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COVID-19 Vaccine Priority Access for Adults and Children with Congenital Heart Disease: A Statement of the Italian Society of Pediatric Cardiology

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Congenital Heart Disease 2021年第5期16卷 427-431页

作者： Gabriele Egidy Assenza biagio Castaldi Serena Flocco Giovanni Battista Luciani Giovanni Meliota Gabriele Rinelli Ugo Vairo Silvia Favilli Board of the Italian Society of Pediatric Cardiology Department of Cardio-Thoracic and Vascular Medicine IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Department of Women’s and Children’s Health University of PadovaPadovaItaly Health Professions Research and Development Unit IRCCS Policlinico San DonatoMilanoItaly Department of Surgery DentistryPediatrics and GynecologyUniversity of VeronaVeronaItaly Pediatric Cardiology ‘Giovanni XXIII’Pediatric HospitalBariItaly Department of Pediatric Cardiology and Cardiac Surgery ‘Ospedale Pediatrico Bambino Gesu’RomaItaly Pediatric Cardiology ‘A.Meyer’Pediatric HospitalFirenzeItaly 不详

COVID-19 pandemic continues to strike across the world with increasing number of infected patients,severe morbidity and mortality,social life and economy *** access to vaccine prophylaxis will be pivotal in controlling this infection and providing individual level ***,mismatch between vaccine request and vaccine availability,as well as constraints in logistics of vaccine campaign is creating a transition phase of progressive but still incomplete inclusion of group of individuals in the vaccination *** patients living with chronic and multisystemic disease may present increased propensity of adverse outcome,should Sars-Cov-2 infection *** these patients,expedite access to COVID-19 vaccination may be *** Italian Society of Pediatric Cardiology National Board is providing a viewpoint to inform policy makers and public authorities during vaccine allocation strategies development,to consider higher priority and expedite access for selected groups of patients living with congenital heart disease.

关键词： COVID-19 vaccine congenital heart disease

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Bilateral calcified Macroplastique®after 12 years

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Asian Journal of Urology 2022年第3期9卷 334-336页

作者： biagio Barone Luigi De Luca Luigi Napolitano Vincenzo Francesco Caputo Mariano Marsicano Gennaro Cancelmo Massimiliano Creta Ferdinando Fusco Department of Neuroscience Reproductive Sciences and DentistryUniversity of Naples Federico IINaplesItaly Department of Woman Child and General and Specialized SurgeryUniversity of Campania Luigi VanvitelliNaplesItaly

Dear editor,In recent years,endoscopic subureteral transurethral injection(STING)has become the first-line therapy for children with vesicoureteral reflux(VUR)owing its diffusion in clinical practice to a high success rate and minimum complications[1].Macroplastique(Uroplasty,Inc.,Minnetonka,MN,USA)is an efficient and safe bulking agent commonly used in VUR,being non-migratory,non-antigenic,and ***,its stability over time,with a virtual no-reabsorption phenomenon,has allowed its application in wider medical fields[2].

关键词： clinical plast editor

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Difficult polypectomy-giant hypopharyngeal polyp: Case report and literature review

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World Journal of Gastroenterology 2013年第35期19卷 5936-5939页

作者： Giovanni Pallabazzer Stefano Santi Solito biagio Simone D'Imporzano Esophageal Surgery Unit Tuscany Regional Referral Center for the Diagnosis and Treatment of Esophageal Disease Medical University of Pisa

Giant esophageal and hypopharyngeal polyps are benign tumors rarely encountered in clinical *** most cases,they are completely asymptomatic;however,despite the rarity of these tumors,interest in giant esophageal polyps derives from their degree of growth(characterized by slow growth into the esophageal lumen)and their *** fact,if regurgitation occurs,they can ascend into the oral cavity and be aspirated into the airways,with potentially lethal *** removal of these giant polyps is *** adequate preoperative evaluation to identify the correct origin of the stalk is mandatory for a successful endoscopic or surgical treatment.A 60-year-old man was admitted to our hospital for *** patient underwent gastroscopy,contrast computed tomography and endoscopic *** the conclusion of the procedure,during the extraction of the echoendoscope,the patient began retching and regurgitated the polyp,without experiencing respiratory *** patient underwent a left cervicotomy and polyp dissection via a pharyngotomy.

