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Comparison of morphological and functional outcomes of mouse sciatic nerve repair with three biodegradable polymer conduits containing poly (lactic acid)

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Neural Regeneration Research 2018年第10期13卷 1811-1819页

作者： Fernanda Marques Pestana Rui C.C.Domingues Júlia Teixeira Oliveira daniela F.P.A.Durco Camila Oliveira Goulart Henrique Rocha Mendonca Anne Caroline Rodrigues dos Santos Natália Tavares de Campos beatriz theodoro da silva Cristina Cardoso Pereira Cristiano Piacsek Borges Ana Maria Blanco Martinez Pós Graduacao em Ciências Morfológicas Instituto de Ciências Biomédicas-UFRJRio de Janeiro RJ Brazil Anatomia Patológica-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil Laboratório de Neurodegeneracao e Reparo-Faculdade de Medicina-HUCFF-UFRJ Rio de Janeiro RJ Brazil Programa de Eng. Química COPPE-UFRJRio de Janeiro Brazil Polo Universitário de Macaé Laboratório Integrado de Produtos Bioativos e BiociênciasMacaê UFRJ Brazil

Poly（lactic acid）（PLA）-containing nerve guidance conduits（NGCs） are currently being investigated for nerve repair as an alternative to autograft, which leads to permanent functional impairment in the territory innervated by the removed nerve. Combination of polymers modifies the physical properties of the conduits, altering their nerve-guidance properties. Conduits made from PLA-only or combined with other polymers have been used successfully for nerve repair, but their efficiency has not been compared. We compared the morphological and functional outcomes of peripheral nerve repair by using NGCs made of poly（lactic acid） and combined or not with polycaprolactone（PLA/PCL） or polyvinylpyrrolidone（PLA/PVP）. To assess the functional recovery, we employed a mechanical hyperalgesia analysis, sciatic functional index（SFI）, and electroneuromyography. The mechanical hyperalgesia analysis showed that the PLA group improved more rapidly than the PLA/PVP and PLA/PCL groups; similarly, in the electroneuromyography assay, the PLA group exhibited higher amplitude than the PLA/PCL and PLA/PVP groups. However, the SFI improvement rates did not differ among the groups. Morphologically, the PLA group showed more vascularization, while the nerve fiber regeneration did not differ among the groups. In conclusion, the PLA-only conduits were superior to the other NGCs tested for nerve repair.

关键词： sciatic nerve tubulization biodegradable conduit poly(lactic acid) regeneration

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Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： david Sanchez-Marin Macrina beatriz silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman Alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

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Radical Prostatectomy by Laparotomy: Retrospective Study Comparing Separate and Continuous Stitches in the Performance of Vesicourethral Anastomosis at a Single Center in the Public Health Network

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Open Journal of Urology 2024年第6期14卷 368-379页

作者： Guilherme Canabrava Rodrigues silva Tarcizo Afonso Nunes Rafael Calvão Barbuto Thiffany Quartarollo Lopes beatriz Melo De Almeida Departamento de Cirurgia da FMUFMG e da PUC-MG Belo Horizonte Brazil Departamento de Cirurgia da FMUFMG Belo Horizonte Brazil Acadmica de Medicina da Universidade Federal de Minas Gerais (UFMG) Belo Horizonte Brasil Acadmica de Medicina da Pontifcia Universidade Catlica de Minas Gerais (PUC-MG) Betim Brasil

Background: Prostate cancer ranks as the second most prevalent malignancy in men, with treatment strategies ranging from observation to various interventions. Radical prostatectomy is a common approach, aiming for a cure, and the technique for vesico-urethral anastomosis varies, employing separate or continuous stitches. However, a consensus on the optimal technique is lacking. This study aims to compare vesico-urethral anastomosis techniques (separate vs. continuous stitches) in laparotomy-based radical prostatectomies, evaluating peri and postoperative outcomes. Materials and Method: A retrospective analysis of 140 patients’ medical records yielded 86 eligible cases, divided into two groups based on anastomosis technique. Both groups underwent surgery at the same urology center between 2016 and 2019, with a follow-up period exceeding 12 months. Pre-operative characteristics were statistically similar between groups. Results: Perioperative complication rates did not significantly differ between the two techniques (p > 0.99). However, the continuous stitch group experienced a 20-minute longer procedure time (p 0.05), patients with continuous stitches had 2.5 times higher diaper usage at twelve months (p Conclusion: This research suggests that vesico-urethral anastomosis with separate stitches yields superior results in laparotomy-based radical prostatectomies compared to continuous stitches, demonstrating benefits in surgical time, hospital stay, sentinel drain duration, stenosis rates, and long-term urinary incontinence outcomes.

