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Template-free nanostructured particle growth via a one-pot continuous gradient nanoprecipitation

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Aggregate 2024年第1期5卷 409-418页

作者： Xie Cheng Shuai Wang Julien bernard François Ganachaud Xibo Yan School of Chemical Engineering and Technology Tianjin UniversityTianjinChina College of Food Science and Engineering Tianjin University of Science and TechnologyTianjinChina Universitéde Lyon CNRSUniversitéClaude Bernard Lyon 1INSA-LyonUniversitéJean MonnetUMR5223Ingénierie des Matériaux PolymèresVilleurbanne CedexFrance

Engineered nanoparticles have emerged as new types of materials for a wide range of applications from therapeutics to ***,fabricating nanomaterials presenting complex inner morphologies and shapes in a simple manner remains a great ***,we report the template-free one-pot continuous gradient nanoprecipitation of different types of non-compatible polymers to spontaneously form nanostructured *** continuous addition of antisolvent induces precipitation and(re)organization of polymer chains at the forming particle interface,ultimately and naturally developing complex inner morphologies and shapes while particle *** low-energy-cost bottom-up assembly approach applies to various functional polymers,possibly embedded with metal nanoparticles,for continuous growth into well-organized *** crosslinking of the particles and core removal allows both confirming the building process and leading to hollow or multivoid nanomaterials.

关键词： aggregation nanoprecipitation phase diagrams polymeric nanoparticles self-assembly

Epidemiological Study of Ametropia at the CHU-BSS of Kati

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Surgical Science 2024年第9期15卷 507-513页

作者： Daouda Konaté Bréhima Mariko Sanata Sogoba Maimouna Yattara Lucienne Dembélé Daouda Doumbia Abdramane Traoré claude Oumar bernard Camara Aminata Kouma Koniba Keita Abdoulaye Napo Fatoumata Sylla Lamine Traoré Bocar Sidy Sall University Hospital (CHU-BSS) of Kati Kati Mail University Hospital-Institute of Tropical Ophthalmology of Africa (CHU-IOTA) Bamako Mali Mali Hospital Bamako Mali International Center of Ophthalmology of Mali (CIOM) Bamako Mali National Eye Care Program Bamako Mali

Introduction: Ametropias or refractive errors are pathologies commonly encountered in ophthalmology characterized by the projection on the retina of a blurry image. There are several types of ametropia and each of them has a specific means of correction. In the literature, numerous data have been reported on the issue through studies that were mostly carried out on infant populations. To better treat ametropia in a more formal way, it is important to know their general characteristics within a larger population, hence the present investigation, the aim of which is to carry out an epidemiological study of ametropia at the Kati University Hospital-BSS. Materials and Methods: The study was carried out at Kati University Hospital-BSS between January 1 and December 31, 2022 and included 663 ametropic patients of all ages. Results: During the study period, 663 cases of ametropia were diagnosed out of 1678 new consultations, representing an incidence of 39.51%. Patients aged between 21 and 40 years were more affected. Depending on the type, these ametropias were dominated by compound astigmatism with 68.75% followed by isolated hyperopia and isolated astigmatism. Visual fatigue was the most mentioned reason for consultation. The female gender was in the majority with 70.9%. Low ametropia (Discussion: The growing visual needs of young people, especially with new information and communication technologies, would push them to consult the ophthalmologist more, and therefore to want optical correction in the event of a refractive anomaly, which would partly explain their high frequency in this age group. Conclusion: It is important to know the general characteristics of ametropia in the general population in order to improve the quality of life of patients affected by it through efficient therapeutic solutions.

