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4-Phenylbutyric acid accelerates rehabilitation of barrier function in IPEC-J2 cell monolayer model

Animal Nutrition 2021年第4期7卷 1061-1069页

作者： Qian Jiang Jie Yin Jiashun Chen Xiaokang Ma Miaomiao Wu Xilong Li kang Yao bi'e Tan Yulong Yin Animal Nutritional Genome and Germplasm Innovation Research Center College of Animal Science and TechnologyHunan Agricultural UniversityChangshaHunan 410128China Key Laboratory of Feed biotechnology of Ministry of Agriculture and Rural Affairs Feed Research InstituteChinese Academy of Agricultural SciencesBeijing 100081China Laboratory of Animal Nutritional Physiology and Metabolic Process Institute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan 410125China

As the first line of defence against pathogens and endotoxins crossing the intestine-blood barrier,the intestinal epithelial barrier plays a determinant role in pigs’health and growth.4-Phenylbutyric acid(4-PBA),an aromatic fatty acid,was reported to benefit homeostasis of endoplasmic reticulum and protein ***,whether 4-PBA affects intestinal epithelial barrier function in pigs is *** study aimed to explore the effects of 4-PBA on the intestinal barrier function,using in vitro models of well-differentiated intestinal porcine epithelial cell(IPEC-J2)monolayers in the transwell *** monolayers with or without 4-PBA(1.0 mmol/L)treatment were challenged with physical scratch,deoxynivalenol(DON,2.0μg/mL,48 h),and lipopolysaccharide(LPS,5.0μg/mL,48 h),*** electrical resistance(TEER)and fluorescein isothiocyanate-dextran(FD-4)permeability were measured to indicate barrier integrity and ***-time PCR and Western blot were conducted to determine relative gene and protein expressions of tight junction *** expected,physical scratch,DON,and LPS challenges decreased TEER and increased FD-4 permeability.4-PBA treatment accelerated cell mitigation and rehabilitation of the physical scratch-damaged intestinal epithelial barrier but did not alleviate DON or LPS induced barrier ***,once 48-h DON and LPS challenges were removed,rehabilitation of the epithelial barrier function of IPEC-J2 monolayer was accelerated by the 4-PBA ***,the relative gene and protein expressions of zonula occludens-1(ZO-1),occludin,and claudin-1 were further upregulated by the 4-PBA treatment during the barrier *** together,4-PBA accelerated the IPEC-J2 cell monolayer barrier recovering from physical scratch,DON-,and LPS-induced damage,via enhancing cell mitigation and expressions of tight junction proteins.

关键词： 4-Phenylbutyric acid Intestinal barrier Tight junction Intestinal porcine epithelial cell Deoxynivalenol Lipopolysaccharide

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定量CT测定锁骨远端骨密度分区指导肩锁关节脱位重建的价值

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中国组织工程研究 2024年第12期28卷 1920-1924页

作者：许健毕文智冀云聪康运康马培旗王家亮张宗夕干阜生于海洋郭标安徽医科大学附属阜阳人民医院(阜阳市人民医院) 安徽省阜阳市236000 安徽省脊柱畸形临床医学研究中心安徽省阜阳市236000

背景:肩锁关节脱位喙锁韧带重建在锁骨侧骨隧道的最佳位置尚未达成共识,且术后会发生锁骨侧骨隧道扩大、骨溶解、锁骨骨折、内固定失效等并发症。骨密度在内植物固定强度及稳定性上起重要作用,锁骨远端骨密度的区域差异在肩锁关节脱位... 详细信息

