were modified, namely, "title", "background and rationale", "objectives", "eligibility criteria", "interventions", "outcomes", and "data collection methods". The Extension includes the introduction of the concept of TCM pattern and 3 major TCM interventions, with examples and explanations. The SPIRIT-TCM Extension 2018 provides suggestion for investigators in designing high quality TCM clinical trials. It is expected that wide dissemination and application of this extension ensure continuous improvement of TCM trial quality throughout the world.

关键词： SPIRIT traditional Chinese medicine clinical trial extension recommendation

Toward Evidence-Based Chinese Medicine：Status Quo,Opportunities and Challenges

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Chinese Journal of Integrative Medicine 2018年第3期24卷 163-170页

作者： CHEN Yao-long zhao Chen ZHANG Li LI Bo WU Chuan-hong MU Wei WANG Jia-ying YANG Ke-hu LI You-ping CHEN Chiehfeng WANG Yong-yan WANG Chen bian zhao-xiang SHANG Hong-cai Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen Hospital Beijing University of ChineseMedicine Beijing 100007 China Evidence Based Medicine Center School of Basic Medical Sciences Lanzhou UniversityLanzhou 730000 China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province Lanzhou 730000 China Chinese GRADE Center Lanzhou 730000China China School of Chinese Medicine Hong Kong Baptist University Hong Kong SAR 999077 China Departmentof Clinical Pharmacology Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Gastroenterology Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing 100091 China State Key Laboratory of Quality Researchin Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macao Macao 999078 China Departmentof Acupuncture and Moxibustion Wuxi People's HospitalJiangsu 214023 China Chinese Cochrane Centre West China Hospital Sichuan University Chengdu 610041 China Division of Plastic Surgery Department of Surgery Wan Fang Hospital Taipei Medical University Taipei 106 China Instituteof Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing 100700 China Department of Respiratory and Critical Care Medicine China-Japan Friendship Hospital. Beiiina 100029. China

How to test the treatments of Chinese medicine（CM） and make them more widely accepted by practitioners of Western medicine and the international healthcare community is a major concern for practitioners and researchers of *** centuries,various approaches have been used to identify and measure the efficacy and safety of ***,the high-quality evidence related to CM that produced in China is still *** the recent years,evidence-based medicine（EBM） has been increasingly applied to CM,strengthening its theoretical *** paper reviews the past and present state of CM,analyzes the status quo,challenges and opportunities of basic research,clinical trials,systematic reviews,clinical practice guidelines and clinical pathways and evidence-based education developed or conducted in China,pointing out how EBM can help to make CM more widely used and recognized worldwide.

关键词： evidence-based medicine Chinese medicine randomized controlled trial systematic review clinical practice guidelines

Matching traditional Chinese medicine and western medicine-based research:Advanced nutraceutical development for proactive gastric cancer prevention

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3798-3819页

作者： Matteo Micucci bian-zhao xiang Chen-Min Ting Hiu-Yee Kwan Michele Mari Michele Retini Sabrina Burattini Riham Osman Udodinma Jude Okeke Fuad Othman Abdullah Federico Gianfanti Michela Battistelli Department of Biomolecular Sciences University of Urbino Carlo BoUrbino 61029Italy Hong Kong Chinese Medicine Clinical Study Centre Chinese EQUATOR CentreSchool of Chinese MedicineChinese Clinical Trial Registry(Hong Kong)Hong Kong Baptist UniversityHong Kong 999077China Centre for Chinese Herbal Medicine Drug Development Hong Kong Baptist UniversityHong Kong 999077China Centre for Cancer and Inflammation Research School of Chinese MedicineHong Kong Baptist UniversityHong Kong 999077China Department of Chemistry College of ScienceSalahaddin University-ErbilErbil 44001Iraq Department of Pharmacognosy Faculty PharmacyTishk International UniversityErbil 44001Iraq Institute of Oncology Research Bellinzona CH6500Switzerland Universitàdella Svizzera Italiana Lugano CH6900Switzerland

Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and *** review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western medical practices,emphasizing the development of nutraceuticals for cancer *** advanced analytical chemistry and food chemistry techniques,this study investigated how TCM components may be optimized for nutraceutical *** on molecular interactions with GC pathways,particularly the NF-κB,PI3K/Akt,and Wnt/β-catenin pathways,we examined the effects of TCM polyherbal formulas,extracts,and isolated *** agents modulate apoptosis and cellular proliferation,underscoring their potential in preventive *** convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health *** approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease *** combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.

