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Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

cellular & Molecular Immunology 2023年第8期20卷 955-968页

作者： Manuel M.Vicente Inês alves Ângela Fernandes Ana M.Dias beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang Alexandra correia Anja Münster-Kühnel Afonso R.M.Almeida Sarina Ravens Gabriel A.Rabinovich Manuel Vilanova Ana E.Sousa SaloméS.Pinho i3S–Institute for Research and Innovation in Health University of PortoPortoPortugal Institute of Biomedical Sciences Abel Salazar(IcBAS) University of PortoPortoPortugal Graduate Program in Areas of Basic and Applied Biology(GABBA) ICBASUniversity of PortoPortoPortugal Faculty of Medicine University of PortoPortoPortugal Nephrology Department Centro Hospitalar e Universitário do PortoPortoPortugal Institute of Immunology Hannover Medical SchoolHannoverGermany Institute of clinical Biochemistry Hannover Medical SchoolHannoverGermany Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Laboratorio de Inmunopatología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Laboratorio de Inmuno-oncología Translacional Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Facultad de ciencias Exactas y Naturales(FcEyN) Universidad de Buenos AiresCiudad de Buenos AiresArgentina

T-cell development ensures the formation of diverse repertoires of T-cell receptors(TcRs)that recognize a variety of *** is a major posttranslational modification present in virtually all cells,including T-lymphocytes,that regulates activity/*** these structures are known to be involved in TcR-selection in DP thymocytes,it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to ***,we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes,as well as dynamic *** restricting the N-glycosylation profile of thymocytes to high-mannose structures,using specific glycoengineered mice(Rag1creMgat1fl/fl),we showed remarkable defects in key developmental checkpoints,includingß-selection,regulatory T-cell generation andγδT-cell development,associated with increased susceptibility to colon and kidney inflammation and *** further demonstrated that a single N-glycan antenna(modeled in Rag1creMgat2fl/fl mice)is the sine-qua-non condition to ensure normal *** conclusion,we revealed that mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inflammation susceptibility.

关键词： N-glycosylation T-cell development Thymocytes Glycocalyx Inflammation

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Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2195-2207页

作者： Manon van der Vlugt beatriz carvalho Joelle Fliers Nahid Montazeri christian Rausch Esmée J Grobbee Manon van Engeland Manon c W Spaander Gerrit A Meijer Evelien Dekker Department of Gastroenterology and Hepatology Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Pathology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands Biostatistics Unit Department of Gastroenterology and HepatologyAmsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Gastroenterology and Hepatology Erasmus MC University Medical CenterRotterdam 3015 CNNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands

BAcKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(cRcs)by FIT(FIT-interval cRcs)is an important *** of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)*** To compare the molecular make-up of FIT-interval cRcs to lesions that are detected by FIT[screen-detected cRcs(SD-cRcs)].METHODS FIT-interval cRcs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-cRcs in a 1:2 ratio,resulting in 27 FIT-interval cRc and 54 *** analyses included microsatellite instability(MSI),cpG island methylator phenotype(cIMP),DNA sequence mutations and copy number alterations(cNAs).RESULTS Although no significant differences were reached,FIT-interval cRcs were more often cIMP positive and MSI positive(33%cIMP in FIT-interval cRcs vs 21%in SD-cRcs(P=0.274);19%MSI in FIT-interval cRcs vs 12%in SD-cRcs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)*** mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-cRcs(68%vs 40%in FIT-interval cRcs P=0.035).Regarding cNAs differences between the two groups;FIT-interval cRcs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).cONcLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval cRcs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in *** indicates that proximal serrated lesions may be overrepresented among FITinterval cRcs.