关键词： Esophagus Giant fibrovascular polyp Esophageal polyp Fibroepithelial polyps

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Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized for COVID-19

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Journal of Geriatric Cardiology 2021年第5期18卷 338-345页

作者： Vincenzo De Marzo Antonio Di biagio Roberta Della Bona Antonio Vena Eleonora Arboscello Harusha Emirjona Sara Mora Mauro Giacomini Giorgio Da Rin Paolo Pelosi Matteo Bassetti Pietro Ameri Italo Porto GECOVID study group Cardiovascular Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Internal Medicine University of GenovaGenovaItaly Infectious Diseases Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Health Sciences University of GenovaGenovaItaly Emergency Department IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Informatics BioengineeringRobotics and System EngineeringUniversity of GenovaGenovaItaly Laboratory Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Anesthesia and Intensive Care Unit IRCCS Ospedale Policlinico San MartinoGenovaItaly Department of Surgical Sciences and Integrated Diagnostics University of GenovaGenovaItaly

BACKGROUND Increases in cardiac troponin(cTn)in coronavirus disease 2019(COVID19)have been associated with worse ***,data about the significance of cTn in elderly subjects with COVID19 are *** From a registry of consecutive patients with COVID19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020,we selected those≥60 yearold and with cTnI measured within three days from the molecular diagnosis of SARSCoV2 *** available,a second cTnI value within 48 h was also *** relationship between increased cTnI and allcause inhospital mortality was evaluated by a Cox regression model and restricted cubic spline functions with three *** Of 343 included patients(median age:75.0(68.0−83.0)years,34.7%men),88(25.7%)had cTnI above the upperreference limit(0.046μg/L).Patients with increased cTnI had more comorbidities,greater impaired respiratory exchange and higher inflammatory markers on admission than those with normal ***,they died more(73.9%vs.37.3%,P<0.001)over 15(6−25)days of *** association of elevated cTnI with mortality was confirmed by the adjusted Cox regression model(HR=1.61,95%CI:1.06−2.52,P=0.039)and was linear until 0.3μg/L,with a subsequent *** 191(55.7%)patients with a second cTnI measurement,49(25.7%)had an increasing trend,which was not associated with mortality(univariate HR=1.39,95%CI:0.87−2.22,P=0.265).CONCLUSIONS In elderly COVID19 patients,an initial increase in cTn is common and predicts a higher risk of *** cTn testing may not confer additional prognostic information.

关键词： patients mortality admitted

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Current evidence on the management of hepatitis B in pregnancy

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World Journal of Hepatology 2018年第9期10卷 585-594页

作者： Alberto Enrico Maraolo Ivan Gentile Antonio Riccardo Buonomo biagio Pinchera Guglielmo Borgia Section of Infectious Diseases Department of Clinical Medicine and SurgeryUniversity of Naples Federico Ⅱ

Hepatitis B virus(HBV) infection is one of the main public health problems across the globe,since almost one third of the world population presents serological markers of contact with the virus. A profound impact on the epidemiology has been exerted by universal vaccination programmes in many countries,nevertheless the infection is still widespread also in its active form. In the areas of high endemicity(prevalence of hepatitis B surface antigen positivity > 7%),mother-to-child transmission represents the main modality of infection spread. That makes the correct management of HBV in pregnancy a matter of utmost importance. Furthermore,the infection in pregnancy needs to be carefully assessed and handled not only with respect to the risk of vertical transmission but also with respect to gravid women health. Each therapeutic or preventive choice deserves to be weighed upon attentively. On many aspects evidence is scarce or controversial. This review will highlight the latest insights into the paramount steps in managing HBV in pregnancy,with particular attention to recommendations from recent guidelines and data from up-do-date research syntheses.

关键词： Pregnancy Hepatitis B immunoglobulin Hepatitis B Therapy Immunoprophylaxis Antiviral prophylaxis

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Gaseous and Particulate Exhaust Emissions of Hybrid and Conventional Cars over Legislative and Real Driving Cycles

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Energy and Power Engineering 2015年第5期7卷 181-192页

作者： Maria Antonietta Costagliola Maria Vittoria Prati Antonio Mariani Andrea Unich biagio Morrone Istituto Motori National Research Council Napoli Italy Department of Industrial and Information Engineering Second University of Naples Aversa (CE) Italy

