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Baosteel Technical Research 2023年第4期17卷 1-16页

作者： HOU Wenjie Maria Elena Navarro Rivero PAN Jin ZOU Boyang benjamin grégoire Anabel Palacios DING Yulong Baowu Carbon Technology Co. Ltd.Shanghai 201999China Birmingham Centre for Energy Storage&School of Chemical Engineering University of BirminghamBirmingham B152TTUnited Kingdom

Concentrating solar power(CSP) has garnered considerable global attention as a reliable means of generating bulk electricity, effectively addressing the intermittent nature of solar *** integration of molten salt technology for thermal energy storage(TES) has further contributed to the growth of CSP plants;however, the corrosive nature of molten salts poses challenges to the durability of container materials, necessitating innovative corrosion mitigation *** review summarizes scientific advancements in high-temperature anticorrosion coatings for molten nitrate salts, highlighting the key challenges and future *** also explores various coating types, including metallic, ceramic, and carbon-based coatings, and compares different coating deposition *** review emphasizes the need for durable coatings that meet long-term performance requirements and regulatory limitations, with an emphasis on carbon-based coatings and emerging nanomaterials.A combination of multiple coatings is required to achieve desirable anticorrosion properties while addressing material compatibility and cost *** overall goal is to advance the manufacturing, assembly, and performance of CSP systems for increased efficiency, reliability, and durability in various applications.

关键词： anticorrosive coating high temperature molten salt concentrated solar power thermal energy storage

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碳基防腐涂层在高温熔盐中的耐腐蚀性能研究

宝钢技术 2023年第4期 69-78页

作者：侯文杰 benjamin grégoire 姚圣泽邓维雨赵弘毅丁玉龙宝武碳业科技股份有限公司上海201999 伯明翰大学储能研究中心&化工学院伯明翰英国B152TT

在聚光太阳能发电(CSP)系统中,高温熔盐带来的腐蚀问题是亟需解决的问题之一,耐高温防腐涂料的研发是解决该问题的一个重点。于565℃的空气、盐蒸汽和熔融太阳盐环境中评价了市售石墨漆grAPHIT 33和碳基浆料C涂层对碳钢A516的保护情况... 详细信息

在聚光太阳能发电(CSP)系统中,高温熔盐带来的腐蚀问题是亟需解决的问题之一,耐高温防腐涂料的研发是解决该问题的一个重点。于565℃的空气、盐蒸汽和熔融太阳盐环境中评价了市售石墨漆grAPHIT 33和碳基浆料C涂层对碳钢A516的保护情况。对比测试分析结果表明:碳基浆料C涂层能够一定程度上减缓A516在565℃太阳盐中的腐蚀,形成的腐蚀层致密且连续。

关键词：碳基涂层防腐高温熔盐

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

Mixing Monte-Carlo and Partial Differential Equations for Pricing Options

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Chinese Annals of Mathematics,Series B 2013年第2期34卷 255-276页

作者： Tobias LIPP grgoire LOEPER Olivier PIRONNEAU LJLL-UPMC Boite 187Place Jussieu75252 Paris cedex 5France BNP-Paribas 20 Boulevard des Italiens75009 ParisFrance

There is a need for very fast option pricers when the financial objects are modeled by complex systems of stochastic differential *** the authors investigate option pricers based on mixed Monte-Carlo partial differential solvers for stochastic volatility models such as Heston'*** is found that orders of magnitude in speed are gained on full Monte-Carlo algorithms by solving all equations but one by a Monte-Carlo method,and pricing the underlying asset by a partial differential equation with random coefficients,derived by Ito *** strategy is investigated for vanilla options,barrier options and American options with stochastic volatilities and jumps optionally.

关键词： Monte-Carlo Partial differential equations Heston model Financial mathematics. Option pricing

Hypoxia Conditioning for High-Altitude Pre-acclimatization Martin

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Journal of Science in Sport and Exercise 2022年第4期4卷 331-345页

作者： Burtscher grégoire P.Millet Johannes Burtscher University of Innsbruck 6020 InnsbruckAustria Austrian Society for Alpine and High-Altitude Medicine 6020 InnsbruckAustria Institute of Sport Sciences University of Lausanne1015 LausanneSwitzerland Department of Biomedical Sciences University of Lausanne1015 LausanneSwitzerland

Purpose Main purposes of pre-acclimatization by hypoxia conditioning(HC)are the prevention of high-altitude illnesses and maintenance of aerobic exercise ***,robust evidence for those effects or evidence-based guidelines for exposure strategies,including recommendations to ensure safety,are largely ***,we summarize the current knowledge on the physiology of acclimatization to hypoxia and HC with the aim to derive implications for pre-acclimatization strategies before going on high-altitude treks and *** Based on the literature search and personal experience,core studies and important observations have been selected in order to present a balanced view on the current knowledge of high-altitude illnesses and the acclimatization process,specifically focusing on pre-acclimatization strategies by *** and Conclusions It may be concluded that in certain cases even short periods(e.g.,7 h)of pre-acclimatization by HC are effective,but longer periods(e.g.,>60 h)are needed to elicit more robust *** 300 h of HC(intermittently applied)may be the optimal preparation for extreme altitude sojourns,although every additional hour spent in hypoxia may confer further *** inclusion of hypobaric exposures(i.e.,real altitude)in pre-acclimatization protocols could further increase their *** level of simulated altitude is progressively increased or individually adjusted *** should not be terminated earlier than 1-2 weeks before altitude *** monitoring of the pre-acclimatization program is strongly recommended.