关键词： Prostate Cancer Urinary Incontinence Urethrovesical Anastomosis

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Clinicopathological Description of a Chronic Lymphocytic Leukemia in a Dog

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Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： Maria Clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana Carolina Capais Rodrigues Sheila Canevese Rahal John P. Kastelic Luíz Guilherme Dercore Benevenuto Iolanda Simões Braga beatriz Poloni Batista Felipe César da silva Brasileiro Fernanda Barthelson Carvalho de Moura Priscylla Tatiana Chalfun Guimarães Okamoto Regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha Department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. Despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

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Possibilities of using silicate rock powder:An overview

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Geoscience Frontiers 2022年第1期13卷 446-456页

作者： Claudete Gindri Ramos James C.Hower Erika Blanco Marcos Leandro silva Oliveira Suzi Huff theodoro Department of Civil and Environmental Engineering Universidad de la CostaCalle 58#55-66BarranquillaColombia Departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600Santiago de Surco 1503Peru Center for Applied Energy Research University of Kentucky2540 Research Park DriveLexingtonKY 40511USA Department of Earth&Environmental Sciences University of KentuckyLexingtonKY 40511USA Postgraduate Program of Environment and Rural Development(PPG-MADER) Área Universitária01Vila Nossa Senhora de Fátima–Campus UnBPlanaltinaDFBrazil

This study evaluates the on use of crushed rocks(remineralizers)to increase soil fertility levels and which contributed to increase agricultural productivity,recovery of degraded areas,decontamination of water,and carbon *** use of these geological materials is part of the assumptions of rock technology and,indirectly,facilitates the achievement of sustainable development goals related to soil management,climate change,and the preservation of water *** over the past 50 years on silicate rocks focused on soil fertility management and agricultural *** recently,the combined use with microorganisms and organic correctives have shown positive results to mitigate soil degradation;to expand carbon sequestration and storage;and to contribute to the adsorption of contaminants from water and *** this article we show results obtained in several countries and we show that this technology can contribute to the sustainability of agriculture,as well as to reverse global *** mineral nutrients are released more slowly from these types of inputs,they remain in the soil for a longer time,stimulating the soil *** addition,they are a technology to soluble synthetic fertilizers replace,since the few nutrients derived from such inputs not consumed by plants are lost by leaching,contaminating groundwater and water *** addition,conventional methods rely heavily on chemical pesticides which cause damage to soil’s microfauna(responsible for the decomposition of organic matter and nutrient cycling)and the loss of organic carbon(in the form of dioxide),which is quickly dispersed in the *** rock powders are applied in natura,have long-lasting residual effects and reduce greenhouse gas emissions.

关键词： Rock powder Soil management Carbon storage Water contaminant adsorption

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Fracture Loci in Sheet Metal Forming: A Review

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Acta Metallurgica Sinica(English Letters) 2015年第12期28卷 1415-1425页

作者： M.beatriz silva Kerim Isik A.Erman Tekkaya Paulo A.F.Martins IDMEC Instituto Superior Técnico Universidade de Lisboa Institute of Forming Technology and Lightweight Construction Technical University of Dortmund

Fracture in sheet metal forming usually occurs as ductile fracture, rarely as brittle fracture, at the operating temperatures and rates of loading that are typical of real processes in two different modes：（1） tensile and（2） in-plane shear（respectively, the same as modes I and II of fracture mechanics）. The circumstances under which each mode will occur are identified in terms of plastic flow and ductile damage by means of an analytical approach to characterize fracture loci under plane stress conditions that takes anisotropy into consideration. Fracture loci was characterized by means of the fracture forming limit line and by the shear fracture forming limit line in the fracture forming limit diagram. Experiments were performed with single point incremental forming and double-notched test specimens loaded in tension, torsion and in-plane shear give support to the presentation and allow determining the fracture loci of AA1050-H111 aluminium sheets with1 mm thickness. The relation between fracture toughness and the fracture forming limits was also investigated by comparing experimental values of the strains at fracture obtained from a truncated conical part produced by single point incremental forming and from double-notched test specimens loaded in tension.