Road transport exhaust emissions represent the main sources of atmospheric pollution in urban areas, due to the growing number of circulating vehicles and travelled distances. In order to reduce this pollution source, stricter emission standards are periodically set by governments through- out the world. Consequently, the concentrations of gaseous pollutants and particulate mass to be measured during type-approval tests of new vehicles are becoming progressively lower;moreover from 2011, diesel cars have to comply with particle number limit. In order to assess emission levels of different technology vehicles and investigate the use of a particulate number measurement technique at the exhaust of very low-emitting vehicles, an experimental activity was carried out on three in-use vehicles: a diesel car equipped with a particulate trap (DPF), a hybrid gasoline-elec- tric car and a bi-fuel passenger car fuelled with compressed natural gas (CNG). Cold and hot gaseous and particulate emission factors and fuel consumption were measured during the execution of real and regulatory driving cycles on a chassis dynamometer. Particulate was characterized in terms of mass only for the diesel car and of particle number for all vehicles. The emissions measured over the NEDC show that all three vehicles comply with their standard limits, except CO for CNG passenger car and NOx for diesel car. Cold start influences CO and HC emissions and fuel consumption for all the tested vehicles and in particular for the hybrid car. The real driving cycle is the most critical pattern for the emissions of almost all pollutants. During constant speed tests, the emissions of particles of hybrid car are an order of magnitude lower than those of the CNG car.

关键词： Particulate Vehicle Emissions Hybrid Car Natural Gas DPF

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Finding the seed of recurrence:Hepatocellular carcinoma circulating tumor cells and their potential to drive the surgical treatment

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 967-978页

作者： Francesca Carissimi Matteo Nazzareno Barbaglia Livia Salmi Cristina Ciulli Linda Roccamatisi Giuseppe Cordaro Venkata Ramana Mallela Rosalba Minisini biagio Eugenio Leone Matteo Donadon Guido Torzilli Mario Pirisi Fabrizio Romano Simone Famularo School of Medicine and Surgery University of Milano-BicoccaMonza 20900Italy Department of Translational Medicine Universitàdel Piemonte OrientaleNovara 28100Italy Unit of Pathology San Gerardo HospitalMonza 20900Italy Department of Hepatobiliary and General Surgery IRCCS Humanitas Clinical and Research Hospital-Department of Biomedical ScienceHumanitas UniversityPieve Emanuele 20090Italy Department of Medicine and Surgery University of Milan-BicoccaMonza 20900Italy

The treatment for hepatocellular carcinoma(HCC)relies on liver resection,which is,however,burdened by a high rate of recurrence after surgery,up to 60%at 5 *** pre-operative tools are currently available to assess the recurrence risk tailored to every single *** liquid biopsy has shown interesting results in diagnosis,prognosis and treatment allocation strategies in other types of cancers,since its ability to identify circulating tumor cells(CTCs)derived from the primary *** cells were advocated to be responsible for the majority of cases of recurrence and cancer-related deaths for *** fact,after being modified by the epithelial-mesenchymal transition,CTCs circulate as“seeds”in peripheral blood,then reach the target organ as dormant cells which could be subsequently“awakened”and activated,and then initiate *** presence may justify the disagreement registered in terms of efficacy of anatomic vs non-anatomic resections,particularly in the case of microvascular invasion,which has been recently pointed as a histological sign of the spread of those ***,their presence,also in the early stages,may justify the recurrence event also in the contest of liver *** the mechanism behind the tumor progression may allow improving the treatment selection according to the biological patient-based ***,it may drive the development of novel biological tailored tests which could address a specific patient to neoadjuvant or adjuvant strategies,and in perspective,it could also become a new method to allocate organs for transplantation,according to the risk of relapse after liver *** present paper will describe the most recent evidence on the role of CTCs in determining the relapse of HCC,highlighting their potential clinical implication as novel tumor behavior biomarkers able to influence the surgical choice.