关键词： Hypoxia Normobaric Hypobaric Conditioning Acclimatization Altitude

Is Hypoxic/Altitude Training an Important Topic in the Field of Hypoxia?

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Journal of Science in Sport and Exercise 2022年第4期4卷 293-305页

作者： grégoire P.Millet Martin Burtscher Johannes Burtscher Institute of Sport Sciences University of LausanneCampus Dorigny1015 LausanneSwitzerland Department of Biomedical Sciences University of Lausanne1015 LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Hypoxia is an essential topic in medical or biological *** main aims of the present study were to examine the most important medical articles(i.e.,the top 100 most cited)on *** examine how the Nobel-prize awarded hypoxia inducible factor(HIF)-pathway discovery in the early 1990s has changed the thematic composition of this body of literature,with a special emphasis on the studies linking hypoxia and *** searched Pubmed for articles with the terms#Hypox,#Altitude,or#Mountain in the title that have been published in biomedical journals and ranked the articles on their number of citations in Web of Science.A second search was performed in all journals for articles related to hypoxia and ***,only 12 of the top-100 most-cited articles on hypoxia and only 3 articles of the top-100 articles related to cancer were published before ***,only 5 articles from prior 1995 reached 1000 citations,while 27 articles published in 1995 or later were cited more than 1000 times,most of them on the HIF-1 *** percent of the top-100 articles were related to the HIF pathway,while there were no articles on the application of hypoxia either for therapeutic use(i.e.,hypoxic conditioning in patients)or for performance enhancement(i.e.,altitude training in athletes).In conclusion,the early-1990s discovery of the HIF pathway and of its molecular regulation has shifted the focus of hypoxia research towards molecular mechanisms and consequences of tissue hypoxia,most notably in *** importance of studies focusing on clinical and performance applications of systemic hypoxia is relatively lower.

关键词： Altitude training Cancer Hypoxia HIF pathway Mountain

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Rationale for the potential use of mesenchymal stromal cells in liver transplantation

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World Journal of Gastroenterology 2014年第44期20卷 16418-16432页

作者： Morgan Vandermeulen Céline grégoire Alexandra Briquet Chantal Lechanteur Yves Beguin Olivier Detry Department of Abdominal Surgery and Transplantation CHU Liege University of Liege Department of Hematology CHU Liege University of Liege Laboratory of Cell and Gene Therapy CHU Liege University of Liege

Mesenchymal stromal cells (MSCs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective tissues of most organs. MSCs represent a heterogeneous population of adult, fibroblast-like cells characterized by their ability to differentiate into tissues of mesodermal lineages including adipocytes, chondrocytes and osteocytes. For several years now, MSCs have been evaluated for their in vivo and in vitro immunomodulatory and ‘tissue reconstruction’ properties, which could make them interesting in various clinical settings, and particularly in organ transplantation. This paper aims to review current knowledge on the properties of MSCs and their use in pre-clinical and clinical studies in solid organ transplantation, and particularly in the field of liver transplantation. The first available clinical data seem to show that MSCs are safe to use, at least in the medium-term, but more time is needed to evaluate the potential adverse effects of long-term use. Many issues must be resolved on the correct use of MSCs. Intensive in vitro and pre-clinical research are the keys to a better understanding of the way that MSCs act, and to eventually lead to clinical success.

关键词： Mesenchymal stem cells Organ transplantation Complication Immunosuppression Tolerance

2D Curves in Conformal Hyperquaternion Algebras H^⊗2m

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Journal of Applied Mathematics and Physics 2023年第10期11卷 2904-2912页

作者： grégoire Lutanda Panga Department of Mathematics and Informatic University of Lubumbashi Lubumbashi the Democratic Republic of the Congo

The aim of this paper is to outline the conditions of a conformal hyperquaternion algebra H⊗2m in which a higher order plane curve can be described by generalizing the well-known cases of conics and cubic curves in 2D. In other words, the determination of the order of a plane curve through n points and its conformal hyperquaternion algebra H⊗2m is the object of this work.

关键词： Clifford Algebra Hyperquaternion Algebra Conformal Hyperquaternion Al-gebra