关键词： Fecal immunochemical test-interval colorectal cancer Mutation analysis colorectal cancer screening Serrated pathway Adenoma-carcinoma pathway

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Restabilization Process in Matching Markets with Workers Proposing

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Open Journal of Discrete Mathematics 2022年第4期12卷 101-112页

作者： Millán beatriz Instituto de Matemática Aplicada San Luis IMASL Universidad Nacional de San Luis and CONICET San Luis Argentina Departamento de Matemática Universidad Nacional de San Juan San Juan Argentina

This paper is focused on the analysis, in the framework of lattice theory, of the matchings obtained from restabilization (after disruption) of stable matchings. When the disruption is due to entry workers or closure of firms the unemployed workers make offers to firms. The stable matching obtained is the firms-worst stable matching of the set of stable matchings that the firms weakly prefer to the initial stable matching (i.e., before being disrupted by changes in the population). More precisely, their position within the lattice of stable matchings is shown.

关键词： Stable Matchings Restabilization Lattice

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Folate Metabolism Interferes with Plant Immunity through 1c Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement

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Molecular Plant 2019年第9期12卷 1227-1242页

作者： beatriz Gonzalez Pablo Vera Instituto de Biologia Molecular y celular de Plantas Universidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain

Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae Dc3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective mutants identified a methionine synthase(METS1),in charge of the synthesis of Met through the folate-dependent 1c metabolism,acting as a nexus between the folate pathway and plant *** of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关键词： folate pathway plant immunity methionine DNA methylation

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Health care System in Portugal for People with Motor Problems

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Open Journal of Pathology 2023年第4期13卷 195-209页

作者： beatriz Ferreira Maria carolina IADE-Faculty of Design Technology and Communication of the European University University of Lisbon Lisbon Portugal

Purpose: From a social and labor inclusion perspective, the article presents a digital prototype conceptualized to provide a “Diagnostic Page”, which delivers various prescribers and suppliers of support products that mitigate the problems of the respective patients. It also provides a “Patient card Page”, where all the information about financing the respective products is placed, as well as all the documents likely to be needed for the commercial transactions to be carried out by all the parties involved. It also aims to provide a digital medium to grow a community in this niche market. In the action research methodology approach, the prototype was taken to funding competitions and conferences, where interviews and surveys were carried out, and a number of suggestions were collected on the type of platform to consider in order to respond to the concerns and needs of end users, such as patients, prescribers, suppliers and associations. Methods: The digital platform where the system is hosted uses algorithms that, on the diagnostic page, consider keywords used by patients and return a series of prescribers and suppliers of support products, in which the corresponding percentage of attenuation is taken into account and the best solution found to overcome the level of difficulty presented by the respective patients is delivered. Results and conclusions: It is hoped that, with this platform, people with motor problems will be able to obtain their diagnosis instantly, through the algorithm implemented, and that they will immediately be provided with a series of prescribers, suppliers and support products best suited to their needs, as well as all the information or conditions necessary to purchase or finance them. On the other hand, prescribers, suppliers and associations have an online platform where they can offer their consultations, products and other support as freelancers who are part of a community.

关键词： Health care System Marketplace Support Products Digital community Patient card

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A comparative study on emergent pollutants photo-assisted degradation using ruthenium modified titanate nanotubes and nanowires as catalysts

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Journal of Environmental Sciences 2020年第6期32卷 38-51页

作者： beatriz Barrocas M.conceicao Oliveira Helena I.S.Nogueira Sara Fateixa Olinda c.Monteiro centro de Química Estrutural Faculdade de CienciasUniversidade de LisboaLisboa 1749-016Portugal centro Química Estrutural Instituto Superior TécnicoUniversidade de LisboaLisboa 1049-001Portugal Department of chemistry CICECO-Aveiro Institute of MaterialsUniversity of AveiroAveiro 3810-193Portugal