关键词： Hepatocellular carcinoma Liquid biopsy Circulating tumor cells Liver surgery Microvascular invasion Hepatocellular carcinoma recurrence

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Is osteoporosis risk in anorexia nervosa underestimated? A case report series

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Open Journal of Internal Medicine 2013年第4期3卷 115-118页

作者： Bruno Pacciardi Claudio Cargioli Simone Belli biagio Cotugno Samanta Augusto Luca Di Paolo Mauro Mauri Clinical and Experimental Medicine Department (Psychiatry Division) University of Pisa Italy

Introduction: Anorexia nervosa (AN) is a mental disorder whose features are deliberate weight loss, disordered body image, and intrusive overvalued fears of gaining weight. Long-term consequences of AN include endocrine dysfunctions leading to secondary amenorrhea, bone loss and/or osteoporosis with an increased risk of bone fracture. Therefore young women with AN may develop a risk for bone fractures comparable to that of postmenopausal women. Methods: In this case report series Bone Mineral Density (BMD) was examined by Dual energy X-ray Absorptiometry (DXA) in 19 hospitalized patients with diagnosis of AN and prolonged amenorrhea. Results: All patients showed a lumbar/femoral bone loss or osteoporosis, with an increased fracture risk comparable to that of postmenopausal women. Conclusions: Our observation suggests that DXA evaluation of anorexic patients with prolonged amenorrhea would be helpful to prevent fracture risk in this population of patients. However, although DXA is almost routinely recommended in women over 65, it is not in young AN patients with prolonged amenorrhea.

关键词： Anorexia Nervosa Amenorrhea Osteoporosis Fracturerisk DXA BMD

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Ego strength and health: An empiric study in hemodialysis patients

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Health 2012年第12期4卷 1328-1333页

作者： Salvatore Settineri Carmela Mento Domenico Santoro Agostino Mallamace Guido Bellinghieri Vincenzo Savica biagio Ricciardi Santina Castellino Domenico Mallamace Department Department of Clinical and Experimental Medicine and Pharmacology University of Messina Messina Italy Department of Human and Social Sciences University of Messina Messina Italy Department of Nephrology University of Messina Messina Italy Department of Neurosciences Psychiatric and Anaesthesiological Sciences Division of Psychiatry University of Messina Messina Italy Nephrology and Dialysis Units Papardo Hospital Messina Italy Researcher in Nephrology Department of Internal Medicine University of Messina Messina Italy Unit of Nephrology ASP5 Milazzo Hospital Milazzo Italy Unit of Nephrology ASP5 Taormina Hospital Taormina Italy

Introduction: Ego strength represents an important variable that could be predictable about health and compliance in chronic diseases. In this study we propose a new questionnaire, E.F.E. “Ego Functioning Experience”, able to reveal the psychological functioning profile in Hemodialysis patients. The aim of this work, is to underline the existing relations between emotional profile and compliance, whit E.F.E., that may be predictive of a state of psychologycal health in hemodialysis patients. Methods: Study population included 90 hemodialysis patients. The study protocol was made by three psychological tests: the E.F.E. Questionnaire, the DMI, the Self-Liking and Self-Competence Scale. Results: Factor analysis extracts three factors: 1) “Need of Ego support”;2) “Ego activity oriented to treatment”;3) “Ego strength”. The correlation coefficients between the E.F.E. Questionnaire factors (three factors) and other measures, showed a direct correlation with the first factor and “turning against object” TAO of the DMI test (correlation is significant at the 0.001 level) and an inverse relation with set mechanisms of “Principalization”, PRN of the DMI (correlation is significant at the 0.005 level). The correlations of the second and the third factors with other measures, were not statistically significant. No relations were found about other variables. Conclusions: The E.F.E. questionnaire is a simple evaluation to detect hemo-dialysis patients who may need greater attention to the psychological health and therefore the need for treatment such as psychological support. In fact, lower presence of ego strength is indicative of poor compliance to clinical treatment in hemodialysis, but also of worsening of psychiatric symptoms such as demoralization and depressed mood. In conclusion, an increased social support is needed in hemodialysis patient in order to achieve better compliance and achieve a better state of psychological health in chronic hemodialysis patients.

关键词： Hemodialysis Compliance Ego Strenght Emotional States

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The effect of endogenous ions in the aggregation of Bovine Serum Albumin

The effect of endogenous ions in the aggregation of Bovine S...

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第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Maria R.Mangione Daniela Giacomazza Donatella Bulone Vincenzo Martorana Pier Luigi San biagio Institute of Biophysics - National Research Council - Palermo - Italy

The relation between several pathological diseases(Alzheimer,BSE,Creutzfeldt-Jacob disease,etc.) and the formation of proteinaceous deposits in plaques,amyloid fibrils and filaments has led a great deal of renewed att... 详细信息

关键词： BSA protein aggregation ions gels HPLC

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