关键词： Epidemiology Ametropia University Hospital Kati

Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey

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World Journal of Gastroenterology 2006年第48期12卷 7810-7814页

作者： Pierre Ingrand Jérme Gournay Pierre bernard Frédéric Oberti Brigitte bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-claude Barbare Isabelle Ingrand Michel Beauchant Clinical Research Center Poitiers University France Hepato-Gastroenterology Centre Hospitalier Universitaire Nantes France Hepato-Gastroenterology Centre Hospitalier Universitaire Saint-André Bordeaux France Hepato-Gastroenterology Centre Hospitalier Universitaire Angers France Hepato-Gastroenterology Centre Hospitalier Universitaire Reims France Hepato-Gastroenterology Centre Hospitalier Gonesse France Hepato-Gastroenterology Centre Hospitalier Argenteuil France Hepato-Gastroenterology Centre Hospitalier Universitaire Amiens France Hepato-Gastroenterology Centre Hospitalier Creil France Hepato-Gastroenterology Centre Hospitalier Compiègne France Hepato-Gastroenterology Centre Hospitalier Universitaire Poitiers France

AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved.

关键词： Digestive bleeding Portal hypertension Cirrhosis Evaluation studies

Pharmacological attenuation of blood pressure variability

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Acta Pharmacologica Sinica 2005年第11期26卷 1288-1289页

作者： claude JULIEN France Laboratoire de Physiologie Faculte de Pharmacie Lyon 69373 Universite claude bernard Lyon 1

Over the past few years, the research team of ProfessorDing-feng SU has reported an impressive quantity of experimental data about the relationships between blood pressurevariability (BPV) and end-organ damage, a topic of obviousclinical interest. This research work has been summarized ina paper that appeared in the August issue of the renownedjournal Trends in Pharmacological Sciences[1]. The studiesby Su et al provide convincing evidence that BPV is an independent cardiovascular risk factor that should be considered as such and, therefore, might become an important target for therapeutic interventions. Besides these exciting perspectives in the prevention and treatment of cardiovascular

关键词： BPV Pharmacological attenuation of blood pressure variability

Multilayered Polyelectrolyte Films:A Tool for Biomaterial Coatings and Tissue Engineering?

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生物医学工程学杂志 2005年第S1期22卷 5-6页

作者： Jean-claude VOEGEL Joёlle OGIER Catherine PICART Nadia JESSEL Philippe LAVALLE Vincent BALL bernard SENGER Pierre SCHAAF Institut National de la Santéet de la Recherche Médicale UMR 595Facultéde Médecine11rue Humann67085 Strasbourg CedexFrance Institut Charles Sadron UPR 22 CNRSUniversitéLouis Pasteur6 rue Boussingault67083 Strasbourg CedexFrance

1 Physicochemical a spects of multilayered polyelectrolyte f ilms Multilayered polyelectrolyte films are obtained by al-ternated depositions on a solid surface of polyanions and polycations[1].The driving force for the build-up results from the charge excess which appears on the top of the film after each new polyelectrolyte *** film top becomes thus positively(respectively negatively)charged when the film is ending by a polycation(respec-tively polyanion).Various polyelectrolyte systems have been used to realize such architectures,in particular syn-thetic polyelectrolytes(poly-styrene sulfonate:PSS,poly-allylylamine:PAH,etc.);polypeptides(poly-glutamic acid:PGA,poly-lysine:PLL,etc.),polysaccharides[-](hyaluronane:HA,chitosan:Chi,etc.).

关键词： Multilayered Polyelectrolyte Films

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Longitudinal trajectories of athlete burnout among young table tennis players: A 3-wave study

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Journal of Sport and Health Science 2020年第4期9卷 367-375页

作者： Guillaume Martinent Benoıt Louvet Jean-claude Decret Laboratory of Vulnerabilities and Innovation in Sport Claude Bernard University Lyon 1Villeurbanne 69622France Center of Research of Transformations of Sports and Physical Activities(CETAPS) University of RouenMont-Saint-Aignan 76821France French Federation of Table Tennis Paris 75625France

