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Antidiabetic effect of Chrysophyllum albidum is mediated by enzyme inhibition and enhancement of glucose uptake via 3T3-L1 adipocytes and C2C12 myotubes

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Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 387-396页

作者： benjamin kingsley harley Rita Akosua Dickson Isaac kingsley Amponsah Robert A Ngala Dorice Berkoh Theophilus Christian Fleischer Department of Pharmacognosy and Herbal Medicine School of PharmacyUniversity of Health and Allied SciencesHoGhana Department of Pharmacognosy Faculty of Pharmacy and Pharmaceutical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Molecular Medicine School of Medical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Basic and Applied Biology School of SciencesUniversity of Energy and Natural ResourcesSunyaniGhana

Objective:To investigate the in vivo and in vitro antidiabetic potential of Chrysophyllum ***:The effects of oral treatment with hydro-ethanolic extract(125,250 and 500 mg/kg)of the stem bark of Chrysophyllum albidum and glibenclamide for 21 d on glucose level,serum enzyme markers for liver function,lipid profile,total protein,serum urea,serum creatinine,and body weight were evaluated in experimental diabetic rats administered with 45 mg/kg of *** vitro assays including glucose uptake in C2 C12 cells and 3 T3-L1 adipose tissues,α-glucosidase andα-amylase inhibition were employed to evaluate the possible mechanism of hypoglycemic action of the *** and nitric oxide radical antioxidant activity of the extract was also ***:The increased levels of blood glucose,triglycerides,lowdensity lipoprotein,total cholesterol,serum aspartate,and alanine transaminases,creatinine,and urea in the diabetic animals were reduced significantly(P<0.01)after treatment with Chrysophyllum albidum *** decreased total protein and high-density lipoprotein concentrations were normalized after *** addition,the extract significantly(P<0.01)increased the transport of glucose in 3 T3-L1 cells and C2 C12 myotubes and exhibited considerable potential to inhibitα-amylase andα-*** also demonstrated potent antioxidant action by scavenging considerably DPPH and nitric oxide ***:Chrysophyllum albidum stem bark extract exhibits considerable antidiabetic effect by stimulating glucose uptake and utilization in C2 C12 myotubes and 3 T3-L1 adipocytes as well as inhibiting the activities ofα-amylase andα-glucosidase.

关键词： Antidiabetic C2C12 myotubes α-glucosidase inhibition α-amylase inhibition Glucose uptake Chrysophyllum albidum

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Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish:Possible involvement of GABAergic and serotonergic pathways

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Natural Products and Bioprospecting 2023年第1期13卷 400-412页

作者： Donatus Wewura Adongo Charles Kwaku Benneh Augustine Tandoh Robert Peter Biney Kennedy Kwami Edem Kukuia Priscilla Kolibea Mante benjamin kingsley harley David Oteng Emmanuel Aduboffour Appiah Ernest Cudjoe Anorbor Eric Woode Department of Pharmacology and Toxicology School of PharmacyUniversity of Health and Allied SciencesHoGhana Department of Pharmacotherapeutics and Pharmacy Practice School of Pharmacy and Pharmaceutical SciencesUniversity of Cape CoastCape CoastGhana Department of Medical Pharmacology University of Ghana Medical SchoolCollege of Health SciencesUniversity of GhanaKorle BuAccraGhana Department of Pharmacology Faculty of Pharmacy and Pharmaceutical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Pharmacognosy and Herbal Medicine School of PharmacyUniversity of Health and Allied SciencesHoGhana

