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Evaluati.n of Rati.nal Use of Anti.etrovi.als before the Dolutegravi. Transi.i.n i. Ki.shasa, Democrati. Republi. of Congo

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World Journal of Ai.S 2021年第2期11卷 41-49页

作者： Eri.k N. Kamangu ben i. bulanda i.ri.s M. Mwanaut Si.pli.e K. Makoka Gauthi.r K. Mesi. “Focus Hi./Ai.S” Research Group Kinshasa Democratic Republic of Congo Hi./Ai.S Uni. Service of Molecular Biology Department of Basic Sciences Faculty of Medicine University of Kinshasa Kinshasa Democratic Republic of Congo Uni. of Cli.i.al Pharmacology and Pharmacovi.i.ance Department of Pharmacology and Therapeutics Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo

Background: The ulti.ate goal of Anti.etroVi.al Treatments (ART) i. to achi.ve complete i.mune restorati.n and lasti.g vi.al suppressi.n i. the i.fected pati.nt. i. order to ensure the effi.acy, safety and accessi.i.i.y of anti.etrovi.al drugs (ARVs), i. i. recommended that they should be prescri.ed accordi.g to nati.nal gui.eli.es;whi.h are evolvi.g wi.h the vari.us recommendati.ns of the World Health Organi.ati.n (WHO) and the arri.al of newer, more effecti.e and safer molecules. Objecti.e: The objecti.e of thi. study was to assess the rati.nal use of Anti.etrovi.als i. pati.nts treated i. Ki.shasa before the use of Dolutegravi. wi.hi. the nati.nal program i. order to assess the correct use of these molecules. Methods: Thi. work i. a descri.ti.e cross-secti.nal study to assess the rati.nal use of fi.st-li.e ARVs among People Li.i.g wi.h Hi. (PLHi.) i. di.ferent Centers of Treatment (ATCs) i. Ki.shasa before the i.troducti.n of Dolutegravi.. The records of pati.nts on ARVs were randomly and rati.nally selected i. 12 di.ferent ATCs for Hi. i. Ki.shasa accordi.g to three centers per di.tri.t i. the peri.d from June to September 2018. i.formati.n on use and consumpti.n of ARVs, compli.nce wi.h gui.eli.es, change of therapeuti. combi.ati.n as well as thei. reasons were consulted for the present study. Results: 507 fi.es of PLHi. were collected i. the vari.us ATCs. 274 (54.1%) were from female pati.nts. The most represented age group was 26 to 35 years wi.h 192 pati.nts (37.9%). The mean durati.n of fi.st-li.e treatment for all pati.nts i.cluded was 16.30 ± 5.85 months. The most wi.ely used combi.ati.n of ARVs overall was TDF + 3TC + EFV at 45.4%. 305 (60.2%) PLHi. kept the same fi.st-li.e treatment molecule throughout the treatment peri.d wi.h an average treatment durati.n of 12.9 ± 2.77 months. The most common combi.ati.n found i. thi. populati.n was TDF + 3TC + EFV (69.2%). 202 (39.8%) PLHi. changed

关键词： Rati.nal Use ARVs Dolutegravi. Ki.shasa

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Geochemi.try, mi.eral paragenesi. and geothermal condi.i.ns of oreformi.g flui.s from the Ai. El Bey Cu–Fe deposi.: potenti.l occurrence of nati.e gold and preci.us metal traces (North Afri.an orogeni. belt, Northern Tuni.i.)

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Acta Geochi.i.a 2024年第2期43卷 366-384页

作者： Rani. ben Ai.sa Wi.m ben Ai.sa Sai. Tli. Lassaad ben Ai.sa Abdessalem ben Haj Amara Faculty of Sci.nce of Bi.erte University of Carthage7021 ZarzounaBizerteTunisia Laboratoi.e de Recherche Ressources Materiaux et EcosystemesUniversity of Carthage7021 ZarzounaBizerteTunisia Department of Geology University Claude Bernard Lyon 169622 VilleurbanneFrance Faculty of Sci.nce of Tuni. University of Tunis-El ManarRommana1068 TunisTunisia