背景:肩锁关节脱位喙锁韧带重建在锁骨侧骨隧道的最佳位置尚未达成共识,且术后会发生锁骨侧骨隧道扩大、骨溶解、锁骨骨折、内固定失效等并发症。骨密度在内植物固定强度及稳定性上起重要作用,锁骨远端骨密度的区域差异在肩锁关节脱位修复重建中不应被忽视,目前临床上尚无人体有关锁骨远端骨密度的定量研究。目的:通过定量CT测量锁骨远端不同区域骨密度的大小,为外科医生修复重建喙锁韧带提供参考。方法:对2022年10-12月在安徽医科大学附属阜阳人民医院(阜阳市人民医院)行定量CT检查的101例患者1616份亚分区进行锁骨远端骨密度测量。对于每个定量CT样本,首先由内侧向外侧划分锁骨远端为以下4个区域,即锥状结节区(A区)、结节间区(B区)、斜方嵴区(C区)以及锁骨远端区(D区),再将每个区域分为前半部分和后半部分确定8个亚分区,在亚分区中设置半自动感兴趣区(ROIA1、A2、B1、B2、C1、C2、D1、D2),将每个定量CT扫描图像传输至QCTpro分析工作站,对锁骨远端感兴趣区松质骨骨密度进行测量,测量时注意避开锁骨骨皮质。结果与结论:①不同侧肩部骨密度比较,差异无显著性意义(P>0.05);②锁骨远端A1、A2、B1、B2、C1、C2、D1、D2亚分区骨密度分析,差异有显著性意义(P0.05),其余亚分区骨密度两两比较差异均有显著性意义(P0.05);斜方韧带解剖止点C1区骨密度高于C2区、D1区及D2区,B区骨密度高于C区及D区,差异有显著性意义(P<0.05);④结果表明,锁骨远端不同区域骨密度存在差异,肩锁关节脱位修复重建时锁骨远端骨密度的区域差异不容忽视,除考虑生物力学因素外,还应考虑将内植物或骨隧道置于骨密度较高的区域,以提高内植物固定强度及稳定性,减少骨隧道扩大、骨溶解、骨折及内植物失效等并发症发生的风险。

关键词：肩锁关节脱位修复重建锁骨骨密度定量CT 区域骨隧道喙锁韧带

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发酵花生粕的营养价值评定及其对仔猪生长性能的影响

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饲料研究 2024年第10期47卷 37-42页

作者：肖晴睿邢芳芳管文波黄蕊王婧谭碧娥崔志英马晓康湖南农业大学动物科学学院湖南长沙410125 临沂市河东区畜牧发展促进中心山东临沂276799 新疆希普生物科技股份有限公司新疆五家渠831300

研究旨在评定发酵花生粕(FPM)的营养价值并研究其对断奶仔猪生长性能影响。试验分为3个部分。试验1:将12头初重为(10.0±2.0) kg的“杜×长×大”三元去势公猪随机分为2组,分别饲喂基础饲粮和FPM饲粮,每组6个重复,每个重复1头猪。利用... 详细信息

研究旨在评定发酵花生粕(FPM)的营养价值并研究其对断奶仔猪生长性能影响。试验分为3个部分。试验1:将12头初重为(10.0±2.0) kg的“杜×长×大”三元去势公猪随机分为2组,分别饲喂基础饲粮和FPM饲粮,每组6个重复,每个重复1头猪。利用全收粪法测定两种饲粮的有效能值,并通过套算法计算FPM的猪消化能与代谢能。试验2:选取12头回肠末端安装T型瘘管的初重为(15.0±2.0) kg的“杜×长×大”三元去势公猪随机分为2组,分别饲喂无氮饲粮和以30%FPM为唯一氮源的半纯合饲粮,每组6个重复,每个重复1头猪。试验期7 d,于最后2 d收集回肠末端食糜以测定FPM的表观回肠消化率(AID)和标准回肠消化率(SID)。试验3:将50头初重为(8.0±1.0) kg的断奶仔猪(公、母各半)随机分为5组,每组10个重复,每个重复1头猪。对照组饲喂玉米-豆粕型基础饲粮,试验组分别饲喂添加2%、4%、6%、8%的FPM试验饲粮,试验期21 d。结果显示:FPM (风干基础)的消化能和代谢能分别为15.17和13.83 MJ/kg,其赖氨酸、蛋氨酸、苏氨酸、色氨酸的SID分别为85.85%、92.44%、87.80%、84.09%。与对照组相比,饲粮中添加FPM对断奶仔猪的平均日采食量和腹泻率无显著影响(P>0.05);添加2%~8%FPM可显著增加平均日增重(P<0.05),降低料重比(P<0.05)。研究表明,FPM的有效能值和氨基酸利用率较高,在断奶仔猪饲粮中添加2%~8%FPM可降低仔猪料重比,其中6%添加比例的饲喂效果较好。

关键词：发酵花生粕断奶仔猪有效能标准回肠氨基酸消化率生长性能

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基于DataOps的企业管理业务全链路的数据中台解决方案

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科学技术创新 2024年第8期 107-110页

作者：熊心雨吕昂李张昆赵康李艳娟张宇航中国电建集团昆明勘测设计研究院有限公司云南昆明云南省水利水电智能建造工程研究中心云南昆明

针对企业管理数字化存在的问题,融入DataOps(数据开发即治理)理念,建立一体化敏捷开发平台,提供异构数据源快速的同步能力,设计标准高效、轻量化、可视化、易运维的数据采集、开发工具,提供标准统一的数据共享服务,通过实际应用表明此... 详细信息