Purpose:The purposes of this study were to examine the trajectories of athlete burnout across a 2-month period characterized by high physical,psychological,and social demands to explore(1)whether several subgroups of athletes representing distinct burnout trajectories emerged from the analyses and(2)whether athlete burnout symptoms(reduced accomplishment,sport devaluation,and exhaustion)developed in tandem or whether some burnout dimensions predicted downstream changes in other dimensions(causal ordering model).Methods:One hundred and fifty-nine table tennis players in intensive training centers completed a self-reported athlete burnout measure across 3 time points within a 2-month period characterized by high *** were analyzed through latent class growth ***:Results of latent class growth analysis showed 3 distinct trajectories for each athlete burnout dimension,indicating not only linear or quadratic change but also stability in longitudinal athlete burnout *** also suggested that the 3 dimensions of athlete burnout did not develop in ***,the likelihood of belonging to particular emerging trajectories of sport devaluation and physical/emotional exhaustion was significantly influenced by the athletes’perception of reduced accomplishment assessed at Time ***,reduced accomplishment predicted downstream changes in the 2 other athlete burnout ***:As a whole,these results highlighted that the multinomial heterogeneity in longitudinal athlete burnout symptoms needs to be accounted for in future research.

关键词： Athlete burnout Intensive training Latent class growth analyses Person-centered approach Table tennis Youth elite athletes

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Sentinel Lymph Node Biopsy Prior to Neoadjuvant Chemotherapy: A Series of 89 Patients

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Journal of Cancer Therapy 2012年第6期3卷 1002-1006页

作者： Flipo bernard Clough Krishna Nos claude Miramand bernard Michel Cecile Houvenaeghel Gilles Meurette Jacques Alfonsi Jean-Pierre Alfonsi Jean-Pierre Clinique St Antoine Ville di Pietrabugno France Breast Surgery Department Centre Antoine Lacassagne Nice France Clough Krishna Institut du Sein Paris France Houvenaeghel Gilles Institut Paoli-Calmettes Marseille France Meurette Jacques Clinique Ste-Amé Lambres lez Douai France Michel Cecile Biostatistics Department Centre Antoine Lacassagne Nice France Miramand bernard Polyclinique Urbain V Avignon France Nos claude Institut du Sein Paris France

Purpose: There are still un-responded questions concerning the type of and the timing of axillary procedures that has to be performed in association with neoadjuvant chemotherapy. Methods: We led a prospective, multicentric, non-randomized study to evaluate the feasibility and accuracy of sentinel lymph node biopsy before neoadjuvant chemotherapy. The clinical and radiological response to chemotherapy was evaluated after 4 treatment cycles and at the end of chemotherapy. Axillary lymph node dissection was performed 3 to 4 weeks after chemotherapy. Histological analysis of sentinel lymph node biopsies and axillary lymph node dissections were studied for each patient. Results: Eighty nine patients had sentinel lymph node biopsy. The identification rate for sentinel lymph nodes was 98.9%. The sentinel lymph node biopsies were metastatic in 44 of 88 patients. Axillary lymph nodes were metastatic in 12 cases. The negative predictive value was 91.1% [95%CI: 85.1% - 97.1%]. Conclusion: Identification rate and negative predictive value of sentinel lymph node biopsy prior to neoadjuvant chemotherapy confirm that the procedure is suitable with its use in standard practice. This approach comprises two surgical procedures, but allows a better nodal status evaluation.

关键词： Breast Cancer Neoadjuvant Therapy Clinical Trial Sentinel Lymph Node Biopsy

真菌Cercospora beticola的12种毒素贝第高林对癌基因ras转导的肾上腺细胞生长的作用(英文)

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Acta Pharmacologica Sinica 2001年第9期22卷 3-10页

作者：丁国庆,Gabriella MAUME,Hanan OSMAN,Martine PADIEU,Marie-Louise MILAT,claude HUMBERT,Jean-Pierre BLEIN,bernard F MAUME Laboratoire de Biochimie des Interactions Cellulaires Faculte de Sciences Universite de Bourgogne BP 400 21011 Dijon Cedex France Laboratoire de Biochimie des Interactions Cellulaires Faculte de Sciences Universite de Bourgogne BP 400 21011 Dijon Cedex France Laboratoire de Biochimie des Interactions Cellulaires Faculte de Sciences Universite de Bourgogne BP 400 21011 Dijon Cedex France Laboratoire de Biochimie des Interactions Cellulaires Faculte de Sciences Universite de Bourgogne BP 400 21011 Dijon Cedex France Laboratoire de Phytopharmacie INRA BV 1540 21034 Dijon Cedex France Laboratoire de Biochimie des Interactions Cellulaires Faculte de Sciences Universite de Bourgogne BP 400 21011 Dijon Cedex France Laboratoire de Phytopharmacie INRA BV 1540 21034 Dijon Cedex France Laboratoire de Biochimie des Interactions Cellulaires Faculte de Sciences Universite de Bourgogne BP 400 21011 Dijon Cedex France Hong Kong Institute of Biotechnology