The Ai. El Bey abandoned mi.e, i. North-West Tuni.i., fi.s i.to the geodynami. context of the European and Afri.an plate boundary. Ore deposi. corresponds to vei.s and brecci. of multi.hase Cu–Fe-ri.h mi.erali.ati.n related to vari.us hydrothermal flui. ci.culati.ns. Petromi.eralogi.al studi.s i.di.ate a ri.h mi.eral paragenesi. wi.h a mi.i.um of seven mi.erali.ati.n phases and, at least, si. pyri.e generati.ns. As i. also the case for galena and nati.e si.ver, nati.e gold i. observed for the fi.st ti.e as i.clusi.n i. quartz whi.h opens up, thus, new perspecti.es for prospecti.g and evaluati.g the potenti.l for noble metals associ.ted wi.h the mi.erali.ati.n. Scanni.g Electron Mi.roscope--Energy Di.persi.e Spectroscopy and Transmi.si.n electron mi.roscopy analyses show, i. addi.i.n, a large i.corporati.n of trace elements, i.cludi.g Ag and Au, i. mi.eral structures such as fahlores(tetrahedri.e-tennanti.e) and chalcopyri.e ones. The mi.eral/mi.eral associ.ti.ns, used as geothermometers, gave esti.ated temperatures for the mi.erali.i.g flui.s varyi.g from 254 to 330 ℃ for phase Ⅲ, from 254 to 350 ℃ for phase Ⅳ, and from 200 to 300 ℃ for phases Ⅴ and Ⅵ. The seventh and last i.enti.i.d mi.erali.ati.n phase, marked by a deposi. of nati.e gold, reflects a drop i. the mi.erali.i.g flui.’s temperature(i.le wi.h boi.i.g condi.i.ns. Such results open up perspecti.es for the development of preci.us metal research and the revaluati.n of the Cu–Fe ore deposi. at the Ai. El Bey abandoned mi.e, as well as at the surroundi.g areas fi.ti.g i. the geodynami. framework of the Afri.a-Europe plate boundary.

关键词： Ore-formi.gﬂui.s Mi.eral geochemi.try Mi.eral geothermometers Nati.e si.ver-gold Ai. El Bey Ore deposi. North Tuni.i.

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Cooperati.e Target Fenci.g of Multi.le Vehi.les for a General Target wi.h Connecti.i.y Preservati.n and Colli.i.n Avoi.ance

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Journal of Systems Sci.nce & Complexi.y 2024年第1期37卷 136-151页

作者： PAN Zi.i.CHEN ben M Department of Mechani.al and Automati.n Engi.eeri.g The Chinese University of Hong KongHong KongChina

i. thi. paper,the authors study the cooperati.e target-fenci.g problem for n-di.ensi.nal systems and a target wi.h a general *** usi.g the veloci.y of the vehi.les,a posi.i.n feedback control law i. proposed to fence the general target i.to the convex hull formed by the ***,the dynami.s of each vehi.le i. descri.ed by a double-i.tegrator *** potenti.l functi.ns are desi.ned to guarantee connecti.i.y preservati.n of the communi.ati.n network and colli.i.n avoi.ance among the *** proposed approach can deal wi.h a target whose trajectory i. any twi.e conti.uously di.ferenti.ble functi.n of *** effecti.eness of the result i. veri.i.d by a numeri.al example.

关键词： Multi.agent systems networked systems target fenci.g

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Prepari.g li.i. nanoparti.les wi.h tunable drug loadi.g capaci.y and morphology vi. i.proved sequenti.l nanopreci.i.ati.n

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Sci.nce Chi.a Chemi.try 2024年第5期67卷 1373-1374页

作者： Haoran Wang ben Zhong Tang Hong Kong Branch of Chi.ese Nati.nal Engi.eeri.g Research Center for Ti.sue Restorati.n and Reconstructi.n Department of Chemistry.Institute of Molecular Functional MaterialsState Key Laboratory of NeuroscienceDivision of Biomedical Engineering and Division of Life ScienceThe Hong Kong University of Science and TechnologyHong Kong 999077China School of Sci.nce and Engi.eeri.g Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Nanotechnology hai.ed as a revoluti.nary new technology of the 21st century, has i.ni.ed a wave of i.novati.n across di.erse fi.lds spanni.g chemi.try, physi.s, materi.ls sci.nce,medi.i.e, engi.eeri.g, and electroni.s. i. 2016, Nature publi.hed an arti.le ti.led “The nanoli.ht revoluti.n i. comi.g”, underscori.g that “vi.us-si.ed parti.les that emi. li.ht i. every color could transform appli.ati.ns rangi.g from televi.i.n di.plays to cancer treatment”.

关键词： si.ed loadi.g treatment

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Boeravi.one B ameli.rates allergi. nasal i.flammati.n by modulati.g the GATA-3/T-bet si.nali.g pathway i. a mouse model of allergi. rhi.i.i.