关键词： Traditional Chinese medicine Precision medicine Molecular network Phytochemistry Food chemistry Nutraceuticals Gastric cancer

Whether Syndrome Differentiation Affects Treatment Result:Study Protocol of MaZiRenWan(麻子仁丸)for Functional Constipation in A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2019年第3期25卷 175-181页

作者： CHENG Chung-wah ZHANG Li zhao Chen ZHONG Linda LD SHI Li-jie DAI Liang ZHENG Rui CHEN Jing LI Ge ZHAI Jing-bo KUN Wai LU Ai-ping SHANG Hong-cai bian zhao-xiang Hong Kong Chinese Medicine Clinical Study Centre School of Chinese Medicine Hong Kong Baptist University Department of Clinical Pharmacology the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Department of Gastroenterology the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Graduate School Tianjin University of Traditional Chinese Medicine Department of Health Care Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine School of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Research Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen Hospital Beijing University of Chinese Medicine

Background: Syndrome is one of the most important concepts in Chinese medicine(CM) theory. However, it was not well accounted in most of randomized controlled trials(RCTs). Objective: To determine whether CM syndrome differentiation affects the treatment results, functional constipation(FC) was selected as a target disease, and MaZiRenWan(麻子仁丸, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. Methods: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up. A total of 120 FC patients diagnosed as excessive heat syndrome will be recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Patients will be randomly allocated into fixed MZRW(f_MZRW) granule group, modified MZRW(m_MZRW) granule group or bisacodyl group. For m_MZRW group, no more than two herbal granules can be added according to the syndrome differentiation for individual participants. The primary end point is the mean of complete spontaneous bowel movements(CSBMs) per week during the treatment period. Secondary end points include mean of CSBMs per week during follow-up, stool form, global symptom improvement, constipation and constipation-related symptoms assessment, CM syndrome change, and reported adverse events. Discussion: This trial is designed to evaluate the effectiveness of these three interventions for FC patients with the CM syndrome of excessive heat, and to determine the change of CM syndrome and the progress of disease during the treatment course. The results are important to explore whether syndrome differentiation is important for the therapeutic effect of a formula on a disease.

关键词： functional constipation Chinese herbal medicine syndrome differentiation MaZiRenWan randomized controlled trial

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随机对照实况试验的概念、设计和实施

中国循证医学杂志 2009年第12期9卷 1277-1280页

作者：吴泰相商洪才卞兆祥四川大学华西医院中国临床试验注册中心中国循证医学中心Chinese Cochrane Centre国际临床流行病学网华西培训中心(INCLEN CERTC)成都610041 天津中医药大学循证医学中心天津中医药大学第一附属医院香港浸会大学中医药学院天津300193

随机对照实况试验由于所纳入的受试者和干预过程接近临床实践的真实状况,其效应量接近或与临床实践真实情况相似,因此其疗效效应量用于评估患者的疗效较之辨析性研究更加准确。由于其特点是干预措施和过程可变,符合包括中医药和针灸在... 详细信息

随机对照实况试验由于所纳入的受试者和干预过程接近临床实践的真实状况,其效应量接近或与临床实践真实情况相似,因此其疗效效应量用于评估患者的疗效较之辨析性研究更加准确。由于其特点是干预措施和过程可变,符合包括中医药和针灸在内的临床治疗特点,因而日益受到国内中医药界的极大兴趣和关注。实际上,随机对照实况试验也适合于比较采用临床路径和不采用临床路径管理患者的效果。本文介绍了随机对照实况试验的原理和概念,并通过举例说明其设计要点。

关键词：随机对照试验实况试验中医药临床路径

辨证论治基本原则下中医群体化研究的思考及二维RCT设计方法的提出

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中华中医药杂志 2015年第5期30卷 1391-1396页

作者：赵晨卞兆祥商洪才天津中医药大学天津300193 北京中医药大学东直门医院中医内科学教育部重点实验室和北京市重点实验室北京100700

辨证论治是中医诊疗的基本原则,其个体化医学特征给目前中医群体化研究的设计和实施带来了困难。中医辨证论治的经验证据总结于特殊的群体观察,难以确切地证真和证伪。以随机对照试验为代表的群体化研究方法是中医证明其临床疗效、实现... 详细信息

辨证论治是中医诊疗的基本原则,其个体化医学特征给目前中医群体化研究的设计和实施带来了困难。中医辨证论治的经验证据总结于特殊的群体观察,难以确切地证真和证伪。以随机对照试验为代表的群体化研究方法是中医证明其临床疗效、实现自身现代化价值的必由之路,而如何有效建立针对辨证论治"辨个体差异"和"随证加减"两大特征的试验方法是目前的难点。文章探讨了中医群体化研究的必要性、价值和关键问题,并基于辨证论治基本原则提出中医群体化研究的二维RCT设计方法等思路。

关键词：辨证论治群体化研究二维RCT 中医学