Pseudospondias microcarpa is used in ethnomedicine to manage central nervous system *** hydroethanolic extract(PME)from the leaves of the plant has shown anxiolytic-like properties in mice anxiety ***,its effects in chronic anxiety models and possible mechanism(s)of action were not ***,the current study evaluated the anxiolytic-like mechanisms of PME in zebrafish models of *** zebrafish light dark test(LDT)and novel tank test(NTT)were employed to assess the anxiolytic-like effects of PME(0.1,0.3,1.0 mg mL^(−1)),fluox-etine(3×10^(−5)mg mL^(−1))and diazepam(1.5×10^(−7)mg mL^(−1)).The chronic unpredictable stress(CUS)test was used to further evaluate the extract’s anxiolytic-like *** potential mechanisms of anxiolytic action of the extract was evaluated after pre-treated with flumazenil,granisetron,methysergide,or pizotifen,all at 1×10^(−3)mg mL^(−1).The extract significantly decreased anxiety behaviours in the NT and LD *** observed effects of the extract were however counteracted by flumazenil,granisetron,methysergide and pizotifen *** addition,PME treatment significantly reversed CUS-induced anxiety behaviours in *** show that PME possesses anxiolytic-like effects possibly through interaction with serotonergic and gamma-aminobutyric acid mediated pathways.

关键词： Anxiety disorders Pseudospondias microcarpa Zebrafish Novel tank Benzodiazepines

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Association of Obesity and Dyslipidaemia with Type 2 Diabetes in Outpatients of Enugu State University Teaching Hospital （ESUTH）in Enugu Nigeria

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Journal of Life Sciences 2018年第2期12卷 92-99页

作者： Godwill Azeh Engwa Amanda Okolie Friday Nweke Nwalo Emmanuela Akaniro-Ejim Marian N.Unachukwu Micheal Ndidiamaka Ozofor kingsley N. Agbafor benjamin Ewa Ubi Department of Chemical Sciences Godfrey Okoye University P. M. B 01014 Thinkers Comer Enugu Nigeria Department of Biotechnology Federal University Ndufu-Alike Ikwo (FUNAI) P. M. B. 1010 Abakaliki Nigeria Department of Biotechnology Godfrey Okoye University P. M. B 01014 Thinkers Corner Enugu Nigeria Department of Microbiology Godfrey Okoye University P. M. B 01014 Thinkers Comer Enugu Nigeria Department of Computer Science and Mathematics Godfrey Okoye University P. M. B 01014 Thinkers Corner Enugu Nigeria Department of Biochemistry Ebonyi State University P. M. B 53 Abakaliki Nigeria Department ofBiotechnology Ebonyi State University P. M. B 53 Abakaliki Nigeria

Obesity is known to be a major risk factor of type 2 diabetes （T2D） and responsible for most lipid abnormalities associated with the disease but limited data on such association are available for diabetic patients of Igbo ethnicity in the South East region of Nigeria. A case-control study involving 72 T2D patients and 75 non-diabetic （ND） patients （control） ofIgbo ethnicity was conducted. Demographic and anthropometric data were obtained followed by blood collection for the determination of fasting blood sugar （FBS）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL） and low density lipoprotein （LDL）. Obesity based on waist circumference （WC） was significantly higher （p 〈 0.001） in T2D patients compared to their non-diabetic counterparts. Similarly, TC, TG and LDL levels were significantly （p 〈 0.001） higher in T2D patients while HDL was significantly lower （p 〈 0.001） in T2D patients compared to the control. The proportion of dyslipidaemia characterized by high TC, high TG, high LDL and low HDL was significantly higher （p 〈 0.001） in T2D patients. BMI correlated positively （p 〈 0.05） with WC, TC, and LDL while FBS correlated positively （p 〈 0.05） with TG but negatively with HDL. In conclusion, dyslipidaemia characterised by hypercholesterolaemia, hypertriglyceridaemia, elevated LDL and reduced HDL, as well as obesity were associated with T2D and correlated with FBS in this population.

关键词： Type 2 diabetes obesity Igbo dyslipidaemia Enugu.