Several methods have been used to tailor nanomaterials structure and ***,slight changes in the structure outcomes expressive improvements in the optical and photocatalytic properties of semiconductor *** this context,the influence of the metal doping and the morphology on a catalyst performance was studied in this ***,ruthenium doped titanate nanotubes(RuTNT)were synthesised for the first time using an amorphous Ru-containing ***,the photocatalytic performance of this sample was compared to the one obtained for ruthenium titanate nanowires(RuTNW),recently *** samples,RuTNW and RuTNT,were produced using the same Ru-containing precursor but distinct hydrothermal *** powders were structural,morphological and optical characterized by X-ray diffraction and fluorescence,transmission electron microscopy,Raman,X-ray photoelectron and photoluminescence *** variations on the structural and optical properties of the RuTNT and RuTNW nanoparticles,due to ruthenium incorporation were *** potential use as photocatalysts was evaluated on the hydroxyl radical photo-assisted *** samples were catalytic for this reaction,presenting better performances than the pristine counterparts,being RuTNT the best ***,the degradation of two emergent pollutants,caffeine and sulfamethazine,was *** demonstrated to be better photocatalyst than RuTNW for caffeine but identical performances were obtained for *** both catalysts,the degradation mechanism of the pollutants was explored through the identification and quantification of the intermediate compounds produced and several differences were *** indicates the importance of the structural and morphological aspects of a material on its catalytic performance.

关键词： Titanate nanotubes and nanowires Ruthenium doping Ru-Ti replacement Emergent pollutants Photocatalytic degradation

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Nutritional therapy for hospitalized patients with cOVID-19:A narrative and integrative review

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Journal of Intensive Medicine 2022年第4期2卷 249-256页

作者： beatriz H.Grecco Paula A.O.Araújo-Rossi carolina F.Nicoletti Department of Nutrition School of Public HealthUniversity of São PauloSão PauloSPBrazil Applied Physiology and Nutrition Research Group Rheumatology DivisionFaculty of MedicineUniversity of São PauloAv Dr Arnaldo 455São PauloSP 01246-903Brazil

Hospitalized patients affected by coronavirus disease 19(cOVID-19)have a sustained pro-inflammatory state and recurrent gastrointestinal symptoms that correlate with a decline in the nutritional status,which is directly related to poor immune response and clinical *** therapy has proven crucial in cOVID-19 treatment through the provision of adequate amounts of *** the beginning of the pandemic,medical societies have mobilized to provide practical nutritional guidelines to support decision-making;despite this,there are only a few studies dedicated to compiling the most relevant *** this narrative review,we aimed to summarize and stratify the current scientific literature on nutritional support for hospitalized cOVID-19 *** carried out a literature review from three databases between January 2020 and July 2021,using nutrition therapy(or medical nutrition or enteral nutrition or parental nutrition or nutritional support)and cOVID-19(SARS-coV-2 infection)as the search *** those studies that evaluated adult hospitalized patients with admissions to wards,specific clinics,or intensive care units were *** nutritional intervention considered was that of specific nutritional support via oral,enteral,or parenteral modes.A total of 37 articles were *** general,the nutritional care provided to cOVID-19 patients follows the same premises as for other patients,i.e.,it opts for the most physiological route and meets nutritional demands based on the clinical ***,some protocols that minimize the risk of contamination exposure for the health team have to be *** requirements varied from 15 kcal/kg/day to 30 kcal/kg/day and protein goals from 1.2 g/kg/day to 2 g/kg/*** both cases,the ramp protocol for increased supply should be *** cases of enteral therapy,ready-to-use diet and continuous mode are *** to refeeding syndrome is essential when parenteral n

关键词： cOVID-19 Nutritional support Enteral nutrition Parenteral nutrition Energy requirement Protein supply

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Optimization of enhanced weathering networks with alternative transportation modes

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carbon Resources conversion 2022年第2期5卷 167-176页

作者： Raymond R.Tan beatriz A.Belmonte Michael Francis D.Benjamin Viknesh Andiappan Kathleen B.Aviso Department of chemical Engineering De La Salle University2401 Taft Avenue0922 ManilaPhilippines Research center for the Natural and Applied Sciences/Department of chemical Engineering University of Santo TomasEspana Blvd.1015 ManilaPhilippines School of Engineering and Physical Sciences Heriot-Watt University Malaysia62200PutrajayaWilayah Persekutuan PutrajayaMalaysia Faculty of Engineering Computing and ScienceSwinburne University of TechnologyJalan Simpang Tiga93350KuchingSarawakMalaysia