关键词： Sheet forming Fracture Fracture forming limit diagram

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Advanced glycation end product:A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study

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World Journal of Gastroenterology 2021年第29期27卷 4913-4928页

作者： Evelyn Nunes Goulart da silva Pereira daniela Polessa Paula beatriz Peres de Araujo Maria de Jesus Mendes da Fonseca Maria de Fátima Haueisen Sander Diniz Anissa daliry Rosane Harter Griep Laboratory of Cardiovascular Investigation Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil National School of Statistical Sciences Brazilian Institute of Geography and StatisticsRio de Janeiro 20231-050Brazil Department of Epidemiology and Quantitative Methods in Health Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil Faculty of Medicine Universidade Federal de Minas GeraisMinas Gerais 31270-901Brazil Laboratory of Health and Environment Education Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil

BACKGROUND Liver diseases are associated with the excess formation of advanced glycation end products(AGEs),which induce tissue inflammation and oxidative ***,the trend of oxidative marker levels according to the steatosis grade in non-alcoholic fatty liver disease(NAFLD)is *** To compare serum AGE levels between participants with NAFLD accordingly to steatosis severity in the baseline ELSA-Brasil *** In 305 individuals at baseline ELSA-Brasil,NAFLD-associated steatosis was classified by ultrasound hepatic *** participants were grouped according to the severity of steatosis:mild and moderate/severe *** measurement of serum fluorescent AGE concentrations was based on spectrofluorimetric *** AGE content and clinical and laboratory characteristics of the participants were compared between *** correlation between serum AGE levels and the grade of steatosis was *** regression analysis was used to investigate the relationship between serum AGE levels and steatosis severity.A P value<0.05 was considered statistically *** According to the steatosis severity spectrum in NAFLD,from mild to moderate/severe,individuals with the most severe steatosis grade had a higher incidence of metabolic syndrome(63%vs 34%,P≤0.001),diabetes mellitus(37%vs 14%,P≤0.001),and high cholesterol levels(51%vs 33%,P<0.001).Moreover,individuals with increasing severity of steatosis presented increasing waist circumference,body mass index,systolic and diastolic blood pressure,fasting blood glucose,glycated hemoglobin,insulin,triglycerides,alanine aminotransferase,gamma-glutamyl transferase,C-reactive protein,and uric acid levels and lower high-density *** serum AGE content was present in the moderate/severe group of individuals than in the mild group(P=0.008).In addition,the serum AGE levels were correlated with the steatosis grade in the overall sample(rho=0.146,P=0.010).Logistic regres

关键词： Advanced glycation end products Non-alcoholic fatty liver disease Steatosis ELSA-Brasil study Spectroscopy

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Usher syndrome:Genetic diagnosis and current therapeutic approaches

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World Journal of Otorhinolaryngology 2024年第1期11卷 1-17页

作者： beatriz Rocha Cuzzuol Jonathan Santos Apolonio Ronaldo Teixeira da silva Júnior Lorena Sousa de Carvalho Luana Kauany de SáSantos Luciano Hasimoto Malheiro Marcel silva Luz Mariana Santos Calmon Henrique de Lima Crivellaro Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Usher Syndrome(USH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf *** genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmentosa,and,in some cases,vestibular *** the subtypes of USH,USH type 1 is considered the most severe form,presenting profound bilateral congenital deafness,vestibular areflexia,and early onset *** type 2 is the most common form,exhibiting congenital moderate to severe HL for low frequencies and severe to profound HL for high ***,type 3 is the rarest,initially manifesting mild symptoms during childhood that become more prominent in the first decades of *** dual impact of USH on both visual and auditory senses significantly impairs patients'quality of life,restricting their daily activities and interactions with *** date,9 genes have been confirmed so far for USH:MYO7A,USH1C,CDH23,PCDH15,USH1G,USH2A,ADGRV1,WHRN and *** genes are inherited in an autosomal recessive manner and encode proteins expressed in the inner ear and retina,leading to functional *** non-genetic methods can assist in patient triage and disease extension evaluation,genetic and molecular tests play a pivotal role in providing genetic counseling,enabling appropriate gene therapy,and facilitating timely cochlear implantation(CI).The CRISPR/Cas9 system and viral-based gene replacement therapy have recently emerged as highly promising techniques for treating *** drug therapy,PTC-124 and Nb54 have been identified as promising drug interventions for genetic HL in ***,CI has proven to be critical in the restoration of *** review aims to summarize the genetic and molecular diagnosis of USH and highlight the importance of early diagnosis in Cuzzuol BR et *** and current treatments of USH WJO https://*** 2 January 19,2024 Volume 11 Issue 1 guiding appropriate treatment strategies and i