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Multispectral Imaging in Combination with Multivariate Analysis Discriminates Selenite Induced Cataractous Lenses from Healthy Lenses of Sprague-Dawley Rats

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Open Journal of Biophysics 2017年第3期7卷 145-156页

作者： Peter Osei-Wusu Adueming Moses Jojo Eghan benjamin Anderson Samuel Kyei Jerry Opoku-Ansah Charles L. Y. Amuah Samuel Sonko Sackey Paul kingsley Buah-Bassuah Laser and Fibre Optics Centre (LAFOC) Department of Physics School of Physical Sciences College of Agriculture and Natural Sciences University of Cape Coast Cape Coast Ghana Department of Optometry School of Allied Health Sciences College of Health and Allied Sciences University of Cape Coast Cape Coast Ghana

Cataracts are the leading cause of blindness worldwide. Current methods for discriminating cataractous lenses from healthy lenses of Sprague-Dawley rats during preclinical studies are based on either histopathological or clinical assessments which are weakened by subjectivity. In this work, both cataractous and healthy lens tissues of Sprague-Dawley rats were studied using multispectral imaging technique in combination with multivariate analysis. Multispectral images were captured in transmission, reflection and scattering modes. In all, five spectral bands were found to be markers for discriminating cataractous lenses from healthy lenses;470 nm and 625 nm discriminated in reflection mode whereas 435 nm, 590 nm and 700 nm discriminated in transmission mode. With Fisher’s Linear discriminant analysis, the midpoints for classifying cataractous from healthy lenses were found to be 14.718 × 10−14 and 3.2374 × 10−14 for the two spectra bands in the reflection mode and the three spectral bands in the transmission mode respectively. Images in scattering mode did not show significant discrimination. These spectral bands in reflection and transmission modes may offer potential diagnostic markers for discriminating cataractous lenses from healthy lenses thereby promising multispectral imaging applications for characterizing cataractous and healthy lenses.

关键词： Multispectral Imaging Cataractous Lenses Principal Component Analysis Fisher’s Linear Discriminant Analysis

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Economic Growth,Industrialization,Trade,Electricity Production and Carbon Dioxide Emissions:Evidence from Ghana

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Journal of Economic Science Research 2021年第1期4卷 31-43页

作者： kingsley Appiah Rhoda Appah Oware Kofi Mintah benjamin Yeboah AAIS Department Kumasi Technical UniversityBox 854KumasiGhana Atwima Kwanwoma Senior High/Technical School Box 5104AdumKumasiGhana Banking and Finance Department Kumasi Technical UniversityBox 854KumasiGhana

The study scrutinized correlation between electricity production,trade,economic growth,industrialization and carbon dioxide emissions in *** study disaggregated trade into export and import to spell out distinctive and individual variable contribution to emissions in *** an attempt to investigate,the study used time-series data set of World Development Indicators from 1971 to *** means of Autoregressive Distributed Lag(ARDL)cointegrating technique,study established that variables are co-integrated and have long-run equilibrium *** of long-term effect of explanatory variables on carbon dioxide emissions indicated that 1%each increase of economic growth and industrialization,will cause an increase of emissions by 16.9%and 79%individually whiles each increase of 1%of electricity production,trade exports,trade imports,will cause a decrease in carbon dioxide emissions by 80.3%,27.7%and 4.1%*** the pursuit of carbon emissions’mitigation and achievement of Sustainable Development Goal(SDG)13,Ghana need to increase electricity production and trade exports.

关键词： ARDL bounds testing Carbon dioxide emission Economic growth Trade Industrialization Ghana

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The impact of COVID-19 on the birth rate in Nigeria:a report from population-based registries

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Infectious Diseases Research 2023年第1期4卷 14-18页