Enhanced weathering of alkaline rocks and minerals is a negative emissions technology (NET) that is potentiallyscalable to deliver gigaton-level carbon dioxide removal (cDR) for climate change mitigation. This techniquerelies on the acceleration of naturally occurring weathering reactions with water and carbon dioxide by reducingthese substances into a fine powder with high specific surface area. The ex situ enhanced weathering processchain consists of the acquisition of suitable natural or synthetic materials, grinding to a fine particle size,transportation, and application on suitable sites. Future enhanced weathering systems can be envisioned assupply chain-like networks which have to be optimized to deliver maximum cDR given physical *** is a notable research gap in the literature on decision support for such systems. To address this gap, amixed integer linear programming (MILP) model is developed in this work to optimize enhanced weatheringnetworks for cDR. The model also incorporates the availability of multiple transportation options and constraintson network topology. Two test cases are used to demonstrate the model capability to determine optimal andnear-optimal networks. The top ten solutions in these two scenarios yield total cDR levels of 3.4316–3.4363 Mtand 15.27017–15.27960 Mt.

关键词： Process integration Optimization Mathematical programming carbon drawdown carbon management network Decarbonization

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Significance Analysis of RTI Tier 2 Metaphonological and Alphabetic Principle Program for Brazilian Schoolchildren at Risk for Dyslexia

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Psychology Research 2022年第7期12卷 552-561页

作者： Melissa Pinotti Marguti Alexandra beatriz Portes de cerqueira césar Simone Aparecida capellini São Paulo State University“Júlio de Mesquita Filho”(UNESP) MariliaSão PauloBrazil

Aim:to analyze the significance of RTI Tier 2 metaphonological and alphabetic principle program for Brazilian schoolchildren at risk for ***:a bibliographic review was carried out in the Scielo and Pubmed databases using the descriptors“intervention studies”,“reading”,“dyslexia”,and“learning”in Portuguese and English for the elaboration of RTI Tier 2 metaphonological and alphabetic principle program for schoolchildren at risk for *** program was designed based on the selection of strategies for metaphonological skills,knowledge of the alphabet,and grapheme-phoneme correspondence described in national and international *** stimuli(real words)and visual stimuli(pictures)were selected to be used in the intervention program *** stimuli were selected from a word bank according to length,regularity,and *** intervention program designed was composed of the following skills:letter-sound knowledge,syllable knowledge,syllabic segmentation,phonemic segmentation,syllabic addition,phonemic addition,syllabic subtraction,phonemic subtraction,syllabic substitution,phonemic substitution,syllabic combination,and phonemic *** program was structured with collective strategies and was applied in small groups of four to five schoolchildren aged six years and 11 months to seven years and 11 months in 50-minute ***:The results revealed that there was a change in the response pattern,showing better performance in the skills of the Early Identification of Reading Problems Protocol,demonstrating significance and positive change in post-testing situations when compared to ***:the program developed in this study proved to be effective and,in this way,it can be used as an intervention instrument based on scientific evidence that helps in the acquisition of skills necessary for the development of reading.

关键词： dyslexia literacy metaphonological skills predictors for literacy clinical significance

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construction of a Quadratic Model for Predicted and Measured Global Solar Radiation in chile

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chinese Physics Letters 2007年第1期24卷 291-293页

作者： Ercan YILMAZ beatriz cANcINO Edmundo LOPEZ Department of Physics Mustafa Kemal University 31040 Antakya Turkey Department of Food Engineering Pontificia Universidad Catdlica de Valparaiso Chile Department of Electrical Engineering Pontificia Universidad Cat61ica de Valparaiso Chile

Global solar radiation data for sites in chile are analysed and presented in a form suitable for their use in engineering. A new model for monthly average data is developed to predict monthly average global radiation with acceptable accuracy by using actinographic data due to scarcing of pyranometer data. Use of the new quadratic model is proposed because of its relatively wider spectrum of values for Angstrom coefficients ao, al, and a2.

关键词： Quadratic Model Global Solar Radiation chile engineering

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