关键词： Usher syndromes Hearing loss Retinitis pigmentosa Diagnosis Genetic therapies Cochlear implantation Quality of life

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Stem cells and pain

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World Journal of Stem Cells 2023年第12期15卷 1035-1062页

作者： Matheus Deroco Veloso da silva Maiara Piva Geovana Martelossi-Cebinelli Mariana Stinglin Rosa Ribas beatriz Hoffmann Salles Bianchini Olivia K Heintz Rubia Casagrande Waldiceu A Verri Jr Department of Pathology Laboratory of PainInflammationNeuropathy and CancerState University of LondrinaLondrina 86057-970ParanáBrazil Morningside Graduate School of Biomedical Sciences University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Pharmaceutical Sciences Center of Health ScienceState University of LondrinaLondrina 86038-440ParanáBrazil Department of Pathology Laboratory of PainInflammationNeuropathy and CancerCenter of Biological SciencesState University of LondrinaLondrina 86057-970ParanáBrazil

ain can be defined as an unpleasant sensory and emotional experience caused by either actual or potential tissue damage or even resemble that unpleasant *** years,science has sought to find treatment alternatives,with minimal side effects,to relieve ***,the currently available pharmacological options on the market show significant adverse ***,the search for a safer and highly efficient analgesic treatment has become a *** cells(SCs)are non-specialized cells with a high capacity for replication,self-renewal,and a wide range of differentiation *** this review,we provide evidence that the immune and neuromodulatory properties of SCs can be a valuable tool in the search for ideal treatment strategies for different types of *** the advantage of multiple administration routes and dosages,therapies based on SCs for pain relief have demonstrated meaningful results with few ***,there are still more questions than answers when it comes to the mechanisms and pathways of pain targeted by ***,this is an evolving field that merits further investigation towards the development of SCbased analgesic therapies,and this review will approach all of these aspects.

关键词： Inflammation Neuropathy Nociceptive Pain Pain treatment Stem cells

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Almond cold-pressed oil by-product as ingredient for cookies with potential health benefits:Chemical and sensory evaluation

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Food Science and Human Wellness 2019年第3期8卷 292-298页

作者： Joao C.M.Barreira M.Antonia Nunes beatriz Vieira da silva Filipa B.Pimentel Anabela S.G.Costa M.Alvarez-Ortic J.E.Pardo M.beatriz P.P.Oliveira REQUIMTE/LAQV Faculdade de Farmácia da Universidade do PortoR.Jorge Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacade Montanha(CIMO) Instituto Politécnico de BragancaCampus de Santa Apolónia5300-253PortoPortugal Escuela Técnica Superior de Ingenieros Agrónomos y de Montes Universidad de Castilla-La ManchaCampus Universitario02071AlbaceteSpain

Nowadays,food security is a global concern and a great scientific ***-industrial by-products can be used as potential ingredients of innovative food products,contributing to solve this societal ***-products of high specialty oils processing,for instance,have remarkable nutritional and organoleptic ***,the partially delipidified almond flour(PdaF)remaining from almond oil extraction,was used as an alternative ingredient in a highly appreciated almond-based cookie(“almendrados”).For comparison purposes,four different“almendrados”formulations(one industrial,two with PdaF,and one with whole almond flour),were compared regarding nutritional composition,vitamin E and fatty acids *** assess the cookie sensory properties,seventy-four consumers evaluated“appearance”,“taste”,“sweetness”,“crunchiness”,“hardness”,“overall quality”using adequate hedonic *** and protein levels showed significant differences among industrial and the other three *** with PdaF presented similar tocopherols and fatty acids to the traditional(more expensive)formulation,besides reaching the highest scores on“appearance”,“sweetness”,“hardness”,“overall quality”and“buying predisposition”***,the incorporation of PdaF might represent an effective way of adding value to an industrial by-product,while providing a pleasant novel cookie formulation.

关键词： By-products Almond Food security Cookie formulation Principal component analysis

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