AIM: To explore different effects of 12 beticolins, Cer-cospora beticola toxins, on ras-transformed adrenocorti-cal cell growth inhibition and their functional mechanism. METHODS: Beticolin-induced inhibition was measured with survival cell number determined by an automated photocolorimetric method. The penetration of beticolin was examined by confocal microscopy. Ras protein determined by Lowry method were separated by 14 % SDS-PAGE and electroblotted to Immobilon-P transfer membrane and detected with pan-Ras (Ab-3) monoclonal antibody. The Ca2+ chelation by beticolin was investigated using a calcium ionophore. RESULTS: Cell growth inhibition was found dose- and time-dependently at submicromolar level for beticolin-1, -2, and -13 (IC50 ≤250 nmol/L) and for beticolin-0, 6, and -11 (400 nmol/L ≤ IC50<500 nmol/L). The inhibition by beticolin-1 was immediate, independent of cell culture step and not reversible for 3-day treatment. Beticolin-3 and -4 were slightly active (1 μmol/L < IC50 ≤ 2 μmol/L) an

关键词：贝第高林细胞分裂转化细胞系肾上腺皮质钙原癌基因蛋白质p21(ras) 共聚焦显微镜检查

Influence of Different Geomorphic Surfaces and Profile Modification on the Growth of <i>Maesopsis eminni</i>(Engl) at the Yongka Western Highlands Research Garden Park Nkwen-Bamenda, North West Cameroon

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American Journal of Plant Sciences 2017年第1期8卷 69-84页

作者： bernard Palmer Kfuban Yerima Roger Kogge Enang claude Assembo Makem Nicole Guehjung Grace Mbakpor Ayuk Department of Soil Science University of Dschang Dschang Cameroon Ministry of Agriculture and Rural Development West Region Cameroon Department of Crop Production University of Dschang Dschang Cameroon

The growth of Maesopsis under the influence of various geomorphic surfaces was followed within a period of 70 months. Young plants of two months old were transplanted into 70 × 70 × 70 cm holes under natural conditions (no inputs such as manure and other amendments). A randomized complete block design was set up for the experiment, alongside a control, and growth parameters followed (height and collar circumference). Three blocks with different geomorphic surfaces were put in place for the experiment (upper slope or block 1, middle slope or block 2 and foot slope or block 3). Results of the experiment indicated that geomorphic surface had a significant effect on height but not on collar circumference. Plant height increased progressively from upper slope to foot slope;less tall trees were found at the upper slope, while the tallest trees were found at the foot slope. After 70 months, maximum average height attained by plants for the experiment was 1228.3 cm, observed in block 3 (foot slope), significant at 0.05 confidence level with respect to geomorphic surface. In blocks 1 and 2 (upper slope and middle slope), maximum average heights attained were 798.5 and 937.5 cm, respectively and were shown to be statistically equal at 0.05 confidence level. Geomorphic surface had no effect on collar circumference. Maximum average collar circumferences attained after 70 months were 62.8 cm (observed at the upper slope), 61.3 cm (observed at the middle slope) and 76.3 cm (observed at the foot slope) and the various collar circumferences were shown to be statistically the same at 0.05 confidence level. For the control, maximum height attained after 70 months was 1240 cm (observed at the foot slope). At the upper slope and middle slope, maximum average heights were respectively, 800 cm and 905 cm, and were statistically equal at the 0.05 confidence level but different from the foot slope value of 1240 cm. Maximum average collar circumference was observed at the foot slope (76.3 c

关键词： Maesopsis Upper Slope Middle Slope Foot Slope Height Collar Circumference Profile Modification Induced Hydrolysis