作者： Charlotte Blanche Oguejiofor Kenechi Miracle Ebubechukwu George Uchenna Eleje Emmanuel Onyebuchi Ugwu Joseph Tochukwu Enebe kingsley Emeka Ekwuazi Chukwuemeka Chukwubuikem Okoro Boniface Chukwuneme Okpala Charles Chukwunomunso Okafor Nnanyelugo Chima Ezeora Emeka Ifeanyi Iloghalu Chidebe Christian Anikwe Chigozie Geoffrey Okafor Polycarp Uchenna Agu Emeka Philip Igbodike Iffiyeosuo Dennis Ake Arinze Anthony Onwuegbuna Osita Samuel Umeononihu Onyedika Promise Anaedu Odigonma Zinobia Ikpeze David Chibuike Ikwuka Henry Ifeanyi Nwaolisa Ekene Agatha Emeka Jude Ogechukwu Okoye Ihechinyerem Kelechi Osuagwu Angela Ogechukwu Ugwu Toochukwu benjamin Ejikeme Eziamaka Pauline Ezenkwele Chijioke Ogomegbunam Ezeigwe Malarchy Ekwunife Nwankwo Gerald Okanandu Udigwe Joseph Ifeanyichukwu Ikechebelu Grace Agbaeze Chukwuebuka Divine Nwanja Ahizechukwu Chigoziem Eke Department of Obstetrics and Gynecology Nnamdi Azikiwe University Teaching HospitalNnewi PMB 5025Nigeria Preventive Medicine and Research Department Clina-Lancet LaboratoriesVictoria IslandLagos 101241Nigeria Effective Care Research Unit Department of Obstetrics and GynecologyNnamdi Azikiwe UniversityNnewi Campus 435001Nigeria Department of Obstetrics and Gynecology College of MedicineUniversity of Nigeria Enugu CampusEnuguEnugu State 400102Nigeria Department of Obstetrics and Gynecology University of Nigeria Teaching HospitalItuku OzallaEnugu State 400102Nigeria Department of Obstetrics and Gynecology ESUT Teaching HospitalParklaneEnugu 400102Nigeria Medical Department Divine Medical CentreSouth West IkoyiLagos 1001233Nigeria Department of Obstetrics and Gynecology Havana Specialist HospitalSurulereLagos 100011Nigeria Clinical Trial Division Drug Evaluation and Research DirectorateNAFDAC office ComplexLagos 100011Nigeria Department of Ophthalmology Nnamdi Azikiwe UniversityNnewi campus 435001Nigeria Department of Human Physiology Nnamdi Azikiwe University NnewiAnambra State 435001Nigeria Department of Family Medicine Faculty of MedicineNnamdi Azikiwe UniversityAwka 435001Nigeria Department of Medical Laboratory Science Faculty of Health Sciences and TechnologyNnamdi Azikiwe UniversityAwka 435001Nigeria Department of Health Services Federal University of TechnologyOwerri 460103Nigeria Department of Haematology and Immunology College of MedicineUniversity of Nigeria Enugu CampusEnuguEnugu State 400102Nigeria Musgrove Park Hospital Somerset NHS Foundation TrustUnited Kingdom TLTp Medical(UHS) Southampton WS15United Kingdom Division of Maternal Fetal Medicine Department of Gynecology and ObstetricsJohns Hopkins University School of MedicineBaltimore 21201U.S.A

Background and objectives:Coronavirus disease 2019(COVID-19)is a pandemic that has become a major source of morbidity and mortality worldwide,affecting the physical and mental health of individuals influencing *** the threat,it poses to maternal health in sub-Saharan Africa and Nigeria,there is little or no data on the impact it has on fertility,conception,gestation and *** compare the birth rate between pre-COVID and COVID times using selected months of the *** and methods:This was a secondary analysis of cross-sectional analytical study data from the birth registries of three tertiary hospitals,comparing two years[2019(Pre-COVID)]versus[2020(COVID era)]using three months of the year(October to December).The data relied upon was obtained from birth registries in three busy maternity clinics all within tertiary hospitals in South-East Nigeria and we aimed at discussing the potential impacts of COVID-19 on fertility in *** secondary outcome measures were;mode of delivery,booking status of the participants,maternal age and ***:There was a significant decrease in tertiary-hospital based birth rate by 92 births(P=0.0009;95%CI:-16.0519 to-4.1481)among mothers in all the three hospitals in 2020 during the COVID period(post lockdown months)of October to *** was a significant difference in the mode of delivery for mothers(P=0.0096)with a 95%confidence interval of 1.0664 to 1.5916,as more gave birth through vaginal delivery during the 2020 COVID-19 period than ***:Tertiary-hospital based birth rates were reduced during the *** multi-centre study extrapolated on possible factors that may have played a role in this decline in their birth rate,which includes but is not limited to;decreased access to hospital care due to the total lockdowns/curfews and worsening inflation and economic recession in the country.

关键词： birth rates COVID-19 lockdown Nigeria pandemic pre-COVID

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