针对企业管理数字化存在的问题,融入DataOps(数据开发即治理)理念,建立一体化敏捷开发平台,提供异构数据源快速的同步能力,设计标准高效、轻量化、可视化、易运维的数据采集、开发工具,提供标准统一的数据共享服务,通过实际应用表明此方案可缩短开发周期,显著提升数据开发效率,有效提升数据治理、分析、服务能力,充分体现数据资源的价值,获得显著应用效果。

关键词：企业数字化 DataOps 数据中台数据治理

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Synthesis and Properties of Hydroxytelechelic Polyisobutylenes by End Capping with tert-Butyl-dimethyl-(4-methyl-pent-4-enyloxy)-silane

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Chinese Journal of Polymer Science 2019年第9期37卷 936-942页

作者： Jing Li kang-Da Wu Huang Shan Jing-Han Zhang Ming Zhao Guang-bi Gong Wen-Li Guo Yi-Bo Wu College of Materials Science & Engineering Beijing Institute of Petrochemical Technology Beijing 102617 China Lanzhou Petrochemical Research Center Petrochina Lanzhou 730060 China Beijing Key Laboratory of Specialty Elastomer Composite Materials Beijing Institute of Petrochemical Technology Beijing 102617 China

The low-activity cationic monomer tert-butyl-dimethyl-(4-methyl-pent-4-enyloxy)-silane was synthesized by Grignard reaction and hydroxyl-protection reaction. Living polyisobutylene chains were initially synthesized by controlled cationic polymerization and then capped with tert-butyl-dimethyl-(4-methyl-pent-4-enyloxy)-silane. The hydrolysis of these polyisobutylenes end capped with tert-butyl-dimethyl-(4-methyl-pent-4-enyloxy)-silane gave rise to hydroxytelechelic polyisobutylene. NMR analysis confirmed that the hydrolysis was complete. Results also showed that a low polymerization temperature favored the participation of tert-butyl-dimethyl-(4- methyl-pent-4?enyloxy)-silane in the end-capping reaction. Moreover, polyisobutylene-based polyurethane exhibited greater acid resistance than commercial polyurethane.

关键词： Carbocationic polymerization Polyisobutylene Hydrolysis Polyisobutylene-based polyurethane

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Py-GC/MS study of lignin pyrolysis and effect of catalysts on product distribution

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International Journal of Agricultural and biological Engineering 2017年第5期10卷 214-225页

作者： Si Zhan Wang Chenguang bi kang Zhang Xinghua Yu Chiling Dong Renjie Ma Longlong Pang Changle bioenergy and Environment Science&Technology Laboratory College of EngineeringChina Agricultural UniversityBeijing 100083China Key Laboratory of Renewable Energy Guangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhou 510640China Key Laboratory of Clean Production and Utilization of Renewable Energy Ministry of AgricultureBeijing 100083China School of Chemical Engineering and Energy Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China National Center for International Research of bioEnergy Science and Technology Ministry of Science and TechnologyBeijing 100083China Department of Vehicle Engineering College of EngineeringChina Agricultural UniversityBeijing 100083China

Fast pyrolysis is one of the most promising methods to convert lignin into fuels and *** the present study,pyrolysis-gas chromatography/mass spectrometry(Py-GC/MS)was used to evaluate vapor phase product distribution of lignin fast *** the non-catalytic pyrolysis process,lignin was pyrolyzed at 400℃,500℃ and 600℃ respectively,finding that the highest yield of aromatic hydrocarbons was obtained at 600℃.Catalytic pyrolysis experiments were also conducted to investigate the effects of catalyst pore structure and acidity on the product *** different catalysts(HZSM-5,MCM-41,TiO_(2),ZrO_(2) and Mg(Al)O)were applied to lignin catalytic pyrolysis,and the catalytic performance was estimated by analyzing the pyrolytic *** catalysts were characterized by using X-ray diffraction(XRD),BET,and NH3(CO_(2))temperature programmed *** on these characterizations,discussion was carried out to explain the formation of the produc *** the five catalysts,HZSM-5 exhibited the best performance on the formation of aromatic hydrocarbons.