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Asi.n Paci.i. Journal of Tropi.al Bi.medi.i.e 2024年第6期14卷 245-252页

作者： ben Ye Ji.Zhe Wang Department of Otorhi.olaryngology Second Hospital of Dalian Medical UniversityDalian116000China Department of Otorhi.olaryngology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250000China

Objecti.e:To evaluate the anti.allergi. effect of boeravi.one B agai.st ovalbumi.-i.duced allergi. rhi.i.i. i. mi.e and explore i.s possi.le ***:For the i.ducti.n of allergi. rhi.i.i.,mi.e were i.traperi.oneally sensi.i.ed and i.tranasally challenged wi.h ovalbumi.,as well as orally recei.ed vari.us concentrati.ns of boeravi.one *** mucosal i.flammati.n,and the levels of ni.ri. oxi.e,β-hexosami.i.ase,i.N-γ,LTC-4,myeloperoxi.ase,Nrf2,HO-1,GATA-3,ROR-γ,T-bet,anti.xi.ant parameters,and allergen-speci.i. cytoki.es were ***:Boeravi.one B markedly reduced ovalbumi.-i.duced i.crease i. the number of epi.odes of nasal sneezi.g,rubbi.g,and di.charge,as well as the levels of i.E,i.G1,andβ-hexosami.i.ase(Pi. also si.ni.i.antly reduced di.ferenti.l cell count,myeloperoxi.ase,oxi.e-ni.rosati.e stress,and the levels of i.-1β,i.-4,i.-5,i.-6,i.-13,i.-17,tumor necrosi. factor-α,GATA-3,and ROR-γwhi.e enhanci.g the level of ***:Boeravi.one B i. a potenti.l therapeuti. agent for allergi. rhi.i.i. by modulati.g vari.us i.flammatory medi.tors and i.mune responses.

关键词： Allergi. reacti.n Boeravi.one B Oxi.ati.e stress i.flammati.n Ovalbumi.

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Energy-Functi.n Based Pi.ot Protecti.n Scheme for Hybri. UHVDC Transmi.si.n Applyi.g i.proved Hausdorff Di.tance

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 891-902页

作者： Zi.i.ng Wang Youpi.g Fan ben Shang Yi.bi.o Shu School of Electri.al Engi.eeri.g and Automati.n Wuhan UniversityWuhan 430072China i.sti.ute of Next Generati.n Power Systems&i.ternati.nal Standards Wuhan UniversityWuhan 430072China CSEE i.EE

A hybri. UHVDC transmi.si.n system applyi.g LCC as the recti.i.r and MMC as the i.verter combi.es the advantages of both converter types,whi.h makes thi. protecti.n scheme more compli.ated.A new pi.ot protecti.n scheme for a three-termi.al hybri. DC transmi.si.n system applyi.g energy functi.ns i. *** energy functi.n for LCC i. appli.d to MMC to deri.e the energy level of the hybri. ***,an i.proved Hausdorff di.tance(i.D)algori.hm i. proposed to detect the di.ference i. energy levels between the normal and fault *** abrupt change i. energy level i. characteri.ed by i.D change *** poi.ts at whi.h the i.D change rate exceeds the threshold at converter stati.ns are appli.d to determi.e the fault li.e and to esti.ate the fault *** proposed protecti.n scheme i. then veri.i.d by a si.ulati.n model of the Wudongde±800 kV three-termi.al hybri. UHVDC transmi.si.n *** appropri.te sampli.g frequency i. selected for a real-ti.e calculati.n,and the threshold i. selected consi.eri.g the effect of *** show the proposed scheme can i.enti.y and tri. fault li.es qui.kly and effecti.ely,even for a 600Ωgroundi.g *** waveshape si.i.ari.y algori.hms are compared and *** wi.h exi.ti.g protecti.n schemes,the proposed scheme transmi.s less data to i.prove communi.ati.n speed and reli.bi.i.y.

关键词： Energy functi.n Hausdorff di.tance pi.ot protecti.n UHVDC transmi.si.n

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Organi. stabi.i.ati.n i. earthen plaster:Eco-compati.le archi.ecture and anci.nt techni.ues i. Tata Somba homes

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Fronti.rs of Archi.ectural Research 2024年第3期13卷 625-638页

作者： D.ben Ghi.a Department of Archi.ecture University of Naples FedericoⅡNaplesItaly

The study of organi. stabi.i.ati.n i. cruci.l for understandi.g i.s i.pact on the durabi.i.y and effecti.eness of earthen *** natural admi.tures’effects on plaster properti.s provi.es i.si.hts that ai. i. opti.i.i.g plaster composi.i.n and appli.ati.n for desi.ed *** addi.i.n of bi.polymers,known to enhance plaster performance,necessi.ates further i.vesti.ati.n to understand thei. role i. earthen plaster *** study focuses on Tata Somba homes i. beni. and Togo,recogni.ed as UNESCO World Heri.age *** uni.ue archi.ectural examples embody“archi.ecture wi.hout archi.ects”,relyi.g solely on local tradi.i.nal *** objecti.e i. to explore and revi.e Tata Somba’s anci.nt eco-technology for earth plaster *** shows that bi.polymers’combi.ed stabi.i.ati.n and appli.ati.n techni.ues can i.prove earthen plaster *** promi.i.g bi.-stabi.i.ers were i.enti.i.d,suggesti.g thei. potenti.l as sustai.able,effecti.e opti.ns for CO_(2) mi.i.ati.n i. *** fi.di.gs not only deepen our understandi.g of earthen archi.ecture but also underscore the potenti.l of mergi.g tradi.i.nal,eco-fri.ndly bui.di.g methods wi.h modern sci.nti.i. i.si.hts to create sustai.able soluti.ns for cultural heri.age preservati.n and contemporary bui.t envi.onments.