关键词： lignin Py-GC/MS fast pyrolysis catalytic upgrading pore structure acid-base property

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模型化研究高分子凝胶体积相变中的共非溶性作用

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原子与分子物理学报 2024年第6期41卷 132-138页

作者：李康睿李循王书恒刘彼得王利云赵新军李九智伊犁师范大学物理科学与技术学院新疆凝聚态相变与微结构实验室伊宁830000 伊犁师范大学微纳电传感器技术与仿生器械实验室伊宁830000 新疆维吾尔自治区人民医院泌尿外科乌鲁木齐830000

基于Flory-Huggins理论,我们建立理论模型,研究在共非溶剂(CNS)中,高分子凝胶(PG)体积相变中的共非溶性作用.理论模型考虑PG中CNS的桥接作用、各种分子的混溶效应.研究发现,当CNS与高分子单体间的吸引强度较小时,CNS与高分子单体间桥接... 详细信息

基于Flory-Huggins理论,我们建立理论模型,研究在共非溶剂(CNS)中,高分子凝胶(PG)体积相变中的共非溶性作用.理论模型考虑PG中CNS的桥接作用、各种分子的混溶效应.研究发现,当CNS与高分子单体间的吸引强度较小时,CNS与高分子单体间桥接作用的减弱,会导致PG体积相变.当CNS与高分子单体间的吸引作用强度较大时,随着CNS与高分子单体间桥接作用的减弱,PG的体积分数呈现两次台阶式的转变,表明PG体系出现两次体积相变.这是由于桥接作用的减弱,虽然会有部分CNS分子被排挤出PG,但是并未完全消除CNS与高分子单体间的桥接吸引作用.所得理论结果符合实验观测,由此表明了共非溶性作用会在很大程度上调控PG的相变行为.

关键词：高分子凝胶共非溶性体积相变

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biosynthesis of Unsaturated Fatty Acids via Mortierella Isabellina Cultivated in a Medium Containing Butanol

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Chemical Research in Chinese Universities 2002年第3期18卷 303-306页

作者： XIAN Mo YAN Ji chang CHENG Tie xin kang Yi jian LI Wen xing bi Ying li ZHEN Kai ji College of Chemistry Jilin UniversityChangchun 130023P.R.China College of Chemistry Northeast Normal UniversityChangchun 130024P.R.China Department of Chemical Engineering Qingdao Chimical Industry InstituteQingdao 266042P.R.China

Mortierella isabellina was found to accumulate large amounts of unsaturated fatty acids when it was grown in a medium containing butanol(5 g/L) and yeast extract(10 g/L) and cultivated at 25 ℃ for 5 d during which additional feeding butanol of 2 g/L was fed after being cultivated for 48 h . The resultant mycelial lipids accounted for 40 1% of the dry mycelia, while about 34% of butanol in the medium was converted. The mycelial lipids contained four kinds of unsaturated fatty acids, i.e ., palmitoleic(4 9%), oleic(54 1%), linoleic(10 4%) and linolenic(5 4%) acids. Those accounted for 74 8% of the total fatty acids. The effects of the culture conditions, such as cultivation temperature, initial pH of the medium and additional feeding butanol in the course of cultivation, on the production of mycelial lipids by M. isabellina were studied.

关键词： Mortierella isabellina Butanol Unsaturated fatty acid biosynthesis

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A Case Report of Inversa Acne and Evaluation for Mutations in the NCSTN, PSENEN, and PSEN1 Genes

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Chinese Medical Journal 2016年第14期129卷 1759-1760页

作者： bi-Rong Guo Cong-Sheng Li Qi-Ming Zhu kang Xu Wei Pan Peng Jiang Department of Dermatology The Third Affiliated Hospital of Anhui Medical University The First People's Hospital of Hefei Hefei Anhui 230061 China Department of Emergency Medicine The Third Affiliated Hospital of Anhui Medical University The First People's Hospital of Hefei Hefei Anhui 230061 China

To the Editor： Acne inversa （AI; OM1M： 142690） is a painful chronic follicular disease, characterized by recurrent draining sinuses and abscesses with subsequent scarring and chronic seepage, predominantly in skin folds that carry terminal hairs and apocrine glands. It mainly affects the scalp, neck, the axillae, perineum, and inframammary regions. AI significantly affects patients＇ quality of life because of the chronic and recurrent nature of symptoms as well as the lack of satisfying treatment options.

关键词： Report Evaluation Genes

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On Spaces with a Locally Countable sn-network

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Chinese Quarterly Journal of Mathematics 2010年第4期25卷 495-499页

作者： kang bi-fang YAN Ming-gang LI Ke-dian Department of Mathematics and Informantion Science Zhangzhou Normal UniversityZhangzhou 363000China Adult Education College Shangqiu Vocational and Technical CollegeShangqiu 476000China

In this paper,spaces with a locally countable sn-network are *** is shown that a space with a locally countable sn-network iff it is an snf-countable space with a locally countable *** its application,almost-open and closed mappings（or finite-to-one and closed mapping） preserve locally countable sn-networks,and a perfect preimage theorem on spaces with a locally countable sn-network is established.

关键词： locally countable family sn-network k-network cs-network

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