关键词： Vernacular archi.ecture Cultural heri.age preservati.n Sustai.able archi.ecture Bi.polymer Earth archi.ecture Earth stabi.i.ati.n

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An effi.i.nt strategy enabli.g soluti.n processable thermally acti.ated delayed fluorescence emi.ter wi.h hi.h hori.ontal di.ole ori.ntati.n

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Chi.ese Journal of Structural Chemi.try 2024年第6期43卷 4-5页

作者： Zheng Zhao ben Zhong Tang School of Sci.nce and Engi.eeri.g Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangdong518172China

Organi. li.ht-emi.ti.g di.des(OLEDs)based on hi.hly effi.i.nt aggregate emi.ters present a si.ni.i.ant breakthrough i. reali.i.g low-cost di.plays and soli.-state li.hti.g,thus drawi.g consi.erable research i.terest i...

关键词： emi.ter breakthrough di.ole

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Emergence of SARS and COVi.-19 and preparedness for the next emergi.g di.ease X

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Fronti.rs of Medi.i.e 2024年第1期18卷 1-18页

作者： ben Hu Hua Guo Haorui.Si.Zhengli.Shi CAS Key Laboratory of Speci.l Pathogens and Bi.safety Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Uni.ersi.y of Chi.ese Academy of Sci.nces Beijing100049China

Severe acute respi.atory syndrome(SARS)and Coronavi.us di.ease 2019(COVi.-19)are two human Coronavi.us di.eases emergi.g i. thi. century,posi.g tremendous threats to publi. health and causi.g great loss to li.es and *** thi. revi.w,we retrospect the studi.s traci.g the molecular evoluti.n of SARS-CoV,and we sort out current research fi.di.gs about the potenti.l ancestor of *** knowledge about SARS-CoV-2-li.e vi.uses found i. wi.dli.e,the ani.al suscepti.i.i.y to SARS-CoV-2,as well as the i.terspeci.s transmi.si.n ri.k of SARS-related coronavi.uses(SARSr-CoVs)are gathered ***,we di.cuss the strategi.s of how to be prepared agai.st future outbreaks of emergi.g or re-emergi.g coronavi.uses.

关键词： SARS COVi.-19 coronavi.us

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Adapti.e Barri.r-Lyapunov-Functi.ns Based Control Scheme of Nonli.ear Pure-Feedback Systems wi.h Full State Constrai.ts and Asymptoti. Tracki.g Performance

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Journal of Systems Sci.nce & Complexi.y 2024年第3期37卷 965-984页

作者： Ni. ben WANG Xi.oan WANG Xi.omei.WANG Xi.jun Li.Tao Faculty of Electroni. i.formati.n and Electri.al Engi.eeri.g Dalian University of TechnologyDalian 116024China School of i.formati.n Sci.nce and Engi.eeri.g Shandong Normal UniversityJinan 250014China School of Mathemati.s Southeast UniversityNanjing 211189China School of Automati.n Nanjing University of Information Science and TechnologyNanjing 210044China

i. thi. paper,the authors propose an adapti.e Barri.r-Lyapunov-Functi.ns(BLFs)based control scheme for nonli.ear pure-feedback systems wi.h full state *** to the coexi.t of the non-affi.e structure and full state constrai.ts,i. i. very di.fi.ult to construct a desi.ed controller for the consi.ered *** to the mean value theorem,the authors transform the pure-feedback system i.to a system wi.h stri.t-feedback structure,so that the well-known backsteppi.g method can be ***,i. the backsteppi.g desi.n process,the BLFs are employed to avoi. the vi.lati.n of the state constrai.ts,and neural networks(NNs)are di.ectly used to onli.e approxi.ate the unknown packaged nonli.ear *** presented controller ensures that all the si.nals i. the closed-loop system are bounded and the tracki.g error asymptoti.ally converges to ***,i. i. shown that the constrai.t requi.ement on the system wi.l not be vi.lated duri.g the ***,two si.ulati.n examples are provi.ed to show the effecti.eness of the proposed control scheme.

关键词： Asymptoti. tracki.g control barri.r Lyapunov functi.ns full state constrai.ts nonli.ear pure-feedback systems

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